| Substance | Relationship Strength | Studies | Trials | Classes | Roles |
|---|
putrescine
[no description available] | 2.03 | 1 | 0 | alkane-alpha,omega-diamine | antioxidant;
fundamental metabolite |
spermidine
[no description available] | 3.13 | 1 | 0 | polyazaalkane;
triamine | autophagy inducer;
fundamental metabolite;
geroprotector |
diminazene
Diminazene: An effective trypanocidal agent.. diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group. | 2 | 1 | 0 | carboxamidine;
triazene derivative | antiparasitic agent;
trypanocidal drug |
eflornithine
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.. eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2. | 3.13 | 1 | 0 | alpha-amino acid;
fluoroamino acid | trypanocidal drug |
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease. | 2.41 | 2 | 0 | aromatic ether;
carboxamidine;
diether | anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic |
dibrompropamidine
[no description available] | 2 | 1 | 0 | aromatic ether | |
adenosine
quinquefolan B: isolated from roots of Panax quinquefolium L.; RN not in Chemline 10/87; RN from Toxlit | 3.13 | 1 | 0 | adenosines;
purines D-ribonucleoside | analgesic;
anti-arrhythmia drug;
fundamental metabolite;
human metabolite;
vasodilator agent |
1-aminooxy-3-aminopropane
1-aminooxy-3-aminopropane: polyamine biosyn inhibitor; structure given in first source | 2.02 | 1 | 0 | | |
s-adenosyl-3-thio-1,8-diaminooctane
S-adenosyl-3-thio-1,8-diaminooctane: structure given in first source | 3.13 | 1 | 0 | | |
trypanothione
trypanothione disulfide : An organic disulfide resulting from the formal oxidative coupling of the thiol groups of N(1),N(8)-bis(glutathionyl)-spermidine from the insect-parasitic trypanosomatid Crithidia fasciculata. | 3.13 | 1 | 0 | organic disulfide | |
diminazene aceturate
diminazene diaceturate : An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine. | 2 | 1 | 0 | N-acetylglycinate salt | antiparasitic agent;
trypanocidal drug |
mitoguazone
Mitoguazone: Antineoplastic agent effective against myelogenous leukemia in experimental animals. Also acts as an inhibitor of animal S-adenosylmethionine decarboxylase.. mitoguazone : A hydrazone obtained by formal condensation of the two carbonyl groups of methylglyoxal with the primary amino groups of two molecules of aminoguanidine. | 1.99 | 1 | 0 | guanidines;
hydrazone | antineoplastic agent;
apoptosis inducer;
EC 4.1.1.50 (adenosylmethionine decarboxylase) inhibitor |
cgp 48664
4-amidinoindan-1-one 2'-amidinohydrazone: structure given in first source | 2.43 | 2 | 0 | | |
robenidine
Robenidine: An anticoccidial agent mainly for poultry. | 4.81 | 10 | 0 | | |