imidazole has been researched along with Chagas Disease in 5 studies
imidazole: RN given refers to parent cpd
1H-imidazole : An imidazole tautomer which has the migrating hydrogen at position 1.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "People with Chagas disease (American Trypanosomiasis) may develop progressive and potentially lethal heart conditions." | 2.43 | Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection). ( Reyes, PA; Vallejo, M, 2005) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 3 (60.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Beltran-Hortelano, I | 1 |
| Alcolea, V | 1 |
| Font, M | 1 |
| Pérez-Silanes, S | 1 |
| Ghashghaei, O | 1 |
| Kielland, N | 1 |
| Revés, M | 1 |
| Taylor, MC | 1 |
| Kelly, JM | 1 |
| Di Pietro, O | 1 |
| Muñoz-Torrero, D | 1 |
| Pérez, B | 1 |
| Lavilla, R | 1 |
| Gopi, E | 1 |
| Kumar, T | 1 |
| Menna-Barreto, RF | 1 |
| Valença, WO | 1 |
| da Silva Júnior, EN | 1 |
| Namboothiri, IN | 1 |
| Salerno, A | 1 |
| Celentano, AM | 1 |
| López, J | 1 |
| Lara, V | 1 |
| Gaozza, C | 1 |
| Balcazar, DE | 1 |
| Carrillo, C | 1 |
| Frank, FM | 1 |
| Blanco, MM | 1 |
| Reyes, PA | 1 |
| Vallejo, M | 1 |
| Trial | Phase | Enrollment | Study Type | Start Date | Status | ||
|---|---|---|---|---|---|---|---|
| Etiologic Treatment With Benznidazole in Adult Patients With Chronic Chagas Disease. A Randomized Double Blind Clinical Trial[NCT02386358] | Phase 3 | 910 participants (Actual) | Interventional | 1999-03-31 | Completed | ||
| [information is prepared from clinicaltrials.gov, extracted Sep-2024] | |||||||
2 reviews available for imidazole and Chagas Disease
| Article | Year |
|---|---|
The role of imidazole and benzimidazole heterocycles in Chagas disease: A review.
Topics: Animals; Benzimidazoles; Chagas Disease; Drug Discovery; Humans; Imidazoles | 2020 |
Trypanocidal drugs for late stage, symptomatic Chagas disease (Trypanosoma cruzi infection).
Topics: Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Clinical Trials as Topic; Humans; Imidazoles | 2005 |
3 other studies available for imidazole and Chagas Disease
| Article | Year |
|---|---|
Tetrasubstituted Imidazolium Salts as Potent Antiparasitic Agents against African and American Trypanosomiases.
Topics: Animals; Cell Survival; Chagas Disease; Humans; Imidazoles; Myoblasts; Parasitic Sensitivity Tests; | 2018 |
Imidazoles from nitroallylic acetates and α-bromonitroalkenes with amidines: synthesis and trypanocidal activity studies.
Topics: Acetates; Amidines; Animals; Chagas Disease; Dose-Response Relationship, Drug; Imidazoles; Mice; Mol | 2015 |
Novel 2-arylazoimidazole derivatives as inhibitors of Trypanosoma cruzi proliferation: Synthesis and evaluation of their biological activity.
Topics: Alkylation; Animals; Cell Line; Chagas Disease; Humans; Imidazoles; Male; Mice; Mice, Inbred BALB C; | 2017 |