Spermine synthase

A spermine synthase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P52788]

SPMSY;
EC 2.5.1.22;
Spermidine aminopropyltransferase

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
s-adenosyl-3-thio-1,8-diaminooctane	Homo sapiens (human)	IC50	0.0500	1	1
s-adenosyl-1,12-diamino-3-thio-9-azadodecane	Homo sapiens (human)	IC50	0.0200	1	1

This protein enables 1 target(s):

Target	Category	Definition
spermine synthase activity	molecular function	Catalysis of the reaction: S-adenosylmethioninamine + spermidine = 5'-methylthioadenosine + spermine. [EC:2.5.1.22]

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular exosome	cellular component	A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894]

This protein is involved in 3 target(s):

Target	Category	Definition
methionine metabolic process	biological process	The chemical reactions and pathways involving methionine (2-amino-4-(methylthio)butanoic acid), a sulfur-containing, essential amino acid found in peptide linkage in proteins. [GOC:jl, ISBN:0198506732]
polyamine metabolic process	biological process	The chemical reactions and pathways involving polyamines, any organic compound containing two or more amino groups. [ISBN:0198506732]
spermine biosynthetic process	biological process	The chemical reactions and pathways resulting in the formation of spermine, a polybasic amine found in human sperm, in ribosomes and in some viruses and involved in nucleic acid packaging. [GOC:curators]