octadecadienoic-acid and Chagas-Disease

octadecadienoic-acid has been researched along with Chagas-Disease* in 1 studies

Other Studies

1 other study(ies) available for octadecadienoic-acid and Chagas-Disease

Article	Year
Identification of plasmenylethanolamine as a major component of the phospholipids of strain DM 28c of Trypanosoma cruzi. Molecular and biochemical parasitology, 1999, Jan-25, Volume: 98, Issue:2 A novel phospholipid has been purified from strain Dm 28c of Trypanosoma cruzi, and characterized by fast atom bombardment mass spectrometry and nuclear magnetic resonance spectroscopy as a plasmenylethanolamine with a hexadec-l-enyl group in the sn-1 position and an approximately equimolar mixture of octadecenoate and octadecadienoate esterified to the sn-2 hydroxyl. The purified plasmenylethanolamine reacted positively when probed with sera from patients with chronic Chagas' disease. Since plasmenylethanolamines of similar structure are abundant in mammalian cardiac and neuronal tissues, cross reactions between these epitopes may be a factor in the mechanism of autoimmune pathology in the chronic phase of Chagas' disease. Topics: Animals; Antibodies, Protozoan; Chagas Disease; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Clone Cells; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Nuclear Magnetic Resonance, Biomolecular; Phospholipids; Plasmalogens; Spectrometry, Mass, Fast Atom Bombardment; Stearic Acids; Trypanosoma cruzi	1999

Article

Year

Identification of plasmenylethanolamine as a major component of the phospholipids of strain DM 28c of Trypanosoma cruzi.

Molecular and biochemical parasitology, 1999, Jan-25, Volume: 98, Issue:2

A novel phospholipid has been purified from strain Dm 28c of Trypanosoma cruzi, and characterized by fast atom bombardment mass spectrometry and nuclear magnetic resonance spectroscopy as a plasmenylethanolamine with a hexadec-l-enyl group in the sn-1 position and an approximately equimolar mixture of octadecenoate and octadecadienoate esterified to the sn-2 hydroxyl. The purified plasmenylethanolamine reacted positively when probed with sera from patients with chronic Chagas' disease. Since plasmenylethanolamines of similar structure are abundant in mammalian cardiac and neuronal tissues, cross reactions between these epitopes may be a factor in the mechanism of autoimmune pathology in the chronic phase of Chagas' disease.

Topics: Animals; Antibodies, Protozoan; Chagas Disease; Chromatography, High Pressure Liquid; Chromatography, Thin Layer; Clone Cells; Fatty Acids, Unsaturated; Gas Chromatography-Mass Spectrometry; Humans; Nuclear Magnetic Resonance, Biomolecular; Phospholipids; Plasmalogens; Spectrometry, Mass, Fast Atom Bombardment; Stearic Acids; Trypanosoma cruzi

1999