Phosphoethanolamine/phosphocholine phosphatase

A phosphoethanolamine/phosphocholine phosphatase that is encoded in the genome of human. [PRO:DNx, UniProtKB:Q8TCT1]

EC 3.1.3.75

Research

Drug	Taxonomy	Measurement	Average (mM)	Bioassay(s)	Publication(s)
2-phenyl-1,2-benzisothiazol-3-(2h)-one	Homo sapiens (human)	IC50	0.9400	1	1
6-fluoro-2-phenyl-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	0.7900	1	1
2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	1.8000	1	1
2-[[3-(3-oxo-1,2-benzothiazol-2-yl)phenyl]sulfonylamino]benzoic acid	Homo sapiens (human)	IC50	0.8100	1	1
N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide	Homo sapiens (human)	IC50	0.5000	1	1
2-(3-chlorophenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	5.2000	1	1
2-(4-fluorophenyl)-1,2-benzothiazol-3-one	Homo sapiens (human)	IC50	4.9000	1	1

This protein enables 6 target(s):

Target	Category	Definition
protein binding	molecular function	Binding to a protein. [GOC:go_curators]
pyrophosphatase activity	molecular function	Catalysis of the hydrolysis of a pyrophosphate bond (diphosphate bond) between two phosphate groups. [GOC:curators, https://en.wikipedia.org/wiki/Pyrophosphatase]
metal ion binding	molecular function	Binding to a metal ion. [GOC:ai]
phosphocholine phosphatase activity	molecular function	Catalysis of the reaction: choline phosphate + H2O = choline + phosphate. [EC:3.1.3.75]
phosphoethanolamine phosphatase activity	molecular function	Catalysis of the reaction: O-phosphoethanolamine + H2O = ethanolamine + phosphate. [EC:3.1.3.75]
phosphatase activity	molecular function	Catalysis of the hydrolysis of phosphoric monoesters, releasing phosphate ions. [GOC:curators, GOC:pg]

This protein is located in 2 target(s):

Target	Category	Definition
cytosol	cellular component	The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl]
extracellular matrix	cellular component	A structure lying external to one or more cells, which provides structural support, biochemical or biomechanical cues for cells or tissues. [GOC:BHF, GOC:mah, GOC:rph, NIF_Subcellular:nlx_subcell_20090513, PMID:21123617, PMID:28089324]

This protein is active in 1 target(s):

Target	Category	Definition
extracellular membrane-bounded organelle	cellular component	Organized structure of distinctive morphology and function, bounded by a lipid bilayer membrane and occurring outside the cell. [GOC:isa_complete]

This protein is involved in 4 target(s):

Target	Category	Definition
endochondral ossification	biological process	Replacement ossification wherein bone tissue replaces cartilage. [GO_REF:0000034, ISBN:0878932437]
bone mineralization	biological process	The deposition of hydroxyapatite, a form of calcium phosphate with the formula Ca10(PO4)6(OH)2, in bone tissue. [GOC:mah, PMID:22936354]
regulation of bone mineralization	biological process	Any process that modulates the frequency, rate or extent of bone mineralization. [GOC:go_curators]
bone mineralization involved in bone maturation	biological process	The deposition of hydroxyapatite, involved in the progression of the skeleton from its formation to its mature state. [GOC:bf, GOC:BHF]