Page last updated: 2024-08-07 13:23:18
Spermine synthase
A spermine synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52788]
Synonyms
SPMSY;
EC 2.5.1.22;
Spermidine aminopropyltransferase
Research
Bioassay Publications (1)
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
Compounds (2)
Drugs with Inhibition Measurements
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| s-adenosyl-3-thio-1,8-diaminooctane | Homo sapiens (human) | IC50 | 0.0500 | 1 | 1 |
| s-adenosyl-1,12-diamino-3-thio-9-azadodecane | Homo sapiens (human) | IC50 | 0.0200 | 1 | 1 |
Enables
This protein enables 1 target(s):
| Target | Category | Definition |
|---|---|---|
| spermine synthase activity | molecular function | Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. [EC:2.5.1.22] |
Located In
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
Involved In
This protein is involved in 3 target(s):
| Target | Category | Definition |
|---|---|---|
| methionine metabolic process | biological process | The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732] |
| polyamine metabolic process | biological process | The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732] |
| spermine biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [GOC:curators] |