Page last updated: 2024-08-17

carbostyril and Chagas Disease

carbostyril has been researched along with Chagas Disease in 9 studies

Research

Studies (9)

TimeframeStudies, this research(%)All Research%
pre-19900 (0.00)18.7374
1990's0 (0.00)18.2507
2000's4 (44.44)29.6817
2010's4 (44.44)24.3611
2020's1 (11.11)2.80

Authors

AuthorsStudies
Hiller, W; Kaiser, M; Kruth, S; Kuhr, K; Lütz, S; Nett, M; Pietruszka, J; Zimmermann, CJ1
Ciapetti, P; Ciesielski, F; Cordeiro-da-Silva, A; Coron, RP; Costa, DM; Gaspar, L; KongThoo Lin, P; MacDougall, J; Major, LL; Pemberton, IK; Perez-Cabezas, B; Ramos, I; Ronin, C; Roura-Ferrer, M; Smith, TK; Tavares, J1
Onofre, TS; Rodrigues, JPF; Yoshida, N1
Brun, R; Ma, X; Zhou, W1
Buckner, FS; Gelb, MH; Karimi, M; Kraus, JM; Lepesheva, GI; Verlinde, CL1
Arif, J; Buckner, FS; Chennamaneni, NK; Gelb, MH1
Arif, J; Buckner, FS; Chennamaneni, NK; Gelb, MH; Karimi, M; Kraus, JM; McGuffin, SA; Tatipaka, HB; Verlinde, CL1
Bahia, MT; Buckner, FS; Charman, SA; Chatelain, E; Chennamaneni, NK; Gelb, MH; Hulverson, MA; Laydbak, JU; Lepesheva, GI; Scandale, I; Shackleford, DM; Suryadevara, PK; Verlinde, CL; White, KL1
Buckner, FS; Gelb, MH; Hucke, O; Verlinde, CL1

Other Studies

9 other study(ies) available for carbostyril and Chagas Disease

ArticleYear
Generation of Aurachin Derivatives by Whole-Cell Biotransformation and Evaluation of Their Antiprotozoal Properties.
    Molecules (Basel, Switzerland), 2023, Jan-20, Volume: 28, Issue:3

    Topics: Antiprotozoal Agents; Biological Products; Biotransformation; Chagas Disease; Escherichia coli; Humans; Leishmania donovani; Parasitic Sensitivity Tests; Plasmodium falciparum; Quinolones; Trypanosoma cruzi

2023
Inhibitors of Trypanosoma cruzi Sir2 related protein 1 as potential drugs against Chagas disease.
    PLoS neglected tropical diseases, 2018, Volume: 12, Issue:1

    Topics: Animals; Antiprotozoal Agents; Chagas Disease; Disease Models, Animal; Enzyme Inhibitors; Mice; Niacinamide; Protozoan Proteins; Quinolones; Spermine; Treatment Outcome; Trypanosoma cruzi

2018
Depletion of Host Cell Focal Adhesion Kinase Increases the Susceptibility to Invasion by
    Frontiers in cellular and infection microbiology, 2019, Volume: 9

    Topics: Actins; Chagas Disease; Disease Susceptibility; Focal Adhesion Kinase 1; Focal Adhesion Protein-Tyrosine Kinases; HeLa Cells; Host-Pathogen Interactions; Humans; Lysosomes; MAP Kinase Signaling System; Phosphorylation; Protozoan Proteins; Quinolones; Recombinant Proteins; Sulfones; Trypanosoma cruzi; Variant Surface Glycoproteins, Trypanosoma

2019
Synthesis, in vitro antitrypanosomal and antibacterial activity of phenoxy, phenylthio or benzyloxy substituted quinolones.
    Bioorganic & medicinal chemistry letters, 2009, Feb-01, Volume: 19, Issue:3

    Topics: Animals; Anti-Bacterial Agents; Antineoplastic Agents; Chagas Disease; Chemistry, Pharmaceutical; Drug Design; Drug Evaluation, Preclinical; Humans; Inhibitory Concentration 50; Magnetic Resonance Spectroscopy; Models, Chemical; Nitroimidazoles; Quinolones; Trypanocidal Agents; Trypanosoma cruzi

2009
Rational modification of a candidate cancer drug for use against Chagas disease.
    Journal of medicinal chemistry, 2009, Mar-26, Volume: 52, Issue:6

    Topics: Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Chagas Disease; Humans; Mice; Mice, Inbred BALB C; Models, Molecular; Quinolones; Rats; Trypanocidal Agents

2009
Isoquinoline-based analogs of the cancer drug clinical candidate tipifarnib as anti-Trypanosoma cruzi agents.
    Bioorganic & medicinal chemistry letters, 2009, Dec-01, Volume: 19, Issue:23

    Topics: Animals; Antineoplastic Agents; Chagas Disease; Drug Evaluation, Preclinical; Mice; Molecular Conformation; Parasitic Sensitivity Tests; Quinolones; Stereoisomerism; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2009
Second generation analogues of the cancer drug clinical candidate tipifarnib for anti-Chagas disease drug discovery.
    Journal of medicinal chemistry, 2010, May-27, Volume: 53, Issue:10

    Topics: 3T3 Cells; Alkyl and Aryl Transferases; Animals; Antineoplastic Agents; Chagas Disease; Cytochrome P-450 CYP3A; Cytochrome P-450 CYP3A Inhibitors; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Isoenzymes; Mice; Models, Molecular; Protein Binding; Quinolones; Rats; Sterol 14-Demethylase; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2010
Pharmacological characterization, structural studies, and in vivo activities of anti-Chagas disease lead compounds derived from tipifarnib.
    Antimicrobial agents and chemotherapy, 2012, Volume: 56, Issue:9

    Topics: 14-alpha Demethylase Inhibitors; Administration, Oral; Alkyl and Aryl Transferases; Animals; Chagas Disease; Crystallography, X-Ray; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Drug Administration Schedule; Female; Humans; Mice; Models, Molecular; Nitroimidazoles; Quinolones; Structure-Activity Relationship; Triazoles; Trypanocidal Agents; Trypanosoma cruzi

2012
The protein farnesyltransferase inhibitor Tipifarnib as a new lead for the development of drugs against Chagas disease.
    Journal of medicinal chemistry, 2005, Aug-25, Volume: 48, Issue:17

    Topics: Alkyl and Aryl Transferases; Animals; Binding Sites; Chagas Disease; Cytochrome P-450 Enzyme Inhibitors; Cytochrome P-450 Enzyme System; Humans; Lanosterol; Models, Molecular; Oxidoreductases; Protein Binding; Quinolones; Sterol 14-Demethylase; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma cruzi

2005