racemetirosine has been researched along with Pheochromocytoma in 38 studies
alpha-Methyltyrosine: An inhibitor of the enzyme TYROSINE 3-MONOOXYGENASE, and consequently of the synthesis of catecholamines. It is used to control the symptoms of excessive sympathetic stimulation in patients with PHEOCHROMOCYTOMA. (Martindale, The Extra Pharmacopoeia, 30th ed)
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Excerpt | Relevance | Reference |
---|---|---|
"We describe 3 cases of malignant pheochromocytoma with multiple metastases which were treated with cyclophosphamide, vincristine and dacarbazine (CVD) combination chemotherapy and alpha-methyl-p-tyrosine." | 7.70 | Three cases of malignant pheochromocytoma treated with cyclophosphamide, vincristine, and dacarbazine combination chemotherapy and alpha-methyl-p-tyrosine to control hypercatecholaminemia. ( Okuda, Y; Tada, K; Yamashita, K, 1998) |
"Changes induced by internal administration of L-tyrosine and L-phenylalanine in high-threshold calcium currents have been studied on perfused PC12 pheochromocytoma cells using whole-cell voltage-clamp technique." | 7.68 | Effects of intracellular administration of L-tyrosine and L-phenylalanine on voltage-operated calcium conductance in PC12 pheochromocytoma cells. ( Kostyuk, PG; Martynyuk, AE; Pogorelaya, NCh, 1991) |
"Changes in the high-threshold calcium current (Ica) induced by intracellular administration of L-tyrosine and L-phenylalanine have been studied on internally perfused PC 12 pheochromocytoma cells using whole-cell voltage-clamp technique." | 7.68 | [Effect of intracellular administration of L-tyrosine and L-phenylalanine on voltage dependent calcium current in PC 12 pheochromocytoma cells]. ( Martyniuk, AE; Pogorelaia, NKh, 1991) |
"A suppression of norepinephrine, epinephrine, and its metabolites in malignant pheochromocytoma by metyrosine was associated with an increase in tyrosine, plasma DOPA, and sulfate esters of DOPA and dopamine, followed, with continuing metyrosine administration, by a further rise of both DOPA sulfate and dopamine sulfate." | 7.68 | Alternative catecholamine pathways after tyrosine hydroxylase inhibition in malignant pheochromocytoma. ( Buu, NT; Edwards, DJ; Kuchel, O, 1990) |
" We combined the alpha-blocker phenoxybenzamine with the tyrosine hydroxylase inhibitor metyrosine in an attempt to better manage the hypertension of patients with pheochromocytoma undergoing surgical resection." | 5.06 | Surgical management of pheochromocytoma with the use of metyrosine. ( Keiser, HR; Linehan, WM; Norton, JA; Pass, HI; Perry, RR; Robertson, CN; Travis, W; Wall, RT; Walther, MM, 1990) |
"To describe outcomes of patients with metyrosine (MET) pretreatment for abdominal surgical resection of pheochromocytoma or paraganglioma (PCC/PGL) compared with patients who had phenoxybenzamine (PBZ) pretreatment." | 3.85 | Perioperative hemodynamics and outcomes of patients on metyrosine undergoing resection of pheochromocytoma or paraganglioma. ( Bancos, I; Butz, JJ; Cavalcante, AN; Martin, DP; McKenzie, TJ; Schroeder, DR; Sprung, J; Weingarten, TN; Young, WF, 2017) |
" Significant hypertension (up to 201/110 mmHg) developed upon tumour manipulation and resolved with phentolamine administration and surgical isolation of the tumour." | 3.81 | Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report. ( Pollmann, AS; Schelew, B; Thanapaalasingham, K, 2015) |
"We describe 3 cases of malignant pheochromocytoma with multiple metastases which were treated with cyclophosphamide, vincristine and dacarbazine (CVD) combination chemotherapy and alpha-methyl-p-tyrosine." | 3.70 | Three cases of malignant pheochromocytoma treated with cyclophosphamide, vincristine, and dacarbazine combination chemotherapy and alpha-methyl-p-tyrosine to control hypercatecholaminemia. ( Okuda, Y; Tada, K; Yamashita, K, 1998) |
"To evaluate the effects of metyrosine (alpha-methyl-p-tyrosine), a catecholamine synthesis inhibitor, and alpha-blockade with prazosin or phenoxybenzamine on cardiovascular morbidity during surgery for pheochromocytoma." | 3.69 | Metyrosine and pheochromocytoma. ( Bransome, ED; Carr, AA; Prisant, LM; Steinsapir, J, 1997) |
"Changes induced by internal administration of L-tyrosine and L-phenylalanine in high-threshold calcium currents have been studied on perfused PC12 pheochromocytoma cells using whole-cell voltage-clamp technique." | 3.68 | Effects of intracellular administration of L-tyrosine and L-phenylalanine on voltage-operated calcium conductance in PC12 pheochromocytoma cells. ( Kostyuk, PG; Martynyuk, AE; Pogorelaya, NCh, 1991) |
"Changes in the high-threshold calcium current (Ica) induced by intracellular administration of L-tyrosine and L-phenylalanine have been studied on internally perfused PC 12 pheochromocytoma cells using whole-cell voltage-clamp technique." | 3.68 | [Effect of intracellular administration of L-tyrosine and L-phenylalanine on voltage dependent calcium current in PC 12 pheochromocytoma cells]. ( Martyniuk, AE; Pogorelaia, NKh, 1991) |
"A suppression of norepinephrine, epinephrine, and its metabolites in malignant pheochromocytoma by metyrosine was associated with an increase in tyrosine, plasma DOPA, and sulfate esters of DOPA and dopamine, followed, with continuing metyrosine administration, by a further rise of both DOPA sulfate and dopamine sulfate." | 3.68 | Alternative catecholamine pathways after tyrosine hydroxylase inhibition in malignant pheochromocytoma. ( Buu, NT; Edwards, DJ; Kuchel, O, 1990) |
"Metastatic pheochromocytoma, a rare complication of pregnancy, was managed from 30 weeks' gestation until delivery three weeks later with a combination of alpha-adrenergic blockade (Minipres) beta-adrenergic blockade (Timolol), and dopamine synthesis inhibition (Demser)." | 3.67 | Metastatic pheochromocytoma in pregnancy and fetal biophysical assessment after maternal administration of alpha-adrenergic, beta-adrenergic, and dopamine antagonists. ( Castillo, RA; Devoe, LD; Hadi, HA; O'Dell, BE; Searle, N, 1986) |
"In a 54-year-old man with a norepinephrine-secreting pheochromocytoma, resistance developed to the alpha-adrenergic blocking agent, phenoxybenzamine hydrochloride." | 3.66 | Pheochromocytoma resistant to alpha-adrenergic blockade. ( Ertel, NH; Hauptman, JB; Modlinger, RS, 1983) |
" Sedation, anemia, and death were reported in 1 patient each as serious adverse drug reactions during the 24-week treatment." | 2.87 | Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan. ( Harada, T; Ichihara, A; Imai, T; Katabami, T; Kawata, N; Matsuda, T; Naruse, M; Nomura, M; Okamoto, T; Satoh, F; Takekoshi, K; Tanabe, A; Tanaka, T; Tsuiki, M; Yamada, M, 2018) |
"Pheochromocytoma is known to increase morbidity and mortality." | 1.30 | Diagnosis and management of pheochromocytoma during pregnancy: a case report. ( Hermayer, KL; Szpiech, M, 1999) |
"Biochemical studies confirmed its recurrence." | 1.29 | An atrial pheochromocytoma-induced hypertensive crisis resistant to nitroprusside. ( Acheson, LS; Anton, AH; Lina, AA; Sherman, BW, 1993) |
"Pheochromocytoma is curable in 90% of cases, yet its diagnosis and localization are among the most challenging problems in clinical medicine." | 1.27 | Pheochromocytoma: diagnosis, localization, and treatment. ( Atuk, NO, 1983) |
"Epidural morphine was administered for postoperative pain control." | 1.27 | Perioperative management of a patient with a malignant pheochromocytoma. ( Miller, D; Robblee, JA, 1985) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 15 (39.47) | 18.7374 |
1990's | 13 (34.21) | 18.2507 |
2000's | 2 (5.26) | 29.6817 |
2010's | 6 (15.79) | 24.3611 |
2020's | 2 (5.26) | 2.80 |
Authors | Studies |
---|---|
Takekoshi, K | 2 |
Satoh, F | 2 |
Tanabe, A | 2 |
Okamoto, T | 2 |
Ichihara, A | 2 |
Tsuiki, M | 2 |
Katabami, T | 2 |
Nomura, M | 2 |
Tanaka, T | 2 |
Matsuda, T | 2 |
Imai, T | 2 |
Yamada, M | 2 |
Asada, S | 1 |
Kawata, N | 2 |
Naruse, M | 2 |
Fang, F | 1 |
Ding, L | 1 |
He, Q | 1 |
Liu, M | 1 |
Gruber, LM | 1 |
Jasim, S | 1 |
Ducharme-Smith, A | 1 |
Weingarten, T | 1 |
Young, WF | 2 |
Bancos, I | 2 |
Butz, JJ | 1 |
Weingarten, TN | 1 |
Cavalcante, AN | 1 |
McKenzie, TJ | 1 |
Schroeder, DR | 1 |
Martin, DP | 1 |
Sprung, J | 1 |
Harada, T | 1 |
Thanapaalasingham, K | 1 |
Pollmann, AS | 1 |
Schelew, B | 1 |
Wachtel, H | 1 |
Kennedy, EH | 1 |
Zaheer, S | 1 |
Bartlett, EK | 1 |
Fishbein, L | 1 |
Roses, RE | 1 |
Fraker, DL | 1 |
Cohen, DL | 1 |
Ionescu, CN | 1 |
Sakharova, OV | 1 |
Harwood, MD | 1 |
Caracciolo, EA | 1 |
Schoenfeld, MH | 1 |
Donohue, TJ | 1 |
Nagata, M | 1 |
Takayama, T | 1 |
Nishijima, N | 1 |
Mugiya, S | 1 |
Ushiyama, T | 1 |
Ozono, S | 1 |
Fernández-Cruz, L | 1 |
Puig-Domingo, M | 1 |
Halperin, I | 1 |
Sesmilo, G | 1 |
Modlinger, RS | 2 |
Ertel, NH | 2 |
Hauptman, JB | 2 |
Atuk, NO | 1 |
Serri, O | 1 |
Comtois, R | 1 |
Bettez, P | 1 |
Dubuc, G | 1 |
Buu, NT | 2 |
Kuchel, O | 2 |
Okun, R | 1 |
Brogden, RN | 1 |
Heel, RC | 1 |
Speight, TM | 1 |
Avery, GS | 1 |
Green, KN | 1 |
Larsson, SK | 1 |
Beevers, DG | 1 |
Bevan, PG | 1 |
Hayes, B | 1 |
Janssens, EN | 1 |
Krenning, EP | 1 |
Derkx, FH | 1 |
Rivero Sánchez, M | 1 |
Selgas Gutiérrez, R | 1 |
Lorenzo Aguiar, MD | 1 |
Martínez Muñoz, I | 1 |
Beberide García, JM | 1 |
Almaraz Jiménez, M | 1 |
Rińon Aguilar, C | 1 |
Sánchez Sicilia, L | 1 |
Anton, AH | 1 |
Sherman, BW | 1 |
Lina, AA | 1 |
Acheson, LS | 1 |
Steinsapir, J | 1 |
Carr, AA | 1 |
Prisant, LM | 1 |
Bransome, ED | 1 |
Sand, J | 1 |
Salmi, J | 1 |
Saaristo, J | 1 |
Auvinen, O | 1 |
Tada, K | 1 |
Okuda, Y | 1 |
Yamashita, K | 1 |
Hermayer, KL | 1 |
Szpiech, M | 1 |
Christensen, NJ | 1 |
Bratholm, P | 1 |
Knudsen, JH | 1 |
Kostyuk, PG | 1 |
Martynyuk, AE | 1 |
Pogorelaya, NCh | 1 |
Martyniuk, AE | 1 |
Pogorelaia, NKh | 1 |
Sheps, SG | 1 |
Jiang, NS | 1 |
Klee, GG | 1 |
van Heerden, JA | 1 |
Edwards, DJ | 1 |
Okada, S | 1 |
Ohshima, K | 1 |
Onai, T | 1 |
Umahara, M | 1 |
Kobayashi, S | 1 |
Ishihara, H | 1 |
Sunaga, Y | 1 |
Taniguchi, N | 1 |
Hayashi, K | 1 |
Koito, M | 1 |
Inada, M | 1 |
Oyaizu, N | 1 |
Shikata, N | 1 |
Perry, RR | 1 |
Keiser, HR | 1 |
Norton, JA | 1 |
Wall, RT | 1 |
Robertson, CN | 1 |
Travis, W | 1 |
Pass, HI | 1 |
Walther, MM | 1 |
Linehan, WM | 1 |
Ram, CV | 1 |
Meese, R | 1 |
Hill, SC | 1 |
Devoe, LD | 1 |
O'Dell, BE | 1 |
Castillo, RA | 1 |
Hadi, HA | 1 |
Searle, N | 1 |
Imperato-McGinley, J | 1 |
Gautier, T | 1 |
Ehlers, K | 1 |
Zullo, MA | 1 |
Goldstein, DS | 1 |
Vaughan, ED | 1 |
Ducornet, B | 1 |
Bacourt, F | 1 |
Gensous, D | 1 |
Jacquillat, C | 1 |
Duprey, J | 1 |
Tcherdakoff, P | 1 |
Bräutigam, M | 1 |
Laschinski, G | 1 |
Kittner, B | 1 |
Herken, H | 1 |
Miller, D | 1 |
Robblee, JA | 1 |
5 reviews available for racemetirosine and Pheochromocytoma
Article | Year |
---|---|
Preoperative Management of Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; alpha-Methyltyro | 2020 |
The Role for Metyrosine in the Treatment of Patients With Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Antineoplastic Combined Chemotherapy Protocols; Drug | 2021 |
Pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenal Glands; alpha-Methyltyrosine; Calcium Channel Blockers; Combined Mo | 2004 |
alpha-Methyl-p-tyrosine: a review of its pharmacology and clinical use.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Blood Pressure; Carbohydrate Metabolism; Cat | 1981 |
Recent developments in the diagnosis and treatment of pheochromocytoma.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Humans; Labetalol; Methyltyrosines; Pheochromocytoma; | 1990 |
3 trials available for racemetirosine and Pheochromocytoma
Article | Year |
---|---|
Correlation between urinary fractionated metanephrines in 24-hour and spot urine samples for evaluating the therapeutic effect of metyrosine: a subanalysis of a multicenter, open-label phase I/II study.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; alpha-Methyltyrosine; Child; Fe | 2019 |
Efficacy and safety of metyrosine in pheochromocytoma/paraganglioma: a multi-center trial in Japan.
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; Aged; Aged, 80 and over; alpha-Methyltyrosine; Antineopl | 2018 |
Surgical management of pheochromocytoma with the use of metyrosine.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Drug Therapy, Combination; Female; Humans; Hyp | 1990 |
30 other studies available for racemetirosine and Pheochromocytoma
Article | Year |
---|---|
Perioperative hemodynamics and outcomes of patients on metyrosine undergoing resection of pheochromocytoma or paraganglioma.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Blood Pressure; Drug Therapy, Combination; Enz | 2017 |
Failure of metyrosine therapy for preoperative management of pheochromocytoma: a case report.
Topics: alpha-Methyltyrosine; Catecholamines; Enzyme Inhibitors; Humans; Hypertension; Intraoperative Compli | 2015 |
Preoperative Metyrosine Improves Cardiovascular Outcomes for Patients Undergoing Surgery for Pheochromocytoma and Paraganglioma.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; alpha-Methyltyrosine; Cardiovascular Diseases; Enzyme Inhibi | 2015 |
Cyclic rapid fluctuation of hypertension and hypotension in pheochromocytoma.
Topics: alpha-Methyltyrosine; Antihypertensive Agents; Antithyroid Agents; Catecholamines; Enzyme Inhibitors | 2008 |
[Clinical course of patient with malignant pheochromocytoma who was treated with CVD chemotherapy and alpha-methyl-p-tyrosine].
Topics: Adult; alpha-Methyltyrosine; Antineoplastic Combined Chemotherapy Protocols; Cyclophosphamide; Dacar | 2010 |
Adrenergic blockade in pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; alpha-Methyltyro | 1983 |
Pheochromocytoma resistant to alpha-adrenergic blockade.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; alpha-Methyltyrosine; Drug Resistance; Humans | 1983 |
Pheochromocytoma: diagnosis, localization, and treatment.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Diagnosis, Differential; Humans; Hype | 1983 |
Reduction in the size of a pheochromocytoma pulmonary metastasis by metyrosine therapy.
Topics: Adrenal Gland Neoplasms; Aged; alpha-Methyltyrosine; Female; Humans; Lung Neoplasms; Methyltyrosines | 1984 |
New medications-1981.
Topics: Administration, Topical; Adrenal Gland Neoplasms; alpha-Methyltyrosine; Antiviral Agents; Daunorubic | 1981 |
Alpha-methyltyrosine in the management of phaeochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Antihypertensive Agents; Bronchiectasis; Femal | 1982 |
Recurrence of phaeochromocytoma, with development of metastases. Effect of treatment with alpha-methylparatyrosine.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Female; Humans; Methyltyrosines; Middle Aged; Neoplas | 1981 |
[Effect of alpha-methyl-paratyrosine on the urinary excretion of catecholamines in patients with pheochromocytoma].
Topics: Adolescent; Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Catecholamines; Drug Therapy, Comb | 1981 |
An atrial pheochromocytoma-induced hypertensive crisis resistant to nitroprusside.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Drug Resistance; Echocardiography; Fe | 1993 |
Metyrosine and pheochromocytoma.
Topics: Adolescent; Adrenal Gland Neoplasms; Adrenergic alpha-Agonists; Adult; Aged; Aged, 80 and over; alph | 1997 |
Preoperative treatment and survival of patients with pheochromocytomas.
Topics: Adrenal Gland Neoplasms; Adrenergic alpha-Antagonists; Adult; Aged; alpha-Methyltyrosine; Catecholam | 1997 |
Three cases of malignant pheochromocytoma treated with cyclophosphamide, vincristine, and dacarbazine combination chemotherapy and alpha-methyl-p-tyrosine to control hypercatecholaminemia.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Antineoplastic Combined Chemotherapy Protocols | 1998 |
Diagnosis and management of pheochromocytoma during pregnancy: a case report.
Topics: Adrenal Gland Neoplasms; Adrenalectomy; Adrenergic Antagonists; Adult; alpha-Methyltyrosine; Catecho | 1999 |
Lymphocyte norepinephrine and epinephrine as indices of long-term changes in sympathoadrenal activity in human subjects.
Topics: alpha-Methyltyrosine; Blood Platelets; Catecholamines; Cyclic AMP; Enzyme Inhibitors; Epinephrine; H | 1997 |
Effects of intracellular administration of L-tyrosine and L-phenylalanine on voltage-operated calcium conductance in PC12 pheochromocytoma cells.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Calcium Channels; Cell Line; Kinetics; Methy | 1991 |
[Effect of intracellular administration of L-tyrosine and L-phenylalanine on voltage dependent calcium current in PC 12 pheochromocytoma cells].
Topics: Adenosine Diphosphate; Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Calcium Channels; Met | 1991 |
Alternative catecholamine pathways after tyrosine hydroxylase inhibition in malignant pheochromocytoma.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Catecholamines; Dihydroxyphenylalanine; Dopamine; Epi | 1990 |
[A long survived case of malignant pheochromocytoma treated with alpha-methyl-p-tyrosine and midaglizol (DG-5128)].
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Diabetes Mellitus, Type 2; Drug Therapy, Combination; | 1990 |
[An autopsy case of extra-adrenal malignant pheochromocytoma].
Topics: Adult; alpha-Methyltyrosine; Catecholamines; Combined Modality Therapy; Female; Humans; Methyltyrosi | 1990 |
Failure of alpha-methyltyrosine to prevent hypertensive crisis in pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Catecholamines; Female; Humans; Hypertension; | 1985 |
Metastatic pheochromocytoma in pregnancy and fetal biophysical assessment after maternal administration of alpha-adrenergic, beta-adrenergic, and dopamine antagonists.
Topics: Adult; alpha-Methyltyrosine; Catecholamines; Drug Therapy, Combination; Female; Fetal Heart; Fetal M | 1986 |
Reversibility of catecholamine-induced dilated cardiomyopathy in a child with a pheochromocytoma.
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Cardiomyopathy, Dilated; Catecholamines; Child; Femal | 1987 |
[Malignant pheochromocytoma. A case].
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Antineoplastic Combined Chemotherapy Protocols | 1985 |
Effect of apomorphine, alpha-methylparatyrosine, haloperidol and reserpine on DOPA production in clonal cell lines (PC-12 and N1E-115).
Topics: Adrenal Gland Neoplasms; alpha-Methyltyrosine; Animals; Apomorphine; Cell Line; Dihydroxyphenylalani | 1985 |
Perioperative management of a patient with a malignant pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Adult; alpha-Methyltyrosine; Anesthesia, Epidural; Bone Cements; Femoral Ne | 1985 |