1-methyl-3-isobutylxanthine has been researched along with Pheochromocytoma in 9 studies
1-Methyl-3-isobutylxanthine: A potent cyclic nucleotide phosphodiesterase inhibitor; due to this action, the compound increases cyclic AMP and cyclic GMP in tissue and thereby activates CYCLIC NUCLEOTIDE-REGULATED PROTEIN KINASES
3-isobutyl-1-methylxanthine : An oxopurine that is xanthine which is substituted at positions 1 and 3 by methyl and isobutyl groups, respectively.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
| Excerpt | Relevance | Reference |
|---|---|---|
| "Atrial natriuretic factors (ANFs) were tested for their effects on cyclic GMP production in two neurally derived cell lines, the C6-2B rat glioma cells and the PC12 rat pheochromocytoma cells." | 7.67 | Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. ( Fiscus, RR; Murad, F; Robles, BT; Waldman, SA, 1987) |
| "Atrial natriuretic factors (ANFs) were tested for their effects on cyclic GMP production in two neurally derived cell lines, the C6-2B rat glioma cells and the PC12 rat pheochromocytoma cells." | 3.67 | Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures. ( Fiscus, RR; Murad, F; Robles, BT; Waldman, SA, 1987) |
| "Nerve growth factor (NGF) rapidly increases the cyclic GMP (cGMP) level about 2-3-fold and enhances the cGMP phosphodiesterase (PDE) activity about 2-fold in rat pheochromocytoma PC12 cells." | 3.67 | Nerve growth factor increases the cyclic GMP level and activates the cyclic GMP phosphodiesterase in PC12 cells. ( Laasberg, T; Neuman, T; Paves, H; Pihlak, A; Saarma, M, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 6 (66.67) | 18.7374 |
| 1990's | 3 (33.33) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Brady, MJ | 2 |
| Nairn, AC | 2 |
| Wagner, JA | 1 |
| Palfrey, HC | 2 |
| Kalman, D | 1 |
| Wong, B | 1 |
| Horvai, AE | 1 |
| Cline, MJ | 1 |
| O'Lague, PH | 1 |
| Delpire, E | 1 |
| Cornet, M | 1 |
| Gilles, R | 1 |
| Tank, AW | 1 |
| Ham, L | 1 |
| Curella, P | 1 |
| Fiscus, RR | 1 |
| Robles, BT | 1 |
| Waldman, SA | 1 |
| Murad, F | 1 |
| Nichols, RA | 1 |
| Hoshi, T | 1 |
| Garber, SS | 1 |
| Aldrich, RW | 1 |
| Laasberg, T | 1 |
| Pihlak, A | 1 |
| Neuman, T | 1 |
| Paves, H | 1 |
| Saarma, M | 1 |
| Shen, RS | 1 |
| Zhang, YX | 1 |
| Perez-Polo, JR | 1 |
9 other studies available for 1-methyl-3-isobutylxanthine and Pheochromocytoma
| Article | Year |
|---|---|
Nerve growth factor-induced down-regulation of calmodulin-dependent protein kinase III in PC12 cells involves cyclic AMP-dependent protein kinase.
Topics: 1-Methyl-3-isobutylxanthine; Calcium-Calmodulin-Dependent Protein Kinases; Down-Regulation; Elongati | 1990 |
Nerve growth factor acts through cAMP-dependent protein kinase to increase the number of sodium channels in PC12 cells.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Animals; Bucladesine; Cell Differentiation; Ce | 1990 |
Volume regulation in rat pheochromocytoma cultured cells submitted to hypoosmotic conditions.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Amiloride; Animals; Colforsin; Hypotonic Solut | 1991 |
Induction of tyrosine hydroxylase by cyclic AMP and glucocorticoids in a rat pheochromocytoma cell line: effect of the inducing agents alone or in combination on the enzyme levels and rate of synthesis of tyrosine hydroxylase.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animal | 1986 |
Atrial natriuretic factors stimulate accumulation and efflux of cyclic GMP in C6-2B rat glioma and PC12 rat pheochromocytoma cell cultures.
Topics: 1-Methyl-3-isobutylxanthine; Adrenal Gland Neoplasms; Animals; Atrial Natriuretic Factor; Cell Line; | 1987 |
Nerve growth factor treatment or cAMP elevation reduces Ca2+/calmodulin-dependent protein kinase III activity in PC12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 2-Chloroadenosine; Adenosine; Adrenal Gland Neoplasms; Animals; Calcium | 1987 |
Effect of forskolin on voltage-gated K+ channels is independent of adenylate cyclase activation.
Topics: 1-Methyl-3-isobutylxanthine; Adenylyl Cyclases; Adrenal Gland Neoplasms; Colforsin; Cyclic AMP; Elec | 1988 |
Nerve growth factor increases the cyclic GMP level and activates the cyclic GMP phosphodiesterase in PC12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 3',5'-Cyclic-AMP Phosphodiesterases; 3',5'-Cyclic-GMP Phosphodiesterase | 1988 |
Regulation of GTP cyclohydrolase I and dihydropteridine reductase in rat pheochromocytoma PC 12 cells.
Topics: 1-Methyl-3-isobutylxanthine; 8-Bromo Cyclic Adenosine Monophosphate; Adrenal Gland Neoplasms; Animal | 1989 |