suramin has been researched along with Chagas Disease in 10 studies
Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.
suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Although suramin (Sur) is suggested as a potential drug candidate in the management of Chagas disease, this issue has not been objectively tested." | 3.81 | Concomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruzi. ( Bahia, MT; Bastos, DS; Cupertino, MC; Fietto, JL; Klein, RC; Novaes, RD; Oliveira, LL; Santos, EC; Silva, EA; Talvani, A, 2015) |
| "Suramin has been previously reported to inhibit distinct cell enzymes and to affect the synthesis and distribution of cytoskeleton proteins." | 1.33 | Effect of suramin on trypomastigote forms of Trypanosoma cruzi: changes on cell motility and on the ultrastructure of the flagellum-cell body attachment region. ( Bisaggio, DF; Campanati, L; Pinto, RC; Souto-Padrón, T, 2006) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 4 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 4 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bollini, M | 1 |
| Casal, JJ | 1 |
| Alvarez, DE | 1 |
| Boiani, L | 1 |
| González, M | 1 |
| Cerecetto, H | 1 |
| Bruno, AM | 1 |
| Sanchez, LM | 1 |
| Knudsen, GM | 1 |
| Helbig, C | 1 |
| De Muylder, G | 1 |
| Mascuch, SM | 1 |
| Mackey, ZB | 1 |
| Gerwick, L | 1 |
| Clayton, C | 1 |
| McKerrow, JH | 1 |
| Linington, RG | 1 |
| Santos, EC | 1 |
| Novaes, RD | 1 |
| Cupertino, MC | 1 |
| Bastos, DS | 1 |
| Klein, RC | 1 |
| Silva, EA | 1 |
| Fietto, JL | 1 |
| Talvani, A | 1 |
| Bahia, MT | 1 |
| Oliveira, LL | 1 |
| Sbaraglini, ML | 1 |
| Vanrell, MC | 1 |
| Bellera, CL | 1 |
| Benaim, G | 1 |
| Carrillo, C | 1 |
| Talevi, A | 1 |
| Romano, PS | 1 |
| Wainwright, M | 1 |
| WALLS, LP | 1 |
| TELLA, A | 1 |
| Bisaggio, DF | 1 |
| Campanati, L | 1 |
| Pinto, RC | 1 |
| Souto-Padrón, T | 1 |
| Gutteridge, WE | 1 |
| Seah, S | 1 |
4 reviews available for suramin and Chagas Disease
| Article | Year |
|---|---|
Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option.
Topics: Antiprotozoal Agents; Chagas Disease; Drug Repositioning; Humans; Leishmaniasis; Neglected Diseases; | 2016 |
Dyes, trypanosomiasis and DNA: a historical and critical review.
Topics: Acridines; Africa; Animals; Azo Compounds; Cattle; Chagas Disease; DNA; History, 19th Century; Histo | 2010 |
THE CHEMOTHERAPY OF TRYPANOSOMIASIS.
Topics: Animals; Anti-Bacterial Agents; Antibiotics, Antitubercular; Antimony; Antiprotozoal Agents; Arsenic | 1963 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suram | 1985 |
6 other studies available for suramin and Chagas Disease
| Article | Year |
|---|---|
New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships.
Topics: Animals; Chagas Disease; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; HeLa Cells; | 2009 |
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.
Topics: Animals; Biological Products; Chagas Disease; Glycolysis; Humans; Leishmania donovani; Lipopeptides; | 2013 |
Concomitant Benznidazole and Suramin Chemotherapy in Mice Infected with a Virulent Strain of Trypanosoma cruzi.
Topics: Administration, Oral; Animals; Antibodies, Protozoan; Chagas Disease; Drug Administration Schedule; | 2015 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
Effect of suramin on trypomastigote forms of Trypanosoma cruzi: changes on cell motility and on the ultrastructure of the flagellum-cell body attachment region.
Topics: Animals; Antigens, Protozoan; Cell Adhesion; Cell Line; Cell Movement; Chagas Disease; Ferritins; Fl | 2006 |
The effect of suramin on experimental Trypanosoma cruzi infection in mice.
Topics: Animals; Blood; Chagas Disease; Injections, Intraperitoneal; Mice; Suramin; Trypanosoma | 1970 |