Phosphomannomutase 2

A phosphomannomutase 2 that is encoded in the genome of human. [PRO:DNx, UniProtKB:O15305]

PMM 2;
EC 5.4.2.8

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-phenyl-1,2-benzisothiazol-3-(2h)-one	Homo sapiens (human)	IC50	20.0000	2	2
6-fluoro-2-phenyl-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	50.0000	1	1
6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	20.0000	1	1
2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	11.0000	1	1
2-[[3-(3-oxo-1,2-benzothiazol-2-yl)phenyl]sulfonylamino]benzoic acid	Homo sapiens (human)	IC50	5.2000	1	1
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide	Homo sapiens (human)	IC50	13.0000	1	1
2-(4-chlorophenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	20.0000	1	1
2-(3-chlorophenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	25.0000	2	2
5-fluoro-2-phenyl-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	80.0000	1	1
2-(4-fluorophenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	20.0000	1	1

This protein enables 3 target(s):

Target	Category	Definition
phosphomannomutase activity	molecular function	Catalysis of the reaction: alpha-D-mannose 1-phosphate = D-mannose 6-phosphate. [EC:5.4.2.8, RHEA:11140]
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]

This protein is located in 3 target(s):

Target	Category	Definition
nucleoplasm	cellular component	That part of the nuclear content other than the chromosomes or the nucleolus. [GOC:ma, ISBN:0124325653]
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
neuronal cell body	cellular component	The portion of a neuron that includes the nucleus, but excludes cell projections such as axons and dendrites. [GOC:go_curators]

This protein is active in 1 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]

This protein is involved in 4 target(s):

Target	Category	Definition
protein glycosylation	biological process	A protein modification process that results in the addition of a carbohydrate or carbohydrate derivative unit to a protein amino acid, e.g. the addition of glycan chains to proteins. [GOC:curators, GOC:pr]
GDP-mannose biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai]
protein N-linked glycosylation	biological process	A protein glycosylation process in which a carbohydrate or carbohydrate derivative unit is added to a protein via the N4 atom of peptidyl-asparagine, the omega-N of arginine, or the N1' atom peptidyl-tryptophan. [GOC:pr, RESID:AA0151, RESID:AA0156, RESID:AA0327]
mannose metabolic process	biological process	The chemical reactions and pathways involving mannose, the aldohexose manno-hexose, the C-2 epimer of glucose. The D-(+)-form is widely distributed in mannans and hemicelluloses and is of major importance in the core oligosaccharide of N-linked oligosaccharides of glycoproteins. [ISBN:0198506732]