withaferin-a has been researched along with Chagas-Disease* in 1 studies
1 other study(ies) available for withaferin-a and Chagas-Disease
Article | Year |
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Multi-target withaferin-A analogues as promising anti-kinetoplastid agents through the programmed cell death.
Leishmaniasis and Chagas disease, two of the most prevalent neglected tropical diseases, are a world health problem. The harsh reality of these infective diseases is the absence of effective and safe therapies. In this framework, natural products play an important role in overcoming the current need to development new antiparasitic agents. The present study reports the synthesis, antikinetoplastid screening, mechanism study of fourteen withaferin A derivatives (2-15). Nine of them (2-6, 8-10 and 12) showed a potent dose-dependent inhibitory effect on the proliferation of Leishmania amazonensis and L. donovani promastigotes and Trypanosoma cruzi epimastigotes with IC Topics: Animals; Antiprotozoal Agents; Apoptosis; Chagas Disease; Leishmania; Mammals; Mice; Parasitic Sensitivity Tests | 2023 |