primaquine has been researched along with Chagas Disease in 8 studies
Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Excerpt | Relevance | Reference |
---|---|---|
"American trypanosomiasis (Chagas' disease) is an endemic parasitic disease afflicting more than 20 million people in Latin America." | 1.30 | Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine. ( Chung, MC; Colli, W; Ferreira, EI; Gonçalves, MF; Miranda, MT, 1997) |
"Primaquine has been used to treat Chagas' disease in humans and has been reported to be active against extracellular Trypanosoma cruzi." | 1.27 | Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi. ( McCabe, RE, 1988) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 4 (50.00) | 18.7374 |
1990's | 2 (25.00) | 18.2507 |
2000's | 2 (25.00) | 29.6817 |
2010's | 0 (0.00) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Oliver, M | 1 |
Wolf, A | 1 |
Théfenne, H | 1 |
Demaison, X | 1 |
Rapp, C | 1 |
Simon, F | 1 |
HEWITT, R | 1 |
ENTWISTLE, J | 1 |
GILL, E | 1 |
PIZZI, T | 1 |
Beveridge, E | 1 |
Caldwell, IC | 1 |
Latter, VS | 1 |
Neal, RA | 1 |
Udall, V | 1 |
Waldron, MM | 1 |
Kinnamon, KE | 1 |
Poon, BT | 1 |
Hanson, WL | 1 |
Waits, VB | 1 |
Chung, MC | 1 |
Gonçalves, MF | 1 |
Colli, W | 1 |
Ferreira, EI | 2 |
Miranda, MT | 1 |
La-Scalea, MA | 1 |
Chin, CM | 1 |
Cruz, ML | 1 |
Serrano, SH | 1 |
McCabe, RE | 1 |
8 other studies available for primaquine and Chagas Disease
Article | Year |
---|---|
[Update on primaquine].
Topics: Antimalarials; Chagas Disease; Humans; Malaria; Pneumonia, Pneumocystis; Primaquine | 2009 |
Quantitative determinations of critical mortality periods in untreated and treated infections with the B strain of Trypanosoma cruzi in mice.
Topics: Animals; Chagas Disease; Mice; Primaquine; Trypanosoma cruzi; Trypanosomiasis; United States | 1963 |
Effect of primaquine on experimental Trypanosoma cruzi infection.
Topics: Chagas Disease; Primaquine; Trypanosoma cruzi; Trypanosomiasis | 1951 |
The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59).
Topics: Aminoquinolines; Animals; Chagas Disease; Culture Techniques; Female; Fetus; Furazolidone; Guinea Pi | 1980 |
Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.
Topics: Animals; Chagas Disease; Chemistry, Pharmaceutical; Female; Mice; Primaquine; Trypanocidal Agents; T | 1996 |
Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine.
Topics: Animals; Cells, Cultured; Chagas Disease; Dipeptides; Kidney; Macaca mulatta; Primaquine; Prodrugs; | 1997 |
Dissociation and electrooxidation of primaquine diphosphate as an approach to the study of anti-chagas prodrugs mechanism of action.
Topics: Antiprotozoal Agents; Chagas Disease; Electrochemistry; Electrodes; Electron Transport; Hydrogen-Ion | 2001 |
Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi.
Topics: Animals; Cell Line; Chagas Disease; Cytoplasm; Drug Therapy, Combination; Extracellular Space; Ketoc | 1988 |