normetanephrine has been researched along with Pheochromocytoma in 235 studies
Normetanephrine: A methylated metabolite of norepinephrine that is excreted in the urine and found in certain tissues. It is a marker for tumors.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "This single-centre, prospective trial investigated the use of CST in 60 patients with suspected PPGL associated with out-patient elevations of plasma normetanephrine (NMN) and/or metanephrine (MN), in most cases accompanied with hypertension or an adrenal mass." | 9.51 | Clonidine suppression test for a reliable diagnosis of pheochromocytoma: When to use. ( Dralle, H; Führer, D; Geroula, A; Pamporaki, C; Schmid, KW; Tsiomidou, S; Unger, N; Van Baal, L; Weber, F, 2022) |
| "Various studies have validated plasma free metanephrines (MNs) as biomarkers for pheochromocytoma and paraganglioma (PPGL)." | 8.95 | ACCURACY OF PLASMA FREE METANEPHRINES IN THE DIAGNOSIS OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS. ( Cao, X; Chen, Y; Huang, X; Li, Y; Xiao, H; Zhou, X, 2017) |
| "Measurement of free metanephrines is recommended for screening of pheochromocytoma (PCC) but requires appropriate reference intervals (RIs)." | 8.31 | Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma. ( Galac, S; Grinwis, GCM; Kema, IP; Kooistra, HS; Teske, E; van den Berg, MF; van Faassen, M; van Nimwegen, SA, 2023) |
| "Sampling of blood in the supine position for diagnosis of pheochromocytoma and paraganglioma (PPGL) results in lower rates of false positives for plasma normetanephrine than seated sampling." | 8.12 | Preanalytical Considerations and Outpatient Versus Inpatient Tests of Plasma Metanephrines to Diagnose Pheochromocytoma. ( Amar, L; Baron, S; Blanchard, A; Braun, L; Ceccato, F; Davies, E; Deinum, J; Deutschbein, T; Dobrowolski, P; Eisenhofer, G; Fassnacht, M; Gruber, S; Hampson, S; Januszewicz, A; Lenzini, L; Müller, LM; Nölting, S; Pamporaki, C; Pecori, A; Peitzsch, M; Pommer, G; Prejbisz, A; Remde, H; Rossi, GP; Stell, A; Timmers, HJLM; Zennaro, MC, 2022) |
| "Accurate diagnosis of pheochromocytoma and paraganglioma (PPGLs) is highly dependent on the detection of metanephrines and catecholamines." | 8.02 | Study of stability and interference for catecholamines and metanephrines, 3-methoxytyramine: key point of an accurate diagnosis for pheochromocytoma and paraganglioma. ( Cong, H; Gao, X; Guo, Y; Shi, X; Sun, N; Wang, K; Xie, L; Zhang, W; Zhou, Z, 2021) |
| "Measurements of plasma free metanephrines are recommended for diagnosing pheochromocytomas and paragangliomas (PPGL)." | 8.02 | Diagnostic Accuracy of Salivary Metanephrines in Pheochromocytomas and Paragangliomas. ( Eijkelenkamp, K; Kema, IP; Kerstens, MN; Links, TP; Osinga, TE; Pacak, K; Sluiter, WJ; van der Horst-Schrivers, ANA; van Faassen, M, 2021) |
| "Urinary measurement of fractionated metanephrines is one of the best available biochemical tests for the diagnosis of pheochromocytoma and paraganglioma; however, false-positive results remain an issue." | 7.96 | Clinical factors affecting spot urine fractionated metanephrines in patients suspected pheochromocytoma/paraganglioma. ( Bokuda, K; Ichihara, A; Seki, Y; Yatabe, M, 2020) |
| "The 24 h urinary-fractionated metanephrine (MN) and normetanephrine (NMN) are recommended as the preferred indicators for laboratory diagnosis of pheochromocytoma and paraganglioma (PPGL)." | 7.96 | Stability and reference intervals of spot urinary fractionated metanephrines and methoxytyramine by tandem mass spectrometry as a screening method for pheochromocytoma and paraganglioma. ( Cong, H; Dai, S; Gao, X; Shi, X; Wang, K; Zhang, W; Zhou, Z, 2020) |
| "In patients with phaeochromocytomas or paragangliomas (PPGLs), 24-h urine collections for metanephrines (uMNs) are cumbersome." | 7.96 | Random 'spot' urinary metanephrines compared with 24-h-urinary and plasma results in phaeochromocytomas and paragangliomas. ( Grossman, AB; Isidori, AM; Jafar-Mohammadi, B; James, T; Maunsell, Z; May, CJH; Sbardella, E; Shine, B; Tadman, M, 2020) |
| "Plasma free metanephrines are commonly used for diagnosis of pheochromocytoma and paraganglioma (PPGLs), but can also provide other information." | 7.96 | Plasma metanephrines and prospective prediction of tumor location, size and mutation type in patients with pheochromocytoma and paraganglioma. ( Bechmann, N; Beuschlein, F; Calsina, B; Constantinescu, G; Deutschbein, T; Eisenhofer, G; Fankhauser, M; Fassnacht, M; Fliedner, S; Langton, K; Lenders, JWM; Monteagudo, M; Nölting, S; Pamporaki, C; Peitzsch, M; Prejbisz, A; Robledo, M; Stell, A; Timmers, HJLM, 2020) |
| "This work discusses the clinical performance of chromogranin A, free metanephrine and normetanephrine determination in plasma using a radioimmunoanalytical methods for the diagnosis of pheochromocytoma and paraganglioma." | 7.85 | Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma. ( Bílek, R; Dušková, J; Michalský, D; Novák, K; Václavíková, E; Vlček, P; Widimský, J; Zelinka, T, 2017) |
| "Plasma metanephrines (PMN) are highly sensitive for diagnosis of pheochromocytoma, but the natural history of PMN before pheochromocytoma diagnosis has not been previously described." | 7.83 | Longitudinal plasma metanephrines preceding pheochromocytoma diagnosis: a retrospective case-control serum repository study. ( Abbott, KC; Baker, T; Oliver, D; Olson, SW; Prince, LK; Yoon, S, 2016) |
| "This work discusses the clinical performance of deconjugated metanephrine (MN), normetanephrine (NMN) and 3-methoxytyramine (3MT) determined in the basal first morning urine using a chromatographic method with electrochemical detection for the clinical diagnosis of pheochromocytoma (PHEO) and paraganglioma (PGL)." | 7.81 | Deconjugated urinary metanephrine, normetanephrine and 3-methoxytyramine in laboratory diagnosis of pheochromocytoma and paraganglioma. ( Bešťák, J; Bílek, R; Dušková, J; Michalský, D; Novák, K; Vlček, P; Widimský, J; Zelinka, T, 2015) |
| "There was no seasonal variation in the plasma concentrations of metanephrines among patients with pheochromocytoma, whereas among those without tumors, the plasma concentrations of normetanephrine were higher (P<0." | 7.80 | Seasonal variation in plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma. ( Bornstein, SR; Bursztyn, M; Eisenhofer, G; Lenders, JW; Pamporaki, C; Reimann, M; Sweep, FC; Timmers, H; Ziemssen, T, 2014) |
| "Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe." | 7.80 | Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients. ( Adachi, M; Arai, Y; Hara, H; Hashimoto, K; Hataya, Y; Ikeda, Y; Imai, T; Isobe, K; Kamide, K; Kato, T; Kawakami, Y; Kikumori, T; Ma, E; Maeda, Y; Matsuda, T; Midorikawa, S; Okada, Y; Sakurai, A; Shimano, H; Takahashi, H; Takekoshi, K; Tanaka, Y; Yanase, T; Yokoyama, C, 2014) |
| "The purpose of this study was to investigate the utility of measurement of plasma free metanephrines in dogs for the diagnosis of pheochromocytoma." | 7.79 | Comparison of plasma free metanephrines between healthy dogs and 3 dogs with pheochromocytoma. ( Frank, EL; Green, BA, 2013) |
| " Determination of metanephrines by high-pressure liquid chromatography has been well established for the diagnosis of pheochromocytomas, demonstrating high sensitivity and specificity." | 7.78 | Plasma and urinary metanephrines determined by an enzyme immunoassay, but not serum chromogranin A for the diagnosis of pheochromocytoma in patients with adrenal mass. ( Deutschbein, T; Hinrichs, J; Mann, K; Petersenn, S; Schmidt, H; Unger, N; Walz, MK, 2012) |
| "All patients with pheochromocytoma/paraganglioma had abnormally elevated concentrations of either plasma metanephrine or normetanephrine." | 7.77 | Comparison of plasma metanephrines measured by a commercial immunoassay and urinary catecholamines in the diagnosis of pheochromocytoma. ( Christensen, TT; Frystyk, J; Poulsen, PL, 2011) |
| " Sensitivity and specificity were compared after expressing each measurement result as a ratio over its upper reference limit, adding the ratios of normetanephrine and metanephrine, and defining cut-off values of 1 or 2 for this sum." | 7.76 | Diagnostic accuracy of free and total metanephrines in plasma and fractionated metanephrines in urine of patients with pheochromocytoma. ( Baudin, E; Buclin, T; Drouard-Troalen, L; Grand, D; Grouzmann, E; Muller, B; Plouin, PF, 2010) |
| "Measurement of free plasma metanephrines (metanephrine and normetanephrine), usually performed by high-performance liquid chromatography with electrochemical detection (HPLC-ECD), has been recommended as the single biochemical test of choice for the diagnosis of pheochromocytoma." | 7.74 | Comparison of free plasma metanephrines enzyme immunoassay with (131)I-MIBG scan in diagnosis of pheochromocytoma. ( Chen, LB; Ding, Y; Gao, YC; Lu, HK; Luo, QY; Zhu, RS, 2008) |
| "Measurement of 24-h urinary fractionated metanephrines by a tandem mass spectrometry assay appears to be an effective biochemical technique in the investigation of pheochromocytoma." | 7.74 | The diagnostic efficacy of urinary fractionated metanephrines measured by tandem mass spectrometry in detection of pheochromocytoma. ( Bajnarek, J; Perry, CG; Sawka, AM; Singh, R; Thabane, L; Young, WF, 2007) |
| "A cross-sectional multicentre study including 1260 subjects assessed the diagnostic efficacy of free plasma metanephrine and normetanephrine in low-risk patients screened for resistant or markedly accelerated hypertension, paroxysmal hypertension, 'flushes' and, in a small proportion, for adrenal incidentaloma or genetic predisposition to pheochromocytoma." | 7.74 | Free plasma metanephrines as a screening test for pheochromocytoma in low-risk patients. ( Frysák, Z; Janosová, M; Jedelský, L; Kadalová, L; Lacnák, B; Lazárová, M; Stejskal, D; Václavík, J; Vlcek, P, 2007) |
| "Measurements of plasma free metanephrines (normetanephrine and metanephrine) provide a useful test for diagnosis of pheochromocytoma and may provide other information about the nature of these tumors." | 7.73 | Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines. ( Brouwers, FM; Csako, G; Eisenhofer, G; Goldstein, DS; Lenders, JW; Mannelli, M; Pacak, K; Walther, MM, 2005) |
| "The sensitivity and specificity of the MS/MS method for urinary conjugated metanephrines offer advantages over colorimetric, immunoassay, HPLC, and gas chromatography-mass spectrometry methods because of elimination of drug interferences, high throughput, and short chromatographic run time." | 7.71 | Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma. ( Singh, RJ; Taylor, RL, 2002) |
| "Measurements of plasma normetanephrine and metanephrine are useful in screening for pheochromocytomas in patients with a familial predisposition to these tumors." | 7.70 | Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. ( Eisenhofer, G; Goldstein, DS; Keiser, HR; Lenders, JW; Linehan, WM; Walther, MM, 1999) |
| "Presently, the diagnosis of pheochromocytoma rests upon the determination of urinary catecholamines, and specially metanephrines which offer 100% sensitivity and 97% specificity." | 7.69 | [Determination of serum metanephrines in the diagnosis of pheochromocytoma]. ( Fathi, M; Marini, M; Vallotton, M, 1994) |
| "To validate the clinical usefulness of recently developed normetanephrine (NM) and metanephrine (M) RIA for the diagnosis of pheochromocytoma, urinary excretion of catecholamines and these metabolites were determined in 30 normal subjects, 40 patients with essential hypertension, 30 patients who were suspected to have but ultimately proven not to have a pheochromocytoma (pheochromocytoma-suspect), and 31 patients with a surgically verified pheochromocytoma." | 7.67 | Urinary normetanephrine and metanephrine measured by radioimmunoassay for the diagnosis of pheochromocytoma: utility of 24-hour and random 1-hour urine determinations. ( Ohno, M; Oishi, S; Sasaki, M; Sato, T, 1988) |
| "This single-centre, prospective trial investigated the use of CST in 60 patients with suspected PPGL associated with out-patient elevations of plasma normetanephrine (NMN) and/or metanephrine (MN), in most cases accompanied with hypertension or an adrenal mass." | 5.51 | Clonidine suppression test for a reliable diagnosis of pheochromocytoma: When to use. ( Dralle, H; Führer, D; Geroula, A; Pamporaki, C; Schmid, KW; Tsiomidou, S; Unger, N; Van Baal, L; Weber, F, 2022) |
| "Amoxicillin interference was assessed by comparison for co-elution with uNMN and by LC-MS/MS analysis." | 5.40 | Amoxicillin-associated interference in an HPLC-EC assay for urinary fractionated metanephrines: potential pitfall in pheochromocytoma biochemical diagnosis. ( Alpigiani, MG; Barco, S; Cangemi, G; Ghiggeri, GM; Maffia, A; Talio, M; Tripodi, G, 2014) |
| "Pheochromocytomas are rare catecholamine-producing tumors derived in more than 30% of cases from mutations in 9 tumor-susceptibility genes identified to date, including von Hippel-Lindau tumor suppressor (VHL); succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB); and succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD)." | 5.37 | Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. ( Adams, K; Bornstein, SR; Bratslavsky, G; Eisenhofer, G; Grebe, SK; Hofbauer, LC; Lenders, JW; Linehan, WM; Mannelli, M; Pacak, K; Tiebel, O; Timmers, H, 2011) |
| "Pheochromocytomas are chromaffin cell tumors, mostly originating from the adrenal medulla, and represent a rare cause of hypertensiondue to excessive production of catecholamines (norepinephrine and/or epinephrine)." | 5.31 | How to detect pheochromocytomas?--the diagnostic relevance of plasma free metanephrines. ( Roden, M, 2002) |
| "Diagnosis of pheochromocytoma has been made by the determination of urinary noradrenaline and adrenaline excretion for 24 hours." | 5.27 | [Biochemical diagnosis of pheochromocytoma by determining normetanephrine and metanephrine concentrations in single voided urine]. ( Abe, Y; Demura, H; Demura, R; Ito, Y; Jibiki, K; Naruse, K; Naruse, M; Nomura, K; Odagiri, E; Sakurai, H, 1988) |
| "To define the test characteristics of an enzyme immunoassay (EIA) for plasma-free metanephrines (metanephrine and normetanephrine) in the diagnosis of pheochromocytoma and paraganglioma." | 5.14 | Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors. ( Akker, SA; Burrin, J; Chew, SL; Drake, WM; Finney, H; Grossman, AB; Procopiou, M, 2009) |
| "Various studies have validated plasma free metanephrines (MNs) as biomarkers for pheochromocytoma and paraganglioma (PPGL)." | 4.95 | ACCURACY OF PLASMA FREE METANEPHRINES IN THE DIAGNOSIS OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS. ( Cao, X; Chen, Y; Huang, X; Li, Y; Xiao, H; Zhou, X, 2017) |
| "Measurements of plasma metanephrines and methoxytyramine provide a sensitive test for diagnosis of pheochromocytoma/paraganglioma." | 4.84 | False-positive results for pheochromocytoma associated with norepinephrine reuptake blockade. ( Biemann, R; Eisenhofer, G; Pamporaki, C; Peitzsch, M; Rayes, N; Rohm, S; Sabri, O; Sandner, B; Schürfeld, R; Tönjes, A, 2024) |
| "Measurement of free metanephrines is recommended for screening of pheochromocytoma (PCC) but requires appropriate reference intervals (RIs)." | 4.31 | Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma. ( Galac, S; Grinwis, GCM; Kema, IP; Kooistra, HS; Teske, E; van den Berg, MF; van Faassen, M; van Nimwegen, SA, 2023) |
| "We previously highlighted the problem of frequent false positives in 24 h urine normetanephrine(UNM) measurements owing to reference intervals that are inappropriately low for the population being screened for pheochromocytoma." | 4.12 | Updated reference intervals for urine normetanephrine have no effect on test sensitivity but fewer false positives. ( Boyd, J; Dong, Y; Hyrcza, M; Kline, GA; Leung, AAC; Pacaud, D; Pasieka, JL; Sadrzadeh, HSM, 2022) |
| "Moderately elevated plasma normetanephrine (NMN) levels are frequent among patients with suspected pheochromocytoma and paraganglioma (PPGL)." | 4.12 | Improved Diagnostic Accuracy of Clonidine Suppression Testing Using an Age-Related Cutoff for Plasma Normetanephrine. ( Deutschbein, T; Eisenhofer, G; Fassnacht, M; Fuss, CT; Masjkur, J; Nölting, S; Pamporaki, C; Prejbisz, A; Quinkler, M; Remde, H; Timmers, HJLM, 2022) |
| "Sampling of blood in the supine position for diagnosis of pheochromocytoma and paraganglioma (PPGL) results in lower rates of false positives for plasma normetanephrine than seated sampling." | 4.12 | Preanalytical Considerations and Outpatient Versus Inpatient Tests of Plasma Metanephrines to Diagnose Pheochromocytoma. ( Amar, L; Baron, S; Blanchard, A; Braun, L; Ceccato, F; Davies, E; Deinum, J; Deutschbein, T; Dobrowolski, P; Eisenhofer, G; Fassnacht, M; Gruber, S; Hampson, S; Januszewicz, A; Lenzini, L; Müller, LM; Nölting, S; Pamporaki, C; Pecori, A; Peitzsch, M; Pommer, G; Prejbisz, A; Remde, H; Rossi, GP; Stell, A; Timmers, HJLM; Zennaro, MC, 2022) |
| " At the univariate regression, normetanephrine was associated with metabolic syndrome (OR = 1." | 4.12 | A retrospective study on the association between urine metanephrines and cardiometabolic risk in patients with nonfunctioning adrenal incidentaloma. ( Bioletto, F; Bollati, M; Di Carlo, MC; Gesmundo, I; Ghigo, E; Giordano, R; Lopez, C; Maccario, M; Mengozzi, G; Parasiliti-Caprino, M; Ponzetto, F; Settanni, F; Sola, C, 2022) |
| "Increased plasma normetanephrine levels in patients with CCHD can be explained by the effect of hypoxia." | 4.12 | Comparison of plasma metanephrines in patients with cyanotic and acyanotic congenital heart disease. ( Goricar, K; Janež, A; Jensterle, M; Podbregar, A; Prokšelj, K; Rakusa, M, 2022) |
| "Accurate diagnosis of pheochromocytoma and paraganglioma (PPGLs) is highly dependent on the detection of metanephrines and catecholamines." | 4.02 | Study of stability and interference for catecholamines and metanephrines, 3-methoxytyramine: key point of an accurate diagnosis for pheochromocytoma and paraganglioma. ( Cong, H; Gao, X; Guo, Y; Shi, X; Sun, N; Wang, K; Xie, L; Zhang, W; Zhou, Z, 2021) |
| "Biochemical testing of urinary metanephrines is useful in the diagnosis and monitoring of pheochromocytoma and paragangliomas." | 4.02 | Verifying Clinically Derived Reference Intervals for Daily Excretion Rates of Fractionated Metanephrines Using Modern Indirect Reference Interval Models. ( Doyle, K; Frank, EL, 2021) |
| "Measurements of plasma free metanephrines are recommended for diagnosing pheochromocytomas and paragangliomas (PPGL)." | 4.02 | Diagnostic Accuracy of Salivary Metanephrines in Pheochromocytomas and Paragangliomas. ( Eijkelenkamp, K; Kema, IP; Kerstens, MN; Links, TP; Osinga, TE; Pacak, K; Sluiter, WJ; van der Horst-Schrivers, ANA; van Faassen, M, 2021) |
| "Urinary measurement of fractionated metanephrines is one of the best available biochemical tests for the diagnosis of pheochromocytoma and paraganglioma; however, false-positive results remain an issue." | 3.96 | Clinical factors affecting spot urine fractionated metanephrines in patients suspected pheochromocytoma/paraganglioma. ( Bokuda, K; Ichihara, A; Seki, Y; Yatabe, M, 2020) |
| "A 24-hour urine nor/metanephrine (urine NM-MN) measurements are a recommended first step in pheochromocytoma diagnosis." | 3.96 | Moderate renal impairment does not preclude the accuracy of 24-hour urine normetanephrine measurements for suspected pheochromoctyoma. ( Boyd, J; Kline, GA; Leung, AA; Sadrzadeh, HM; Tang, A, 2020) |
| "The 24 h urinary-fractionated metanephrine (MN) and normetanephrine (NMN) are recommended as the preferred indicators for laboratory diagnosis of pheochromocytoma and paraganglioma (PPGL)." | 3.96 | Stability and reference intervals of spot urinary fractionated metanephrines and methoxytyramine by tandem mass spectrometry as a screening method for pheochromocytoma and paraganglioma. ( Cong, H; Dai, S; Gao, X; Shi, X; Wang, K; Zhang, W; Zhou, Z, 2020) |
| "In patients with phaeochromocytomas or paragangliomas (PPGLs), 24-h urine collections for metanephrines (uMNs) are cumbersome." | 3.96 | Random 'spot' urinary metanephrines compared with 24-h-urinary and plasma results in phaeochromocytomas and paragangliomas. ( Grossman, AB; Isidori, AM; Jafar-Mohammadi, B; James, T; Maunsell, Z; May, CJH; Sbardella, E; Shine, B; Tadman, M, 2020) |
| "Plasma free metanephrines are commonly used for diagnosis of pheochromocytoma and paraganglioma (PPGLs), but can also provide other information." | 3.96 | Plasma metanephrines and prospective prediction of tumor location, size and mutation type in patients with pheochromocytoma and paraganglioma. ( Bechmann, N; Beuschlein, F; Calsina, B; Constantinescu, G; Deutschbein, T; Eisenhofer, G; Fankhauser, M; Fassnacht, M; Fliedner, S; Langton, K; Lenders, JWM; Monteagudo, M; Nölting, S; Pamporaki, C; Peitzsch, M; Prejbisz, A; Robledo, M; Stell, A; Timmers, HJLM, 2020) |
| "This work discusses the clinical performance of chromogranin A, free metanephrine and normetanephrine determination in plasma using a radioimmunoanalytical methods for the diagnosis of pheochromocytoma and paraganglioma." | 3.85 | Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma. ( Bílek, R; Dušková, J; Michalský, D; Novák, K; Václavíková, E; Vlček, P; Widimský, J; Zelinka, T, 2017) |
| "The measurement of urine catecholamine and metanephrine concentrations is important for biochemical screening and diagnosis of pheochromocytoma." | 3.85 | [Determination of urine catecholamines and metanephrines by reversed-phase liquid chromatography-tandem mass spectrometry]. ( Cheuk, MY; Lo, YC; Poon, WT, 2017) |
| "Plasma metanephrines (PMN) are highly sensitive for diagnosis of pheochromocytoma, but the natural history of PMN before pheochromocytoma diagnosis has not been previously described." | 3.83 | Longitudinal plasma metanephrines preceding pheochromocytoma diagnosis: a retrospective case-control serum repository study. ( Abbott, KC; Baker, T; Oliver, D; Olson, SW; Prince, LK; Yoon, S, 2016) |
| "This work discusses the clinical performance of deconjugated metanephrine (MN), normetanephrine (NMN) and 3-methoxytyramine (3MT) determined in the basal first morning urine using a chromatographic method with electrochemical detection for the clinical diagnosis of pheochromocytoma (PHEO) and paraganglioma (PGL)." | 3.81 | Deconjugated urinary metanephrine, normetanephrine and 3-methoxytyramine in laboratory diagnosis of pheochromocytoma and paraganglioma. ( Bešťák, J; Bílek, R; Dušková, J; Michalský, D; Novák, K; Vlček, P; Widimský, J; Zelinka, T, 2015) |
| " The workup included an endocrinological examination, which revealed a moderately elevated urine normetanephrine level, suggesting the possibility of a pheochromocytoma." | 3.80 | Obstructive sleep apnea and tricyclic antidepressant use presenting as a pseudopheochromocytoma in an active duty sailor: a case report. ( Brainard, T, 2014) |
| "An elevation of fractionated plasma or urinary metanephrine (MN) or nor-metanephrine (NMN), collectively called metanephrines (MN and NMN), >4-fold above the upper limit of normal (ULN) is usually considered to be diagnostic for pheochromocytoma (PHEO)." | 3.80 | Biochemical and radiological relationships in patients with pheochromocytoma: lessons from a case control study. ( Bena, J; Berber, E; Bravo, E; Faiman, C; Fergany, A; Hamrahian, AH; Kannan, S; Purysko, A; Remer, EM; Shah, L; Siperstein, A, 2014) |
| "There was no seasonal variation in the plasma concentrations of metanephrines among patients with pheochromocytoma, whereas among those without tumors, the plasma concentrations of normetanephrine were higher (P<0." | 3.80 | Seasonal variation in plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma. ( Bornstein, SR; Bursztyn, M; Eisenhofer, G; Lenders, JW; Pamporaki, C; Reimann, M; Sweep, FC; Timmers, H; Ziemssen, T, 2014) |
| "Measuring the levels of the plasma free metanephrines (PFMs) represents a recently developed and promising test for the diagnosis of pheochromocytoma in the United States and Europe." | 3.80 | Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients. ( Adachi, M; Arai, Y; Hara, H; Hashimoto, K; Hataya, Y; Ikeda, Y; Imai, T; Isobe, K; Kamide, K; Kato, T; Kawakami, Y; Kikumori, T; Ma, E; Maeda, Y; Matsuda, T; Midorikawa, S; Okada, Y; Sakurai, A; Shimano, H; Takahashi, H; Takekoshi, K; Tanaka, Y; Yanase, T; Yokoyama, C, 2014) |
| "Measurements of plasma normetanephrine (NMN) and metanephrine (MN) provide a sensitive test for diagnosis of phaeochromocytomas and paragangliomas (PPGLs), but do not allow detection of dopamine-producing tumours." | 3.79 | Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma. ( Arlt, W; Beuschlein, F; Eisenhofer, G; Januszewicz, A; Kroiß, M; Peitzsch, M; Prejbisz, A; Siegert, G, 2013) |
| "The purpose of this study was to investigate the utility of measurement of plasma free metanephrines in dogs for the diagnosis of pheochromocytoma." | 3.79 | Comparison of plasma free metanephrines between healthy dogs and 3 dogs with pheochromocytoma. ( Frank, EL; Green, BA, 2013) |
| " All patients were screened for pheochromocytoma with 24-h urinary metanephrines and normetanephrines and for hypercortisolism (1 mg dexamethasone test and ACTH)." | 3.78 | Is biochemical screening for pheochromocytoma in adrenal incidentalomas expressing low unenhanced attenuation on computed tomography necessary? ( Raade, M; Sane, T; Schalin-Jäntti, C, 2012) |
| " Determination of metanephrines by high-pressure liquid chromatography has been well established for the diagnosis of pheochromocytomas, demonstrating high sensitivity and specificity." | 3.78 | Plasma and urinary metanephrines determined by an enzyme immunoassay, but not serum chromogranin A for the diagnosis of pheochromocytoma in patients with adrenal mass. ( Deutschbein, T; Hinrichs, J; Mann, K; Petersenn, S; Schmidt, H; Unger, N; Walz, MK, 2012) |
| "All patients with pheochromocytoma/paraganglioma had abnormally elevated concentrations of either plasma metanephrine or normetanephrine." | 3.77 | Comparison of plasma metanephrines measured by a commercial immunoassay and urinary catecholamines in the diagnosis of pheochromocytoma. ( Christensen, TT; Frystyk, J; Poulsen, PL, 2011) |
| "Determination of urinary metanephrines is requested frequently for the differential diagnosis and monitoring of pheochromocytoma." | 3.77 | Urinary metanephrines by liquid chromatography tandem mass spectrometry: using multiple quantification methods to minimize interferences in a high throughput method. ( Clark, ZD; Frank, EL, 2011) |
| " Sensitivity and specificity were compared after expressing each measurement result as a ratio over its upper reference limit, adding the ratios of normetanephrine and metanephrine, and defining cut-off values of 1 or 2 for this sum." | 3.76 | Diagnostic accuracy of free and total metanephrines in plasma and fractionated metanephrines in urine of patients with pheochromocytoma. ( Baudin, E; Buclin, T; Drouard-Troalen, L; Grand, D; Grouzmann, E; Muller, B; Plouin, PF, 2010) |
| "Measurements of the 3-O-methylated metabolites of catecholamines [metanephrines (MNs)] in plasma or urine are recommended for diagnosis of pheochromocytoma." | 3.75 | Dietary influences on plasma and urinary metanephrines: implications for diagnosis of catecholamine-producing tumors. ( de Jong, WH; de Vries, EG; Eisenhofer, G; Kema, IP; Muskiet, FA; Post, WJ, 2009) |
| "Measurement of free plasma metanephrines (metanephrine and normetanephrine), usually performed by high-performance liquid chromatography with electrochemical detection (HPLC-ECD), has been recommended as the single biochemical test of choice for the diagnosis of pheochromocytoma." | 3.74 | Comparison of free plasma metanephrines enzyme immunoassay with (131)I-MIBG scan in diagnosis of pheochromocytoma. ( Chen, LB; Ding, Y; Gao, YC; Lu, HK; Luo, QY; Zhu, RS, 2008) |
| "Measurement of 24-h urinary fractionated metanephrines by a tandem mass spectrometry assay appears to be an effective biochemical technique in the investigation of pheochromocytoma." | 3.74 | The diagnostic efficacy of urinary fractionated metanephrines measured by tandem mass spectrometry in detection of pheochromocytoma. ( Bajnarek, J; Perry, CG; Sawka, AM; Singh, R; Thabane, L; Young, WF, 2007) |
| "A cross-sectional multicentre study including 1260 subjects assessed the diagnostic efficacy of free plasma metanephrine and normetanephrine in low-risk patients screened for resistant or markedly accelerated hypertension, paroxysmal hypertension, 'flushes' and, in a small proportion, for adrenal incidentaloma or genetic predisposition to pheochromocytoma." | 3.74 | Free plasma metanephrines as a screening test for pheochromocytoma in low-risk patients. ( Frysák, Z; Janosová, M; Jedelský, L; Kadalová, L; Lacnák, B; Lazárová, M; Stejskal, D; Václavík, J; Vlcek, P, 2007) |
| "Measurements of plasma free metanephrines (normetanephrine and metanephrine) provide a useful test for diagnosis of pheochromocytoma and may provide other information about the nature of these tumors." | 3.73 | Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines. ( Brouwers, FM; Csako, G; Eisenhofer, G; Goldstein, DS; Lenders, JW; Mannelli, M; Pacak, K; Walther, MM, 2005) |
| "Plasma metanephrines measured by RIA are reliable screening parameters for the diagnosis of pheochromocytoma." | 3.73 | Diagnostic value of various biochemical parameters for the diagnosis of pheochromocytoma in patients with adrenal mass. ( Mann, K; Petersenn, S; Philipp, T; Pitt, C; Schmid, KW; Schmidt, IL; Unger, N; Walz, MK, 2006) |
| "Measurements of plasma normetanephrine and metanephrine provide a highly sensitive test for diagnosis of pheochromocytoma, but false-positive results remain a problem." | 3.72 | Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results. ( Eisenhofer, G; Friberg, P; Goldstein, DS; Keiser, HR; Lenders, JW; Pacak, K; Walther, MM, 2003) |
| " Physical characteristics, daily urinary metanephrine and normetanephrine excretions, preoperative functional limitation, pre-existing congestive heart failure, type and duration of surgery, and haemodynamic instability in the intra and postoperative periods were compared in patients with normal and abnormal echocardiographic findings." | 3.72 | Predictive value of preoperative transthoracic echocardiography in patients undergoing adrenalectomy for pheochromocytoma. ( Devaux, B; Dousset, B; Jude, N; Lentschener, C; Ozier, Y; Pili-Floury, S; Valensi, L, 2004) |
| "Patients with a pheochromocytoma (24 out of 2003 patients) were diagnosed by the combination of normetanephrine and metanephrine determination." | 3.71 | Lessons from an unpleasant surprise: a biochemical strategy for the diagnosis of pheochromocytoma. ( Chêne, G; Corcuff, JB; Ducassou, D; Gardet, V; Gatta, B; Simonnet, G; Tabarin, A, 2001) |
| "The sensitivity and specificity of the MS/MS method for urinary conjugated metanephrines offer advantages over colorimetric, immunoassay, HPLC, and gas chromatography-mass spectrometry methods because of elimination of drug interferences, high throughput, and short chromatographic run time." | 3.71 | Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma. ( Singh, RJ; Taylor, RL, 2002) |
| "Measurements of plasma normetanephrine and metanephrine are useful in screening for pheochromocytomas in patients with a familial predisposition to these tumors." | 3.70 | Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2. ( Eisenhofer, G; Goldstein, DS; Keiser, HR; Lenders, JW; Linehan, WM; Walther, MM, 1999) |
| "Presently, the diagnosis of pheochromocytoma rests upon the determination of urinary catecholamines, and specially metanephrines which offer 100% sensitivity and 97% specificity." | 3.69 | [Determination of serum metanephrines in the diagnosis of pheochromocytoma]. ( Fathi, M; Marini, M; Vallotton, M, 1994) |
| " Overnight catecholamines, metanephrines, and 4-hydroxy-3-methoxymandelic acid (HMMA) levels were measured in 16 patients with histologically confirmed pheochromocytomas, 166 patients with hypertension, and 24 normotensive subjects." | 3.69 | Overnight excretion of urinary catecholamines and metabolites in the detection of pheochromocytoma. ( Lai, LC; Lennard, TW; Peaston, RT, 1996) |
| "Determination of urinary 3-O-methylated catecholamines (metanephrines) is generally considered a principal test for the clinical chemical diagnosis of pheochromocytoma and is currently performed predominantly with chromatographic techniques such as gas-liquid chromatography and HPLC." | 3.69 | Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometry. ( Kema, IP; Manz, B; Volmer, M; Wesemann, R; Westermann, J; Wolthers, BG, 1997) |
| "To study the relation of normetanephrine (NM) and metanephrine (M) to norepinephrine (NE) and epinephrine (E), plasma free NM (f-NM), free M (f-M), total NM (t-NM) and total M (t-M) were measured in normal subjects and patients with pheochromocytoma (PHEO), neuroblastoma, Cushing's syndrome, primary aldosteronism and chronic renal failure (CRF) by radioimmunoassay." | 3.67 | [Plasma normetanephrine and metanephrine levels and their relationship to norepinephrine and epinephrine]. ( Funyu, T; Igarashi, R; Nigawara, K; Suzuki, T; Terayama, Y; Yamaya, K, 1988) |
| "To validate the clinical usefulness of recently developed normetanephrine (NM) and metanephrine (M) RIA for the diagnosis of pheochromocytoma, urinary excretion of catecholamines and these metabolites were determined in 30 normal subjects, 40 patients with essential hypertension, 30 patients who were suspected to have but ultimately proven not to have a pheochromocytoma (pheochromocytoma-suspect), and 31 patients with a surgically verified pheochromocytoma." | 3.67 | Urinary normetanephrine and metanephrine measured by radioimmunoassay for the diagnosis of pheochromocytoma: utility of 24-hour and random 1-hour urine determinations. ( Ohno, M; Oishi, S; Sasaki, M; Sato, T, 1988) |
| "The biochemical diagnosis of pheochromocytoma is essentially based on the plasma and urinary levels of catecholamines and their derivatives, the metanephrines and vanyl-mandelic acid." | 3.66 | [Catecholamines and their derivatives in the study of pheochromocytoma]. ( Landault, C; Legrand, JC; Salmon, N; Zoghbi, F, 1983) |
| "The concentrations of free and total normetanephrine (NMN) were determined in the plasma of normotensives and patients with primary hypertension and pheochromocytoma." | 3.66 | The relationships of free to conjugated normetanephrine in plasma and spinal fluid of hypertensive patients. ( Adachi, M; DeQuattro, V; Foti, A, 1982) |
| "The diurnal variation of urinary vanillylmandelic acid (VMA) and metanephrine-normetanephrine levels was studied in six patients with phechromocytoma and 32 patients with essential hypertension." | 3.65 | The diagnosis of pheochromocytoma. Overnight excretion of catecholamine metabolites. ( Solomon, HS; Sullivan, JM, 1975) |
| "Both RA and LA for pheochromocytoma are safe and effective." | 2.94 | Surgical outcomes of a randomized controlled trial compared robotic versus laparoscopic adrenalectomy for pheochromocytoma. ( Dai, J; Fang, C; He, W; Ma, W; Mao, Y; Sun, F; Wang, C; Xu, D; Zhao, J; Zhu, Y; Zhuo, R, 2020) |
| "018), in a dose-response manner across increasing urinary normetanephrine quartile categories (P for trend = 0." | 2.87 | Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma. ( Kim, BJ; Kim, JS; Koh, JM; Kwak, MK; Lee, SH, 2018) |
| "The dosage of urinary catecholamines and their metabolites is a main element of diagnosis in the research of a pheochromocytoma in patients with high blood pressure." | 2.67 | [Absence of labetalol interference on urine metanephrine determination in hypertensive patients]. ( Billaud, EM; Girerd, X; Laurent, S; Ropers, J; Safar, M; Safavian, A; Sorrel-Dejerine, A, 1992) |
| "Pheochromocytoma are rare tumors, usually symptomatic due to their hormonal activity with excessive catecholamine secretion." | 2.58 | [CME: Pheochromocytoma in the General Practice]. ( Erlic, Z; Fischli, S, 2018) |
| "Pheochromocytomas are an uncommon but challenging tumour to manage." | 1.91 | Stereotactic body radiation therapy as an alternative to adrenalectomy for the treatment of pheochromocytomas in 8 dogs. ( Hsieh, YH; Jacovino, J; Linder, T; Mueller, M; Wakamatsu, C, 2023) |
| "Sulfasalazine can cause analytical interference in some assays for urinary normetanephrine and result in spuriously elevated levels, leading to misdiagnosis of phaeochromocytoma." | 1.91 | Sulfasalazine as a cause of false-positive elevation of urinary normetanephrine in patients with adrenal mass and suspected phaeochromocytoma: a diagnostic challenge. ( Balasubramanian, S; Debono, M; Rab, E; Zuling, ET, 2023) |
| "Pheochromocytoma is a hormonally active tumour originating from neuroendocrine cells of the adrenal medulla." | 1.72 | ProSAAS peptide of the granin protein family in biochemical diagnostics of pheochromocytoma. ( Glinicki, P; Ostrowska, M; Papierska, L; Zgliczyński, W, 2022) |
| "Pheochromocytomas are rare tumors and biochemically silent ones with normal catecholamine levels are even rarer." | 1.72 | Pre- and peri-operative characteristics, complications and outcomes of patients with biochemically silent pheochromocytomas; a case series. ( Aggeli, C; Christou, MA; Dimakopoulou, A; Fountas, A; Giagourta, I; Glycofridi, S; Kalantzi, A; Kanti, G; Kounadi, T; Markou, A; Ntali, G; Papanastasiou, L; Saoulidou, E; Tigas, S; Zografos, GN, 2022) |
| "In conclusion, intraoperative complications in pheochromocytoma surgery are common and can be potentially life-threatening." | 1.62 | Risk factors for intraoperative complications in pheochromocytomas. ( Álvarez-Escolá, C; Araujo-Castro, M; Blanco-Carrera, C; Calatayud Gutiérrez, M; de Miguel Novoa, P; Fernández-Ladreda, MT; Garcia Centeno, R; Gómez Dos Santos, V; Gracia Gimeno, P; Hanzu, FA; Lamas, C; López-García, MC; Mínguez Ojeda, C; Mora, M; Percovich Hualpa, JC; Serrano Romero, A; Valdés, N; Vidal, Ó, 2021) |
| "Glucose intolerance is often observed in patients with pheochromocytoma." | 1.51 | Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma. ( Abe, I; Abe, M; Fujii, H; Kobayashi, K; Kudo, T; Minezaki, M; Nakagawa, M; Ohe, K; Ohishi, H; Sugimoto, K; Takahara, S; Yanase, T, 2019) |
| "BACKGROUND Pheochromocytoma is a rare catecholamine-producing tumor with an estimated incidence of less than 0." | 1.46 | A Case Report of Cystic Pheochromocytoma. ( Heimann, DM; Junejo, SZ; Reich, D; Sachmechi, I; Tuli, S, 2017) |
| "Amoxicillin interference was assessed by comparison for co-elution with uNMN and by LC-MS/MS analysis." | 1.40 | Amoxicillin-associated interference in an HPLC-EC assay for urinary fractionated metanephrines: potential pitfall in pheochromocytoma biochemical diagnosis. ( Alpigiani, MG; Barco, S; Cangemi, G; Ghiggeri, GM; Maffia, A; Talio, M; Tripodi, G, 2014) |
| "Pheochromocytoma is a rare tumour, but one of great clinical importance as a risk factor of malignancy, cardiovascular diseases and sudden death." | 1.39 | Pheochromocytoma--analysis of 15 consecutive cases from one centre. ( Dadan, J; Górska, M; Kościuszk, M; Myśliwiec, J; Myśliwiec, P; Popławska, A; Siewko, K; Szelachowska, M; Zukowski, L, 2013) |
| "Pheochromocytomas are rare catecholamine-producing tumors derived in more than 30% of cases from mutations in 9 tumor-susceptibility genes identified to date, including von Hippel-Lindau tumor suppressor (VHL); succinate dehydrogenase complex, subunit B, iron sulfur (Ip) (SDHB); and succinate dehydrogenase complex, subunit D, integral membrane protein (SDHD)." | 1.37 | Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma. ( Adams, K; Bornstein, SR; Bratslavsky, G; Eisenhofer, G; Grebe, SK; Hofbauer, LC; Lenders, JW; Linehan, WM; Mannelli, M; Pacak, K; Tiebel, O; Timmers, H, 2011) |
| "Pheochromocytoma is a rare tumor responsible for paroxysmal hypertension which is difficult to control." | 1.35 | [Pheochromocytoma in end-stage renal disease patient treated by peritoneal dialysis]. ( Abdallah, NB; Abdallah, TB; Abderrahim, E; Bacha, MM; Gorsane, I; Goucha, R; Hedri, H; Kheder, A; Khiari, K; Maiz, HB; Moussa, FB; Zouaghi, K, 2008) |
| "Pheochromocytoma is a rare neuroendocrine tumor that secretes high levels of catecholamines and usually causes paroxysmal or sustained hypertension." | 1.33 | Pheochromocytoma presenting as heart failure. ( Farroni, JA, 2005) |
| "Pheochromocytoma is a rare cause of hypertension resulting from increased catecholamine secretion." | 1.31 | Quantification of unconjugated metanephrines in human plasma without interference by acetaminophen. ( Bernroider, E; Gasic, S; Niederle, B; Raber, W; Raffesberg, W; Roden, M; Waldhäusl, W, 2001) |
| "Pheochromocytomas are chromaffin cell tumors, mostly originating from the adrenal medulla, and represent a rare cause of hypertensiondue to excessive production of catecholamines (norepinephrine and/or epinephrine)." | 1.31 | How to detect pheochromocytomas?--the diagnostic relevance of plasma free metanephrines. ( Roden, M, 2002) |
| "Paragangliomas are rare neuroendocrine tumors and the malignant behaviour, higher than pheochromocytomas, is based on metastases or local recurrence." | 1.30 | [Secreting retroperitoneal paraganglioma. Apropos of a case]. ( Farthouat, P; Meusnier, F; Platel, JP; Pourrière, M; Thouard, H, 1997) |
| "Metanephrines were adsorbed from plasma onto a cation-exchange column and eluted with ammoniacal methanol." | 1.29 | Determination of metanephrines in plasma by liquid chromatography with electrochemical detection. ( Armando, I; Eisenhofer, G; Goldstein, DS; Keiser, HR; Kopin, IJ; Lenders, JW, 1993) |
| "We studied 15 patients with MEN 2A who underwent adrenal surgery between 1981 and 1992." | 1.29 | Bilateral adrenalectomy with autotransplantation of adrenocortical tissue or unilateral adrenalectomy: treatment options for pheochromocytomas in multiple endocrine neoplasia type 2A. ( Hirose, K; Iihara, M; Ito, Y; Kanbe, M; Obara, T; Okamoto, T; Yamashita, T; Yamazaki, K, 1996) |
| "Diagnosis of pheochromocytoma has been made by the determination of urinary noradrenaline and adrenaline excretion for 24 hours." | 1.27 | [Biochemical diagnosis of pheochromocytoma by determining normetanephrine and metanephrine concentrations in single voided urine]. ( Abe, Y; Demura, H; Demura, R; Ito, Y; Jibiki, K; Naruse, K; Naruse, M; Nomura, K; Odagiri, E; Sakurai, H, 1988) |
| " Inhibition of catecholamine synthesis in the range of 50-80% was achieved with divided daily drug dosage of from 1." | 1.25 | Biochemical and pharmacologic effects of alpha-methyltyrosine in man. ( Engelman, K; Horwitz, D; Jéquier, E; Sjoerdsma, A, 1968) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 69 (29.36) | 18.7374 |
| 1990's | 19 (8.09) | 18.2507 |
| 2000's | 33 (14.04) | 29.6817 |
| 2010's | 83 (35.32) | 24.3611 |
| 2020's | 31 (13.19) | 2.80 |
| Authors | Studies |
|---|---|
| Wang, K | 2 |
| Gao, X | 2 |
| Zhang, W | 2 |
| Sun, N | 1 |
| Xie, L | 1 |
| Cong, H | 2 |
| Guo, Y | 1 |
| Shi, X | 2 |
| Zhou, Z | 2 |
| Kline, GA | 3 |
| Boyd, J | 3 |
| Hyrcza, M | 1 |
| Pacaud, D | 1 |
| Pasieka, JL | 1 |
| Dong, Y | 1 |
| Sadrzadeh, HSM | 1 |
| Leung, AAC | 1 |
| Yu, S | 1 |
| Zhou, W | 2 |
| Yu, J | 1 |
| Li, M | 1 |
| Zhang, S | 1 |
| Jiang, X | 1 |
| Wang, H | 1 |
| Ma, X | 1 |
| Zou, Y | 1 |
| Wang, D | 1 |
| Cheng, Q | 1 |
| Xie, S | 1 |
| Luo, W | 1 |
| Guo, X | 1 |
| Qiu, L | 1 |
| Tsiomidou, S | 1 |
| Pamporaki, C | 11 |
| Geroula, A | 1 |
| Van Baal, L | 1 |
| Weber, F | 1 |
| Dralle, H | 1 |
| Schmid, KW | 2 |
| Führer, D | 1 |
| Unger, N | 4 |
| Remde, H | 3 |
| Quinkler, M | 1 |
| Nölting, S | 4 |
| Prejbisz, A | 8 |
| Timmers, HJLM | 3 |
| Masjkur, J | 1 |
| Fuss, CT | 1 |
| Fassnacht, M | 4 |
| Eisenhofer, G | 31 |
| Deutschbein, T | 6 |
| Glinicki, P | 1 |
| Ostrowska, M | 1 |
| Papierska, L | 1 |
| Zgliczyński, W | 1 |
| Pommer, G | 1 |
| Peitzsch, M | 10 |
| Müller, LM | 1 |
| Braun, L | 1 |
| Gruber, S | 1 |
| Pecori, A | 1 |
| Hampson, S | 1 |
| Davies, E | 1 |
| Stell, A | 3 |
| Rossi, GP | 1 |
| Lenzini, L | 1 |
| Ceccato, F | 1 |
| Deinum, J | 2 |
| Amar, L | 1 |
| Blanchard, A | 1 |
| Baron, S | 1 |
| Dobrowolski, P | 1 |
| Januszewicz, A | 6 |
| Zennaro, MC | 1 |
| Parasiliti-Caprino, M | 1 |
| Lopez, C | 1 |
| Bollati, M | 1 |
| Bioletto, F | 1 |
| Sola, C | 1 |
| Di Carlo, MC | 1 |
| Ponzetto, F | 1 |
| Gesmundo, I | 1 |
| Settanni, F | 1 |
| Ghigo, E | 1 |
| Mengozzi, G | 1 |
| Maccario, M | 1 |
| Giordano, R | 1 |
| Fountas, A | 1 |
| Kanti, G | 1 |
| Glycofridi, S | 1 |
| Christou, MA | 1 |
| Kalantzi, A | 1 |
| Giagourta, I | 1 |
| Markou, A | 1 |
| Ntali, G | 1 |
| Aggeli, C | 1 |
| Saoulidou, E | 1 |
| Dimakopoulou, A | 1 |
| Zografos, GN | 1 |
| Kounadi, T | 1 |
| Tigas, S | 1 |
| Papanastasiou, L | 1 |
| Linder, T | 1 |
| Wakamatsu, C | 1 |
| Jacovino, J | 1 |
| Hsieh, YH | 1 |
| Mueller, M | 1 |
| Jensterle, M | 1 |
| Podbregar, A | 1 |
| Janež, A | 1 |
| Rakusa, M | 1 |
| Goricar, K | 1 |
| Prokšelj, K | 1 |
| Ziegler, CG | 1 |
| Riediger, C | 1 |
| Gruber, M | 1 |
| Kunath, C | 1 |
| Ullrich, M | 1 |
| Pietzsch, J | 1 |
| Siepmann, T | 1 |
| Bornstein, SR | 9 |
| Constantinescu, G | 2 |
| Zeng, HL | 1 |
| Wang, X | 2 |
| Li, HJ | 1 |
| Yang, Q | 1 |
| van den Berg, MF | 1 |
| Kooistra, HS | 1 |
| Grinwis, GCM | 1 |
| van Nimwegen, SA | 1 |
| van Faassen, M | 2 |
| Kema, IP | 8 |
| Teske, E | 1 |
| Galac, S | 2 |
| Prego, MT | 1 |
| Dias, MJ | 1 |
| Mestrinho, L | 1 |
| Englar, R | 1 |
| Grinwis, G | 1 |
| Leal, RO | 1 |
| Rossi, L | 1 |
| Ambrosini, CE | 1 |
| Torregrossa, L | 1 |
| de Santi, MM | 1 |
| Guazzo, R | 1 |
| Simoncini, T | 1 |
| Bacca, A | 1 |
| Gjeloshi, B | 1 |
| Pignatelli, F | 1 |
| Iachini, M | 1 |
| Loguercio, E | 1 |
| Becucci, C | 1 |
| Materazzi, G | 1 |
| De Filpo, G | 1 |
| Parenti, G | 1 |
| Sparano, C | 1 |
| Rastrelli, G | 1 |
| Rapizzi, E | 1 |
| Martinelli, S | 1 |
| Amore, F | 1 |
| Badii, B | 1 |
| Paolo, P | 1 |
| Ercolino, T | 1 |
| Mannelli, M | 5 |
| Maggi, M | 1 |
| Canu, L | 1 |
| Zuling, ET | 1 |
| Debono, M | 1 |
| Rab, E | 1 |
| Balasubramanian, S | 1 |
| Schürfeld, R | 1 |
| Rayes, N | 1 |
| Sabri, O | 1 |
| Rohm, S | 1 |
| Biemann, R | 1 |
| Sandner, B | 1 |
| Tönjes, A | 1 |
| Takekoshi, K | 3 |
| Satoh, F | 1 |
| Tanabe, A | 1 |
| Okamoto, T | 3 |
| Ichihara, A | 2 |
| Tsuiki, M | 1 |
| Katabami, T | 1 |
| Nomura, M | 1 |
| Tanaka, T | 1 |
| Matsuda, T | 2 |
| Imai, T | 3 |
| Yamada, M | 1 |
| Asada, S | 1 |
| Kawata, N | 1 |
| Naruse, M | 2 |
| Bokuda, K | 1 |
| Yatabe, M | 1 |
| Seki, Y | 1 |
| Leung, AA | 2 |
| Tang, A | 1 |
| Sadrzadeh, HM | 1 |
| Dai, S | 1 |
| Sbardella, E | 1 |
| Maunsell, Z | 1 |
| May, CJH | 1 |
| Tadman, M | 1 |
| James, T | 1 |
| Jafar-Mohammadi, B | 1 |
| Isidori, AM | 1 |
| Grossman, AB | 3 |
| Shine, B | 1 |
| Ma, W | 1 |
| Mao, Y | 1 |
| Zhuo, R | 1 |
| Dai, J | 1 |
| Fang, C | 1 |
| Wang, C | 1 |
| Zhao, J | 1 |
| He, W | 1 |
| Zhu, Y | 2 |
| Xu, D | 1 |
| Sun, F | 2 |
| Langton, K | 1 |
| Calsina, B | 1 |
| Monteagudo, M | 1 |
| Fliedner, S | 2 |
| Bechmann, N | 1 |
| Fankhauser, M | 1 |
| Beuschlein, F | 4 |
| Lenders, JWM | 1 |
| Robledo, M | 2 |
| Jian, M | 1 |
| Huang, H | 1 |
| Li, K | 1 |
| Chuan, L | 1 |
| Li, L | 1 |
| Jiang, L | 1 |
| Doyle, K | 1 |
| Frank, EL | 4 |
| Eijkelenkamp, K | 1 |
| Osinga, TE | 3 |
| Kerstens, MN | 4 |
| Pacak, K | 13 |
| Sluiter, WJ | 2 |
| Links, TP | 3 |
| van der Horst-Schrivers, ANA | 1 |
| Ananthakrishnan, N | 1 |
| Sanniyasi, S | 1 |
| Ravikumar, D | 1 |
| Koyama, K | 1 |
| Miura, N | 1 |
| Watanabe, R | 2 |
| Sawada, Y | 1 |
| Noda, T | 1 |
| Nishimura, K | 1 |
| Asai, S | 1 |
| Fukumoto, T | 1 |
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| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Evaluation of Stress Hormone Concentration During the Resection of Pheochromocytoma. Comparison of Surgeon - Anesthesiologist - Patient[NCT00948181] | 8 participants (Anticipated) | Observational | 2009-06-30 | Active, not recruiting | |||
| Pheochromocytoma Randomised Study Comparing Adrenoreceptor Inhibiting Agents for Preoperative Treatment[NCT01379898] | Phase 4 | 134 participants (Actual) | Interventional | 2011-12-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
14 reviews available for normetanephrine and Pheochromocytoma
| Article | Year |
|---|---|
ACCURACY OF PLASMA FREE METANEPHRINES IN THE DIAGNOSIS OF PHEOCHROMOCYTOMA AND PARAGANGLIOMA: A SYSTEMATIC REVIEW AND META-ANALYSIS.
Topics: Adrenal Gland Neoplasms; Biomarkers; Chromatography, Liquid; Humans; Immunoenzyme Techniques; Metane | 2017 |
Excessive Catecholamine Secretion and the Activation of the Renin-Angiotensin-Aldosterone-System in Patients with Pheochromocytoma: A Single Center Experience and Overview of the Literature.
Topics: Adrenal Gland Neoplasms; Aldosterone; Catecholamines; Essential Hypertension; Female; Humans; Male; | 2017 |
[CME: Pheochromocytoma in the General Practice].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Diagnosis, Differential; Humans; Laparoscopy; Magnetic Reson | 2018 |
Diagnosis of endocrine disease: Biochemical diagnosis of phaeochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Adult; Biomarkers, Tumor; Catecholamines; Dopamine; False Negative Reaction | 2014 |
[Programs for continuing medical education: a session; 6. Differential diagnosis and treatment of adrenal incidentaloma].
Topics: Adrenal Gland Neoplasms; Aldosterone; Biomarkers; Catecholamines; Cushing Syndrome; Diagnosis, Diffe | 2014 |
Laboratory evaluation of pheochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Clinical Laboratory Techniques; Dopamine; Humans; Metanephrine; Normetaneph | 2014 |
[Measurement of catecholamine in plasma and urine for detecting pheochromocytomas].
Topics: Adrenal Gland Neoplasms; Catecholamines; Humans; Metanephrine; Normetanephrine; Pheochromocytoma | 2011 |
[Metanephrine (M), normetanephrine (NM) and fractionated metanephrines].
Topics: Adrenal Gland Neoplasms; Autonomic Nervous System Diseases; Biomarkers; Chromatography, High Pressur | 2005 |
Flushing, pheochromocytoma, and the dermatologist.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Blood Platelets; Flushing; Genes, Tumor Suppr | 2006 |
[Plasma metanephrine measurements make the diagnosis of pheochromocytoma easier].
Topics: Adrenal Gland Neoplasms; Diagnosis, Differential; Diagnostic Errors; False Negative Reactions; Human | 1998 |
[Metanephrine (M) and normetanephrine (NM)].
Topics: Adolescent; Adult; Child; Child, Preschool; Humans; Infant; Metanephrine; Neuroblastoma; Normetaneph | 1999 |
Phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Blood Pressure; Chromaffin Granules; Chromatography, High P | 1985 |
Pheochromocytoma: advances in diagnosis and treatment.
Topics: Adrenal Gland Neoplasms; Catecholamines; Child; Creatinine; Diagnosis, Differential; Epinephrine; Fe | 1972 |
Pitfalls in the technique and interpretation of regional venous sampling for localizing pheochromocytoma.
Topics: Adult; Catheterization; Child; Epinephrine; Female; Humans; Male; Methods; Norepinephrine; Normetane | 1974 |
11 trials available for normetanephrine and Pheochromocytoma
| Article | Year |
|---|---|
Clonidine suppression test for a reliable diagnosis of pheochromocytoma: When to use.
Topics: Adrenal Gland Neoplasms; Clonidine; Humans; Hypertension; Metanephrine; Normetanephrine; Paraganglio | 2022 |
Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; alpha-Methyltyrosine; Child; Fe | 2019 |
Surgical outcomes of a randomized controlled trial compared robotic versus laparoscopic adrenalectomy for pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Blood Loss, Surgical; Female; Hospitalization; Humans | 2020 |
Higher sympathetic activity as a risk factor for skeletal deterioration in pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Bone and Bones; Bone Density; Bone Resorption; Cancellous Bone | 2018 |
Change of skeletal muscle mass in patients with pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Female; Humans; Linear Models; Male; Metanephrine; Middle Aged; Muscle, Ske | 2019 |
Biochemical diagnosis of phaeochromocytoma using plasma-free normetanephrine, metanephrine and methoxytyramine: importance of supine sampling under fasting conditions.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Blood Specim | 2014 |
Evaluation of an enzyme immunoassay for plasma-free metanephrines in the diagnosis of catecholamine-secreting tumors.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Catecholamines; Child; Cohort S | 2009 |
Influence of various confounding variables and storage conditions on metanephrine and normetanephrine levels in plasma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Blood Chemical Analysis; Blood Specimen Collection; Conf | 2010 |
Parkinson's disease: the effect of L-dopa therapy on urinary free catecholamines and metabolites.
Topics: Adolescent; Adult; Aged; Antiparkinson Agents; Catecholamines; Creatinine; Dopamine; Female; Homovan | 2007 |
[Absence of labetalol interference on urine metanephrine determination in hypertensive patients].
Topics: Adrenal Gland Neoplasms; Adult; Aged; Chromatography, Liquid; Female; Humans; Hypertension; Labetalo | 1992 |
[Biochemical measurement of the function of the adrenal medulla and sympathetic system in the clinic].
Topics: Adrenal Medulla; Catecholamines; Clinical Trials as Topic; Depression, Chemical; Epinephrine; Female | 1970 |
210 other studies available for normetanephrine and Pheochromocytoma
| Article | Year |
|---|---|
Study of stability and interference for catecholamines and metanephrines, 3-methoxytyramine: key point of an accurate diagnosis for pheochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Anticoagulants; Catecholamines; Dopamine; Epinephrine; Hemoglobins; Humans; | 2021 |
Updated reference intervals for urine normetanephrine have no effect on test sensitivity but fewer false positives.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; False Positive Reactions; Female; Humans; Male; Mi | 2022 |
An automated magnetic bead extraction method for measuring plasma metanephrines and 3-methoxytyramine using liquid chromatography tandem mass spectrometry.
Topics: Adrenal Gland Neoplasms; Chromatography, High Pressure Liquid; Chromatography, Liquid; Dopamine; Hum | 2022 |
Improved Diagnostic Accuracy of Clonidine Suppression Testing Using an Age-Related Cutoff for Plasma Normetanephrine.
Topics: Adrenal Gland Neoplasms; Clonidine; Humans; Metanephrine; Normetanephrine; Paraganglioma; Pheochromo | 2022 |
ProSAAS peptide of the granin protein family in biochemical diagnostics of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Chromogranin A; Chromogranins; Female; Humans; Male; Metanephrine; Normetan | 2022 |
Preanalytical Considerations and Outpatient Versus Inpatient Tests of Plasma Metanephrines to Diagnose Pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Humans; Inpatients; Metanephrine; Normetanephrine; Outpatients; Paraganglio | 2022 |
A retrospective study on the association between urine metanephrines and cardiometabolic risk in patients with nonfunctioning adrenal incidentaloma.
Topics: Adrenal Gland Neoplasms; Cross-Sectional Studies; Humans; Hypertension; Metabolic Syndrome; Metaneph | 2022 |
Pre- and peri-operative characteristics, complications and outcomes of patients with biochemically silent pheochromocytomas; a case series.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Humans; Hypertension; Male; Middle Aged; Normetanephrine; Phen | 2022 |
Stereotactic body radiation therapy as an alternative to adrenalectomy for the treatment of pheochromocytomas in 8 dogs.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Anesthetics; Animals; Creatinine; Dog Diseases; Dogs; Humans | 2023 |
Comparison of plasma metanephrines in patients with cyanotic and acyanotic congenital heart disease.
Topics: Adrenal Gland Neoplasms; Adult; Cross-Sectional Studies; Female; Heart Defects, Congenital; Humans; | 2022 |
Case report: Incidentally discovered case of pheochromocytoma as a cause of long COVID-19 syndrome.
Topics: Adrenal Gland Neoplasms; Adult; Blood Pressure Monitoring, Ambulatory; COVID-19; Dizziness; Humans; | 2022 |
Quantitative analysis of catecholamines and their metabolites in 491 patients with adrenal tumors: a retrospective single-center cohort study.
Topics: Adrenal Gland Neoplasms; Cohort Studies; Humans; Metanephrine; Normetanephrine; Paraganglioma; Pheoc | 2023 |
Reference intervals for plasma, urinary, and salivary concentrations of free metanephrines in dogs: Relevance to the diagnosis of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenocortical Hyperfunction; Animals; Chromatography, Liquid; Dog Diseases | 2023 |
Diagnosis, treatment and outcome of pheochromocytoma in a cat.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Animals; Cat Diseases; Cats; Male; Metanephrine; Normetaneph | 2023 |
An adrenal cortical adenoma with neuroendocrine-type granules mimicking pheochromocytoma.
Topics: Adrenal Cortex Neoplasms; Adrenal Gland Neoplasms; Adrenalectomy; Adrenocortical Adenoma; Humans; No | 2023 |
Hemodynamic parameters in patients undergoing surgery for pheochromocytoma/paraganglioma: a retrospective study.
Topics: Adrenal Gland Neoplasms; Catecholamines; Doxazosin; Female; Hemodynamics; Humans; Male; Middle Aged; | 2023 |
Sulfasalazine as a cause of false-positive elevation of urinary normetanephrine in patients with adrenal mass and suspected phaeochromocytoma: a diagnostic challenge.
Topics: Adrenal Gland Neoplasms; Humans; Metanephrine; Normetanephrine; Pheochromocytoma; Sulfasalazine | 2023 |
False-positive results for pheochromocytoma associated with norepinephrine reuptake blockade.
Topics: Adrenal Gland Neoplasms; Antidepressive Agents, Tricyclic; Humans; Metanephrine; Norepinephrine; Nor | 2024 |
Clinical factors affecting spot urine fractionated metanephrines in patients suspected pheochromocytoma/paraganglioma.
Topics: Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Aged, 80 and over; Female; Humans; Male; Metaneph | 2020 |
Moderate renal impairment does not preclude the accuracy of 24-hour urine normetanephrine measurements for suspected pheochromoctyoma.
Topics: Adrenal Gland Neoplasms; Glomerular Filtration Rate; Humans; Metanephrine; Normetanephrine; Pheochro | 2020 |
Stability and reference intervals of spot urinary fractionated metanephrines and methoxytyramine by tandem mass spectrometry as a screening method for pheochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Chromatography, Liquid; Dopamine; Female; Humans; Male; Metanephrine; Norme | 2020 |
Random 'spot' urinary metanephrines compared with 24-h-urinary and plasma results in phaeochromocytomas and paragangliomas.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Aged, 80 and over; Area Under Curve; | 2020 |
Plasma metanephrines and prospective prediction of tumor location, size and mutation type in patients with pheochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Algorithms; Biomarkers, Tumor; Dopamine; Fe | 2020 |
A 3-min UPLC-MS/MS method for the simultaneous determination of plasma catecholamines and their metabolites: Method verification and diagnostic efficiency.
Topics: Adrenal Gland Neoplasms; Calibration; Catecholamines; Chromatography, Liquid; Dopamine; Female; Huma | 2021 |
Verifying Clinically Derived Reference Intervals for Daily Excretion Rates of Fractionated Metanephrines Using Modern Indirect Reference Interval Models.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Child; Female; Humans; Likeliho | 2021 |
Diagnostic Accuracy of Salivary Metanephrines in Pheochromocytomas and Paragangliomas.
Topics: Adrenal Gland Neoplasms; Adult; Chromatography, Liquid; Humans; Male; Metanephrine; Normetanephrine; | 2021 |
Malignant pheochromocytoma: pain, palpitation, perspiration and perplexities.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Chest Pain; Humans; Male; Middle Aged; Normetanephrine; Pheo | 2021 |
Predictors of Hypotension after Adrenalectomy for Pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Biomarkers; Humans; Hypotension; Japan; Metanep | 2021 |
Risk factors for intraoperative complications in pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Doxazosin; Female; Humans; Hydrocortisone; Hypo | 2021 |
Abdominal pain and hipertensive crisis as initial manifestation of a malignant pheocromocytoma.
Topics: Abdominal Pain; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Bone Neoplasms; Carcinoma; Diagnosis, | 2017 |
A Case Report of Cystic Pheochromocytoma.
Topics: Abdominal Pain; Adrenal Gland Neoplasms; Humans; Hypertension; Male; Metanephrine; Middle Aged; Norm | 2017 |
Hypertensive emergency masquerading as phaeochromocytoma: a report of two cases.
Topics: Adrenal Gland Neoplasms; Aged; Diagnosis, Differential; False Positive Reactions; Humans; Hypertensi | 2017 |
Radioimmunoassay of chromogranin A and free metanephrines in diagnosis of pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Biomarkers, Tumor; Chromogranin A; Female; Humans; | 2017 |
[Determination of urine catecholamines and metanephrines by reversed-phase liquid chromatography-tandem mass spectrometry].
Topics: Catecholamines; Chromatography, High Pressure Liquid; Chromatography, Liquid; Chromatography, Revers | 2017 |
Next-generation panel sequencing identifies
Topics: Adrenal Gland Neoplasms; Adult; Base Sequence; Carcinoma, Neuroendocrine; Codon, Nonsense; Epinephri | 2018 |
A laparoscopic revelation: incidental nodule in a patient with bilateral phaeochromocytoma in multiple endocrine neoplasia Type 2A.
Topics: Adrenal Glands; Adult; Calcitonin; Carcinoma, Medullary; Catecholamines; Female; Humans; Laparoscopy | 2017 |
When Biochemical Phenotype Predicts Genotype: Pheochromocytoma and Paraganglioma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Female; Genotype; Germ-Line Mutatio | 2018 |
Multifocal pheochromocytoma-paraganglioma in a 29-year-old woman with cyanotic congenital heart disease.
Topics: Adrenal Gland Neoplasms; Adult; Female; Heart Defects, Congenital; Humans; Norepinephrine; Normetane | 2019 |
Differences in the actions of adrenaline and noradrenaline with regard to glucose intolerance in patients with pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Aged; Blood Glucose; Epinephrine; Female; Glucose Intolerance; Glycated Hem | 2019 |
Colorimetric detection of normetanephrine, a pheochromocytoma biomarker, using bifunctionalised gold nanoparticles.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Cell Line, Tumor; Colorimetry; Gold; Humans; Limit of De | 2019 |
Age-specific pediatric reference intervals for plasma free normetanephrine, metanephrine, 3-methoxytyramine and 3-O-methyldopa: Particular importance for early infancy.
Topics: Adolescent; Adrenal Gland Neoplasms; Aging; Blood Chemical Analysis; Catecholamines; Child; Child, P | 2019 |
A high rate of modestly elevated plasma normetanephrine in a population referred for suspected PPGL when measured in a seated position.
Topics: Adrenal Gland Neoplasms; Adult; Canada; Female; Humans; Male; Middle Aged; Normetanephrine; Paragang | 2019 |
Plasma-free vs deconjugated metanephrines for diagnosis of phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Biomarkers, Tumor; Chromatography, Liquid; Electrochemical Technique | 2013 |
Analysis of plasma 3-methoxytyramine, normetanephrine and metanephrine by ultraperformance liquid chromatography-tandem mass spectrometry: utility for diagnosis of dopamine-producing metastatic phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Blood Chemical Analysis; Chromatography, High Pressure Liquid; | 2013 |
The role of urinary fractionated metanephrines in the diagnosis of phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Female; Humans; Immunoenzyme Techniques; Male; Metanephrine; Middle | 2013 |
Phasing-in plasma metanephrines determination.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Chromatograp | 2013 |
Pheochromocytoma--analysis of 15 consecutive cases from one centre.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Female; Genetic Predisposition to Disease; Huma | 2013 |
Levodopa therapy in Parkinson's disease: influence on liquid chromatographic tandem mass spectrometric-based measurements of plasma and urinary normetanephrine, metanephrine and methoxytyramine.
Topics: Aged; Aged, 80 and over; Chromatography, Liquid; Dopamine; Epinephrine; Female; Humans; Levodopa; Ma | 2014 |
A 12-cm mass with no symptoms and unremarkable laboratory results.
Topics: Adrenal Gland Neoplasms; Female; Humans; Metanephrine; Middle Aged; Normetanephrine; Pheochromocytom | 2013 |
Comparison of plasma free metanephrines between healthy dogs and 3 dogs with pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Animals; Biomarkers, Tumor; Blood Chemical Analysis; Case-Control Studies; | 2013 |
Obstructive sleep apnea and tricyclic antidepressant use presenting as a pseudopheochromocytoma in an active duty sailor: a case report.
Topics: Adrenal Gland Neoplasms; Adult; Amitriptyline; Antidepressive Agents, Tricyclic; Diagnosis, Differen | 2014 |
Biochemical and radiological relationships in patients with pheochromocytoma: lessons from a case control study.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Case-Control Studies; Child; Fa | 2014 |
Seasonal variation in plasma free normetanephrine concentrations: implications for biochemical diagnosis of pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Child; Female; Forearm; Hot Tem | 2014 |
Seasonal variations of plasma normetanephrine levels in Los Angeles.
Topics: Adrenal Gland Neoplasms; Female; Humans; Male; Metanephrine; Normetanephrine; Pheochromocytoma; Seas | 2014 |
Seasonal variations of plasma normetaneprine levels: the authors reply.
Topics: Adrenal Gland Neoplasms; Female; Humans; Male; Metanephrine; Normetanephrine; Pheochromocytoma; Seas | 2014 |
Plasma free metanephrines in the diagnosis of pheochromocytoma: diagnostic accuracy and strategies for Japanese patients.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adult; Biomarkers; Cohort Studies; Female; Hospitals, Munic | 2014 |
Amoxicillin-associated interference in an HPLC-EC assay for urinary fractionated metanephrines: potential pitfall in pheochromocytoma biochemical diagnosis.
Topics: Adolescent; Adrenal Gland Neoplasms; Amoxicillin; Child; Chromatography, High Pressure Liquid; Femal | 2014 |
Supine or sitting? Economic considerations regarding patient position during plasma metanephrine analysis for the exclusion of chromaffin tumours.
Topics: Adrenal Gland Neoplasms; Blood Specimen Collection; Dopamine; Female; Humans; Male; Metanephrine; No | 2015 |
Supine or Sitting? Economic and other considerations for use of plasma metanephrines for diagnosis of phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Blood Specimen Collection; Dopamine; Female; Humans; Male; Metanephrine; No | 2015 |
Supine or sitting? the voice of the patient stakeholders: economics vs clinically and medically sound.
Topics: Adrenal Gland Neoplasms; Blood Specimen Collection; Dopamine; Female; Humans; Male; Metanephrine; No | 2015 |
Inhibin alpha-subunit, Melan A and MNF116 in pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Female; Humans; Inhibins; Keratins; Male; MART-1 Antigen; Metanephrine; Mid | 2014 |
Supine or sitting plasma metanephrine screening? A unifying solution for patients and doctors.
Topics: Adrenal Gland Neoplasms; Blood Specimen Collection; Dopamine; Female; Humans; Male; Metanephrine; No | 2015 |
Catecholamine-Synthesizing Enzymes Are Expressed in Parasympathetic Head and Neck Paraganglioma Tissue.
Topics: Aromatic-L-Amino-Acid Decarboxylases; Dopamine; Dopamine beta-Hydroxylase; Female; Head and Neck Neo | 2015 |
[Analysis of laboratory data of 155 patients with pheochromocytoma-paraganglioma syndrome diagnosed during the past 20 years].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Biomarkers; Catecholamines; Child; Chromatography, | 2015 |
Development and validation of liquid chromatography-tandem mass spectrometry method for quantification of plasma metanephrines for differential diagnosis of adrenal incidentaloma.
Topics: Adrenal Gland Neoplasms; Case-Control Studies; Chromatography, High Pressure Liquid; Diagnosis, Diff | 2015 |
Much more than anxiety...
Topics: 3-Iodobenzylguanidine; Abdomen; Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Anxiety; Chromo | 2015 |
Different values of urinary fractionated metanephrines after unilateral adrenalectomy for pheochromocytoma according to time intervals after surgery.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Biomarkers; Case-Control Studies; Female; Humans; Mal | 2017 |
Longitudinal plasma metanephrines preceding pheochromocytoma diagnosis: a retrospective case-control serum repository study.
Topics: Adrenal Gland Neoplasms; Adult; Case-Control Studies; Essential Hypertension; Female; Humans; Hypert | 2016 |
Deconjugated urinary metanephrine, normetanephrine and 3-methoxytyramine in laboratory diagnosis of pheochromocytoma and paraganglioma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Clinical Lab | 2015 |
Morphology, Biochemistry, and Pathophysiology of MENX-Related Pheochromocytoma Recapitulate the Clinical Features.
Topics: Adrenal Gland Neoplasms; Adrenal Medulla; Animals; Blood Pressure; Disease Models, Animal; Epinephri | 2016 |
Symptom-dependent cut-offs of urine metanephrines improve diagnostic accuracy for detecting pheochromocytomas in two separate cohorts, compared to symptom-independent cut-offs.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Female; Humans; Male; Metanephrine; Middle Aged | 2016 |
Venlafaxine drug interaction in the diagnosis of pheochromocytoma.
Topics: Abdominal Pain; Adrenal Gland Neoplasms; Aged; Catecholamines; False Positive Reactions; Female; Gas | 2016 |
Comparison of free plasma metanephrines enzyme immunoassay with (131)I-MIBG scan in diagnosis of pheochromocytoma.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adult; Chromatography, High Pressure Liquid; Female; | 2008 |
[Pheochromocytoma in end-stage renal disease patient treated by peritoneal dialysis].
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Female; Headache; Humans; Kidney Failure, Chronic; Ma | 2008 |
Myocardial infarction in a 30-year-old patient with pheochromocytoma and type 1 neurofibromatosis.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Female; Humans; Myocardial Infarction; Neurofibromato | 2008 |
Dietary influences on plasma and urinary metanephrines: implications for diagnosis of catecholamine-producing tumors.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Cross-Over Studies; Diet; Dopamine; Female; | 2009 |
Diagnostic accuracy of free and total metanephrines in plasma and fractionated metanephrines in urine of patients with pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Child; Femal | 2010 |
Plasma free metanephrines in healthy cats, cats with non-adrenal disease and a cat with suspected phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Animals; Case-Control Studies; Cat Diseases; Cats; Chromato | 2010 |
Measurement of urinary metadrenaline and normetadrenaline by liquid chromatography tandem mass spectrometry for the diagnosis of phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Chromatography, Liquid; Humans; Linear Models; Metanephrine; Normetanephrin | 2010 |
An audit of management of patients with borderline increased plasma-free metanephrines.
Topics: Adrenal Gland Neoplasms; Chromatography, High Pressure Liquid; Humans; Metanephrine; Normetanephrine | 2010 |
[Metanephrine (M), normetanephrine (NM), and fractionated metanephrines].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Child; Child, Preschool; Humans; Infant; Metanephrine; N | 2010 |
Biochemical misdiagnosis of pheochromocytoma in patients treated with sulfasalazine.
Topics: Adrenal Gland Neoplasms; Aged; Anti-Inflammatory Agents, Non-Steroidal; Diagnostic Errors; False Pos | 2010 |
Measurements of plasma methoxytyramine, normetanephrine, and metanephrine as discriminators of different hereditary forms of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Diagnosis, Differential; Dopamine; Humans; Metanephrine; | 2011 |
Predictive factors for malignant pheochromocytoma: analysis of 136 patients.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Analysis of Variance; Biomarkers, Tumor; Cyclooxygenase 2; Dia | 2011 |
Is there still a place for adrenal venous sampling in the diagnostic localization of pheochromocytoma?
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Biomarkers, Tumor; Catecholamines; Female; H | 2011 |
[Diagnostic difficulties in recognizing of pheochromocytoma].
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Aged; Biomarkers, Tumor; Catecholamines; | 2010 |
Phaeochromocytoma: a catecholamine and oxidative stress disorder.
Topics: Adenosine Triphosphate; Adrenal Gland Neoplasms; Catecholamines; Humans; Metanephrine; Multiple Endo | 2011 |
Drugs and pheochromocytoma--don't be fooled by every elevated metanephrine.
Topics: Adrenal Gland Neoplasms; Biomarkers, Tumor; Cyclohexanols; Female; Humans; Metanephrine; Middle Aged | 2011 |
Improved plasma free metadrenaline analysis requires mixed mode cation exchange solid-phase extraction prior to liquid chromatography tandem mass spectrometry detection.
Topics: Adrenal Gland Neoplasms; Analytic Sample Preparation Methods; Cation Exchange Resins; Chromatography | 2011 |
A patient with a large recurrent pheochromocytoma demonstrating the pitfalls of diagnosis.
Topics: Abdominal Pain; Adrenal Gland Neoplasms; Antihypertensive Agents; Chromogranin A; Diabetes Mellitus, | 2011 |
Enzyme-linked immunoassay for plasma-free metanephrines in the biochemical diagnosis of phaeochromocytoma in adults is not ideal.
Topics: Adrenal Gland Neoplasms; Diagnostic Errors; Humans; Immunoenzyme Techniques; Metanephrine; Normetane | 2011 |
Comparison of plasma metanephrines measured by a commercial immunoassay and urinary catecholamines in the diagnosis of pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Aged, 80 and over; Catecholamines; | 2011 |
Urinary metanephrines by liquid chromatography tandem mass spectrometry: using multiple quantification methods to minimize interferences in a high throughput method.
Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography, Liquid; Humans; Limit of Detection; Linear | 2011 |
Plasma methoxytyramine: a novel biomarker of metastatic pheochromocytoma and paraganglioma in relation to established risk factors of tumour size, location and SDHB mutation status.
Topics: Adrenal Gland Neoplasms; Adult; Biomarkers, Tumor; Dopamine; Female; Humans; Male; Middle Aged; Muta | 2012 |
The half-lives of plasma free metanephrines.
Topics: Adrenal Gland Neoplasms; Female; Half-Life; Humans; Metanephrine; Middle Aged; Normetanephrine; Pheo | 2012 |
A phaeochromocytoma occurring in a patient with Parkinson's disease on L-dopa therapy: a diagnostic challenge.
Topics: Adrenal Gland Neoplasms; Antiparkinson Agents; Creatinine; Humans; Levodopa; Male; Metanephrine; Mid | 2012 |
[Falsely increased urinary normetanephrine levels during sulfasalazine treatment].
Topics: Adrenal Gland Neoplasms; Adult; Female; Humans; Normetanephrine; Pheochromocytoma; Sulfasalazine | 2012 |
Is biochemical screening for pheochromocytoma in adrenal incidentalomas expressing low unenhanced attenuation on computed tomography necessary?
Topics: Abdominal Pain; Adrenal Gland Neoplasms; Adrenocorticotropic Hormone; Adult; Aged; Aged, 80 and over | 2012 |
Plasma and urinary metanephrines determined by an enzyme immunoassay, but not serum chromogranin A for the diagnosis of pheochromocytoma in patients with adrenal mass.
Topics: Adrenal Gland Neoplasms; Adrenocortical Adenoma; Adult; Aldosterone; Chromogranin A; Diagnosis, Diff | 2012 |
Plasma normetanephrine concentrations are affected by dietary sodium intake.
Topics: Adrenal Gland Neoplasms; Artifacts; Female; Humans; Male; Normetanephrine; Pheochromocytoma; Sodium, | 2012 |
Different diagnostic cut-off values of urinary fractionated metanephrines according to sex for the diagnosis of pheochromocytoma in Korean subjects.
Topics: Academic Medical Centers; Adrenal Gland Neoplasms; Adrenal Glands; Adult; Aged; Chromatography, High | 2012 |
Reference intervals for plasma free metanephrines with an age adjustment for normetanephrine for optimized laboratory testing of phaeochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Aged; Aged, 80 and over; Case-Control Studi | 2013 |
[Diagnosis of pheochromocytoma and paraganglioma: the clonidine suppression test in patients with borderline elevations of plasma free normetanephrine].
Topics: Adrenal Gland Neoplasms; Adult; Aged; Biomarkers; Clonidine; Female; Humans; Male; Middle Aged; Norm | 2013 |
Unilateral and bilateral adrenalectomy for pheochromocytoma requires adjustment of urinary and plasma metanephrine reference ranges.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Chemistry, Clinical; Epinephrine; Female; Follow-Up S | 2013 |
Pheochromocytoma: a disease with many faces.
Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography, High Pressure Liquid; Clonidine; Diagnosis, | 2002 |
Biochemical diagnosis of pheochromocytoma: how to distinguish true- from false-positive test results.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adult; Antidepressive Agents, Tricyclic; Bioc | 2003 |
[NORMAL AND PATHOLOGICAL URINARY ELIMINATION OF THE M-O-METHYLADRENALINE + M-O-METHYLNORADRENALINE MASS].
Topics: Body Fluids; Epinephrine; Metabolism; Neoplasms; Neuroblastoma; Norepinephrine; Normetanephrine; Phe | 1963 |
STUDIES OF FUNCTIONAL NEURAL TUMORS. I. URINARY 3-METHOXY-4-HYDROXY-PHENYL-METABOLITES.
Topics: Adolescent; Alcohols; Amino Acids; Benzoates; Catecholamines; Child; Ganglioneuroma; Humans; Infant; | 1963 |
[DISCUSSION ON A SIMPLE METHOD OF ANALYZING METANEPHRINE PLUS NORMETANEPHRINE IN THE DIFFERENTIAL ANALYSIS OF PHEOCHROMOCYTOMA].
Topics: Body Fluids; Diagnosis, Differential; Humans; Metanephrine; Normetanephrine; Phenethylamines; Pheoch | 1963 |
TURNOVER AND METABOLISM OF CATECHOLAMINES IN PATIENTS WITH PHEOCHROMOCYTOMA.
Topics: Catecholamines; Epinephrine; Humans; Mandelic Acids; Metabolism; Norepinephrine; Normetanephrine; Ph | 1964 |
[DETERMINATION OF METANEPHRINE AND NORMETANEPHRINE IN URINE].
Topics: Catecholamines; Humans; Metabolism; Metanephrine; Normetanephrine; Phenethylamines; Pheochromocytoma | 1963 |
[COLORIMETRIC DETERMINATION OF METADRENALINE AND NORMETADRENALINE IN THE URINE].
Topics: Body Fluids; Clinical Laboratory Techniques; Colorimetry; Epinephrine; Humans; Metanephrine; Norepin | 1963 |
NEW RAPID TEST FOR PHEOCHROMOCYTOMA. URINARY ASSAY OF NORMETANEPHRINE, METANEPHRINE, AND 3-METHOXY-4-HYDROXYPHENYLGLYCOL.
Topics: Electrophoresis; Epinephrine; Ethylene Glycols; Glycols; Humans; Metanephrine; Normetanephrine; Phen | 1964 |
[METANEPHRINE, NORMETANEPHRINE AND METABOLITES OF CATECHOLAMINES].
Topics: Catecholamines; Chromatography; Electrophoresis; Epinephrine; Humans; Metanephrine; Normetanephrine; | 1963 |
QUANTITATIVE DETERMINATION OF METANEPHRINE AND NORMETANEPHRINE IN URINE.
Topics: Amines; Chromatography; Dihydroxyphenylalanine; Epinephrine; Fluorescence; Fluorometry; Humans; Indi | 1964 |
[PRESSOR AMINES AND ESSENTIAL ARTERIAL HYPERTENSION].
Topics: Amines; Blood Vessels; Epinephrine; Essential Hypertension; Hypertension; Metabolism; Norepinephrine | 1964 |
Measurement of plasma free metanephrine and normetanephrine by liquid chromatography-tandem mass spectrometry for diagnosis of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Calibration; Chromatography, Liquid; Humans; Mass Spectrometry | 2004 |
Diagnosis and localization of pheochromocytoma.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Aged; Algorithms; Anesthesia, General; Biomarkers; B | 2004 |
Predictive value of preoperative transthoracic echocardiography in patients undergoing adrenalectomy for pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Chest Pain; Diagnostic Tests, Routine; Echocardiography; Ech | 2004 |
Malignant pheochromocytoma associated with germline mutation of the SDHB gene.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adrenalectomy; Antineoplastic Combined Chemotherapy Protoco | 2004 |
Nonparametric determination of reference intervals for plasma metanephrine and normetanephrine.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Biomarkers, Tumor; Humans; Metanephrine; Middle Aged; Normetan | 2004 |
Pheochromocytoma catecholamine phenotypes and prediction of tumor size and location by use of plasma free metanephrines.
Topics: Adrenal Gland Neoplasms; Catecholamines; Humans; Metanephrine; Normetanephrine; Phenotype; Pheochrom | 2005 |
Pheochromocytoma presenting as heart failure.
Topics: Acute Disease; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Anxiety; Causality; Diagnosis, Differe | 2005 |
Diagnostic value of various biochemical parameters for the diagnosis of pheochromocytoma in patients with adrenal mass.
Topics: Adrenal Gland Neoplasms; Adult; Biomarkers; Catecholamines; Chromatography, High Pressure Liquid; Fe | 2006 |
The role of chromogranin A in the management of patients with phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Area Under Curve; Biomarkers, Tumor; Case-Control Studies; Cat | 2006 |
Adrenal incidentaloma: review of 197 patients and report of a drug-related false-positive urinary normetanephrine result.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adult; Anti-Inflammatory Agents, Non-Steroidal; Biomarkers, | 2006 |
Pheochromocytoma: recommendations for clinical practice from the First International Symposium. October 2005.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Biomarkers, Tumor; Child; Humans; Metanephrine; Middle A | 2007 |
The diagnostic efficacy of urinary fractionated metanephrines measured by tandem mass spectrometry in detection of pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Biomarkers, Tumor; Child; Femal | 2007 |
Free plasma metanephrines as a screening test for pheochromocytoma in low-risk patients.
Topics: Adrenal Gland Neoplasms; Area Under Curve; Cross-Sectional Studies; Czech Republic; Female; Humans; | 2007 |
Another cause of 'pseudophaeochromocytoma'--quetiapine associated with a false positive normetanephrine result.
Topics: Adrenal Gland Neoplasms; Adult; Antipsychotic Agents; Diagnosis, Differential; Dibenzothiazepines; F | 2007 |
An apparent phaeochromocytoma and abnormal thyroid function tests.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adult; Epinephrine; Female; Humans; Metanephrine; Normetane | 2008 |
[Determination of vanillylmandelic acid in the metadrenaline and normetadrenaline unit. Value in pheochromocytoma].
Topics: Adolescent; Adult; Child; Child, Preschool; Epinephrine; Female; Humans; Male; Mandelic Acids; Middl | 1967 |
A new method for the simultaneous analysis of free and sulfoconjugated normetanephrine, metanephrine, and 3-methoxytyramine in human urine by HPLC with electrochemical detection.
Topics: Adrenal Gland Neoplasms; Adult; Chromatography, High Pressure Liquid; Dopamine; Epinephrine; Female; | 1984 |
[Catecholamines and their derivatives in the study of pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Catecholamines; Humans; Metanephrine; Normetanephrine; Pheochromocytoma; Va | 1983 |
[Strategy for the biochemical study of pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Catecholamines; Humans; Metanephrine; Normetanephrine; Pheochromocytoma; Va | 1983 |
A radioenzymatic assay for free and conjugated normetanephrine and octopamine excretion in man.
Topics: Adult; Chromatography, Thin Layer; Humans; Middle Aged; Normetanephrine; Octopamine; Phenylethanolam | 1980 |
High-performance liquid chromatography with electrochemical detection for the simultaneous determination of the methoxylated amines, normetanephrine, metanephrine and 3-methoxytyramine, in urine.
Topics: Adolescent; Adult; Child; Child, Preschool; Chromatography, High Pressure Liquid; Dopamine; Electroc | 1983 |
Quantitation of urinary normetanephrine and metanephrine by reversed-phase extraction and mass-fragmentographic analysis.
Topics: Chromatography, Liquid; Epinephrine; Gas Chromatography-Mass Spectrometry; Humans; Hypertension; Met | 1982 |
The relationships of free to conjugated normetanephrine in plasma and spinal fluid of hypertensive patients.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Humans; Hypertension; Middle Aged; Normetanephrine; Pheo | 1982 |
Scintigraphic localization of pheochromocytoma.
Topics: 3-Iodobenzylguanidine; Adolescent; Adrenal Gland Neoplasms; Adult; Epinephrine; Female; Guanidines; | 1981 |
A radioenzymatic assay for plasma normetanephrine in man and patients with pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Child, Preschool; Chromatography, Ion Exchange; Chromato | 1980 |
Central and regional normetadrenaline in evaluation of neurogenic aspects of hypertension: aid to diagnosis of phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Epinephrine; Humans; Hypertension; Middle Aged; Norepinephrine; Norm | 1980 |
Regional release and removal of catecholamines and extraneuronal metabolism to metanephrines.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Angina Pectoris; Cardiomyopathy, Dilated; Cardiovascular Disea | 1995 |
[Plasma methoxyamines assay: a practical advance for the diagnosis of pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Adult; Aged; Angiotensin-Converting Enzyme Inhibitors; Chromatography, High | 1994 |
Urinary and plasma catecholamines and urinary catecholamine metabolites in pheochromocytoma: diagnostic value in 19 cases.
Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography, High Pressure Liquid; Epinephrine; Female; | 1994 |
[Determination of serum metanephrines in the diagnosis of pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Adult; Chromatography, High Pressure Liquid; Female; Humans; Male; Metaneph | 1994 |
Biochemical detection of phaeochromocytoma: should we still be measuring urinary HMMA?
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Chromatography, High Pressure Liquid; Epinephrine; Human | 1993 |
Determination of metanephrines in plasma by liquid chromatography with electrochemical detection.
Topics: Adrenal Gland Neoplasms; Chromatography, High Pressure Liquid; Epinephrine; Humans; Isoproterenol; M | 1993 |
Biochemical diagnosis of phaeochromocytoma: two instructive case reports.
Topics: Adrenal Gland Neoplasms; Adult; Dopamine; Epinephrine; Female; Homovanillic Acid; Humans; Lactates; | 1993 |
Phaeochromocytoma diagnosis.
Topics: Adrenal Gland Neoplasms; Catecholamines; Epinephrine; Humans; Metanephrine; Norepinephrine; Normetan | 1995 |
Overnight excretion of urinary catecholamines and metabolites in the detection of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Biomarkers; Chromatography, High Pressure Liquid; Chromatograp | 1996 |
Bilateral adrenalectomy with autotransplantation of adrenocortical tissue or unilateral adrenalectomy: treatment options for pheochromocytomas in multiple endocrine neoplasia type 2A.
Topics: Adolescent; Adrenal Cortex; Adrenal Gland Neoplasms; Adrenalectomy; Adult; Female; Humans; Male; Met | 1996 |
Evaluation of urinary metanephrine and normetanephrine enzyme immunoassay (ELISA) kits by comparison with isotope dilution mass spectrometry.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Child; Child, Preschool; Enzyme-Linked Immunosorbent Ass | 1997 |
Clues to the diagnosis of pheochromocytoma from the differential tissue metabolism of catecholamines.
Topics: Adrenal Gland Neoplasms; Biomarkers; Epinephrine; Humans; Metanephrine; Norepinephrine; Normetanephr | 1998 |
Efficacy of single-voided urine metanephrine and normetanephrine assay for diagnosing pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Biomarkers, Tumor; Female; Humans; Male; Metanephrine; Normetanephri | 1998 |
[Secreting retroperitoneal paraganglioma. Apropos of a case].
Topics: Chemotherapy, Adjuvant; Dehydroepiandrosterone; Female; Humans; Metanephrine; Middle Aged; Normetane | 1997 |
Plasma normetanephrine and metanephrine for detecting pheochromocytoma in von Hippel-Lindau disease and multiple endocrine neoplasia type 2.
Topics: Adolescent; Adult; Aged; Epinephrine; Female; Humans; Male; Metanephrine; Middle Aged; Multiple Endo | 1999 |
A case of giant malignant phaeochromocytoma.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Antineoplastic Agents; Antineoplastic Agents, Hormon | 2000 |
[The diagnosis of atypical pheochromocytoma: a challenge for the biologist as well].
Topics: Adrenal Gland Neoplasms; Adult; Aged; Biomarkers, Tumor; Catecholamines; Epinephrine; Female; Humans | 2001 |
Quantification of unconjugated metanephrines in human plasma without interference by acetaminophen.
Topics: Acetaminophen; Analgesics, Non-Narcotic; Biomarkers; Chromatography, High Pressure Liquid; Drug Inte | 2001 |
Lessons from an unpleasant surprise: a biochemical strategy for the diagnosis of pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Catecholamines; Chromatography, High Pressure Liqu | 2001 |
A "pheo" lurks: novel approaches for locating occult pheochromocytoma.
Topics: 3-Iodobenzylguanidine; Adrenal Gland Neoplasms; Adrenalectomy; Carrier Proteins; Dopamine; Epinephri | 2001 |
Evaluation of specific high-performance liquid-chromatographic determinations of urinary metanephrine and normetanephrine by comparison with isotope dilution mass spectrometry.
Topics: Adrenal Gland Neoplasms; Adult; Aged; Chromatography, High Pressure Liquid; Dopamine; Electrochemist | 2001 |
Validation of liquid chromatography-tandem mass spectrometry method for analysis of urinary conjugated metanephrine and normetanephrine for screening of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Biomarkers; Calibration; Chromatography, High Pressure Liquid; Colorimetry; | 2002 |
How to detect pheochromocytomas?--the diagnostic relevance of plasma free metanephrines.
Topics: Adrenal Gland Neoplasms; Humans; Metanephrine; Multiple Endocrine Neoplasia Type 2a; Neoplastic Synd | 2002 |
Labetalol and urinary metadrenalines.
Topics: Adrenal Gland Neoplasms; Epinephrine; Ethanolamines; Humans; Labetalol; Metanephrine; Normetanephrin | 1979 |
Plasma normetanephrine measurements for detection of pheochromocytoma in patients with hypertension.
Topics: Adrenal Gland Neoplasms; Humans; Hypertension; Normetanephrine; Pheochromocytoma | 1979 |
The urinary excretion of catecholamines and their derivatives in primary hypertension in man.
Topics: Adult; Catecholamines; Circadian Rhythm; Epinephrine; Humans; Hypertension; Male; Metanephrine; Midd | 1977 |
[Apropos of biological diagnosis of pheochromocytoma].
Topics: Adrenal Gland Neoplasms; Diagnosis, Differential; Epinephrine; Humans; Metanephrine; Normetanephrine | 1978 |
A simple and specific radioenzymatic assay for measurement of urinary normetanephrine.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; Adult; Female; Humans; Male; Methods; Middle Aged; Normetan | 1978 |
The diagnosis of pheochromocytoma. Overnight excretion of catecholamine metabolites.
Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Circadian Rhythm; Epinephrine; Fluorometry; Humans; | 1975 |
Gas-liquid chromatographic and mass fragmentographic determination of 3-O-methylated catecholamines in human plasma.
Topics: Adult; Aged; Catecholamines; Child; Chromatography, Gas; Chromatography, Ion Exchange; Female; Gas C | 1975 |
Measurement of plasma methoxyamines for the diagnosis of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Chromatography, High Pressure Liquid; Humans; Hypertension; Metaneph | 1991 |
[Clinical significance of metanephrine and normetanephrine analysis in endocrine tests of the adrenal medulla and sympathetic nervous system].
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenal Medulla; Adult; Child; Child, Preschool; Chromatography | 1989 |
Radioimmunoassay of metanephrine and normetanephrine for diagnosis of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Antibody Specificity; Epinephrine; Humans; Immune Sera; Iodine Radioisotope | 1986 |
[Plasma normetanephrine and metanephrine levels and their relationship to norepinephrine and epinephrine].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Epinephrine; Female; Humans; Kidney Failure, Chron | 1988 |
[Biochemical diagnosis of pheochromocytoma by determining normetanephrine and metanephrine concentrations in single voided urine].
Topics: Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Epinephrine; Female; Humans; Hypertension; | 1988 |
Simultaneous quantitation of catecholamines and O-methylated metabolites in urine by isocratic ion-pairing high-performance liquid chromatography with amperometric detection.
Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography, High Pressure Liquid; Dopamine; Electrochem | 1988 |
Urinary normetanephrine and metanephrine measured by radioimmunoassay for the diagnosis of pheochromocytoma: utility of 24-hour and random 1-hour urine determinations.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; Circadian Rhythm; Epinephrine; | 1988 |
Clinical and biochemical aspects of pheochromocytoma. Report of 110 cases.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Child; Circadian Rhythm; Dihydroxyphenylalanine; D | 1985 |
Familial extra-adrenal pheochromocytoma. A new syndrome.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Child; Epinephrine; Female; Humans; Kidney Neoplasms; Ma | 1985 |
Evaluation of screening tests for pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Catecholamines; Humans; Hypertension; Metanephrine; Normetanephrine; Pheoch | 1985 |
[Ultrastructural differentiation of pheochromocytoma (author's transl)].
Topics: Adrenal Gland Neoplasms; Adult; Child; Endoplasmic Reticulum; Epinephrine; Female; Humans; Male; Mic | 1973 |
[Studies on the secretion of various metabolites of adrenaline and noradrenaline in normotensive and hypertensive patients].
Topics: Catecholamines; Epinephrine; Humans; Hypertension; Mandelic Acids; Neuroblastoma; Norepinephrine; No | 1967 |
[A thin layer chromatography-colorimetry method of determination of urinary metanephrine and normetanephrine].
Topics: Catecholamines; Chemistry, Clinical; Chromatography, Thin Layer; Colorimetry; Methods; Normetanephri | 1970 |
Catecholamines-cyclic amp-angiotensin receptors. Plasma catecholamine concentrations in patients with hypertension.
Topics: Adrenal Gland Neoplasms; Biological Assay; Carbon Isotopes; Catecholamines; Cyclic AMP; Epinephrine; | 1970 |
An asymptomatic catecholamine-secreting pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Body Weight; Catecholamines; Dopamine; Epinephrine; Female; Headache; Human | 1974 |
A new urinary assay for separate normetanephrine and metanephrine with application for the diagnosis of phaeochromocytoma.
Topics: Densitometry; Electrophoresis, Paper; Epinephrine; Humans; Hypertension; Methods; Normetanephrine; P | 1973 |
Pheochromocytoma of the urinary bladder, with inconclusive chemical and pharmacologic tests.
Topics: Adult; Electrocardiography; Epinephrine; Humans; Hypertension; Male; Norepinephrine; Normetanephrine | 1972 |
[Biochemical diagnosis of pheochromocytoma, neuroblastoma and other neuro-ectodermal neoplasms].
Topics: Adolescent; Adult; Catecholamines; Child; Child, Preschool; Dihydroxyphenylalanine; Dopamine; Electr | 1972 |
Laboratory and clinical observations with a two-column plasma catecholamine assay.
Topics: Adrenal Gland Neoplasms; Catecholamines; Chromatography; Epinephrine; Humans; Hypertension; Methods; | 1973 |
Rigorous biochemical criteria for the diagnosis of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Epinephrine; False Positive Reactions; Humans; Hydrogen-Ion Concentration; | 1973 |
Pediatric and adult pheochromocytomas. A biochemical and clinical comparison.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Age Factors; Catecholamines; Child; Child, Preschool; Ep | 1973 |
A metanephrine test for a screening of catecholamine-producing tumors.
Topics: Catecholamines; Epinephrine; Flavoring Agents; Humans; Methods; Methyl Ethers; Neuroblastoma; Normet | 1973 |
[Urinary normetadrenaline and metadrenaline determination after extraction by solvants and bidimensional chromatography. Normal results and in pheochromocytoma].
Topics: Catecholamines; Chromatography, Paper; Methods; Normetanephrine; Pheochromocytoma; Solvents | 1973 |
[Methods of determination of urinary methadrenaline and of normethadrenaline. Critical study].
Topics: Catecholamines; Humans; Normetanephrine; Phenethylamines; Pheochromocytoma | 1968 |
Interference in Pisano's urinary metanephrine assay after use of x-ray contrast media.
Topics: Amino Alcohols; Amino Sugars; Catecholamines; Chromatography, Ion Exchange; Contrast Media; Dextrans | 1972 |
Pheochromocytoma. Fine structural, biochemical and clinical observations.
Topics: Adult; Aged; Blood Pressure; Catecholamines; Epinephrine; Female; Follow-Up Studies; Humans; Hyperte | 1972 |
Multidisciplinary challenge of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; Catecholamines; Female; Humans; Hypertension; Normetanephrine; Pheoc | 1971 |
A gas-liquid chromatographic method for the separation and quantitation of normetanephrine and metanephrine in human urine.
Topics: Chromatography, Gas; Female; Fluoroacetates; Fluorometry; Humans; Male; Methods; Neuroblastoma; Norm | 1970 |
[Catecholamine metabolism in the tissue of malignant and benign tumors of the sympathetic nervous system].
Topics: Catecholamines; Dihydroxyphenylalanine; Dopamine; Epinephrine; Humans; Microscopy, Electron; Neurobl | 1971 |
Metabolism of alpha-methyltyrosine in man: relationship to its potency as an inhibitor of catecholamine biosynthesis.
Topics: Carbon Isotopes; Catecholamines; Chromatography, Paper; Humans; Hypertension; Kinetics; Methyldopa; | 1968 |
Biochemical and pharmacologic effects of alpha-methyltyrosine in man.
Topics: Adolescent; Adult; Aged; Basal Metabolism; Benzoates; Blood Pressure; Catecholamines; Female; Glauco | 1968 |
Thin-layer chromatographic techniques for the investigation of abnormal urinary catecholamine metabolite patterns.
Topics: Adult; Catecholamines; Chromatography, Thin Layer; Circadian Rhythm; Epinephrine; Female; Glycols; H | 1968 |
[Clinical studies on urinary metanephrine and normetanephrine in various endocrine diseases. 2. Clinical studies on urinary metanephrine and normetanephrine in patients with pheochromyocytoma and a patient with neuroblastoma].
Topics: Adult; Bretylium Compounds; Catecholamines; Child, Preschool; Female; Histamine; Humans; Male; Methy | 1968 |
[Diagnosis of pheochromocytoma].
Topics: Aged; Epinephrine; Humans; Male; Mandelic Acids; Norepinephrine; Normetanephrine; Pheochromocytoma | 1965 |
[Pheochromocytoma].
Topics: Dopamine; Epinephrine; Humans; In Vitro Techniques; Norepinephrine; Normetanephrine; Pheochromocytom | 1965 |
Distribution of metanephrine and normetanephrine in various animals and their analysis in diverse biologic material.
Topics: Animals; Anura; Brain; Cats; Dogs; Epinephrine; Female; Guinea Pigs; Humans; In Vitro Techniques; Ki | 1966 |
A new screening test for phaeochromocytoma.
Topics: Chromatography, Paper; Humans; In Vitro Techniques; Normetanephrine; Pheochromocytoma | 1966 |
Paper chromatographic identification of catecholamines.
Topics: Adrenal Medulla; Adult; Animals; Catecholamines; Child; Chromatography, Paper; Dihydroxyphenylalanin | 1966 |