aristolochic acid i has been researched along with Chagas Disease in 1 studies
aristolochic acid I: phospholipase A inhibitor
aristolochic acid A : An aristolochic acid that is phenanthrene-1-carboxylic acid that is substituted by a methylenedioxy group at the 3,4 positions, by a methoxy group at position 8, and by a nitro group at position 10. It is the most abundant of the aristolochic acids and is found in almost all Aristolochia (birthworts or pipevines) species. It has been tried in a number of treatments for inflammatory disorders, mainly in Chinese and folk medicine. However, there is concern over their use as aristolochic acid is both carcinogenic and nephrotoxic.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "The need for novel drugs for American trypanosomiasis is evident, and these secondary metabolites from A." | 1.36 | Antitrypanosomal activity of a diterpene and lignans isolated from Aristolochia cymbifera. ( Carvalho, CS; Lorenzi, H; Reimão, JQ; Sartorelli, P; Tempone, AG, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sartorelli, P | 1 |
| Carvalho, CS | 1 |
| Reimão, JQ | 1 |
| Lorenzi, H | 1 |
| Tempone, AG | 1 |
1 other study available for aristolochic acid i and Chagas Disease
| Article | Year |
|---|---|
Antitrypanosomal activity of a diterpene and lignans isolated from Aristolochia cymbifera.
Topics: Animals; Aristolochia; Chagas Disease; Diterpenes; Hemolytic Agents; Inhibitory Concentration 50; Li | 2010 |