1-(3-astatobenzyl)guanidine profile

You're asking about **1-(3-azatobenzyl)guanidine**, also sometimes referred to as **1-(3-pyridinylmethyl)guanidine**.

Let's break down why this compound is interesting for research:

**What it is:**

* **Guanidine:** This is a nitrogen-rich functional group commonly found in biologically important molecules like arginine.
* **3-Azatobenzyl:** This part refers to a benzyl group (a benzene ring with a CH2 group attached) where one of the carbon atoms in the ring has been replaced by a nitrogen atom (creating a pyridine ring).

**Why it's important for research:**

* **Potential therapeutic target:** Guanidines can interact with specific targets in the body, making them valuable for drug discovery. 1-(3-azatobenzyl)guanidine has shown potential as a:
* **Anti-inflammatory agent:** Some studies suggest it can reduce inflammation, which is crucial in treating various diseases.
* **Anti-cancer agent:** It may exhibit cytotoxic effects (killing cancer cells) and potentially interfere with cancer cell growth and proliferation.
* **Anti-microbial agent:** It might be effective against certain bacteria or fungi.
* **Versatile building block:** This compound can be used as a starting point to synthesize a variety of other molecules with potential medicinal applications.

**Current research:**

* **Limited clinical data:** While pre-clinical studies have shown promising results, clinical trials in humans are still limited for 1-(3-azatobenzyl)guanidine.
* **Mechanism of action:** Researchers are still working to fully understand how this compound interacts with various biological targets and how it exerts its effects.

**Overall:** 1-(3-azatobenzyl)guanidine is a molecule with potential applications in various fields. Further research is needed to fully evaluate its therapeutic potential and clarify its mechanism of action.

1-(3-astatobenzyl)guanidine: structure given in first source; might prove useful for treating neuroblastoma [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	164244
MeSH ID	M0210819

Synonym
211at-mabg
127367-45-7
1-(m-astatobenzyl)guanidine
1-(3-astatobenzyl)guanidine
guanidine, ((3-(astato-(211)at)phenyl)methyl)-
[3-(carbamimidamidomethyl)phenyl](~211~at)astatine
DTXSID60925866
[3-[(diaminomethylideneamino)methyl]phenyl](211at)astatine-211

Excerpt	Reference	Relevance
" The Auger electron-emitting conjugates ([123I]MIBG and [125I]MIBG) and the alpha-emitting conjugate ([211At]MABG) were highly toxic to monolayers and small spheroids, whereas the beta-emitting conjugate [131I]MIBG was relatively ineffective."	( Toxicity to neuroblastoma cells and spheroids of benzylguanidine conjugated to radionuclides with short-range emissions. Cunningham, SH; Mairs, RJ; Vaidyanathan, G; Welsh, PC; Wheldon, TE; Zalutsky, MR, 1998)	0.3

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	7 (77.78)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (11.11)	24.3611
2020's	1 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	11 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
sodium iodide Sodium Iodide: A compound forming white, odorless deliquescent crystals and used as iodine supplement, expectorant or in its radioactive (I-131) form as an diagnostic aid, particularly for thyroid function tests.. sodium iodide : A metal iodide salt with a Na(+) counterion.	1.99	1	inorganic sodium salt; iodide salt
reserpine Reserpine: An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria. Reserpine inhibits the uptake of norepinephrine into storage vesicles resulting in depletion of catecholamines and serotonin from central and peripheral axon terminals. It has been used as an antihypertensive and an antipsychotic as well as a research tool, but its adverse effects limit its clinical use.. reserpine : An alkaloid found in the roots of Rauwolfia serpentina and R. vomitoria.	1.98	1	alkaloid ester; methyl ester; yohimban alkaloid	adrenergic uptake inhibitor; antihypertensive agent; EC 3.4.21.26 (prolyl oligopeptidase) inhibitor; environmental contaminant; first generation antipsychotic; plant metabolite; xenobiotic
tetrabenazine 9,10-dimethoxy-3-isobutyl-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-one : A benzoquinolizine that is 1,2,3,4,4a,9,10,10a-octahydrophenanthrene in which the carbon at position 10a is replaced by a nitrogen and which is substituted by an isobutyl group at position 2, an oxo group at position 3, and methoxy groups at positions 6 and 7.	1.98	1	benzoquinolizine; cyclic ketone; tertiary amino compound
actinium Actinium: A trivalent radioactive element and the prototypical member of the actinide family. It has the atomic symbol Ac, and atomic number 89. Its principal isotope is 227 and it decays primarily by beta-emission.	2.41	1	actinoid atom; f-block element atom; scandium group element atom
3-iodobenzylguanidine 3-Iodobenzylguanidine: A guanidine analog with specific affinity for tissues of the sympathetic nervous system and related tumors. The radiolabeled forms are used as antineoplastic agents and radioactive imaging agents. (Merck Index, 12th ed) MIBG serves as a neuron-blocking agent which has a strong affinity for, and retention in, the adrenal medulla and also inhibits ADP-ribosyltransferase.	3.24	6	organoiodine compound
(4-fluoro-3-iodobenzyl)guanidine (4-fluoro-3-iodobenzyl)guanidine: a potential MIBG analog for positron emission tomography; structure given in first source; RN refers to (18F)-labelled compound	1.99	1
astatine Astatine: Astatine. A radioactive halogen with the atomic symbol At, and atomic number 85. Its isotopes range in mass number from 200 to 219 and all have an extremely short half-life. Astatine may be of use in the treatment of hyperthyroidism because it emits ALPHA PARTICLES.	3.51	8	elemental astatine

Condition	Relationship Strength	Studies
Pheochromocytoma, Extra-Adrenal [description not available]	2.17	1
Pheochromocytoma A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)	2.17	1
Neuroblastoma A common neoplasm of early childhood arising from neural crest cells in the sympathetic nervous system, and characterized by diverse clinical behavior, ranging from spontaneous remission to rapid metastatic progression and death. This tumor is the most common intraabdominal malignancy of childhood, but it may also arise from thorax, neck, or rarely occur in the central nervous system. Histologic features include uniform round cells with hyperchromatic nuclei arranged in nests and separated by fibrovascular septa. Neuroblastomas may be associated with the opsoclonus-myoclonus syndrome. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2099-2101; Curr Opin Oncol 1998 Jan;10(1):43-51)	3.09	5
Benign Cerebellar Neoplasms [description not available]	1.98	1
Arachnoidal Cerebellar Sarcoma, Circumscribed [description not available]	1.98	1
Medulloblastoma A malignant neoplasm that may be classified either as a glioma or as a primitive neuroectodermal tumor of childhood (see NEUROECTODERMAL TUMOR, PRIMITIVE). The tumor occurs most frequently in the first decade of life with the most typical location being the cerebellar vermis. Histologic features include a high degree of cellularity, frequent mitotic figures, and a tendency for the cells to organize into sheets or form rosettes. Medulloblastoma have a high propensity to spread throughout the craniospinal intradural axis. (From DeVita et al., Cancer: Principles and Practice of Oncology, 5th ed, pp2060-1)	1.98	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.99	1
Benign Neoplasms [description not available]	2	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2	1

1-(3-astatobenzyl)guanidine

Description

Cross-References

Synonyms (8)

Research Excerpts

Toxicity

Research

Studies (9)

Market Indicators

Research Demand Index: 12.18

Study Types