ketoconazole has been researched along with Chagas Disease in 28 studies
1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "We previously reported that the cancer drug clinical candidate tipifarnib kills the causative agent of Chagas disease, Trypanosoma cruzi, by blocking ergosterol biosynthesis at the level of inhibition of lanosterol 14alpha-demethylase." | 7.76 | Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. ( Arif, J; Buckner, FS; Chennamaneni, NK; Gelb, MH; Karimi, M; Kraus, JM; McGuffin, SA; Tatipaka, HB; Verlinde, CL, 2010) |
| "We previously reported that the cancer drug clinical candidate tipifarnib kills the causative agent of Chagas disease, Trypanosoma cruzi, by blocking ergosterol biosynthesis at the level of inhibition of lanosterol 14alpha-demethylase." | 3.76 | Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery. ( Arif, J; Buckner, FS; Chennamaneni, NK; Gelb, MH; Karimi, M; Kraus, JM; McGuffin, SA; Tatipaka, HB; Verlinde, CL, 2010) |
| " Benznidazole, the drug generally used for the treatment of Chagas disease, was initially used in one case but discontinued because of an adverse effect (retrobulbar neuritis) and replaced by itraconazole." | 3.75 | Aetiological treatment with itraconazole or ketoconazole in individuals with Trypanosoma cruzi/HIV co-infection. ( Aoki, FH; de Almeida, EA; Guariento, ME; Pedro, Rde J; Silva, EL, 2009) |
| "American trypanosomiasis, or Chagas' disease, is caused by Trypanosoma cruzi and affects around 15 million people throughout the American continent." | 1.38 | In vitro and in vivo trypanocidal synergistic activity of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide associated with benznidazole. ( Dias Filho, BP; Kaneshima, EN; Nakamura, CV; Sarragiotto, MH; Silva, SO; Tonin, LT; Ueda-Nakamura, T; Valdez, RH; Yamada-Ogatta, SF; Yamauchi, LM, 2012) |
| "Chagas disease is one of the major neglected diseases of the world." | 1.35 | Rational modification of a candidate cancer drug for use against Chagas disease. ( Buckner, FS; Gelb, MH; Karimi, M; Kraus, JM; Lepesheva, GI; Verlinde, CL, 2009) |
| "Nifurtimox was able to accumulate squalene only at lower incubation times." | 1.35 | 5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene. ( Alvarez, G; Benítez, D; Boiani, L; Cerecetto, H; Gerpe, A; González, M; Hernández, P; Quiroga, M; Sortino, M; Zacchino, S, 2009) |
| "New benzofuroxans were developed and studied as antiproliferative Trypanosoma cruzi agents." | 1.34 | In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives. ( Aguirre, G; Basombrío, MA; Boiani, L; Boiani, M; Campillo, NE; Castro, A; Cazzulo, JJ; Cerecetto, H; Chidichimo, A; Davies, C; González, M; Hernández, P; Krauth-Siegel, RL; Paez, JA; Porcal, W, 2007) |
| "Persons with hemophilia who receive multiple blood product transfusions from blood banks with little or no screening for infectious agents are at particularly high risk for infections with both HIV and T." | 1.29 | Successful treatment of Trypanosoma cruzi encephalitis in a patient with hemophilia and AIDS. ( Acuña, G; Brengues, C; Cuny, G; Labarca, J; Muñoz, S; Oddó, D; Saavedra, H; Sepúlveda, C; Solari, A; Veas, F, 1993) |
| "In vivo studies with a murine model of Chagas' disease showed that mevinolin can also potentiate the therapeutic effects of ketoconazole in this system; combined treatment with the two drugs at doses that alone offered only limited protection against the parasite was able to essentially eliminate circulating parasites and produce complete protection against death." | 1.29 | Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies. ( Aguirre, T; de Souza, W; Lazardi, K; Maldonado, RA; Marchan, E; Payares, G; Piras, MM; Piras, R; Urbina, JA; Visbal, G, 1993) |
| "Ketoconazole treatment of mice resulted in no positive cultures." | 1.28 | Gamma interferon suppresses acute and chronic Trypanosoma cruzi infection in cyclosporin-treated mice. ( McCabe, R; Meagher, S; Mullins, B, 1991) |
| "Primaquine has been used to treat Chagas' disease in humans and has been reported to be active against extracellular Trypanosoma cruzi." | 1.27 | Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi. ( McCabe, RE, 1988) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 9 (32.14) | 18.7374 |
| 1990's | 6 (21.43) | 18.2507 |
| 2000's | 6 (21.43) | 29.6817 |
| 2010's | 4 (14.29) | 24.3611 |
| 2020's | 3 (10.71) | 2.80 |
| Authors | Studies |
|---|---|
| Porcal, W | 1 |
| Hernández, P | 2 |
| Boiani, M | 1 |
| Aguirre, G | 1 |
| Boiani, L | 2 |
| Chidichimo, A | 1 |
| Cazzulo, JJ | 1 |
| Campillo, NE | 1 |
| Paez, JA | 1 |
| Castro, A | 1 |
| Krauth-Siegel, RL | 1 |
| Davies, C | 1 |
| Basombrío, MA | 1 |
| González, M | 2 |
| Cerecetto, H | 2 |
| Kraus, JM | 2 |
| Verlinde, CL | 2 |
| Karimi, M | 2 |
| Lepesheva, GI | 1 |
| Gelb, MH | 2 |
| Buckner, FS | 2 |
| Gerpe, A | 1 |
| Alvarez, G | 1 |
| Benítez, D | 1 |
| Quiroga, M | 1 |
| Sortino, M | 1 |
| Zacchino, S | 1 |
| Tatipaka, HB | 1 |
| McGuffin, SA | 1 |
| Chennamaneni, NK | 1 |
| Arif, J | 1 |
| Hasslocher-Moreno, AM | 1 |
| Sousa, AS | 1 |
| Xavier, SS | 1 |
| Mendes, FSNS | 1 |
| Nunes, EP | 1 |
| Grinsztejn, BGJ | 1 |
| Mediano, MFF | 1 |
| Soba, M | 1 |
| Scalese, G | 1 |
| Casuriaga, F | 1 |
| Pérez, N | 2 |
| Veiga, N | 1 |
| Echeverría, GA | 1 |
| Piro, OE | 1 |
| Faccio, R | 1 |
| Pérez-Díaz, L | 1 |
| Gasser, G | 1 |
| Machado, I | 1 |
| Gambino, D | 1 |
| Dumoulin, PC | 1 |
| Vollrath, J | 1 |
| Tomko, SS | 1 |
| Wang, JX | 1 |
| Burleigh, B | 1 |
| Peron, F | 1 |
| Lazarin-Bidóia, D | 1 |
| Ud Din, Z | 1 |
| Rodrigues-Filho, E | 1 |
| Ueda-Nakamura, T | 2 |
| Silva, SO | 2 |
| Nakamura, CV | 2 |
| de Almeida, EA | 1 |
| Silva, EL | 1 |
| Guariento, ME | 1 |
| Aoki, FH | 1 |
| Pedro, Rde J | 1 |
| Valdez, RH | 1 |
| Tonin, LT | 1 |
| Dias Filho, BP | 1 |
| Kaneshima, EN | 1 |
| Yamada-Ogatta, SF | 1 |
| Yamauchi, LM | 1 |
| Sarragiotto, MH | 1 |
| Kessler, RL | 1 |
| Soares, MJ | 1 |
| Probst, CM | 1 |
| Krieger, MA | 1 |
| McCabe, RE | 5 |
| Remington, JS | 4 |
| Araujo, FG | 4 |
| Raether, W | 1 |
| Seidenath, H | 1 |
| Maldonado, RA | 2 |
| Molina, J | 2 |
| Payares, G | 3 |
| Urbina, JA | 4 |
| Solari, A | 1 |
| Saavedra, H | 1 |
| Sepúlveda, C | 1 |
| Oddó, D | 1 |
| Acuña, G | 1 |
| Labarca, J | 1 |
| Muñoz, S | 1 |
| Cuny, G | 1 |
| Brengues, C | 1 |
| Veas, F | 1 |
| Lazardi, K | 2 |
| Marchan, E | 1 |
| Visbal, G | 1 |
| Aguirre, T | 1 |
| Piras, MM | 2 |
| Piras, R | 2 |
| de Souza, W | 1 |
| Sanoja, C | 1 |
| Liendo, A | 1 |
| Wincker, P | 1 |
| Ryley, JF | 1 |
| Kinnamon, KE | 1 |
| Poon, BT | 1 |
| Hanson, WL | 1 |
| Waits, VB | 1 |
| Araújo, MS | 1 |
| Martins-Filho, OA | 1 |
| Pereira, ME | 1 |
| Brener, Z | 1 |
| Navarro, M | 1 |
| Cisneros-Fajardo, EJ | 1 |
| Lehmann, T | 1 |
| Sánchez-Delgado, RA | 1 |
| Atencio, R | 1 |
| Silva, P | 1 |
| Lira, R | 1 |
| McCabe, R | 2 |
| Meagher, S | 1 |
| Mullins, B | 1 |
| Goad, LJ | 1 |
| Berens, RL | 1 |
| Marr, JJ | 1 |
| Beach, DH | 1 |
| Holz, GG | 1 |
| Scott, VR | 1 |
| Matthews, TR | 1 |
28 other studies available for ketoconazole and Chagas Disease
| Article | Year |
|---|---|
In vivo anti-Chagas vinylthio-, vinylsulfinyl-, and vinylsulfonylbenzofuroxan derivatives.
Topics: Animals; Antibodies, Protozoan; Benzoxazoles; Cell Line; Chagas Disease; Cysteine Endopeptidases; Fe | 2007 |
Rational modification of a candidate cancer drug for use against Chagas disease.
Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Chagas Disease; Humans; Mice; Mice, Inb | 2009 |
5-Nitrofuranes and 5-nitrothiophenes with anti-Trypanosoma cruzi activity and ability to accumulate squalene.
Topics: Animals; Chagas Disease; Drug Design; Humans; Mice; Nitrofurans; Quantitative Structure-Activity Rel | 2009 |
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.
Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Chagas Disease; Cytochrome P | 2010 |
Epidemiological-clinical profile and mortality in patients coinfected with Trypanosoma cruzi/HIV: experience from a Brazilian reference center.
Topics: Acquired Immunodeficiency Syndrome; Brazil; Chagas Disease; Coinfection; Female; HIV Infections; Hum | 2022 |
Multifunctional organometallic compounds for the treatment of Chagas disease: Re(I) tricarbonyl compounds with two different bioactive ligands.
Topics: Antiprotozoal Agents; Chagas Disease; Humans; Ketoconazole; Organometallic Compounds; Trypanosoma cr | 2023 |
Glutamine metabolism modulates azole susceptibility in
Topics: 14-alpha Demethylase Inhibitors; Animals; Azoles; Cell Line; Chagas Disease; Drug Interactions; Drug | 2020 |
Effects of (1
Topics: Chagas Disease; Drug Combinations; Drug Synergism; Fluconazole; Humans; Ketoconazole; Nitroimidazole | 2017 |
Aetiological treatment with itraconazole or ketoconazole in individuals with Trypanosoma cruzi/HIV co-infection.
Topics: Adult; AIDS-Related Opportunistic Infections; Brazil; Chagas Disease; Drug Therapy, Combination; Fat | 2009 |
In vitro and in vivo trypanocidal synergistic activity of N-butyl-1-(4-dimethylamino)phenyl-1,2,3,4-tetrahydro-β-carboline-3-carboxamide associated with benznidazole.
Topics: Amphotericin B; Animals; Body Weight; Carbolines; Cell Count; Cell Line; Chagas Disease; Drug Combin | 2012 |
Trypanosoma cruzi response to sterol biosynthesis inhibitors: morphophysiological alterations leading to cell death.
Topics: Biosynthetic Pathways; Cell Death; Chagas Disease; Enzyme Inhibitors; Ketoconazole; Lovastatin; Mito | 2013 |
Ketoconazole inhibition of intracellular multiplication of Trypanosoma cruzi and protection of mice against lethal infection with the organism.
Topics: Animals; Chagas Disease; Female; Ketoconazole; Macrophages; Mice; Trypanosoma cruzi | 1984 |
Ketoconazole protects against infection with Trypanosoma cruzi in a murine model.
Topics: Animals; Chagas Disease; Female; Ketoconazole; Macrophages; Mice; Time Factors; Trypanosoma cruzi | 1983 |
Ketoconazole and other potent antimycotic azoles exhibit pronounced activity against Trypanosoma cruzi, Plasmodium berghei and Entamoeba histolytica in vivo.
Topics: Amebiasis; Animals; Antifungal Agents; Chagas Disease; Entamoeba histolytica; Entamoebiasis; Ketocon | 1984 |
Experimental chemotherapy with combinations of ergosterol biosynthesis inhibitors in murine models of Chagas' disease.
Topics: Animals; Antifungal Agents; Chagas Disease; Disease Models, Animal; Ergosterol; Female; Ketoconazole | 1993 |
Successful treatment of Trypanosoma cruzi encephalitis in a patient with hemophilia and AIDS.
Topics: Acquired Immunodeficiency Syndrome; Adult; AIDS-Related Opportunistic Infections; Chagas Disease; Dr | 1993 |
Mevinolin (lovastatin) potentiates the antiproliferative effects of ketoconazole and terbinafine against Trypanosoma (Schizotrypanum) cruzi: in vitro and in vivo studies.
Topics: Animals; Cell Division; Chagas Disease; Drug Synergism; Female; Growth Inhibitors; Ketoconazole; Lov | 1993 |
Cure of short- and long-term experimental Chagas' disease using D0870.
Topics: Animals; Base Sequence; Chagas Disease; Drug Administration Schedule; Ketoconazole; Molecular Sequen | 1996 |
In pursuit of drugs for American trypanosomiasis: evaluation of some "standards" in a mouse model.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Female; Imipramine; Ketoconaz | 1997 |
A combination of benznidazole and ketoconazole enhances efficacy of chemotherapy of experimental Chagas' disease.
Topics: Animals; Anti-Infective Agents; Antifungal Agents; Chagas Disease; Drug Combinations; Drug Synergism | 2000 |
Toward a novel metal-based chemotherapy against tropical diseases. 6. Synthesis and characterization of new copper(II) and gold(I) clotrimazole and ketoconazole complexes and evaluation of their activity against Trypanosoma cruzi.
Topics: Algorithms; Animals; Antiprotozoal Agents; Chagas Disease; Chemical Phenomena; Chemistry, Physical; | 2001 |
Gamma interferon suppresses acute and chronic Trypanosoma cruzi infection in cyclosporin-treated mice.
Topics: Acute Disease; Animals; Chagas Disease; Chronic Disease; Cyclosporins; Interferon-gamma; Ketoconazol | 1991 |
The activity of ketoconazole and other azoles against Trypanosoma cruzi: biochemistry and chemotherapeutic action in vitro.
Topics: Animals; Cell Membrane; Chagas Disease; Growth Inhibitors; Ketoconazole; Sterols; Trypanosoma cruzi | 1989 |
In vitro and in vivo effects of itraconazole against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Chemical Phenomena; Chemistry; Dose-Response Relationship, Drug; Female; In | 1986 |
The efficacy of an N-substituted imidazole, RS-49676, against a Trypanosoma cruzi infection in mice.
Topics: Animals; Chagas Disease; Chemical Phenomena; Chemistry; Female; Ketoconazole; Mice; Mice, Inbred C3H | 1987 |
Ketoconazole promotes parasitological cure of mice infected with Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Drug Resistance; Female; Ketoconazole; Mi | 1987 |
Primaquine is lethal for intracellular but not extracellular Trypanosoma cruzi.
Topics: Animals; Cell Line; Chagas Disease; Cytoplasm; Drug Therapy, Combination; Extracellular Space; Ketoc | 1988 |
Failure of ketoconazole to cure chronic murine Chagas' disease.
Topics: Animals; Chagas Disease; Female; Ketoconazole; Mice | 1988 |