Page last updated: 2024-08-21

isoxazoles and Chagas Disease

isoxazoles has been researched along with Chagas Disease in 9 studies

*Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. [MeSH]

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19901 (11.11)18.7374
1990's0 (0.00)18.2507
2000's0 (0.00)29.6817
2010's3 (33.33)24.3611
2020's5 (55.56)2.80

Authors

AuthorsStudies
Barbosa-Silva, AN; Brito, CRDN; da Câmara, ACJ; de Araújo-Neto, VT; de Medeiros, HR; de Sena, ER; Dos Santos, WV; Fagundes-Neto, JC; Ferreira, HRP; Galvão, LMDC; Gama, RA; Gomez, LCP; Guedes, PMM; Lima, RKDR; Nascimento, MSL; Queiroga, TBD1
Acevedo-Arcique, CM; Baak-Baak, CM; Chan-Pérez, JI; Gutiérrez-Blanco, E; Jiménez-Coello, M; Ortega-Pacheco, A; Poot-Ramos, A1
Alvedro, A; Cardinal, MV; Enriquez, GF; Gaspe, MS; Gürtler, RE; Laiño, MA; Macchiaverna, NP2
Arruda, CCP; Baroni, ACM; Cardoso, IA; Carvalho, DB; Costa, PAN; das Neves, AR; de Albuquerque, S; Gaspari, PDM; Lopes, NP; Luccas, PH; Nonato, MC; Pelizaro, BI; Piranda, EM; Portapilla, GB; Shiguemoto, CYK; Silva, F1
Alvedro, A; Cardinal, MV; Enriquez, GF; Gaspe, MS; Gürtler, RE; Laiño, MA1
Aguiar, AP; Bozza, MT; Capasso, C; Feijó, DF; Pan, P; Parkkila, S; Rodrigues, GC; Supuran, CT; Vermelho, AB; Vullo, D1
Ilies, MA1
Arison, BH; Eskola, P; Kulsa, P; Miller, AK; Miller, BM; Miller, TW; Mrozik, H; Skeggs, H; Vandenheuvel, WJ; Zimmerman, SB1

Trials

2 trial(s) available for isoxazoles and Chagas Disease

ArticleYear
Control of pyrethroid-resistant populations of Triatoma infestans, the main vector of Trypanosoma cruzi, by treating dogs with fluralaner in the Argentine Chaco.
    Medical and veterinary entomology, 2022, Volume: 36, Issue:2

    Topics: Animals; Argentina; Chagas Disease; Dog Diseases; Dogs; Insect Vectors; Insecticides; Isoxazoles; Pyrethrins; Triatoma; Trypanosoma cruzi

2022
An oral dose of Fluralaner administered to dogs kills pyrethroid-resistant and susceptible Chagas disease vectors for at least four months.
    Veterinary parasitology, 2019, Volume: 268

    Topics: Administration, Oral; Animals; Chagas Disease; Dog Diseases; Dogs; Drug Resistance; Insect Vectors; Insecticides; Isoxazoles; Nymph; Pyrethrins; Random Allocation; Treatment Outcome; Triatoma

2019

Other Studies

7 other study(ies) available for isoxazoles and Chagas Disease

ArticleYear
Insecticidal efficacy of fluralaner (Bravecto
    Parasites & vectors, 2021, Sep-06, Volume: 14, Issue:1

    Topics: Animals; Brazil; Chagas Disease; Dog Diseases; Dogs; Female; Insect Vectors; Insecticides; Isoxazoles; Male; Nymph; Random Allocation; Triatoma

2021
Evaluation of the effectiveness of fluralaner against adult stages of Rhodnius prolixus in dogs.
    Parasitology international, 2022, Volume: 87

    Topics: Animals; Chagas Disease; Dog Diseases; Dogs; Female; Insect Vectors; Isoxazoles; Male; Rhodnius; Trypanosoma cruzi

2022
Treatment of dogs with fluralaner reduced pyrethroid-resistant Triatoma infestans abundance, Trypanosoma cruzi infection and human-triatomine contact in the Argentine Chaco.
    Parasites & vectors, 2022, Jul-13, Volume: 15, Issue:1

    Topics: Animals; Argentina; Chagas Disease; Dogs; Humans; Insect Vectors; Insecticides; Isoxazoles; Pyrethrins; Triatoma; Trypanosoma cruzi

2022
Design, synthesis and antitrypanosomatid activity of 2-nitroimidazole-3,5-disubstituted isoxazole compounds based on benznidazole.
    European journal of medicinal chemistry, 2023, Nov-15, Volume: 260

    Topics: Antiprotozoal Agents; Chagas Disease; Cycloaddition Reaction; Humans; Isoxazoles; Nitroimidazoles; Structure-Activity Relationship; Trypanosoma cruzi

2023
Design, synthesis, and evaluation of hydroxamic acid derivatives as promising agents for the management of Chagas disease.
    Journal of medicinal chemistry, 2014, Jan-23, Volume: 57, Issue:2

    Topics: Animals; Carbonic Anhydrase Inhibitors; Carbonic Anhydrases; Cell Line, Tumor; Chagas Disease; Drug Design; Humans; Hydroxamic Acids; Isoenzymes; Isoxazoles; Macrophages, Peritoneal; Mice; Mice, Inbred BALB C; Peptide Hydrolases; Protease Inhibitors; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2014
New synthetic strategies for the management of Chagas disease (American trypanosomiasis).
    Journal of medicinal chemistry, 2014, Jan-23, Volume: 57, Issue:2

    Topics: Animals; Carbonic Anhydrase Inhibitors; Chagas Disease; Humans; Hydroxamic Acids; Isoxazoles; Protease Inhibitors; Trypanocidal Agents

2014
Urinary metabolites of 3a,4,5,6,7,7a-hexahydro-3-(1-methyl-5-nitro-1H-imidazol-2-yl)-1,2-benzisoxazole in the dog.
    Journal of pharmaceutical sciences, 1979, Volume: 68, Issue:9

    Topics: Animals; Antiprotozoal Agents; Biotransformation; Chagas Disease; Chromatography, Gas; Dogs; Female; Isoxazoles; Mass Spectrometry; Mice; Nitroimidazoles; Oxazoles; Salmonella

1979