piperazine has been researched along with Chagas Disease in 1 studies
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " cruzi infection after once daily oral dosing at 20, 50 and 100 mg/kg for 5 days." | 1.39 | Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi. ( Alexander, PW; Best, WM; Charman, SA; Chatelain, E; Diao, H; Gregg, AD; Keenan, M; Kerfoot, M; Khong, A; Ryan, E; Scandale, I; Shackleford, DM; Thompson, RC; von Geldern, TW; White, KL, 2013) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Keenan, M | 1 |
| Alexander, PW | 1 |
| Diao, H | 1 |
| Best, WM | 1 |
| Khong, A | 1 |
| Kerfoot, M | 1 |
| Thompson, RC | 1 |
| White, KL | 1 |
| Shackleford, DM | 1 |
| Ryan, E | 1 |
| Gregg, AD | 1 |
| Charman, SA | 1 |
| von Geldern, TW | 1 |
| Scandale, I | 1 |
| Chatelain, E | 1 |
1 other study available for piperazine and Chagas Disease
| Article | Year |
|---|---|
Design, structure-activity relationship and in vivo efficacy of piperazine analogues of fenarimol as inhibitors of Trypanosoma cruzi.
Topics: Administration, Oral; Animals; Chagas Disease; Drug Design; Humans; Mice; Piperazine; Piperazines; P | 2013 |