vincaleukoblastine and Chagas-Disease

vincaleukoblastine has been researched along with Chagas-Disease* in 1 studies

Other Studies

1 other study(ies) available for vincaleukoblastine and Chagas-Disease

Article	Year
Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi. Bioorganic & medicinal chemistry letters, 2020, 01-01, Volume: 30, Issue:1 The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline's recently disclosed open-resource "Chagas box" and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chemistry efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery. Topics: Animals; Chagas Disease; Humans; Piperidines; Structure-Activity Relationship; Trypanosoma cruzi	2020

Article

Year

Structure-activity relationship of 4-azaindole-2-piperidine derivatives as agents against Trypanosoma cruzi.

Bioorganic & medicinal chemistry letters, 2020, 01-01, Volume: 30, Issue:1

The structure-activity relationship of a 4-Azaindole-2-piperidine compound selected from GlaxoSmithKline's recently disclosed open-resource "Chagas box" and possessing moderate activity against Trypanosoma cruzi, the parasite responsible for Chagas disease, is presented. Despite considerable medicinal chemistry efforts, a suitably potent and metabolically stable compound could not be identified to advance the series into in vivo studies. This research should be of interest to those in the area of neglected diseases and in particular anti-kinetoplastid drug discovery.

Topics: Animals; Chagas Disease; Humans; Piperidines; Structure-Activity Relationship; Trypanosoma cruzi

2020