| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
1,3-dipropyl-8-cyclopentylxanthine
DPCPX : An oxopurine that is 7H-xanthine substituted at positions 1 and 3 by propyl groups and at position 8 by a cyclohexyl group. | 3.48 | 2 | 0 | oxopurine | adenosine A1 receptor antagonist;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor |
1,3-dipropyl-8-(4-sulfophenyl)xanthine
1,3-dipropyl-8-(4-sulfophenyl)xanthine: adenosine receptor antagonist | 2.38 | 2 | 0 | | |
enprofylline
enprofylline : Xanthine bearing a propyl substituent at position 3. A bronchodilator, it is used for the symptomatic treatment of asthma and chronic obstructive pulmonary disease, and in the management of cerebrovascular insufficiency, sickle cell disease, and diabetic neuropathy. | 1.97 | 1 | 0 | oxopurine | anti-arrhythmia drug;
anti-asthmatic drug;
bronchodilator agent;
non-steroidal anti-inflammatory drug |
8-(4-sulfophenyl)theophylline
8-(4-sulfophenyl)theophylline: adenosine antagonist | 3.48 | 2 | 0 | | |
8-cyclopentyl-1,3-dimethylxanthine
8-cyclopentyl-1,3-dimethylxanthine: prolongs epileptic seizures in rats | 3.48 | 2 | 0 | oxopurine | |
8-phenyltheophylline
8-phenyltheophylline: purinergic P1 receptor antagonist | 3.48 | 2 | 0 | | |
theophylline
[no description available] | 3.77 | 3 | 0 | dimethylxanthine | adenosine receptor antagonist;
anti-asthmatic drug;
anti-inflammatory agent;
bronchodilator agent;
drug metabolite;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
fungal metabolite;
human blood serum metabolite;
immunomodulator;
muscle relaxant;
vasodilator agent |
caffeine
[no description available] | 9 | 4 | 0 | purine alkaloid;
trimethylxanthine | adenosine A2A receptor antagonist;
adenosine receptor antagonist;
adjuvant;
central nervous system stimulant;
diuretic;
EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
environmental contaminant;
food additive;
fungal metabolite;
geroprotector;
human blood serum metabolite;
mouse metabolite;
mutagen;
plant metabolite;
psychotropic drug;
ryanodine receptor agonist;
xenobiotic |
cgs 15943
9-chloro-2-(2-furyl)-(1,2,4)triazolo(1,5-c)quinazolin-5-imine: non-xanthine triazoloquinazoline adenosine antagonist. CGS 15943 : A member of the class of triazoloquinazolines that is [1,2,4]triazolo[1,5-c]quinazoline substited at positions 2, 5 and 9 by furan-2-yl, amino and chloro groups respectively. A potent antagonist at adenosine A1 and adenosine A2A receptors. | 3.08 | 1 | 0 | aromatic amine;
biaryl;
furans;
organochlorine compound;
primary amino compound;
quinazolines;
triazoloquinazoline | adenosine A1 receptor antagonist;
adenosine A2A receptor antagonist;
antineoplastic agent;
central nervous system stimulant |
8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine
8-(4-((2-aminoethyl)aminocarbonylmethyloxy)phenyl)-1,3-dipropylxanthine: adenosine receptor antagonist | 3.08 | 1 | 0 | | |
2-chloroadenosine
5-chloroformycin A: structure given in first source | 3.49 | 2 | 0 | purine nucleoside | |
rolofylline
rolofylline: selective antagonist for adenosine receptors; a cardiovascular agent | 3.08 | 1 | 0 | oxopurine | |
3-methylxanthine
3-methyl-9H-xanthine : A 3-methylxanthine tautomer where the imidazole proton is located at the 9-position.. 3-methyl-7H-xanthine : A 3-methylxanthine tautomer where the imidazole proton is located at the 7-position. | 1.97 | 1 | 0 | 3-methylxanthine | metabolite |
1-methylxanthine
1-methylxanthine: urinary metabolite of caffeine. 1-methylxanthine : A monomethylxanthine having the methyl group located at the 1-position. It is a metabolite of caffeine in humans.. 1-methyl-7H-xanthine : A 1-methylxanthine tautomer where the imidazole proton is located at the 7-position. | 1.97 | 1 | 0 | 1-methylxanthine | mouse metabolite |
1,3-dipropyl-8-(2-amino-4-chlorophenyl)xanthine
[no description available] | 3.08 | 1 | 0 | | |
phenylisopropyladenosine
[no description available] | 3.08 | 1 | 0 | aromatic amine;
benzenes;
hydrocarbyladenosine;
purine nucleoside;
secondary amino compound | adenosine A1 receptor agonist;
neuroprotective agent |
3,7-dimethyl-1-propargylxanthine
3,7-dimethyl-1-propargylxanthine: potent & selective in vivo antagonist of adenosine analogs | 3.49 | 2 | 0 | | |
n(6)-phenyladenosine
[no description available] | 3.08 | 1 | 0 | purine nucleoside | |
bw a1433u
BW A1433U: adenosine A3 receptor antagonist; attenuates hypoxia-induced AH interval prolongation; derivative of 1,3-dipropyl-8-phenylxanthine | 1.97 | 1 | 0 | | |
2-chloro-n(6)cyclopentyladenosine
2-chloro-N(6)cyclopentyladenosine: highly selective agonist at A1 adenosine receptors | 3.08 | 1 | 0 | | |
cp 66713
CP 66713: adenosine receptor antagonist; structure given in first source | 3.08 | 1 | 0 | | |
adenosine amine congener
adenosine amine congener: a highly potent & selective adenosine A1 receptor agonist | 3.08 | 1 | 0 | | |
8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine
8-(4-carboxymethyloxy)phenyl-1,3-dipropylxanthine: used to localize adenosine receptors in the brain | 3.08 | 1 | 0 | | |
1,3-dipropyl-8-phenylxanthine
1,3-dipropyl-8-phenylxanthine: selective antagonist at adenosine A1 receptors | 1.97 | 1 | 0 | oxopurine | |
8-(dicyclopropylmethyl)-1,3-dipropylxanthine
8-(dicyclopropylmethyl)-1,3-dipropylxanthine: selective A1 adenosine receptor antagonist; structure given in first source | 3.08 | 1 | 0 | | |
kfm 19
KFM 19: a potential cognitive enhancer and a selective adenosine A1 receptor antagonist | 3.08 | 1 | 0 | | |
2-(1-octynyl)adenosine
YT 146: an adenosine receptor agonist; structure given in first source | 3.08 | 1 | 0 | | |
1-isoamyl-3-isobutylxanthine
[no description available] | 1.97 | 1 | 0 | | |
1,3-dipropyl-7-methylxanthine
1,3-dipropyl-7-methylxanthine: structure given in first source | 1.97 | 1 | 0 | | |
1,3-dipropylxanthine
1,3-dipropylxanthine: has high affinity for adenosine receptors; structure given in first source | 1.97 | 1 | 0 | | |
adenosine-5'-(n-ethylcarboxamide)
Adenosine-5'-(N-ethylcarboxamide): A stable adenosine A1 and A2 receptor agonist. Experimentally, it inhibits cAMP and cGMP phosphodiesterase activity.. N-ethyl-5'-carboxamidoadenosine : A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by an N-ethylcarboxamido group. | 3.08 | 1 | 0 | adenosines;
monocarboxylic acid amide | adenosine A1 receptor agonist;
adenosine A2A receptor agonist;
antineoplastic agent;
EC 3.1.4.* (phosphoric diester hydrolase) inhibitor;
vasodilator agent |
n(6)-cyclopentyladenosine
[no description available] | 3.08 | 1 | 0 | | |
2-((2-aminoethylamino)carbonylethylphenylethylamino)-5'-n-ethylcarboxamidoadenosine
2-((2-aminoethylamino)carbonylethylphenylethylamino)-5'-N-ethylcarboxamidoadenosine: structure given in first source | 3.08 | 1 | 0 | | |
2-(4-(2-carboxyethyl)phenethylamino)-5'-n-ethylcarboxamidoadenosine
2-(4-(2-carboxyethyl)phenethylamino)-5'-N-ethylcarboxamidoadenosine: A2 adenosine receptor agonist; structure given in first source. CGS-21680 : A derivative of adenosine in which the 5'-hydroxymethyl group is replaced by N-ethylcarboxamido and the hydrogen at position 2 on the adenine is replaced by a 4-(2-carboxyethyl)phenethylamino group. | 3.08 | 1 | 0 | adenosines;
dicarboxylic acid monoamide;
monocarboxylic acid | adenosine A2A receptor agonist;
anti-inflammatory agent |
8-(3-chlorostyryl)caffeine
8-(3-chlorostyryl)caffeine: adenosine antagonist. 8-(3-chlorostyryl)caffeine : Caffeine substituted at its 8-position by an (E)-3-chlorostyryl group. | 2.39 | 2 | 0 | monochlorobenzenes;
trimethylxanthine | adenosine A2A receptor antagonist;
EC 1.4.3.4 (monoamine oxidase) inhibitor |
kf 17837
[no description available] | 2.39 | 2 | 0 | | |
cv 1808
2-phenylaminoadenosine: has coronary & cardiohemodynamic effects | 3.08 | 1 | 0 | purine nucleoside | |
n(6)-cyclohexyladenosine
N(6)-cyclohexyladenosine: structure given in first source; receptors, purinergic P1 agonist | 3.08 | 1 | 0 | | |
n(6)-(2,2-diphenylethyl)adenosine
N(6)-(2,2-diphenylethyl)adenosine: adenosine receptor agonist; structure given in first source | 3.08 | 1 | 0 | | |
cgs 24012
CGS 24012: adenosine agonist with both high affinity & selectivity for the adenosine A2 receptor | 3.08 | 1 | 0 | | |