Page last updated: 2024-10-26

donepezil and Pheochromocytoma

donepezil has been researched along with Pheochromocytoma in 2 studies

Donepezil: An indan and piperidine derivative that acts as a selective and reversible inhibitor of ACETYLCHOLINESTERASE. Donepezil is highly selective for the central nervous system and is used in the management of mild to moderate DEMENTIA in ALZHEIMER DISEASE.
donepezil : A racemate comprising equimolar amounts of (R)- and (S)-donepezil. A centrally acting reversible acetylcholinesterase inhibitor, its main therapeutic use is in the treatment of Alzheimer's disease where it is used to increase cortical acetylcholine.
2-[(1-benzylpiperidin-4-yl)methyl]-5,6-dimethoxyindan-1-one : A member of the class of indanones that is 5,6-dimethoxyindan-1-one which is substituted at position 2 by an (N-benzylpiperidin-4-yl)methyl group.

Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Research Excerpts

ExcerptRelevanceReference
"The effect of the cholinesterase inhibitors tacrine and donepezil on A beta(25-35)-induced toxicity was investigated in rat pheochromocytoma PC12 cells by measuring the mitochondrial activity."3.70Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells. ( Nordberg, A; Svensson, AL, 1998)

Research

Studies (2)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's1 (50.00)18.2507
2000's1 (50.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Reid, RT1
Sabbagh, MN1
Svensson, AL1
Nordberg, A1

Other Studies

2 other studies available for donepezil and Pheochromocytoma

ArticleYear
Effects of donepezil treatment on rat nicotinic acetylcholine receptor levels in vivo and in vitro.
    Journal of Alzheimer's disease : JAD, 2003, Volume: 5, Issue:6

    Topics: Aconitine; Animals; Binding Sites; Bridged Bicyclo Compounds, Heterocyclic; Cholinesterase Inhibitor

2003
Tacrine and donepezil attenuate the neurotoxic effect of A beta(25-35) in rat PC12 cells.
    Neuroreport, 1998, May-11, Volume: 9, Issue:7

    Topics: Adrenal Gland Neoplasms; Amyloid beta-Peptides; Animals; Cell Survival; Cholinesterase Inhibitors; D

1998