Page last updated: 2024-12-07

dopamine 3-o-sulfate

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Dopamine 3-O-sulfate is a sulfated metabolite of dopamine, formed by the action of sulfotransferases. It is found in various tissues, including the brain, and is thought to play a role in neurotransmission. Its synthesis involves the transfer of a sulfate group from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to the 3-hydroxyl group of dopamine. Research suggests that dopamine 3-O-sulfate may have both excitatory and inhibitory effects on dopamine receptors, depending on the specific receptor subtype and the concentration of the compound. Its role in neurotransmission is still under investigation, but it is thought to modulate dopamine signaling in the brain. Dopamine 3-O-sulfate is studied in relation to its potential involvement in various neurological and psychiatric disorders, including Parkinson's disease, schizophrenia, and drug addiction. Understanding its role in these conditions could lead to the development of new therapeutic strategies.'

dopamine 3-O-sulfate: end product of L-Dopa metabolism in Parkinson patients; see also record for dopamine 4-O-sulfate [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

dopamine 3-O-sulfate : An aryl sulfate that is dopamine in which the phenolic hydrogen at position 3 has been replaced by a sulfo group. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID122136
CHEBI ID37946
SCHEMBL ID3145497
MeSH IDM0050826

Synonyms (21)

Synonym
dopamine 3-sulfate
51317-41-0
dopamine 3-o-sulfate
[5-(2-aminoethyl)-2-hydroxyphenyl]oxidanesulfonic acid
5-(2-aminoethyl)-2-hydroxyphenyl hydrogen sulfate
CHEBI:37946
4-(2-aminoethyl)-1,2-benzenediol 2-(hydrogen sulfate)
dopamine 3-monosulfate
[5-(2-aminoethyl)-2-hydroxyphenyl] hydrogen sulfate
1,2-benzenediol, 4-(2-aminoethyl)-, 2-(hydrogen sulfate)
BRD-K58442346-001-01-1
SCHEMBL3145497
DTXSID40199321
AKOS030254926
4-(2-aminoethyl)-1,2-benzenediol 2-(hydrogen sulphate)
4-(2-aminoethyl)-1-hydroxy-2-sulfooxy-benzene
4-(2-aminoethyl)-1-hydroxy-2-sulfooxybenzene
FT-0701316
Q27104429
HY-113305
CS-0059555

Research Excerpts

Pharmacokinetics

ExcerptReferenceRelevance
" Plasma concentrations of DA, DA-SO4, and DOPAC after oral administration of DA to dogs, were analysed using the pharmacokinetic model assuming the contribution of first-pass metabolism for the formation of DA-SO4 and DOPAC."( Pharmacokinetic analysis of absorption and metabolism of dopamine and a dopamine prodrug in dogs.
Kohno, K; Murata, K; Noda, K; Samejima, M, 1990
)
0.28
"A pharmacokinetic model of oral levodopa is proposed to elucidate the effects of carbidopa on the pharmacokinetics of levodopa."( Pharmacokinetic model of oral levodopa and role of carbidopa in parkinsonian patients.
Hasegawa, T; Mizutani, Y; Nabeshima, T; Ogawa, M; Okada, Y, 1995
)
0.29

Bioavailability

ExcerptReferenceRelevance
" The apparent absorption rate constant of DA(K1) was proved to be much smaller than the apparent formation rate constants of DA-SO4(K2) or DOPAC(K3)."( Pharmacokinetic analysis of absorption and metabolism of dopamine and a dopamine prodrug in dogs.
Kohno, K; Murata, K; Noda, K; Samejima, M, 1990
)
0.28
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Roles (2)

RoleDescription
human blood serum metaboliteAny metabolite (endogenous or exogenous) found in human blood serum samples.
human urinary metaboliteAny metabolite (endogenous or exogenous) found in human urine samples.
human blood serum metaboliteAny metabolite (endogenous or exogenous) found in human blood serum samples.
human urinary metaboliteAny metabolite (endogenous or exogenous) found in human urine samples.
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (4)

ClassDescription
aryl sulfate
phenolsOrganic aromatic compounds having one or more hydroxy groups attached to a benzene or other arene ring.
primary amino compoundA compound formally derived from ammonia by replacing one hydrogen atom by an organyl group.
zwitterionA neutral compound having formal unit electrical charges of opposite sign on non-adjacent atoms. Sometimes referred to as inner salts, dipolar ions (a misnomer).
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Pathways (4)

PathwayProteinsCompounds
Metabolism14961108
Biological oxidations150276
Phase II - Conjugation of compounds73122
Cytosolic sulfonation of small molecules1747

Research

Studies (44)

TimeframeStudies, This Drug (%)All Drugs %
pre-199031 (70.45)18.7374
1990's9 (20.45)18.2507
2000's2 (4.55)29.6817
2010's0 (0.00)24.3611
2020's2 (4.55)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 10.14

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index10.14 (24.57)
Research Supply Index3.87 (2.92)
Research Growth Index4.01 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (10.14)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials2 (4.44%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other43 (95.56%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]