A mannose-6-phosphate isomerase that is encoded in the genome of human. [PRO:DNx, UniProtKB:P34949]
EC 5.3.1.8;
Phosphohexomutase;
Phosphomannose isomerase;
PMI
| Timeframe | Studies on this Protein(%) | All Drugs % |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Drug | Taxonomy | Measurement | Average (mM) | Bioassay(s) | Publication(s) |
|---|---|---|---|---|---|
| 2-phenyl-1,2-benzisothiazol-3-(2h)-one | Homo sapiens (human) | IC50 | 6.4000 | 2 | 2 |
| 6-fluoro-2-phenyl-1,2-benzothiazol-3-one | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| 6-fluoro-2-(2-methylphenyl)-1,2-benzothiazol-3-one | Homo sapiens (human) | IC50 | 2.9000 | 1 | 1 |
| 2-[4-methyl-3-(1-piperidinylsulfonyl)phenyl]-1,2-benzothiazol-3-one | Homo sapiens (human) | IC50 | 3.1000 | 1 | 1 |
| 2-[[3-(3-oxo-1,2-benzothiazol-2-yl)phenyl]sulfonylamino]benzoic acid | Homo sapiens (human) | IC50 | 0.7100 | 1 | 1 |
| N,N-dimethyl-3-(3-oxo-1,2-benzothiazol-2-yl)benzenesulfonamide | Homo sapiens (human) | IC50 | 2.8000 | 1 | 1 |
| 2-(4-chlorophenyl)-1,2-benzothiazol-3-one | Homo sapiens (human) | IC50 | 1.9000 | 1 | 1 |
| 2-(3-chlorophenyl)-1,2-benzothiazol-3-one | Homo sapiens (human) | IC50 | 4.8000 | 2 | 2 |
| 5-fluoro-2-phenyl-1,2-benzothiazol-3-one | Homo sapiens (human) | IC50 | 1.3000 | 1 | 1 |
| 2-(4-fluorophenyl)-1,2-benzothiazol-3-one | Homo sapiens (human) | IC50 | 3.4000 | 1 | 1 |
This protein enables 2 target(s):
| Target | Category | Definition |
|---|---|---|
| mannose-6-phosphate isomerase activity | molecular function | Catalysis of the reaction: D-mannose 6-phosphate = D-fructose 6-phosphate. [EC:5.3.1.8] |
| zinc ion binding | molecular function | Binding to a zinc ion (Zn). [GOC:ai] |
This protein is located in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
| extracellular exosome | cellular component | A vesicle that is released into the extracellular region by fusion of the limiting endosomal membrane of a multivesicular body with the plasma membrane. Extracellular exosomes, also simply called exosomes, have a diameter of about 40-100 nm. [GOC:BHF, GOC:mah, GOC:vesicles, PMID:15908444, PMID:17641064, PMID:19442504, PMID:19498381, PMID:22418571, PMID:24009894] |
This protein is active in 1 target(s):
| Target | Category | Definition |
|---|---|---|
| cytosol | cellular component | The part of the cytoplasm that does not contain organelles but which does contain other particulate matter, such as protein complexes. [GOC:hjd, GOC:jl] |
This protein is involved in 2 target(s):
| Target | Category | Definition |
|---|---|---|
| GDP-mannose biosynthetic process | biological process | The chemical reactions and pathways resulting in the formation of GDP-mannose, a substance composed of mannose in glycosidic linkage with guanosine diphosphate. [GOC:ai] |
| mannose to fructose-6-phosphate catabolic process | biological process | The chemical reactions and pathways in which mannose, the aldohexose manno-hexose, is converted to fructose-6-phosphate. [GOC:dph, ISBN:0201090910, ISBN:0879010479] |