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primaquine and Chagas Disease

primaquine has been researched along with Chagas Disease in 8 studies

Primaquine: An aminoquinoline that is given by mouth to produce a radical cure and prevent relapse of vivax and ovale malarias following treatment with a blood schizontocide. It has also been used to prevent transmission of falciparum malaria by those returning to areas where there is a potential for re-introduction of malaria. Adverse effects include anemias and GI disturbances. (From Martindale, The Extra Pharmacopeia, 30th ed, p404)
primaquine : An N-substituted diamine that is pentane-1,4-diamine substituted by a 6-methoxyquinolin-8-yl group at the N(4) position. It is a drug used in the treatment of malaria and Pneumocystis pneumonia.

Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.

Research Excerpts

ExcerptRelevanceReference
"American trypanosomiasis (Chagas' disease) is an endemic parasitic disease afflicting more than 20 million people in Latin America."1.30Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine. ( Chung, MC; Colli, W; Ferreira, EI; Gonçalves, MF; Miranda, MT, 1997)
"Primaquine has been used to treat Chagas' disease in humans and has been reported to be active against extracellular Trypanosoma cruzi."1.27Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi. ( McCabe, RE, 1988)

Research

Studies (8)

TimeframeStudies, this research(%)All Research%
pre-19904 (50.00)18.7374
1990's2 (25.00)18.2507
2000's2 (25.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Oliver, M1
Wolf, A1
Théfenne, H1
Demaison, X1
Rapp, C1
Simon, F1
HEWITT, R1
ENTWISTLE, J1
GILL, E1
PIZZI, T1
Beveridge, E1
Caldwell, IC1
Latter, VS1
Neal, RA1
Udall, V1
Waldron, MM1
Kinnamon, KE1
Poon, BT1
Hanson, WL1
Waits, VB1
Chung, MC1
Gonçalves, MF1
Colli, W1
Ferreira, EI2
Miranda, MT1
La-Scalea, MA1
Chin, CM1
Cruz, ML1
Serrano, SH1
McCabe, RE1

Other Studies

8 other studies available for primaquine and Chagas Disease

ArticleYear
[Update on primaquine].
    Medecine tropicale : revue du Corps de sante colonial, 2009, Volume: 69, Issue:5

    Topics: Antimalarials; Chagas Disease; Humans; Malaria; Pneumonia, Pneumocystis; Primaquine

2009
Quantitative determinations of critical mortality periods in untreated and treated infections with the B strain of Trypanosoma cruzi in mice.
    The Journal of parasitology, 1963, Volume: 49

    Topics: Animals; Chagas Disease; Mice; Primaquine; Trypanosoma cruzi; Trypanosomiasis; United States

1963
Effect of primaquine on experimental Trypanosoma cruzi infection.
    Proceedings of the Society for Experimental Biology and Medicine. Society for Experimental Biology and Medicine (New York, N.Y.), 1951, Volume: 78, Issue:2

    Topics: Chagas Disease; Primaquine; Trypanosoma cruzi; Trypanosomiasis

1951
The activity against Trypanosoma cruzi and cutaneous leishmaniasis, and toxicity, of moxipraquine (349C59).
    Transactions of the Royal Society of Tropical Medicine and Hygiene, 1980, Volume: 74, Issue:1

    Topics: Aminoquinolines; Animals; Chagas Disease; Culture Techniques; Female; Fetus; Furazolidone; Guinea Pi

1980
Primaquine analogues that are potent anti-Trypanosoma cruzi agents in a mouse model.
    Annals of tropical medicine and parasitology, 1996, Volume: 90, Issue:5

    Topics: Animals; Chagas Disease; Chemistry, Pharmaceutical; Female; Mice; Primaquine; Trypanocidal Agents; T

1996
Synthesis and in vitro evaluation of potential antichagasic dipeptide prodrugs of primaquine.
    Journal of pharmaceutical sciences, 1997, Volume: 86, Issue:10

    Topics: Animals; Cells, Cultured; Chagas Disease; Dipeptides; Kidney; Macaca mulatta; Primaquine; Prodrugs;

1997
Dissociation and electrooxidation of primaquine diphosphate as an approach to the study of anti-chagas prodrugs mechanism of action.
    Bioelectrochemistry (Amsterdam, Netherlands), 2001, Volume: 53, Issue:1

    Topics: Antiprotozoal Agents; Chagas Disease; Electrochemistry; Electrodes; Electron Transport; Hydrogen-Ion

2001
Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi.
    The Journal of parasitology, 1988, Volume: 74, Issue:5

    Topics: Animals; Cell Line; Chagas Disease; Cytoplasm; Drug Therapy, Combination; Extracellular Space; Ketoc

1988