verapamil has been researched along with Chagas Disease in 12 studies
Verapamil: A calcium channel blocker that is a class IV anti-arrhythmia agent.
verapamil : A racemate comprising equimolar amounts of dexverapamil and (S)-verapamil. An L-type calcium channel blocker of the phenylalkylamine class, it is used (particularly as the hydrochloride salt) in the treatment of hypertension, angina pectoris and cardiac arrhythmia, and as a preventive medication for migraine.
2-(3,4-dimethoxyphenyl)-5-{[2-(3,4-dimethoxyphenyl)ethyl](methyl)amino}-2-(propan-2-yl)pentanenitrile : A tertiary amino compound that is 3,4-dimethoxyphenylethylamine in which the hydrogens attached to the nitrogen are replaced by a methyl group and a 4-cyano-4-(3,4-dimethoxyphenyl)-5-methylhexyl group.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Verapamil treatment of infected animals restored RV beta AR receptor density, alpha s and alpha i1-3 to control levels but had no influence on any aspect of pertussis-toxin-dependent [32P]ADP-ribosylation." | 5.29 | Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease. ( Barr, S; Bilezikian, JP; Brewer, A; Chen, G; Morris, SA; Rohde, S; Tanowitz, HB; Walsh, D; Wittner, M, 1996) |
| "In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease." | 5.28 | Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989) |
| "These findings, consistent with a dilated cardiomyopathy, were ameliorated in the early but not in the late treatment group, demonstrating that late treatment with verapamil is ineffective in reversing the development of chagasic cardiomyopathy in chronically infected mice." | 1.32 | Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection. ( Chandra, M; De Souza, AP; Factor, SM; Huang, H; Jelicks, LA; Morris, SA; Shirani, J; Shtutin, V; Tanowitz, HB; Weiss, LM; Wittner, M, 2004) |
| "Verapamil was given in drinking water (1 gm/l) continuously from the day of infection for a total of 120 days." | 1.31 | Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain): an echocardiographic study. ( Chandra, M; Dominguez-Rosales, JA; Factor, SM; Jelicks, LA; Morris, SA; Petkova, SB; Rojkind, M; Shirani, J; Shtutin, V; Tanowitz, HB; Weiss, LM; Wittner, M, 2002) |
| "To further assess the effect of Trypanosoma cruzi infection on the microcirculation, we examined the cremaster microvascular model in CD-1 male mice infected with the Brazil strain at 20-25 days postinfection." | 1.29 | Compromised microcirculation in acute murine Trypanosoma cruzi infection. ( Chen, B; Factor, SM; Kaul, DK; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1996) |
| "Verapamil treatment of infected animals restored RV beta AR receptor density, alpha s and alpha i1-3 to control levels but had no influence on any aspect of pertussis-toxin-dependent [32P]ADP-ribosylation." | 1.29 | Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease. ( Barr, S; Bilezikian, JP; Brewer, A; Chen, G; Morris, SA; Rohde, S; Tanowitz, HB; Walsh, D; Wittner, M, 1996) |
| "In previous work, we have shown that the chronic administration of verapamil, a calcium channel blocker, ameliorated the mortality, pathology, and biochemical alterations associated with acute murine Chagas' disease." | 1.28 | Effect of verapamil on the development of chronic experimental Chagas' disease. ( Bilezikian, JP; Factor, SM; Morris, SA; Tanowitz, HB; Weiss, LM; Wittner, M, 1989) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 3 (25.00) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 3 (25.00) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Papadopoulou, MV | 3 |
| Bloomer, WD | 3 |
| Lepesheva, GI | 1 |
| Rosenzweig, HS | 3 |
| Kaiser, M | 3 |
| Aguilera-Venegas, B | 1 |
| Wilkinson, SR | 3 |
| Chatelain, E | 2 |
| Ioset, JR | 2 |
| O'Shea, IP | 2 |
| Ang, CW | 1 |
| Lee, BM | 1 |
| Jackson, CJ | 1 |
| Wang, Y | 1 |
| Franzblau, SG | 1 |
| Francisco, AF | 1 |
| Kelly, JM | 1 |
| Bernhardt, PV | 1 |
| Tan, L | 1 |
| West, NP | 1 |
| Sykes, ML | 1 |
| Hinton, AO | 1 |
| Bolisetti, R | 1 |
| Avery, VM | 1 |
| Cooper, MA | 1 |
| Blaskovich, MAT | 1 |
| Pavão, RB | 1 |
| Moreira, HT | 1 |
| Pintya, AO | 1 |
| Haddad, JL | 1 |
| Badran, AV | 1 |
| Lima-Filho, MO | 1 |
| Lago, IM | 1 |
| Chierice, JRA | 1 |
| Schmidt, A | 1 |
| Marin-Neto, JA | 1 |
| De Souza, AP | 1 |
| Tanowitz, HB | 6 |
| Chandra, M | 2 |
| Shtutin, V | 2 |
| Weiss, LM | 5 |
| Morris, SA | 6 |
| Factor, SM | 4 |
| Huang, H | 2 |
| Wittner, M | 6 |
| Shirani, J | 2 |
| Jelicks, LA | 2 |
| Kaul, DK | 1 |
| Chen, B | 2 |
| Chen, G | 1 |
| Barr, S | 1 |
| Walsh, D | 1 |
| Rohde, S | 1 |
| Brewer, A | 1 |
| Bilezikian, JP | 3 |
| Christ, GJ | 1 |
| Braunstein, V | 1 |
| Petkova, SB | 1 |
| Rojkind, M | 1 |
| Dominguez-Rosales, JA | 1 |
| Vichi, FL | 1 |
| Nobre, F | 1 |
| Evora, P | 1 |
| Ribeiro, PJ | 1 |
| Papa, MV | 1 |
2 trials available for verapamil and Chagas Disease
| Article | Year |
|---|---|
Aspirin plus verapamil relieves angina and perfusion abnormalities in patients with coronary microvascular dysfunction and Chagas disease: a pilot non-randomized study.
Topics: Angina Pectoris; Aspirin; Chagas Disease; Female; Humans; Male; Middle Aged; Perfusion; Quality of L | 2021 |
[Use of verapamil in the treatment of ventricular extrasystole in chronic Chagas' heart disease].
Topics: Cardiomyopathies; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Coronary Disease; Drug | 1977 |
10 other studies available for verapamil and Chagas Disease
| Article | Year |
|---|---|
Novel 3-nitrotriazole-based amides and carbinols as bifunctional antichagasic agents.
Topics: Amides; Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Methanol; Mice; Mice, | 2015 |
Discovery of potent nitrotriazole-based antitrypanosomal agents: In vitro and in vivo evaluation.
Topics: Animals; Binding Sites; Cell Line; Chagas Disease; Disease Models, Animal; Leishmania donovani; Mice | 2015 |
3-Nitrotriazole-based piperazides as potent antitrypanosomal agents.
Topics: Animals; Cell Line; Chagas Disease; Dose-Response Relationship, Drug; Humans; Leishmania donovani; M | 2015 |
Nitroimidazopyrazinones with Oral Activity against Tuberculosis and Chagas Disease in Mouse Models of Infection.
Topics: Animals; Chagas Disease; Disease Models, Animal; Mice; Mycobacterium tuberculosis; Nitroimidazoles; | 2022 |
Effects of early and late verapamil administration on the development of cardiomyopathy in experimental chronic Trypanosoma cruzi (Brazil strain) infection.
Topics: Animals; Anti-Arrhythmia Agents; Cardiomyopathy, Dilated; Chagas Cardiomyopathy; Chagas Disease; Dis | 2004 |
Compromised microcirculation in acute murine Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Blood Flow Velocity; Chagas Disease; Dilatation, Pathologic; Disease Models, | 1996 |
Cardioprotective actions of verapamil on the beta-adrenergic receptor complex in acute canine Chagas' disease.
Topics: Adenylyl Cyclases; Animals; Calcium Channel Blockers; Chagas Disease; Dogs; Heart; Myocardium; Recep | 1996 |
Effects of verapamil on acute murine Chagas' disease.
Topics: Acute Disease; Adenylyl Cyclases; Adrenergic alpha-Antagonists; Adrenergic beta-Antagonists; Animals | 1996 |
Cardioprotective effects of verapamil on myocardial structure and function in a murine model of chronic Trypanosoma cruzi infection (Brazil Strain): an echocardiographic study.
Topics: Animals; Calcium Channel Blockers; Cardiotonic Agents; Chagas Disease; Collagen; Disease Models, Ani | 2002 |
Effect of verapamil on the development of chronic experimental Chagas' disease.
Topics: Adenylyl Cyclases; Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, | 1989 |