propylnitrosourea profile

ID Source	ID
PubMed CID	13157
SCHEMBL ID	3500621
MeSH ID	M0074942

Synonym
unii-240is3j248
n-propylnitrosoharnstoff [german]
240is3j248 ,
n-nitroso-n-propylurea
urea, 1-nitroso-1-propyl-
n-propylnitrosoharnstoff
1-propyl-1-nitrosourea
n-propylnitrosourea
wln: zvn3&no
PNU ,
1-nitroso-1-propylurea
urea, n-nitroso-n-propyl-
nsc-46792
nitrosopropylurea
n-propyl-n-nitrosourea
nsc46792
NPU ,
816-57-9
n-propylnitrosoharnstoff [german]
n-nitrosopropylurea
nitroso-n-propylurea
ccris 543
brn 2354437
propylnitrosourea
nsc 46792
n-(n-propyl)-n-nitrosourea
1-n-propyl-1-nitrosourea
n-nitroso-n-propyl urea, contains 40% water, 1.8% acetic acid
AKOS006276787
FT-0672994
urea,n-nitroso-n-propyl-
SCHEMBL3500621
YGGSSUISOYLCBF-UHFFFAOYSA-N
1-(aminocarbonyl)-2-oxo-1-propylhydrazine #
DTXSID0021204
n-nitroso-n-propyl urea,contains 40% water,1.8% acetic acid
propyl-1-nitrosourea, 1-
EN300-840447
n-nitroso-n-propyl urea
n-nitroso-n-propyl urea, contains 40% water, ~2% acetic acid
n-nitroso-n-propyl urea, contains 40per cent water, ~2per cent acetic acid

Excerpt	Relevance	Reference
"N-Propyl-N-nitrosourea (PNU) is shown to be active in male mouse bone marrow micronucleus assays when dosed at either 100 or 200 mg/kg in saline."	( Mutagenicity to the mouse bone marrow by the mouse germ cell mutagen N-propyl-N-nitrosourea. Ashby, J; Tinwell, H; Yendle, J, 1996)	0.29

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	22 (62.86)	18.7374
1990's	10 (28.57)	18.2507
2000's	0 (0.00)	29.6817
2010's	1 (2.86)	24.3611
2020's	2 (5.71)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	37 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
urea pseudourea: clinical use; structure. isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.	1.96	1	isourea; monocarboxylic acid amide; one-carbon compound	Daphnia magna metabolite; Escherichia coli metabolite; fertilizer; flour treatment agent; human metabolite; mouse metabolite; Saccharomyces cerevisiae metabolite
phenylbutazone Phenylbutazone: A butyl-diphenyl-pyrazolidinedione that has anti-inflammatory, antipyretic, and analgesic activities. It has been used in ANKYLOSING SPONDYLITIS; RHEUMATOID ARTHRITIS; and REACTIVE ARTHRITIS.. phenylbutazone : A member of the class of pyrazolidines that is 1,2-diphenylpyrazolidine-3,5-dione carrying a butyl group at the 4-position.	2.37	2	pyrazolidines	antirheumatic drug; EC 1.1.1.184 [carbonyl reductase (NADPH)] inhibitor; metabolite; non-narcotic analgesic; non-steroidal anti-inflammatory drug; peripheral nervous system drug
procarbazine Procarbazine: An antineoplastic agent used primarily in combination with mechlorethamine, vincristine, and prednisone (the MOPP protocol) in the treatment of Hodgkin's disease.. procarbazine : A benzamide obtained by formal condensation of the carboxy group of 4-[(2-methylhydrazino)methyl]benzoic acid with the amino group of isopropylamine. An antineoplastic chemotherapy drug used for treatment of Hodgkin's lymphoma. Metabolism yields azo-procarbazine and hydrogen peroxide, which results in the breaking of DNA strands.	7.78	3	benzamides; hydrazines	antineoplastic agent
mitomycin Mitomycin: An antineoplastic antibiotic produced by Streptomyces caespitosus. It is one of the bi- or tri-functional ALKYLATING AGENTS causing cross-linking of DNA and inhibition of DNA synthesis.. mitomycin : A family of aziridine-containing natural products isolated from Streptomyces caespitosus or Streptomyces lavendulae.	2.17	1	mitomycin	alkylating agent; antineoplastic agent
4-nitroquinoline-1-oxide 4-nitroquinoline N-oxide : A quinoline N-oxide carrying a nitro substituent at position 4.	2	1	C-nitro compound; quinoline N-oxide	carcinogenic agent
9,10-dimethyl-1,2-benzanthracene 9,10-Dimethyl-1,2-benzanthracene: Polycyclic aromatic hydrocarbon found in tobacco smoke that is a potent carcinogen.. 7,12-dimethyltetraphene : A tetraphene having methyl substituents at the 7- and 12-positions. It is a potent carcinogen and is present in tobacco smoke.	2	1	ortho-fused polycyclic arene; tetraphenes	carcinogenic agent
thiophenes Thiophenes: A monocyclic heteroarene furan in which the oxygen atom is replaced by a sulfur.. thiophenes : Compounds containing at least one thiophene ring.	2.17	1	mancude organic heteromonocyclic parent; monocyclic heteroarene; thiophenes; volatile organic compound	non-polar solvent
n-nitroso(di-n-propyl)amine [no description available]	2	1	nitroso compound
propylurea [no description available]	1.96	1
methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.	1.97	1	N-nitrosoureas	alkylating agent; carcinogenic agent; mutagen; teratogenic agent
ethylnitrosourea Ethylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-ethyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by ethyl and nitroso groups.	2.66	3	N-nitrosoureas	alkylating agent; carcinogenic agent; genotoxin; mutagen
1,3-propane sultone 1,3-propane sultone: sultone is usually defined as a derivative of 1,8-naphtholsulfonic acid; structure	2.17	1	sultone
bromochloroacetic acid Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.. bromochloroacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.	1.97	1	2-bromocarboxylic acid; monocarboxylic acid; organochlorine compound
beraprost beraprost: stable prostacyclin analog; structure given in first source. beraprost : An organic heterotricyclic compound that is (3aS,8bS)-2,3,3a,8b-tetrahydro-1H-benzo[b]cyclopenta[d]furan in which the hydrogens at positions 1R, 2R and 5 are replaced by (3S)-3-hydroxy-4-methyloct-1-en-6-yn-1-yl, hydroxy and 3-carboxypropyl groups, respectively. It is a prostaglandin receptor agonist which is approved to treat pulmonary arterial hypertension in Asia.	1.97	1	enyne; monocarboxylic acid; organic heterotricyclic compound; secondary alcohol; secondary allylic alcohol	anti-inflammatory agent; antihypertensive agent; platelet aggregation inhibitor; prostaglandin receptor agonist; vasodilator agent

Condition	Relationship Strength	Studies
Germinoblastoma [description not available]	3.98	14
Cancer of the Thymus [description not available]	4.11	16
Lymphoma A general term for various neoplastic diseases of the lymphoid tissue.	3.98	14
Thymus Neoplasms Tumors or cancer of the THYMUS GLAND.	4.11	16
Body Weight The mass or quantity of heaviness of an individual. It is expressed by units of pounds or kilograms.	2.37	2
Pregnancy The status during which female mammals carry their developing young (EMBRYOS or FETUSES) in utero before birth, beginning from FERTILIZATION to BIRTH.	2.36	2
Experimental Leukemia [description not available]	3.06	5
Experimental Neoplasms [description not available]	3.06	5
Adenocarcinoma, Basal Cell [description not available]	2.36	2
Carcinoma, Anaplastic [description not available]	1.96	1
Cancer of Duodenum [description not available]	2.36	2
Endothelioma, Vascular [description not available]	1.96	1
Papilloma, Squamous Cell [description not available]	2.37	2
Cancer of Spleen [description not available]	1.96	1
Cancer of Stomach [description not available]	1.96	1
Cancer of the Vagina [description not available]	1.96	1
Adenocarcinoma A malignant epithelial tumor with a glandular organization.	2.36	2
Carcinoma A malignant neoplasm made up of epithelial cells tending to infiltrate the surrounding tissues and give rise to metastases. It is a histological type of neoplasm and not a synonym for cancer.	1.96	1
Hemangioendothelioma A neoplasm derived from blood vessels, characterized by numerous prominent endothelial cells that occur singly, in aggregates, and as the lining of congeries of vascular tubes or channels. Hemangioendotheliomas are relatively rare and are of intermediate malignancy (between benign hemangiomas and conventional angiosarcomas). They affect men and women about equally and rarely develop in childhood. (From Stedman, 25th ed; Holland et al., Cancer Medicine, 3d ed, p1866)	1.96	1
Papilloma A circumscribed benign epithelial tumor projecting from the surrounding surface; more precisely, a benign epithelial neoplasm consisting of villous or arborescent outgrowths of fibrovascular stroma covered by neoplastic cells. (Stedman, 25th ed)	2.37	2
Stomach Neoplasms Tumors or cancer of the STOMACH.	1.96	1
Vaginal Neoplasms Tumors or cancer of the VAGINA.	1.96	1
Cancer of Gastrointestinal Tract [description not available]	1.95	1
Carcinoma, Thymic [description not available]	2.37	2
Thymoma A neoplasm originating from thymic tissue, usually benign, and frequently encapsulated. Although it is occasionally invasive, metastases are extremely rare. It consists of any type of thymic epithelial cell as well as lymphocytes that are usually abundant. Malignant lymphomas that involve the thymus, e.g., lymphosarcoma, Hodgkin's disease (previously termed granulomatous thymoma), should not be regarded as thymoma. (From Stedman, 25th ed)	2.37	2
T-Cell Lymphoma [description not available]	2	1
Lymphoma, T-Cell A group of heterogeneous lymphoid tumors representing malignant transformations of T-lymphocytes.	2	1
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	1.98	1
Diathesis [description not available]	2.38	2
Cancer of Lung [description not available]	1.97	1
Peritoneal Carcinomatosis [description not available]	2.37	2
Lung Neoplasms Tumors or cancer of the LUNG.	1.97	1
Mesothelioma A tumor derived from mesothelial tissue (peritoneum, pleura, pericardium). It appears as broad sheets of cells, with some regions containing spindle-shaped, sarcoma-like cells and other regions showing adenomatous patterns. Pleural mesotheliomas have been linked to exposure to asbestos. (Dorland, 27th ed)	1.97	1
Peritoneal Neoplasms Tumors or cancer of the PERITONEUM.	2.37	2
Cancer of Digestive System [description not available]	2.38	2
Neoplasms, Nervous System [description not available]	1.97	1
Neoplasms, Sebaceous Gland [description not available]	1.97	1
Digestive System Neoplasms Tumors or cancer of the DIGESTIVE SYSTEM.	2.38	2
Carcinoma, Epidermoid [description not available]	1.97	1
Deficiency, Vitamin A [description not available]	1.97	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.97	1
Vitamin A Deficiency A nutritional condition produced by a deficiency of VITAMIN A in the diet, characterized by NIGHT BLINDNESS and other ocular manifestations such as dryness of the conjunctiva and later of the cornea (XEROPHTHALMIA). Vitamin A deficiency is a very common problem worldwide, particularly in developing countries as a consequence of famine or shortages of vitamin A-rich foods. In the United States it is found among the urban poor, the elderly, alcoholics, and patients with malabsorption. (From Cecil Textbook of Medicine, 19th ed, p1179)	1.97	1
Abnormalities, Autosome [description not available]	1.97	1
B-Cell Chronic Lymphocytic Leukemia [description not available]	1.97	1
Autosomal Chromosome Disorders [description not available]	1.97	1
Leukemia, Lymphocytic, Chronic, B-Cell A chronic leukemia characterized by abnormal B-lymphocytes and often generalized lymphadenopathy. In patients presenting predominately with blood and bone marrow involvement it is called chronic lymphocytic leukemia (CLL); in those predominately with enlarged lymph nodes it is called small lymphocytic lymphoma. These terms represent spectrums of the same disease.	1.97	1
Adrenal Cancer [description not available]	1.97	1
Experimental Hepatoma [description not available]	1.97	1
Pheochromocytoma, Extra-Adrenal [description not available]	1.97	1
Cancer of the Thyroid [description not available]	1.97	1
Pheochromocytoma A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)	1.97	1
Thyroid Neoplasms Tumors or cancer of the THYROID GLAND.	1.97	1
Cancer of Granulosa Cells [description not available]	1.96	1
Cancer of Ovary [description not available]	1.96	1
Sertoli Cell Tumor Gonadal neoplasm composed entirely of SERTOLI CELLS or may have a component of GRANULOSA CELLS. Some of the Sertoli cell tumors produce ESTROGEN or ANDROGENS, but seldom in sufficient quantity to cause clinical symptoms such as FEMINIZATION or masculinization (VIRILISM).	1.96	1
Ovarian Neoplasms Tumors or cancer of the OVARY. These neoplasms can be benign or malignant. They are classified according to the tissue of origin, such as the surface EPITHELIUM, the stromal endocrine cells, and the totipotent GERM CELLS.	1.96	1
Hyperplasia An increase in the number of cells in a tissue or organ without tumor formation. It differs from HYPERTROPHY, which is an increase in bulk without an increase in the number of cells.	1.96	1

propylnitrosourea

Cross-References

Synonyms (41)

Research Excerpts

Dosage Studied

Research

Studies (35)

Market Indicators

Research Demand Index: 10.77

Study Types

propylnitrosourea

Cross-References

Synonyms (41)

Research Excerpts

Dosage Studied

Research

Studies (35)

Market Indicators

Research Demand Index: 10.77

Study Types

Related Drugs (14)

Related Conditions (57)