indomethacin has been researched along with Pheochromocytoma in 5 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Pheochromocytoma: A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
Excerpt | Relevance | Reference |
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" Here we report that various NSAIDs, such as the cyclooxygenase inhibitors, nimesulide, ibuprofen and indomethacin, as well as thalidomide (Thal) and its non-teratogenic analogue, supidimide, significantly stimulated the secretion of the non-amyloidogenic alpha-secretase form of the soluble amyloid precursor protein (sAPP alpha) into the conditioned media of SH-SY5Y neuroblastoma and PC12 cells." | 3.71 | Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein. ( Amit, T; Avramovich, Y; Youdim, MB, 2002) |
"Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction occur in aortas from New England Deaconess Hospital (NEDH) rats harboring pheochromocytoma (PHEO) and following chronic exposure to the alpha-adrenergic agonist phenylephrine in vitro." | 3.68 | Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction: role of the endothelium. ( Hiremath, AN; Hoffman, BB; Hu, ZW, 1991) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 1 (20.00) | 18.7374 |
1990's | 3 (60.00) | 18.2507 |
2000's | 1 (20.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
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Sondergaard, SB | 1 |
Knudsen, JH | 1 |
Christensen, NJ | 1 |
Avramovich, Y | 1 |
Amit, T | 1 |
Youdim, MB | 1 |
Hiremath, AN | 1 |
Hu, ZW | 1 |
Hoffman, BB | 1 |
Fujita, T | 1 |
Uchida, T | 1 |
Kuwao, S | 1 |
Ishibashi, A | 1 |
Koshiba, K | 1 |
5 other studies available for indomethacin and Pheochromocytoma
Article | Year |
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Regulation of cAMP in a lymphocyte preparation isolated from peripheral venous blood in human subjects: the significance of residual thrombocytes, noradrenaline and prostaglandins.
Topics: Adrenergic beta-Agonists; Aged; Analysis of Variance; Biomarkers; Blood Platelets; Cells, Cultured; | 1998 |
Non-steroidal anti-inflammatory drugs stimulate secretion of non-amyloidogenic precursor protein.
Topics: Amyloid beta-Protein Precursor; Animals; Anti-Inflammatory Agents, Non-Steroidal; Cyclooxygenase Inh | 2002 |
Desensitization of alpha-adrenergic receptor-mediated smooth muscle contraction: role of the endothelium.
Topics: Adrenal Gland Neoplasms; Animals; Aorta, Thoracic; Endothelium, Vascular; Female; Hemoglobins; In Vi | 1991 |
[Frequency of various types of secondary hypertension and pathogenic mechanisms].
Topics: Adrenal Gland Neoplasms; Cushing Syndrome; Diagnosis, Differential; Glycyrrhetinic Acid; Glycyrrhizi | 1990 |
Elevated prostaglandin and indomethacin-responsive hypercalcemia in a patient with malignant pheochromocytoma.
Topics: Adrenal Gland Neoplasms; Bone Neoplasms; Calcium; Humans; Hypercalcemia; Indomethacin; Male; Middle | 1985 |