Page last updated: 2024-12-07

sulfamide

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Description

Sulfamide is a colorless crystalline solid with the formula SO2(NH2)2. It is a sulfonamide, meaning it contains a sulfonyl group (-SO2-) bonded to two nitrogen atoms. Sulfamide is a weak acid and is readily soluble in water. It is used in the synthesis of other sulfonamides, which have a wide range of applications in medicine, agriculture, and industry. Sulfamide is also used as a reagent in organic chemistry. It is studied due to its potential as a precursor for various pharmaceuticals and its unique reactivity in organic synthesis. Sulfamide is also of interest because it is a relatively simple molecule that can be used to study the properties of sulfonamides in general.'

sulfamide : The simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to two amino groups and by double bonds to two oxygen atoms. [Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Cross-References

ID SourceID
PubMed CID82267
CHEMBL ID355001
CHEBI ID29368

Synonyms (52)

Synonym
BB 0260582
h2nso2nh2
[s(nh2)2o2]
diamidodioxidosulfur
CHEBI:29368 ,
sulfamamide
sulfuryl diamide
sulfamide
nsc-252
sulfuryl amide
7803-58-9
sulfuric diamide
imidosulfamic acid
sulfonyl diamide
nsc252
sulfamide, 99%
chembl355001 ,
sulfamoylamine
bdbm26995
STK505662
AKOS000201755
A839317
imidosulfamic acid (van)
ai3-30237
einecs 232-262-9
nsc 252
vs7tzw634v ,
sulphuric diamide
unii-vs7tzw634v
h4n2o2s
FT-0601025
BBL019229
S12311
FUS ,
sulfamide [mi]
SY004124
mfcd00011606
DTXSID5064885
nh2so2nh2
sulphamide
aminosulfonamide
Q-201768
STR07407
sulfamide, purum, >=99.0% (n)
CS-W013732
Q3048282
s o2 (n h2)2
Z104503438
BCP13844
CCG-266025
S5606
sulfuricdiamide

Research Excerpts

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

ClassDescription
sulfamidesCompounds where two amino groups are bound to an SO2 unit.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (24)

Inhibition Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase Astrosclera willeyanaKi8.90000.03201.51729.6000AID647373
Carbonic anhydrase Stylophora pistillataKi0.00000.00000.686710.0000AID552130
Carbonic anhydraseStylophora pistillataKi0.00000.00000.50715.7100AID552131
Carbonic anhydrase 12Homo sapiens (human)Ki830.00000.00021.10439.9000AID310902; AID484163
Carbonic anhydrase 1Homo sapiens (human)Ki287.79570.00001.372610.0000AID1161930; AID1262263; AID1278739; AID1306523; AID1798763; AID1803484; AID238210; AID238317; AID238410; AID238578; AID238687; AID238957; AID310899; AID367653; AID392569; AID411397; AID484154; AID50355; AID50356; AID552127; AID587130; AID598726; AID724722; AID730754; AID763569
Carbonic anhydrase 2Homo sapiens (human)Ki29,195.05700.00000.72369.9200AID1058395; AID1070020; AID1161931; AID1161950; AID1235241; AID1237475; AID1262264; AID1278740; AID1306524; AID1336557; AID1430526; AID1461934; AID1798763; AID1803485; AID238222; AID238327; AID238440; AID238604; AID238715; AID238986; AID310900; AID367654; AID392568; AID411398; AID47903; AID47904; AID484155; AID552128; AID587131; AID598728; AID724721; AID730373; AID730753; AID732714; AID749809; AID758952; AID763568
Carbonic anhydrase 3Homo sapiens (human)Ki1,090.00000.00022.010210.0000AID484156
Carbonic anhydrase 4Homo sapiens (human)Ki172.42220.00021.97209.9200AID1798763; AID238441; AID238605; AID367655; AID392570; AID484157
Carbonic anhydrase 6Homo sapiens (human)Ki35.00000.00011.47109.9200AID484160; AID552129
Mu-type opioid receptorRattus norvegicus (Norway rat)Ki1,130.00000.00000.38458.6000AID1161931
Carbonic anhydrase 5A, mitochondrialHomo sapiens (human)Ki630.00020.00001.27259.9000AID238411; AID238579; AID238688; AID484158
Carbonic anhydraseMethanosarcina thermophilaKi57.45500.06000.97148.5000AID1803493; AID238607; AID239145; AID239146
Carbonic anhydrase 7Homo sapiens (human)Ki6.80000.00021.37379.9000AID265737; AID484161
Carbonic anhydraseSaccharomyces cerevisiae S288CKi8.70000.08200.56098.7000AID411400
Neuronal acetylcholine receptor subunit alpha-7Rattus norvegicus (Norway rat)Ki750.00000.00000.73078.0000AID484165
Carbonic anhydrase 9Homo sapiens (human)Ki38.40000.00010.78749.9000AID238442; AID310901; AID484162
Carbonic anhydraseMethanothermobacter thermautotrophicus str. Delta HKi271,500.00005.35005.35005.3500AID238958; AID239250
Carbonic anhydraseCandida albicans SC5314Ki300.00000.01051.44448.3470AID411399
Carbonic anhydrase Nakaseomyces glabratus CBS 138Ki420.00000.00701.21749.1700AID433253
Carbonic anhydrase 15Mus musculus (house mouse)Ki258.84670.00091.884610.0000AID1798763; AID392571; AID484166
Carbonic anhydrase 13Mus musculus (house mouse)Ki140.00000.00021.39749.9000AID238853; AID484164
Carbonic anhydrase Pseudomonas aeruginosa PAO1Ki8.00000.07596.26909.0000AID1237477
Carbonic anhydrase 14Homo sapiens (human)Ki750.00000.00021.50999.9000AID310903; AID484165
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Ki308.00030.00001.34129.9700AID238579; AID238688; AID484159
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Other Measurements

ProteinTaxonomyMeasurementAverageMin (ref.)Avg (ref.)Max (ref.)Bioassay(s)
Carbonic anhydrase 1Homo sapiens (human)Kinact310.00000.01000.93878.6000AID387187
Carbonic anhydrase 2Homo sapiens (human)Kinact1,130.00000.00300.794610.0000AID387188
Carbonic anhydrase 6Homo sapiens (human)Kinact70.00000.00090.72615.3000AID305488
Carbonic anhydraseCandida albicans SC5314Kinact300.00000.13200.13200.1320AID387434
Carbonic anhydrase 5B, mitochondrialHomo sapiens (human)Kinact84.00000.00900.92319.0400AID301197
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (20)

Processvia Protein(s)Taxonomy
estrous cycleCarbonic anhydrase 12Homo sapiens (human)
chloride ion homeostasisCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 12Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 1Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 2Homo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 2Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 2Homo sapiens (human)
angiotensin-activated signaling pathwayCarbonic anhydrase 2Homo sapiens (human)
regulation of monoatomic anion transportCarbonic anhydrase 2Homo sapiens (human)
secretionCarbonic anhydrase 2Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 2Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 2Homo sapiens (human)
positive regulation of dipeptide transmembrane transportCarbonic anhydrase 2Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 2Homo sapiens (human)
carbon dioxide transportCarbonic anhydrase 2Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 2Homo sapiens (human)
response to bacteriumCarbonic anhydrase 3Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 3Homo sapiens (human)
bicarbonate transportCarbonic anhydrase 4Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 4Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter tasteCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 6Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
positive regulation of synaptic transmission, GABAergicCarbonic anhydrase 7Homo sapiens (human)
positive regulation of cellular pH reductionCarbonic anhydrase 7Homo sapiens (human)
neuron cellular homeostasisCarbonic anhydrase 7Homo sapiens (human)
regulation of chloride transportCarbonic anhydrase 7Homo sapiens (human)
regulation of intracellular pHCarbonic anhydrase 7Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 7Homo sapiens (human)
response to hypoxiaCarbonic anhydrase 9Homo sapiens (human)
morphogenesis of an epitheliumCarbonic anhydrase 9Homo sapiens (human)
response to xenobiotic stimulusCarbonic anhydrase 9Homo sapiens (human)
response to testosteroneCarbonic anhydrase 9Homo sapiens (human)
secretionCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 9Homo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 14Homo sapiens (human)
response to bacteriumCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
one-carbon metabolic processCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (8)

Processvia Protein(s)Taxonomy
zinc ion bindingCarbonic anhydrase 12Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 12Homo sapiens (human)
arylesterase activityCarbonic anhydrase 1Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 1Homo sapiens (human)
protein bindingCarbonic anhydrase 1Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 1Homo sapiens (human)
hydro-lyase activityCarbonic anhydrase 1Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 1Homo sapiens (human)
arylesterase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 2Homo sapiens (human)
protein bindingCarbonic anhydrase 2Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 2Homo sapiens (human)
cyanamide hydratase activityCarbonic anhydrase 2Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 3Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 3Homo sapiens (human)
nickel cation bindingCarbonic anhydrase 3Homo sapiens (human)
protein bindingCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 4Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 4Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 6Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 7Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 9Homo sapiens (human)
protein bindingCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 9Homo sapiens (human)
molecular function activator activityCarbonic anhydrase 9Homo sapiens (human)
zinc ion bindingCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 14Homo sapiens (human)
carbonate dehydratase activityCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
zinc ion bindingCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (25)

Processvia Protein(s)Taxonomy
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
membraneCarbonic anhydrase 12Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 12Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 12Homo sapiens (human)
plasma membraneCarbonic anhydrase 12Homo sapiens (human)
cytosolCarbonic anhydrase 1Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 1Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
myelin sheathCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 2Homo sapiens (human)
cytoplasmCarbonic anhydrase 2Homo sapiens (human)
plasma membraneCarbonic anhydrase 2Homo sapiens (human)
apical part of cellCarbonic anhydrase 2Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytosolCarbonic anhydrase 3Homo sapiens (human)
cytoplasmCarbonic anhydrase 3Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 4Homo sapiens (human)
rough endoplasmic reticulumCarbonic anhydrase 4Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartmentCarbonic anhydrase 4Homo sapiens (human)
Golgi apparatusCarbonic anhydrase 4Homo sapiens (human)
trans-Golgi networkCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
external side of plasma membraneCarbonic anhydrase 4Homo sapiens (human)
cell surfaceCarbonic anhydrase 4Homo sapiens (human)
membraneCarbonic anhydrase 4Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 4Homo sapiens (human)
transport vesicle membraneCarbonic anhydrase 4Homo sapiens (human)
secretory granule membraneCarbonic anhydrase 4Homo sapiens (human)
brush border membraneCarbonic anhydrase 4Homo sapiens (human)
perinuclear region of cytoplasmCarbonic anhydrase 4Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 4Homo sapiens (human)
plasma membraneCarbonic anhydrase 4Homo sapiens (human)
extracellular regionCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
cytosolCarbonic anhydrase 6Homo sapiens (human)
extracellular exosomeCarbonic anhydrase 6Homo sapiens (human)
extracellular spaceCarbonic anhydrase 6Homo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5A, mitochondrialHomo sapiens (human)
cytosolCarbonic anhydrase 7Homo sapiens (human)
cytoplasmCarbonic anhydrase 7Homo sapiens (human)
nucleolusCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
membraneCarbonic anhydrase 9Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 9Homo sapiens (human)
microvillus membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 9Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
membraneCarbonic anhydrase 14Homo sapiens (human)
basolateral plasma membraneCarbonic anhydrase 14Homo sapiens (human)
apical plasma membraneCarbonic anhydrase 14Homo sapiens (human)
plasma membraneCarbonic anhydrase 14Homo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrial matrixCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
mitochondrionCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
cytoplasmCarbonic anhydrase 5B, mitochondrialHomo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (170)

Assay IDTitleYearJournalArticle
AID1803485ChEMBL_158305 (CHEMBL763190) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1798763CA Inhibition Assay from Article 10.1016/j.bmcl.2008.12.082: \\Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.\\2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
AID1803491ChEMBL_158311 (CHEMBL763368) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1803493ChEMBL_158313 (CHEMBL763370) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1803487ChEMBL_158307 (CHEMBL763192) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1803254CA Inhibition Assay from Article 10.3109/14756366.2011.649268: \\Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions.\\2013Journal of enzyme inhibition and medicinal chemistry, Apr, Volume: 28, Issue:2
Inhibition of the alpha- and beta-carbonic anhydrases from the gastric pathogen Helycobacter pylori with anions.
AID1803484ChEMBL_158304 (CHEMBL763189) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1803486ChEMBL_158306 (CHEMBL763191) from Article 10.1016/j.bmc.2016.05.029: \\Anion inhibition profiles of a-, u00DF- and u00BF-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.\\2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1278741Inhibition of Vibrio cholerae alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID1430528Inhibition of Burkholderia pseudomallei recombinant His-tagged carbonic anhydrase beta (256 residues) expressed in Escherichia coli BL21 (DE3) incubated for 15 mins prior to testing by stopped flow CO2 hydration method
AID484158Inhibition of full length human carbonic anhydrase 5a preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID484163Inhibition of human carbonic anhydrase 12 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID1161951Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration method2014Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.
AID1237484Induction of growth delay of Pseudomonas aeruginosa PAO1 assessed as growth delay time2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
AID411399Inhibition of Candida albicans carbonic anhydrase overexpressed in Escherichia coli BL21 (DE3) by CO2 hydration stopped-flow assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.
AID1235242Inhibition of archaeon Methanosarcina thermophila gamma-CA after 15 mins by stopped-flow/Co2 hydration assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID1336557Inhibition of human recombinant carbonic anhydrase 2 assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method
AID238653Inhibitory constant against carbonic anhydrase IV; nt= not tested2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
AID239250Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum2004Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID552130Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay2011Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID238688Inhibitory activity against human carbonic anhydrase V expressed in Escherichia coli2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
AID1278739Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID484164Inhibition of full length mouse carbonic anhydrase 13 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID239145Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila2004Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID724719Inhibition of human recombinant CA10 mutant after 15 mins by stopped-flow CO2 hydration method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.
AID238986Inhibitory activity against human carbonic anhydrase II at 0.01 uM2004Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID1312218Inhibition of Plasmodium falciparum full length recombinant His-fused Eta-carbonic anhydrase domain preincubated for 15 mins by stopped-flow CO2 hydrase assay2016Bioorganic & medicinal chemistry, 09-15, Volume: 24, Issue:18
Anion inhibition profiles of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.
AID47903Inhibitory activity against human cloned carbonic anhydrase II (hCA II)2003Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.
AID265737Inhibition of human recombinant CA72006Bioorganic & medicinal chemistry letters, Jun-15, Volume: 16, Issue:12
Carbonic anhydrase inhibitors: inhibition of the cytosolic human isozyme VII with anions.
AID552131Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay2011Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID48125Inhibitory activity against carbonic anhydrase isolated from bovine lung microsome (bCA IV); nt is not tested2003Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.
AID392570Inhibition of human recombinant carbonic anhydrase 4 by CO2 hydration reaction2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
AID1161930Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration method2014Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.
AID647373Inhibition of Astrosclera willeyana recombinant GST-tagged astrosclerin 3 expressed in Escherichia coli BL21-DE3-RIPL cells preincubated for 15 mins measured for 10 to 100 secs by stopped flow CO2 hydration assay2012Bioorganic & medicinal chemistry letters, Feb-01, Volume: 22, Issue:3
Anion inhibition studies of an α-carbonic anhydrase from the living fossil Astrosclera willeyana.
AID1461935Inhibition of Burkholderia pseudomallei beta-CA incubated for 15 mins by stopped-flow CO2 hydration assay
AID411398Inhibition of human carbonic anhydrase 2 by CO2 hydration stopped-flow assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.
AID1306524Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID730753Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID1336561Inhibition of Pseudoalteromonas haloplanktis recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method
AID763567Inhibition of Brucella suis beta carbonic anhydrase-1 at 20 degC by stopped-flow CO2 hydrase assay2013Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
AID433253Inhibition of Candida glabrata carbonic anhydrase by stopped flow CO2 hydration assay2009Bioorganic & medicinal chemistry letters, Aug-15, Volume: 19, Issue:16
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the pathogenic yeast Candida glabrata with anions.
AID50356Inhibitory activity against human cloned isoenzyme carbonic anhydrase I (hCA I), by esterase method.2003Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
AID238715Inhibitory activity against human carbonic anhydrase II expressed in Escherichia coli2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
AID1161952Inhibition of Porphyromonas gingivalis beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration method2014Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.
AID411397Inhibition of human carbonic anhydrase 1 by CO2 hydration stopped-flow assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.
AID1161932Inhibition of recombinant Plasmodium falciparum eta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration method2014Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.
AID1461938Inhibition of recombinant His6-tagged Francisella tularensis beta-CA (227 residues) expressed in Escherichia coli BL21(DE3) incubated for 15 mins by stopped-flow CO2 hydration assay
AID749809Inhibition of human carbonic anhydrase-2 preincubated for 15 mins by stopped-flow CO2 hydration assay2013Bioorganic & medicinal chemistry, Jun-01, Volume: 21, Issue:11
Synthesis and carbonic anhydrase inhibitory properties of sulfamides structurally related to dopamine.
AID484159Inhibition of full length human carbonic anhydrase 5b preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID387188Inhibition of human carbonic anhydrase 2 at 20 degC by CO2 hydration method2008Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
AID295046Inhibition of human recombinant carbonic anhydrase 12007Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
AID392568Inhibition of human recombinant carbonic anhydrase 2 by CO2 hydration reaction2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
AID1235244Inhibition of Nostoc commune CA after 15 mins by stopped-flow/Co2 hydration assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID587130Inhibition of human carbonic anhydrase 1 after 15 mins by CO2 hydrase assay at pH 7.52011Bioorganic & medicinal chemistry, Mar-15, Volume: 19, Issue:6
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.
AID730752Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID732714Inhibition of human erythrocytes esterase activity of carbonic anhydrase-2 using 4-nitrophenylacetate as substrate after 3 mins by Lineweaver-Burk plot analysis2013Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6
Novel sulfamides as potential carbonic anhydrase isoenzymes inhibitors.
AID677271Inhibition of Helicobacter pylori alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.
AID1235245Inhibition of Pseudoalteromonas haloplanktis gamma-CA after 15 mins by stopped-flow/Co2 hydration assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID484162Inhibition of human carbonic anhydrase 9 catalytic domain preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID730373Inhibition of human cytosolic carbonic anhydrase-2 preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.
AID1336562Inhibition of Burkholderia pseudomallei recombinant His-tagged carbonic anhydrase gamma expressed in Escherichia coli BL21 (DE3) assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method
AID305488Inhibition of full length human recombinant full length CA6 expressed in Escherichia coli BL21 by CO2 hydration method2007Bioorganic & medicinal chemistry letters, Feb-15, Volume: 17, Issue:4
Carbonic anhydrase inhibitors. Inhibition studies of the human secretory isoform VI with anions.
AID47904Inhibitory activity against human cloned isoenzyme carbonic anhydrase II (hCA II), by esterase method.2003Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
Carbonic anhydrase inhibitors: inhibition of cytosolic isozymes I and II with sulfamide derivatives.
AID387190Inhibition of Cryptococcus neoformans Can2 at 20 degC by CO2 hydration method2008Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
AID238222Inhibitory constant against human Carbonic anhydrase II2005Bioorganic & medicinal chemistry letters, May-02, Volume: 15, Issue:9
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
AID598731Inhibition of Salmonella Typhimurium carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.32011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.
AID552785Inhibition of Streptococcus pneumoniae beta-carbonic anhydrase after 15 mins by stopped flow CO2 hydration assay2011Bioorganic & medicinal chemistry, Jan-01, Volume: 19, Issue:1
Inhibition of the β-carbonic anhydrase from Streptococcus pneumoniae by inorganic anions and small molecules: Toward innovative drug design of antiinfectives?
AID552127Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay2011Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID238327Inhibitory constant against carbonic anhydrase II2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
AID1058389Inhibition of Clostridium perfringens carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens.
AID1336560Inhibition of Nostoc commune recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method
AID724718Inhibition of human recombinant CA11 mutant after 15 mins by stopped-flow CO2 hydration method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.
AID295047Inhibition of human recombinant carbonic anhydrase 22007Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
AID730754Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID724721Inhibition of human recombinant wild type CA2 by stopped-flow CO2 hydration method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.
AID238687Inhibitory activity against human carbonic anhydrase I expressed in Escherichia coli2004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
AID484154Inhibition of full length human carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID1306530Inhibition of Vibrio cholerae carbonic anhydrase beta preincubated for 15 mins by stopped-flow CO2 hydrase assay2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1306525Inhibition of Helicobacter pylori alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID758952Inhibition of human recombinant CA2 by CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14
A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.
AID1430527Inhibition of Burkholderia pseudomallei recombinant carbonic anhydrase gamma incubated for 15 mins prior to testing by stopped flow CO2 hydration method
AID677270Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 alpha-carbonic anhydrase-catalyzed CO2 hydration reaction preincubated for 15 mins by stopped flow CO2 hydrase assay2012Bioorganic & medicinal chemistry letters, Sep-01, Volume: 22, Issue:17
Anion inhibition studies of an α-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1.
AID1306532Inhibition of Vibrio cholerae recombinant carbonic anhydrase gamma expressed in Escherichia coli DE3 cells preincubated for 15 mins by stopped-flow CO2 hydrase assay2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID763566Inhibition of Brucella suis beta carbonic anhydrase-2 at 20 degC by stopped-flow CO2 hydrase assay2013Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
AID1461934Inhibition of human CA2 incubated for 15 mins by stopped-flow CO2 hydration assay
AID310902Inhibition of human recombinant catalytic domain CA122007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
AID1269931Inhibition of Colwellia psychrerythraea gamma carbonic anhydrase expressed in Escherichia coli incubated for 15 mins prior to testing by stopped flow CO2 hydration method2016Bioorganic & medicinal chemistry, Feb-15, Volume: 24, Issue:4
Cloning, characterization and anion inhibition studies of a γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
AID238210Inhibitory constant against human Carbonic anhydrase I2005Bioorganic & medicinal chemistry letters, May-02, Volume: 15, Issue:9
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
AID484166Inhibition of full length mouse carbonic anhydrase 15 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID238604Inhibition constant against human carbonic anhydrase isozyme hCA II2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
AID295049Inhibition of human recombinant carbonic anhydrase 12 catalytic domain by CO2 hydrase method2007Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
AID587131Inhibition of human carbonic anhydrase 2 after 15 mins by CO2 hydrase assay at pH 7.52011Bioorganic & medicinal chemistry, Mar-15, Volume: 19, Issue:6
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.
AID484155Inhibition of full length human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID484156Inhibition of human carbonic anhydrase 3 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID1306526Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydrase assay2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID238605Inhibition constant against human carbonic anhydrase isozyme hCA IV2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
AID367655Inhibition of human secreted carbonic anhydrase 4 measured by CO2 hydration reaction assay2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
AID763569Inhibition of human carbonic anhydrase-1 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay2013Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
AID484160Inhibition of human carbonic anhydrase 6 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID301197Inhibition of human mitochondrial CA5B by CO2 hydration assay2007Bioorganic & medicinal chemistry, Nov-01, Volume: 15, Issue:21
Carbonic anhydrase inhibitors: the inhibition profiles of the human mitochondrial isoforms VA and VB with anions are very different.
AID1278742Inhibition of recombinant Vibrio cholerae beta-carbonic anhydrase expressed in competent Escherichia coli BL21(DE3) cells preincubated for 15 mins by stopped-flow CO2 hydration assay2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID238579Inhibition constant against human carbonic anhydrase isozyme hCA V2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
AID484157Inhibition of full length human carbonic anhydrase 4 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID763565Inhibition of recombinant Trypanosoma cruzi CL Brener alpha carbonic anhydrase expressed in baculovirus infected SF9 cells at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay2013Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
AID238410Inhibitory activity against human Carbonic anhydrase I2005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
AID367653Inhibition of human carbonic anhydrase 1 measured by CO2 hydration reaction assay2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
AID1237486Growth inhibition of Pseudomonas aeruginosa PAO12015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
AID387434Inhibition of Candida albicans Nce103 at 20 degC by CO2 hydration method2008Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
AID730751Inhibition of Vibrio cholerae alpha carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Anion inhibition studies of the α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID238957Inhibitory activity against human carbonic anhydrase I at 0.09 uM2004Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID239146Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila2004Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID1336559Inhibition of Porphyromonas gingivalis recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method
AID392569Inhibition of human recombinant carbonic anhydrase 1 by CO2 hydration reaction2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
AID367654Inhibition of human carbonic anhydrase 2 measured by CO2 hydration reaction assay2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
AID387189Inhibition of Methanobacterium thermoautotrophicum Cab at 20 degC by CO2 hydration method2008Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
AID50355Inhibitory activity against human cloned carbonic anhydrase I (hCA I)2003Bioorganic & medicinal chemistry letters, Mar-10, Volume: 13, Issue:5
Carbonic anhydrase inhibitors: SAR and X-ray crystallographic study for the interaction of sugar sulfamates/sulfamides with isozymes I, II and IV.
AID730368Inhibition of Helicobacter pylori beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.
AID310903Inhibition of human recombinant full length CA142007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
AID552129Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay2011Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID598728Inhibition of recombinant human carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.32011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.
AID1262263Inhibition of human CA1 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.
AID758948Inhibition of Porphyromonas gingivalis recombinant CA by CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14
A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.
AID238411Inhibitory activity against human Carbonic anhydrase V2005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
AID724722Inhibition of human recombinant wild type CA1 by stopped-flow CO2 hydration method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.
AID1262267Inhibition of Chionodraco hamatus alphaCA incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.
AID484161Inhibition of full length human carbonic anhydrase 7 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID238441Inhibitory activity against human Carbonic anhydrase IV2005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
AID392571Inhibition of mouse recombinant carbonic anhydrase 15 expressed in COS7 cells by CO2 hydration reaction2009Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4
Carbonic anhydrase inhibitors: the membrane-associated isoform XV is highly inhibited by inorganic anions.
AID238853Inhibitory activity against mouse carbonic anhydrase XIII expressed in Escherichia coli TOP 102004Bioorganic & medicinal chemistry letters, Nov-01, Volume: 14, Issue:21
Carbonic anhydrase inhibitors. Inhibition of the newly isolated murine isozyme XIII with anions.
AID598732Inhibition of Salmonella Typhimurium carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay at pH 8.32011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.
AID1161950Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method2014Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
Anion inhibition study of the β-class carbonic anhydrase (PgiCAb) from the oral pathogen Porphyromonas gingivalis.
AID1070021Inhibition of Legionella pneumophila carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydrase assay2014Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4
Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID238226Inhibitory constant against human tumor Carbonic anhydrases IX or XII2005Bioorganic & medicinal chemistry letters, May-02, Volume: 15, Issue:9
Carbonic anhydrase inhibitors: synthesis and inhibition of cytosolic/tumor-associated carbonic anhydrase isozymes I, II, IX, and XII with N-hydroxysulfamides--a new zinc-binding function in the design of inhibitors.
AID310901Inhibition of human recombinant catalytic domain CA92007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
AID238607Inhibitory constant against Zn-Cam (Methanosarcina thermophila)2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
AID763568Inhibition of human carbonic anhydrase-2 at 20 degC preincubated for 15 mins by stopped-flow CO2 hydrase assay2013Bioorganic & medicinal chemistry, Aug-01, Volume: 21, Issue:15
Anion inhibition studies of the α-carbonic anhydrase from the protozoan pathogen Trypanosoma cruzi, the causative agent of Chagas disease.
AID239224Inhibitory activity against human carbonic anhydrase IX at 0.09 uM; not tested2004Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID587132Inhibition of Leptonychotes weddellii alpha-carbonic anhydrase after 15 mins by CO2 hydrase assay at pH 7.52011Bioorganic & medicinal chemistry, Mar-15, Volume: 19, Issue:6
Purification and inhibition studies with anions and sulfonamides of an α-carbonic anhydrase from the Antarctic seal Leptonychotes weddellii.
AID1430526Inhibition of recombinant human carbonic anhydrase 2 assessed as inhibition of CO2 hydration incubated for 15 mins prior to testing by stopped flow CO2 hydration method
AID724720Inhibition of human recombinant CA8 mutant after 15 mins by stopped-flow CO2 hydration method2013Bioorganic & medicinal chemistry letters, Jan-01, Volume: 23, Issue:1
Restoring catalytic activity to the human carbonic anhydrase (CA) related proteins VIII, X and XI affords isoforms with high catalytic efficiency and susceptibility to anion inhibition.
AID411400Inhibition of Saccharomyces cerevisiae carbonic anhydrase overexpressed in Escherichia coli BL21 (DE3) by CO2 hydration stopped-flow assay2008Bioorganic & medicinal chemistry letters, Dec-15, Volume: 18, Issue:24
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with anions.
AID730372Inhibition of Flaveria bidentis beta-carbonic anhydrase-1 preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Mar-15, Volume: 23, Issue:6
Kinetic and anion inhibition studies of a β-carbonic anhydrase (FbiCA 1) from the C4 plant Flaveria bidentis.
AID1235241Inhibition of human CA2 after 15 mins by stopped-flow/Co2 hydration assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID598726Inhibition of recombinant human carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay at pH 8.32011Bioorganic & medicinal chemistry letters, Jun-15, Volume: 21, Issue:12
Inhibition studies with anions and small molecules of two novel β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium.
AID238317Inhibitory constant against carbonic anhydrase I2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
AID1070022Inhibition of Legionella pneumophila carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay2014Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4
Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID387187Inhibition of human carbonic anhydrase 1 at 20 degC by CO2 hydration method2008Bioorganic & medicinal chemistry letters, Sep-15, Volume: 18, Issue:18
Carbonic anhydrase inhibitors: inhibition of the beta-class enzymes from the fungal pathogens Candida albicans and Cryptococcus neoformans with simple anions.
AID238578Inhibition constant against human carbonic anhydrase isozyme hCA I2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
AID238440Inhibitory activity against human Carbonic anhydrase II2005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
AID1336558Inhibition of Methanosarcina thermophila recombinant carbonic anhydrase gamma assessed as inhibition of CO2 hydration preincubated for 15 mins by Lineweaver-burk plot method
AID238958Inhibitory constant against methanoarchaeon Methanobacterium thermoautotrophicum (Cab)2004Bioorganic & medicinal chemistry letters, Sep-06, Volume: 14, Issue:17
Carbonic anhydrase inhibitors. Inhibition of the beta-class enzyme from the methanoarchaeon Methanobacterium thermoautotrophicum (Cab) with anions.
AID310900Inhibition of human recombinant CA22007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
AID758950Inhibition of Methanosarcina thermophila recombinant gamma-CA by CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Jul-15, Volume: 23, Issue:14
A highly catalytically active γ-carbonic anhydrase from the pathogenic anaerobe Porphyromonas gingivalis and its inhibition profile with anions and small molecules.
AID1058395Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay2013Bioorganic & medicinal chemistry letters, Dec-15, Volume: 23, Issue:24
Anion inhibition studies of a β-carbonic anhydrase from Clostridium perfringens.
AID1161931Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration method2014Bioorganic & medicinal chemistry letters, Sep-15, Volume: 24, Issue:18
Discovery of a new family of carbonic anhydrases in the malaria pathogen Plasmodium falciparum--the η-carbonic anhydrases.
AID1237475Inhibition of human carbonic anhydrase-2 by CO2 hydration reaction based colorimetric stopped-flow method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
AID1237477Inhibition of Pseudomonas aeruginosa PAO1 type-2 beta-carbonic anhydrase psCA3 expressed in Escherichia coli Tuner BL21 (DE3) cells pre-incubated for 15 mins at pH 8.3 and 293K by CO2 hydration reaction based colorimetric stopped-flow method2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
AID1070020Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay2014Bioorganic & medicinal chemistry letters, Feb-15, Volume: 24, Issue:4
Anion inhibition studies of two new β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID484165Inhibition of full length human carbonic anhydrase 14 preincubated for 15 mins by CO2 hydration stopped-flow assay2010Bioorganic & medicinal chemistry letters, Jun-15, Volume: 20, Issue:12
Carbonic anhydrase inhibitors: crystallographic and solution binding studies for the interaction of a boron-containing aromatic sulfamide with mammalian isoforms I-XV.
AID1262264Inhibition of human CA2 incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay2015Bioorganic & medicinal chemistry letters, Dec-01, Volume: 25, Issue:23
Anion and sulfonamide inhibition studies of an α-carbonic anhydrase from the Antarctic hemoglobinless fish Chionodraco hamatus.
AID1235243Inhibition of Porphyromonas gingivalis CA after 15 mins by stopped-flow/Co2 hydration assay2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Cloning, characterization and anion inhibition studies of a new γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID310899Inhibition of human recombinant carbonic anhydrase 12007Bioorganic & medicinal chemistry letters, Mar-15, Volume: 17, Issue:6
Carbonic anhydrase inhibitors. Inhibition of transmembrane isozymes XII (cancer-associated) and XIV with anions.
AID1278740Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay2016Bioorganic & medicinal chemistry letters, Mar-01, Volume: 26, Issue:5
Anion inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID367656Inhibition of Stylophora pistillata carbonic anhydrase measured by CO2 hydration reaction assay2009Bioorganic & medicinal chemistry letters, Feb-01, Volume: 19, Issue:3
Carbonic anhydrase inhibitors: inhibition studies of a coral secretory isoform with inorganic anions.
AID238442Inhibitory activity against human Carbonic anhydrase IX2005Bioorganic & medicinal chemistry letters, Feb-01, Volume: 15, Issue:3
Carbonic anhydrase inhibitors. Inhibition of isozymes I, II, IV, V, and IX with anions isosteric and isoelectronic with sulfate, nitrate, and carbonate.
AID238606Inhibition constant against human carbonic anhydrase isozyme hCA IX2004Bioorganic & medicinal chemistry letters, Dec-06, Volume: 14, Issue:23
Carbonic anhydrase inhibitors: inhibition of the membrane-bound human isozyme IV with anions.
AID552128Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay2011Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2
Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID295048Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by CO2 hydrase method2007Bioorganic & medicinal chemistry letters, May-15, Volume: 17, Issue:10
Carbonic anhydrase inhibitors: the X-ray crystal structure of the adduct of N-hydroxysulfamide with isozyme II explains why this new zinc binding function is effective in the design of potent inhibitors.
AID1306523Inhibition of human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydrase assay2016Bioorganic & medicinal chemistry, 08-15, Volume: 24, Issue:16
Anion inhibition profiles of α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1237485Induction of growth defect in Pseudomonas aeruginosa PAO1 up to 1 mM2015Bioorganic & medicinal chemistry, Aug-01, Volume: 23, Issue:15
Structure and inhibition studies of a type II beta-carbonic anhydrase psCA3 from Pseudomonas aeruginosa.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (47)

TimeframeStudies, This Drug (%)All Drugs %
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's18 (38.30)29.6817
2010's29 (61.70)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 61.86

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index61.86 (24.57)
Research Supply Index3.87 (2.92)
Research Growth Index4.59 (4.65)
Search Engine Demand Index100.39 (26.88)
Search Engine Supply Index2.00 (0.95)

This Compound (61.86)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other47 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]