2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one has been researched along with Pheochromocytoma in 4 studies
2-(4-morpholinyl)-8-phenyl-4H-1-benzopyran-4-one: specific inhibitor of phosphatidylinositol 3-kinase; structure in first source
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "In a previous study, we show that stimulation of chemotaxis in rat pheochromocytoma PC12 cells by nerve growth factor (NGF) and epidermal growth factor (EGF) requires activation of the RAS-ERK signaling pathway." | 3.73 | Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells. ( Chan, BM; Ho, WC; Morris, VL; Uniyal, S; Zhou, H, 2005) |
| "Sixteen pheochromocytomas were analyzed for expression of phosphorylated Akt and the NE marker achaete scute complex-like 1 (ASCL1)." | 1.35 | Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells. ( Adler, JT; Chen, H; Hottinger, DG; Kunnimalaiyaan, M, 2009) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (75.00) | 29.6817 |
| 2010's | 1 (25.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Adler, JT | 1 |
| Hottinger, DG | 1 |
| Kunnimalaiyaan, M | 1 |
| Chen, H | 1 |
| Lv, T | 1 |
| Wang, SD | 1 |
| Bai, J | 1 |
| Ho, WC | 1 |
| Uniyal, S | 1 |
| Zhou, H | 1 |
| Morris, VL | 1 |
| Chan, BM | 1 |
| Pap, M | 1 |
| Szeberényi, J | 1 |
4 other studies available for 2-(4-morpholinyl)-8-phenyl-4h-1-benzopyran-4-one and Pheochromocytoma
| Article | Year |
|---|---|
Inhibition of the PI3K pathway suppresses hormonal secretion and limits growth in pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Cell Proliferation; Chromones; Enzyme Inhibitors; Humans; Morpholines; Pheo | 2009 |
Thioredoxin-1 was required for CREB activity by methamphetamine in rat pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Survival; Chromones; Cyclic AMP Response Element-Binding Prot | 2013 |
Threshold levels of ERK activation for chemotactic migration differ for NGF and EGF in rat pheochromocytoma PC12 cells.
Topics: Adrenal Gland Neoplasms; Animals; Cell Movement; Cell Proliferation; Chemotaxis; Chromones; Differen | 2005 |
Involvement of proteolytic activation of protein kinase R in the apoptosis of PC12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; Animals; Anisomycin; Apoptosis; Caspase 3; Caspase 9; Chromones; Culture Me | 2008 |