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mk 436 and Chagas Disease

mk 436 has been researched along with Chagas Disease in 5 studies

*Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. [MeSH]

Research

Studies (5)

TimeframeStudies, this research(%)All Research%
pre-19903 (60.00)18.7374
1990's2 (40.00)18.2507
2000's0 (0.00)29.6817
2010's0 (0.00)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Habbersett, MC; Meurer, RD; Murray, PK1
Calixto, MA; Teixeira, AR; Teixeira, ML1
Cunha Neto, E; Rizzo, LV; Silva, R; Teixeira, AR1
Andrade, SG; Santiago, CM; Silva, RC1
Andrade, SG; Freitas, LA; Santiago, CM; Silva, RC1

Other Studies

5 other study(ies) available for mk 436 and Chagas Disease

ArticleYear
Trypanosoma cruzi: efficacy of the 2-substituted, 5-nitroimidazoles, MK-436 and L634,549, in tissue culture and mice.
    The American journal of tropical medicine and hygiene, 1983, Volume: 32, Issue:6

    Topics: Animals; Antiprotozoal Agents; Benzimidazoles; Cell Line; Chagas Disease; Drug Evaluation, Preclinical; Female; Fibroblasts; Humans; Mice; Mice, Inbred BALB C; Muscles; Nifurtimox; Nitroimidazoles; Rats; Trypanosoma cruzi

1983
Chagas' disease: carcinogenic activity of the antitrypanosomal nitroarenes in mice.
    Mutation research, 1994, Mar-01, Volume: 305, Issue:2

    Topics: Animals; Carcinogens; Cell Division; Chagas Disease; Female; Liver; Lymph Nodes; Lymphoma; Mice; Molecular Structure; Nifurtimox; Nitroimidazoles; Trypanocidal Agents

1994
Trypanocidal nitroarene treatment of experimental Trypanosoma cruzi infection does not prevent progression of chronic-phase heart lesions in rabbits.
    The Journal of infectious diseases, 1990, Volume: 162, Issue:6

    Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Nifurtimox; Nitroimidazoles; Rabbits; Trypanocidal Agents

1990
Treatment of chronic experimental Trypanosoma cruzi infections in mice with MK-436, a 2-substituted 5-nitroimidazole.
    Bulletin of the World Health Organization, 1989, Volume: 67, Issue:5

    Topics: Animals; Antiprotozoal Agents; Chagas Disease; Drug Evaluation, Preclinical; Mice; Nitroimidazoles

1989
Therapeutic action of MK-436 (2,5-nitroimidazole) on Trypanosoma cruzi infections in mice: a parasitological, serological, histopathological, and ultrastructural study.
    Bulletin of the World Health Organization, 1987, Volume: 65, Issue:5

    Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Female; Male; Mice; Myocardium; Nitroimidazoles; Trypanocidal Agents; Trypanosoma cruzi

1987