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indomethacin and Pheochromocytoma

indomethacin has been researched along with Pheochromocytoma in 5 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)

Research Excerpts

ExcerptRelevanceReference
" Here we report that various NSAIDs, such as the cyclooxygenase inhibitors, nimesulide, ibuprofen and indomethacin, as well as thalidomide (Thal) and its non-teratogenic analogue, supidimide, significantly stimulated the secretion of the non-amyloidogenic alpha-secretase form of the soluble amyloid precursor protein (sAPP alpha) into the conditioned media of SH-SY5Y neuroblastoma and PC12 cells."3.71Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. ( Amit, T; Avramovich, Y; Youdim, MB, 2002)
"Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction occur in aortas from New England Deaconess Hospital (NEDH) rats harboring pheochromocytoma (PHEO) and following chronic exposure to the alpha-adrenergic agonist phenylephrine in vitro."3.68Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction: role of the endothelium. ( Hiremath, AN; Hoffman, BB; Hu, ZW, 1991)

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19901 (20.00)18.7374
1990's3 (60.00)18.2507
2000's1 (20.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Sondergaard, SB1
Knudsen, JH1
Christensen, NJ1
Avramovich, Y1
Amit, T1
Youdim, MB1
Hiremath, AN1
Hu, ZW1
Hoffman, BB1
Fujita, T1
Uchida, T1
Kuwao, S1
Ishibashi, A1
Koshiba, K1

Other Studies

5 other studies available for indomethacin and Pheochromocytoma

ArticleYear
Regulation of cAMP in a lymphocyte preparation isolated from peripheral venous blood in human subjects: the significance of residual thrombocytes, noradrenaline and prostaglandins.
    Clinical science (London, England : 1979), 1998, Volume: 95, Issue:3

    Topics: Adrenergic beta-Agonists; Aged; Analysis of Variance; Biomarkers; Blood Platelets; Cells, Cultured;

1998
Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein.
    The Journal of biological chemistry, 2002, Aug-30, Volume: 277, Issue:35

    Topics: Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inh

2002
Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction: role of the endothelium.
    Journal of cardiovascular pharmacology, 1991, Volume: 18, Issue:1

    Topics: Adrenal Gland Neoplasms; Animals; Aorta, Thoracic; Endothelium, Vascular; Female; Hemoglobins; In Vi

1991
[Frequency of various types of secondary hypertension and pathogenic mechanisms].
    Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine, 1990, Jan-10, Volume: 79, Issue:1

    Topics: Adrenal Gland Neoplasms; Cushing Syndrome; Diagnosis, Differential; Glycyrrhetinic Acid; Glycyrrhizi

1990
Elevated prostaglandin and indomethacin-responsive hypercalcemia in a patient with malignant pheochromocytoma.
    The Journal of urology, 1985, Volume: 134, Issue:4

    Topics: Adrenal Gland Neoplasms; Bone Neoplasms; Calcium; Humans; Hypercalcemia; Indomethacin; Male; Middle

1985