spermidine has been researched along with Chagas Disease in 12 studies
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The only approved therapeutics for the treatment of Chagas disease are two nitroheterocyclic compounds as a nitrofuran (nifurtimox; Lampit) and a nitroimidazole (benznidazole; Rochagan)." | 2.46 | Chagas disease: progress and new perspectives. ( Campillo, NE; Páez, JA; Sánchez-Sancho, F, 2010) |
| "Trypanothione synthetase was ruled out as molecular target for the anti-parasitic activity of these compounds." | 1.43 | Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning. ( Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A, 2016) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 2 (16.67) | 29.6817 |
| 2010's | 7 (58.33) | 24.3611 |
| 2020's | 2 (16.67) | 2.80 |
| Authors | Studies |
|---|---|
| Mesías, AC | 1 |
| Garg, NJ | 1 |
| Zago, MP | 1 |
| González-Chávez, Z | 1 |
| Vázquez, C | 1 |
| Moreno-Sánchez, R | 1 |
| Saavedra, E | 1 |
| Saccoliti, F | 1 |
| Di Santo, R | 1 |
| Costi, R | 1 |
| Vanrell, MC | 1 |
| Losinno, AD | 1 |
| Cueto, JA | 1 |
| Balcazar, D | 2 |
| Fraccaroli, LV | 1 |
| Carrillo, C | 2 |
| Romano, PS | 1 |
| Beig, M | 1 |
| Oellien, F | 1 |
| Garoff, L | 1 |
| Noack, S | 1 |
| Krauth-Siegel, RL | 1 |
| Selzer, PM | 1 |
| Alberca, LN | 1 |
| Sbaraglini, ML | 1 |
| Fraccaroli, L | 1 |
| Medeiros, A | 1 |
| Benitez, D | 1 |
| Comini, M | 1 |
| Talevi, A | 1 |
| Seguel, V | 1 |
| Castro, L | 1 |
| Reigada, C | 1 |
| Cortes, L | 1 |
| Díaz, MV | 1 |
| Miranda, MR | 1 |
| Pereira, CA | 1 |
| Lapier, M | 1 |
| Campos-Estrada, C | 1 |
| Morello, A | 1 |
| Kemmerling, U | 1 |
| Maya, JD | 1 |
| López-Muñoz, R | 1 |
| Bocedi, A | 1 |
| Dawood, KF | 1 |
| Fabrini, R | 1 |
| Federici, G | 1 |
| Gradoni, L | 1 |
| Pedersen, JZ | 1 |
| Ricci, G | 1 |
| Sánchez-Sancho, F | 1 |
| Campillo, NE | 1 |
| Páez, JA | 1 |
| Heby, O | 1 |
| Persson, L | 1 |
| Rentala, M | 1 |
| D'Silva, C | 1 |
| Daunes, S | 1 |
| Walsh, C | 1 |
| Bradley, M | 1 |
| Nadeau, K | 1 |
6 reviews available for spermidine and Chagas Disease
| Article | Year |
|---|---|
Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in
Topics: Animals; Antioxidants; Antiparasitic Agents; Chagas Disease; Glutathione; Homeostasis; Humans; Insec | 2019 |
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
Topics: Amide Synthases; Amidohydrolases; Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; L | 2020 |
Chagas disease: progress and new perspectives.
Topics: Chagas Disease; Enzyme Inhibitors; Ergosterol; Glutathione; Humans; Hypoxanthine Phosphoribosyltrans | 2010 |
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornith | 2007 |
The therapeutic potential of inhibitors of the trypanothione cycle.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidored | 2002 |
Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Binding Sites; Chagas Disease; Crithidia; Drug D | 1992 |
6 other studies available for spermidine and Chagas Disease
| Article | Year |
|---|---|
Metabolic Control Analysis for Drug Target Prioritization in Trypanosomatids.
Topics: Cell Extracts; Chagas Disease; Computer Simulation; Drug Development; Glutathione; Humans; Kinetics; | 2020 |
The regulation of autophagy differentially affects Trypanosoma cruzi metacyclogenesis.
Topics: Adult; Animals; Autophagosomes; Autophagy; Cell Differentiation; Chagas Disease; Gene Expression Reg | 2017 |
Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.
Topics: Chagas Disease; Chlorhexidine; Computer Simulation; Drug Evaluation, Preclinical; Enzyme Inhibitors; | 2015 |
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Topics: Amide Synthases; Antiprotozoal Agents; Chagas Disease; Computer Simulation; Drug Repositioning; Glut | 2016 |
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glu | 2016 |
Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Glutathione; Iron; Leishmania infantum; N | 2010 |