trifluralin has been researched along with Chagas Disease in 5 studies
Trifluralin: A microtubule-disrupting pre-emergence herbicide.
trifluralin : A substituted aniline that is N,N-dipropylaniline substituted by a nitro groups at positions 2 and 6 and a trifluoromethyl group at position 4. It is an agrochemical used as a pre-emergence herbicide.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Even though trifluralin (alpha,alpha,alpha-2,6-dinitro-N-N-dipropyl-p-toluidine) is effective for the treatment of experimental Chagas disease, more preclinical toxicity studies need to be performed." | 7.74 | Trifluralin toxicity in a Chagas disease mouse model. ( Drut, R; Gómez, P; Luong, T; Marra, C; Milani, L; Villagra, S; Zaidenberg, A, 2007) |
| "We tested trifluralin against Trypanosoma cruzi in a model of chronic Chagas disease in mice." | 7.73 | Treatment of experimental chronic chagas disease with trifluralin. ( Bleiz, J; Buschiazzo, H; Del Buono, MB; Drut, R; Kozubsky, L; Lirussi, D; Luong, T; Marron, A; Quijano, G; Zaidenberg, A, 2006) |
| "Trifluralin displays anti-Trypanosoma cruzi activity and a potential therapeutic effect for the treatment of Chagas disease." | 3.75 | Pharmacokinetics of trifluralin in blood and heart tissue of mice. ( Marra, C; Rule, R; Villagra, S; Zaidenberg, A, 2009) |
| "Even though trifluralin (alpha,alpha,alpha-2,6-dinitro-N-N-dipropyl-p-toluidine) is effective for the treatment of experimental Chagas disease, more preclinical toxicity studies need to be performed." | 3.74 | Trifluralin toxicity in a Chagas disease mouse model. ( Drut, R; Gómez, P; Luong, T; Marra, C; Milani, L; Villagra, S; Zaidenberg, A, 2007) |
| "We tested trifluralin against Trypanosoma cruzi in a model of chronic Chagas disease in mice." | 3.73 | Treatment of experimental chronic chagas disease with trifluralin. ( Bleiz, J; Buschiazzo, H; Del Buono, MB; Drut, R; Kozubsky, L; Lirussi, D; Luong, T; Marron, A; Quijano, G; Zaidenberg, A, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (100.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Zaidenberg, A | 4 |
| Marra, C | 2 |
| Villagra, S | 2 |
| Rule, R | 1 |
| Luong, T | 2 |
| Lirussi, D | 1 |
| Bleiz, J | 1 |
| Del Buono, MB | 1 |
| Quijano, G | 1 |
| Drut, R | 2 |
| Kozubsky, L | 1 |
| Marron, A | 1 |
| Buschiazzo, H | 2 |
| Gómez, P | 1 |
| Milani, L | 1 |
| Traub-Cseko, YM | 1 |
| Ramalho-Ortigão, JM | 1 |
| Dantas, AP | 1 |
| de Castro, SL | 1 |
| Barbosa, HS | 1 |
| Downing, KH | 1 |
| Marra, CA | 1 |
| de Alaniz, MJ | 1 |
1 review available for trifluralin and Chagas Disease
| Article | Year |
|---|---|
Dinitroaniline herbicides against protozoan parasites: the case of Trypanosoma cruzi.
Topics: Amino Acid Sequence; Aniline Compounds; Animals; Chagas Disease; Herbicides; Humans; Molecular Seque | 2001 |
4 other studies available for trifluralin and Chagas Disease
| Article | Year |
|---|---|
Pharmacokinetics of trifluralin in blood and heart tissue of mice.
Topics: Adipose Tissue; Animals; Chagas Cardiomyopathy; Chagas Disease; Feces; Humans; Liver; Male; Mice; My | 2009 |
Treatment of experimental chronic chagas disease with trifluralin.
Topics: Animals; Chagas Disease; Disease Models, Animal; Electrocardiography; Heart; Herbicides; Male; Mice; | 2006 |
Trifluralin toxicity in a Chagas disease mouse model.
Topics: Animals; Body Weight; Chagas Disease; Chlorocebus aethiops; Disease Models, Animal; Dose-Response Re | 2007 |
The restoring effect of trifluralin and benznidazole on the abnormal fatty-acid pattern induced by Trypanosoma cruzi in the liver microsomes of infected mice.
Topics: Animals; Chagas Disease; Cholesterol; Cholesterol Esters; Fatty Acids; Male; Mice; Mice, Inbred Stra | 2002 |