Compounds > methoprene
Page last updated: 2024-09-28

methoprene

Description

Methoprene: Juvenile hormone analog and insect growth regulator used to control insects by disrupting metamorphosis. Has been effective in controlling mosquito larvae. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID1711973
CHEMBL ID1875086
CHEBI ID39255
SCHEMBL ID43694
SCHEMBL ID1190845
MeSH IDM0013594
PubMed CID5366546
CHEMBL ID291057
CHEBI ID34839
CHEBI ID39257
SCHEMBL ID19795
MeSH IDM0013594

Synonyms (183)

Synonym
SPECTRUM5_001410
(+)-methoprene
d-methoprene
s-methoprene
zr 2458
2,4-dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, 1-methylethyl ester, (2e,4e,7s)-
flea killer plus
(7s)-methoprene
isopropyl (2e,4e,7s)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
epa pesticide chemical code 105402
(2e,4e,7s)-1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
BSPBIO_003468
(s)-methoprene
CHEBI:39255 ,
isopropyl (2e,4e,7s)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
propan-2-yl (2e,4e,7s)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
NCGC00163814-01
SPECTRUM1504100
NCGC00163814-02
HMS1923M17
dtxsid1035783 ,
cas-65733-16-6
dtxcid9015783
NCGC00255607-01
tox21_301409
nsc-758655
methoprene (s)
pharmakon1600-01504100
nsc758655
preco
altoside cp 2
unii-4yiq0a94ur
7s)-methoprene
altoside cp 10
4yiq0a94ur ,
methoprene (7s)-form
65733-16-6
diacon ii
altosid xr briquets
extinguish
CHEMBL1875086
CCG-39694
s-(+)-methoprene
(s)-methoprene component of broadline
broadline component (s)-methoprene
methoprene, (s)-
methoprene (7s)-form [mi]
pharorid
zr-2458
methoprene, (s)- [ema epar veterinary]
NFGXHKASABOEEW-GYMWBFJFSA-N
SCHEMBL43694
SCHEMBL1190845
AB01563364_01
SBI-0207033.P001
(s,2e,4e)-isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
isopropyl (s,2e,4e)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
DB11495
Q27119791
AS-18089
methoprene-(s)
E78309
A913960
AKOS037643628
zr2458
CS-0020254
HY-B1161A
zodiac
isopropyl(2e,4e)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
bioprene bm fire ant killer bait
11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid isopropyl ester
isopropyl-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
apex
2,4-dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, isopropyl ester
pharoid
ent 70460
oms 1697
altosid
isopropyl (2e,4e)-(7s)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
methoprene [inn]
methoprenum [inn-latin]
starbar inhibitor
kabat
methoprene [ansi:bsi:iso]
epa pesticide chemical code 105401
methoprene s
altosid liquid larvicide
2,4-dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, 1-methylethyl ester, (e,e)-
dianex
precor
apex (pesticide)
juvemon
isopropylmethoxytrimethyldodecadienoate
einecs 254-993-2
yuvemon
manta
hsdb 6926
caswell no. 028aaa
altosid sr 10
altosid igr
zpa 1019
diacon
metopreno [inn-spanish]
dl-isopropyl 11-methoxy-3,7,11-trimethyl-trans-2,4-dodecadienoate
minex
(e,e)-1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
methoprene
NCGC00090777-01
40596-69-8
41205-06-5
1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
propan-2-yl (2e,4e)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid, 1-methylethyl ester
propan-2-yl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
CHEBI:34839 ,
(e,e)-isopropyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
isopropyl (ee)-(rs)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
zr 515
(e,e)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid 1-methylethyl ester
CHEBI:39257
isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
isopropyl (2e,4e)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
36557-27-4
NCGC00090777-03
NCGC00090777-02
NCGC00090777-05
NCGC00090777-04
smr001227198
MLS001055477
CHEMBL291057
methoprene (inn)
zodiac [veterinary] (tn)
D08200
STK677200
AKOS005594513
NCGC00090777-06
HMS3039C11
tox21_200654
NCGC00258208-01
dtxsid8032627 ,
dtxcid6012627
tox21_111019
cas-40596-69-8
ent-70460
manina
sb-515
zpa-1019
metoprag 20ce
methoprenum
nsc 758655
metopreno
2,4-dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, 1-methylethyl ester, (2e,4e)-
unii-8b830oj2ux
8b830oj2ux ,
ro 10-6425
2,4-dodecadienoic acid, 11-methoxy-3,7,11-trimethyl-, 1-methylethyl ester
methoprene [iso]
methoprene [hsdb]
methoprene [who-dd]
methoprene [mi]
1-methylethyl (2e,4e)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
isopropyl (2e,4e,7rs)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
dl-isopropyl 11-methoxy-3,7,11-trimethyl-trans-trans-2,4-dodecadienoate
(2e,4e)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoic acid 1-methylethyl ester
isopropyl (e,e)-(rs)-11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
methoprene [jan]
methoprene [mart.]
SCHEMBL19795
tox21_111019_1
NCGC00263657-01
CS-4762
(2e,4e)-3,7,11-trimethyl-11-methoxydodeca-2,4-dienoic acid 1-methylethyl ester
NFGXHKASABOEEW-LDRANXPESA-N
isopropyl (2e,4e)-11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate
HY-B1161
SR-01000854669-2
sr-01000854669
methoprene, pestanal(r), analytical standard
(2e,4e)-isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
Q27119793
Q2329841
methoprene 1000 microg/ml in acetone
MS-24524

Roles (1)

RoleDescription
juvenile hormone mimicnull
[role information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Drug Classes (3)

ClassDescription
methoprene
isopropyl 11-methoxy-3,7,11-trimethyldodeca-2,4-dienoate
isopropyl esterAny carboxylic ester resulting from the formal condensation of a carboxylic acid with the hydroxy group of propan-2-ol.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein Targets (60)

Potency Measurements

ProteinTaxonomyMeasurementAverage (µ)Min (ref.)Avg (ref.)Max (ref.)Bioassay(s)
GLI family zinc finger 3Homo sapiens (human)Potency45.84150.000714.592883.7951AID1259392
AR proteinHomo sapiens (human)Potency54.39080.000221.22318,912.5098AID588516; AID743035; AID743042; AID743054; AID743063
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency30.63790.001022.650876.6163AID1224838
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency24.54120.000214.376460.0339AID720692
retinoid X nuclear receptor alphaHomo sapiens (human)Potency15.48450.000817.505159.3239AID1159531
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency54.48270.001530.607315,848.9004AID1224848; AID1224849
farnesoid X nuclear receptorHomo sapiens (human)Potency54.94100.375827.485161.6524AID743217
pregnane X nuclear receptorHomo sapiens (human)Potency24.33650.005428.02631,258.9301AID1346982
estrogen nuclear receptor alphaHomo sapiens (human)Potency49.20280.000229.305416,493.5996AID743069; AID743075; AID743079
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency61.64480.001024.504861.6448AID743215
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency37.23810.001019.414170.9645AID588537; AID743191
vitamin D (1,25- dihydroxyvitamin D3) receptorHomo sapiens (human)Potency38.89520.023723.228263.5986AID743223
Histone H2A.xCricetulus griseus (Chinese hamster)Potency126.79300.039147.5451146.8240AID1224845
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency57.80670.000323.4451159.6830AID743065; AID743067
histone deacetylase 9 isoform 3Homo sapiens (human)Potency68.58960.037617.082361.1927AID1259364
heat shock protein beta-1Homo sapiens (human)Potency29.65170.042027.378961.6448AID743210; AID743228
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency49.61370.000627.21521,122.0200AID651741; AID743219
Cellular tumor antigen p53Homo sapiens (human)Potency68.58960.002319.595674.0614AID651631
Chain A, TYROSYL-DNA PHOSPHODIESTERASEHomo sapiens (human)Potency30.25860.004023.8416100.0000AID485290
Chain A, JmjC domain-containing histone demethylation protein 3AHomo sapiens (human)Potency56.23410.631035.7641100.0000AID504339
pregnane X receptorRattus norvegicus (Norway rat)Potency49.28850.025127.9203501.1870AID651751
USP1 protein, partialHomo sapiens (human)Potency22.98330.031637.5844354.8130AID504865
TDP1 proteinHomo sapiens (human)Potency24.16680.000811.382244.6684AID686978; AID686979
aldehyde dehydrogenase 1 family, member A1Homo sapiens (human)Potency25.11890.011212.4002100.0000AID1030
nuclear receptor subfamily 1, group I, member 3Homo sapiens (human)Potency31.65210.001022.650876.6163AID1224838; AID1224839; AID1224893
cytochrome P450 family 3 subfamily A polypeptide 4Homo sapiens (human)Potency38.90180.01237.983543.2770AID1645841
glucocorticoid receptor [Homo sapiens]Homo sapiens (human)Potency33.77410.000214.376460.0339AID588533; AID720692
retinoic acid nuclear receptor alpha variant 1Homo sapiens (human)Potency75.70830.003041.611522,387.1992AID1159553
retinoid X nuclear receptor alphaHomo sapiens (human)Potency44.76470.000817.505159.3239AID1159531; AID588544
estrogen-related nuclear receptor alphaHomo sapiens (human)Potency46.03160.001530.607315,848.9004AID1224849; AID1259401
farnesoid X nuclear receptorHomo sapiens (human)Potency42.23950.375827.485161.6524AID588526; AID588527
pregnane X nuclear receptorHomo sapiens (human)Potency29.18890.005428.02631,258.9301AID1346982; AID1346985; AID720659
estrogen nuclear receptor alphaHomo sapiens (human)Potency5.00110.000229.305416,493.5996AID743075
GVesicular stomatitis virusPotency38.90180.01238.964839.8107AID1645842
bromodomain adjacent to zinc finger domain 2BHomo sapiens (human)Potency56.23410.707936.904389.1251AID504333
peroxisome proliferator-activated receptor deltaHomo sapiens (human)Potency39.81070.001024.504861.6448AID588535
peroxisome proliferator activated receptor gammaHomo sapiens (human)Potency42.23950.001019.414170.9645AID588537
aryl hydrocarbon receptorHomo sapiens (human)Potency47.97940.000723.06741,258.9301AID743085; AID743122
thyroid stimulating hormone receptorHomo sapiens (human)Potency40.97100.001628.015177.1139AID1224895
vitamin D3 receptor isoform VDRAHomo sapiens (human)Potency50.11870.354828.065989.1251AID504847
chromobox protein homolog 1Homo sapiens (human)Potency56.23410.006026.168889.1251AID540317
potassium voltage-gated channel subfamily H member 2 isoform dHomo sapiens (human)Potency31.62280.01789.637444.6684AID588834
thyroid hormone receptor beta isoform 2Rattus norvegicus (Norway rat)Potency31.67040.000323.4451159.6830AID743065; AID743067
nuclear factor erythroid 2-related factor 2 isoform 1Homo sapiens (human)Potency53.70930.000627.21521,122.0200AID651741; AID720636; AID743202; AID743219
gemininHomo sapiens (human)Potency20.59620.004611.374133.4983AID624297
DNA polymerase kappa isoform 1Homo sapiens (human)Potency3.98110.031622.3146100.0000AID588579
peripheral myelin protein 22Rattus norvegicus (Norway rat)Potency16.13660.005612.367736.1254AID624032
cytochrome P450 3A4 isoform 1Homo sapiens (human)Potency31.62280.031610.279239.8107AID884; AID885
histone acetyltransferase KAT2A isoform 1Homo sapiens (human)Potency39.81070.251215.843239.8107AID504327
lamin isoform A-delta10Homo sapiens (human)Potency35.48130.891312.067628.1838AID1487
Gamma-aminobutyric acid receptor subunit piRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Interferon betaHomo sapiens (human)Potency38.90180.00339.158239.8107AID1645842
HLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)Potency38.90180.01238.964839.8107AID1645842
Gamma-aminobutyric acid receptor subunit beta-1Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit deltaRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-5Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-3Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-1Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-2Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-4Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit gamma-3Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit alpha-6Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Nuclear receptor ROR-gammaHomo sapiens (human)Potency2.37100.026622.448266.8242AID651802
Gamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-3Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Gamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
GABA theta subunitRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
Inositol hexakisphosphate kinase 1Homo sapiens (human)Potency38.90180.01238.964839.8107AID1645842
Gamma-aminobutyric acid receptor subunit epsilonRattus norvegicus (Norway rat)Potency31.62281.000012.224831.6228AID885
cytochrome P450 2C9, partialHomo sapiens (human)Potency38.90180.01238.964839.8107AID1645842
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Biological Processes (178)

Processvia Protein(s)Taxonomy
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycle G2/M phase transitionCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
ER overload responseCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
mitophagyCellular tumor antigen p53Homo sapiens (human)
in utero embryonic developmentCellular tumor antigen p53Homo sapiens (human)
somitogenesisCellular tumor antigen p53Homo sapiens (human)
release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
hematopoietic progenitor cell differentiationCellular tumor antigen p53Homo sapiens (human)
T cell proliferation involved in immune responseCellular tumor antigen p53Homo sapiens (human)
B cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
T cell lineage commitmentCellular tumor antigen p53Homo sapiens (human)
response to ischemiaCellular tumor antigen p53Homo sapiens (human)
nucleotide-excision repairCellular tumor antigen p53Homo sapiens (human)
double-strand break repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
protein import into nucleusCellular tumor antigen p53Homo sapiens (human)
autophagyCellular tumor antigen p53Homo sapiens (human)
DNA damage responseCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrestCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediatorCellular tumor antigen p53Homo sapiens (human)
transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
Ras protein signal transductionCellular tumor antigen p53Homo sapiens (human)
gastrulationCellular tumor antigen p53Homo sapiens (human)
neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of neuroblast proliferationCellular tumor antigen p53Homo sapiens (human)
protein localizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA replicationCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell population proliferationCellular tumor antigen p53Homo sapiens (human)
determination of adult lifespanCellular tumor antigen p53Homo sapiens (human)
mRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
rRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
response to salt stressCellular tumor antigen p53Homo sapiens (human)
response to inorganic substanceCellular tumor antigen p53Homo sapiens (human)
response to X-rayCellular tumor antigen p53Homo sapiens (human)
response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
positive regulation of gene expressionCellular tumor antigen p53Homo sapiens (human)
cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of cardiac muscle cell apoptotic processCellular tumor antigen p53Homo sapiens (human)
glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
viral processCellular tumor antigen p53Homo sapiens (human)
glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
cerebellum developmentCellular tumor antigen p53Homo sapiens (human)
negative regulation of cell growthCellular tumor antigen p53Homo sapiens (human)
DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
negative regulation of transforming growth factor beta receptor signaling pathwayCellular tumor antigen p53Homo sapiens (human)
mitotic G1 DNA damage checkpoint signalingCellular tumor antigen p53Homo sapiens (human)
negative regulation of telomere maintenance via telomeraseCellular tumor antigen p53Homo sapiens (human)
T cell differentiation in thymusCellular tumor antigen p53Homo sapiens (human)
tumor necrosis factor-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
regulation of tissue remodelingCellular tumor antigen p53Homo sapiens (human)
cellular response to UVCellular tumor antigen p53Homo sapiens (human)
multicellular organism growthCellular tumor antigen p53Homo sapiens (human)
positive regulation of mitochondrial membrane permeabilityCellular tumor antigen p53Homo sapiens (human)
cellular response to glucose starvationCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of apoptotic processCellular tumor antigen p53Homo sapiens (human)
entrainment of circadian clock by photoperiodCellular tumor antigen p53Homo sapiens (human)
mitochondrial DNA repairCellular tumor antigen p53Homo sapiens (human)
regulation of DNA damage response, signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
transcription initiation-coupled chromatin remodelingCellular tumor antigen p53Homo sapiens (human)
negative regulation of proteolysisCellular tumor antigen p53Homo sapiens (human)
negative regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of DNA-templated transcriptionCellular tumor antigen p53Homo sapiens (human)
positive regulation of RNA polymerase II transcription preinitiation complex assemblyCellular tumor antigen p53Homo sapiens (human)
positive regulation of transcription by RNA polymerase IICellular tumor antigen p53Homo sapiens (human)
response to antibioticCellular tumor antigen p53Homo sapiens (human)
fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
negative regulation of fibroblast proliferationCellular tumor antigen p53Homo sapiens (human)
circadian behaviorCellular tumor antigen p53Homo sapiens (human)
bone marrow developmentCellular tumor antigen p53Homo sapiens (human)
embryonic organ developmentCellular tumor antigen p53Homo sapiens (human)
positive regulation of peptidyl-tyrosine phosphorylationCellular tumor antigen p53Homo sapiens (human)
protein stabilizationCellular tumor antigen p53Homo sapiens (human)
negative regulation of helicase activityCellular tumor antigen p53Homo sapiens (human)
protein tetramerizationCellular tumor antigen p53Homo sapiens (human)
chromosome organizationCellular tumor antigen p53Homo sapiens (human)
neuron apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of cell cycleCellular tumor antigen p53Homo sapiens (human)
hematopoietic stem cell differentiationCellular tumor antigen p53Homo sapiens (human)
negative regulation of glial cell proliferationCellular tumor antigen p53Homo sapiens (human)
type II interferon-mediated signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cardiac septum morphogenesisCellular tumor antigen p53Homo sapiens (human)
positive regulation of programmed necrotic cell deathCellular tumor antigen p53Homo sapiens (human)
protein-containing complex assemblyCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stressCellular tumor antigen p53Homo sapiens (human)
thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of thymocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
necroptotic processCellular tumor antigen p53Homo sapiens (human)
cellular response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
cellular response to xenobiotic stimulusCellular tumor antigen p53Homo sapiens (human)
cellular response to ionizing radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to gamma radiationCellular tumor antigen p53Homo sapiens (human)
cellular response to UV-CCellular tumor antigen p53Homo sapiens (human)
stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
signal transduction by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
cellular response to actinomycin DCellular tumor antigen p53Homo sapiens (human)
positive regulation of release of cytochrome c from mitochondriaCellular tumor antigen p53Homo sapiens (human)
cellular senescenceCellular tumor antigen p53Homo sapiens (human)
replicative senescenceCellular tumor antigen p53Homo sapiens (human)
oxidative stress-induced premature senescenceCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
oligodendrocyte apoptotic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of execution phase of apoptosisCellular tumor antigen p53Homo sapiens (human)
negative regulation of mitophagyCellular tumor antigen p53Homo sapiens (human)
regulation of mitochondrial membrane permeability involved in apoptotic processCellular tumor antigen p53Homo sapiens (human)
regulation of intrinsic apoptotic signaling pathway by p53 class mediatorCellular tumor antigen p53Homo sapiens (human)
positive regulation of miRNA transcriptionCellular tumor antigen p53Homo sapiens (human)
negative regulation of G1 to G0 transitionCellular tumor antigen p53Homo sapiens (human)
negative regulation of miRNA processingCellular tumor antigen p53Homo sapiens (human)
negative regulation of glucose catabolic process to lactate via pyruvateCellular tumor antigen p53Homo sapiens (human)
negative regulation of pentose-phosphate shuntCellular tumor antigen p53Homo sapiens (human)
intrinsic apoptotic signaling pathway in response to hypoxiaCellular tumor antigen p53Homo sapiens (human)
regulation of fibroblast apoptotic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
positive regulation of reactive oxygen species metabolic processCellular tumor antigen p53Homo sapiens (human)
negative regulation of stem cell proliferationCellular tumor antigen p53Homo sapiens (human)
positive regulation of cellular senescenceCellular tumor antigen p53Homo sapiens (human)
positive regulation of intrinsic apoptotic signaling pathwayCellular tumor antigen p53Homo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell activation involved in immune responseInterferon betaHomo sapiens (human)
cell surface receptor signaling pathwayInterferon betaHomo sapiens (human)
cell surface receptor signaling pathway via JAK-STATInterferon betaHomo sapiens (human)
response to virusInterferon betaHomo sapiens (human)
positive regulation of autophagyInterferon betaHomo sapiens (human)
cytokine-mediated signaling pathwayInterferon betaHomo sapiens (human)
natural killer cell activationInterferon betaHomo sapiens (human)
positive regulation of peptidyl-serine phosphorylation of STAT proteinInterferon betaHomo sapiens (human)
cellular response to interferon-betaInterferon betaHomo sapiens (human)
B cell proliferationInterferon betaHomo sapiens (human)
negative regulation of viral genome replicationInterferon betaHomo sapiens (human)
innate immune responseInterferon betaHomo sapiens (human)
positive regulation of innate immune responseInterferon betaHomo sapiens (human)
regulation of MHC class I biosynthetic processInterferon betaHomo sapiens (human)
negative regulation of T cell differentiationInterferon betaHomo sapiens (human)
positive regulation of transcription by RNA polymerase IIInterferon betaHomo sapiens (human)
defense response to virusInterferon betaHomo sapiens (human)
type I interferon-mediated signaling pathwayInterferon betaHomo sapiens (human)
neuron cellular homeostasisInterferon betaHomo sapiens (human)
cellular response to exogenous dsRNAInterferon betaHomo sapiens (human)
cellular response to virusInterferon betaHomo sapiens (human)
negative regulation of Lewy body formationInterferon betaHomo sapiens (human)
negative regulation of T-helper 2 cell cytokine productionInterferon betaHomo sapiens (human)
positive regulation of apoptotic signaling pathwayInterferon betaHomo sapiens (human)
response to exogenous dsRNAInterferon betaHomo sapiens (human)
B cell differentiationInterferon betaHomo sapiens (human)
natural killer cell activation involved in immune responseInterferon betaHomo sapiens (human)
adaptive immune responseInterferon betaHomo sapiens (human)
T cell activation involved in immune responseInterferon betaHomo sapiens (human)
humoral immune responseInterferon betaHomo sapiens (human)
positive regulation of T cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
adaptive immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class I via ER pathway, TAP-independentHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of T cell anergyHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
defense responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
detection of bacteriumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-12 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of interleukin-6 productionHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protection from natural killer cell mediated cytotoxicityHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
innate immune responseHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
regulation of dendritic cell differentiationHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
antigen processing and presentation of endogenous peptide antigen via MHC class IbHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
negative regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
xenobiotic metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of glucose metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
regulation of steroid metabolic processNuclear receptor ROR-gammaHomo sapiens (human)
intracellular receptor signaling pathwayNuclear receptor ROR-gammaHomo sapiens (human)
circadian regulation of gene expressionNuclear receptor ROR-gammaHomo sapiens (human)
cellular response to sterolNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of circadian rhythmNuclear receptor ROR-gammaHomo sapiens (human)
regulation of fat cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
positive regulation of DNA-templated transcriptionNuclear receptor ROR-gammaHomo sapiens (human)
adipose tissue developmentNuclear receptor ROR-gammaHomo sapiens (human)
T-helper 17 cell differentiationNuclear receptor ROR-gammaHomo sapiens (human)
regulation of transcription by RNA polymerase IINuclear receptor ROR-gammaHomo sapiens (human)
inositol phosphate metabolic processInositol hexakisphosphate kinase 1Homo sapiens (human)
phosphatidylinositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
negative regulation of cold-induced thermogenesisInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol phosphate biosynthetic processInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Molecular Functions (54)

Processvia Protein(s)Taxonomy
transcription cis-regulatory region bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
cis-regulatory region sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
core promoter sequence-specific DNA bindingCellular tumor antigen p53Homo sapiens (human)
TFIID-class transcription factor complex bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription activator activity, RNA polymerase II-specificCellular tumor antigen p53Homo sapiens (human)
protease bindingCellular tumor antigen p53Homo sapiens (human)
p53 bindingCellular tumor antigen p53Homo sapiens (human)
DNA bindingCellular tumor antigen p53Homo sapiens (human)
chromatin bindingCellular tumor antigen p53Homo sapiens (human)
DNA-binding transcription factor activityCellular tumor antigen p53Homo sapiens (human)
mRNA 3'-UTR bindingCellular tumor antigen p53Homo sapiens (human)
copper ion bindingCellular tumor antigen p53Homo sapiens (human)
protein bindingCellular tumor antigen p53Homo sapiens (human)
zinc ion bindingCellular tumor antigen p53Homo sapiens (human)
enzyme bindingCellular tumor antigen p53Homo sapiens (human)
receptor tyrosine kinase bindingCellular tumor antigen p53Homo sapiens (human)
ubiquitin protein ligase bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase regulator activityCellular tumor antigen p53Homo sapiens (human)
ATP-dependent DNA/DNA annealing activityCellular tumor antigen p53Homo sapiens (human)
identical protein bindingCellular tumor antigen p53Homo sapiens (human)
histone deacetylase bindingCellular tumor antigen p53Homo sapiens (human)
protein heterodimerization activityCellular tumor antigen p53Homo sapiens (human)
protein-folding chaperone bindingCellular tumor antigen p53Homo sapiens (human)
protein phosphatase 2A bindingCellular tumor antigen p53Homo sapiens (human)
RNA polymerase II-specific DNA-binding transcription factor bindingCellular tumor antigen p53Homo sapiens (human)
14-3-3 protein bindingCellular tumor antigen p53Homo sapiens (human)
MDM2/MDM4 family protein bindingCellular tumor antigen p53Homo sapiens (human)
disordered domain specific bindingCellular tumor antigen p53Homo sapiens (human)
general transcription initiation factor bindingCellular tumor antigen p53Homo sapiens (human)
molecular function activator activityCellular tumor antigen p53Homo sapiens (human)
promoter-specific chromatin bindingCellular tumor antigen p53Homo sapiens (human)
cytokine activityInterferon betaHomo sapiens (human)
cytokine receptor bindingInterferon betaHomo sapiens (human)
type I interferon receptor bindingInterferon betaHomo sapiens (human)
protein bindingInterferon betaHomo sapiens (human)
chloramphenicol O-acetyltransferase activityInterferon betaHomo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
signaling receptor bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
peptide antigen bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
TAP bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
protein-folding chaperone bindingHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
RNA polymerase II cis-regulatory region sequence-specific DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription repressor activity, RNA polymerase II-specificNuclear receptor ROR-gammaHomo sapiens (human)
DNA-binding transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
protein bindingNuclear receptor ROR-gammaHomo sapiens (human)
oxysterol bindingNuclear receptor ROR-gammaHomo sapiens (human)
zinc ion bindingNuclear receptor ROR-gammaHomo sapiens (human)
ligand-activated transcription factor activityNuclear receptor ROR-gammaHomo sapiens (human)
sequence-specific double-stranded DNA bindingNuclear receptor ROR-gammaHomo sapiens (human)
nuclear receptor activityNuclear receptor ROR-gammaHomo sapiens (human)
inositol-1,3,4,5,6-pentakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol heptakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
protein bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
ATP bindingInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 1-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol hexakisphosphate 3-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol 5-diphosphate pentakisphosphate 5-kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
inositol diphosphate tetrakisphosphate kinase activityInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Ceullar Components (36)

Processvia Protein(s)Taxonomy
nuclear bodyCellular tumor antigen p53Homo sapiens (human)
nucleusCellular tumor antigen p53Homo sapiens (human)
nucleoplasmCellular tumor antigen p53Homo sapiens (human)
replication forkCellular tumor antigen p53Homo sapiens (human)
nucleolusCellular tumor antigen p53Homo sapiens (human)
cytoplasmCellular tumor antigen p53Homo sapiens (human)
mitochondrionCellular tumor antigen p53Homo sapiens (human)
mitochondrial matrixCellular tumor antigen p53Homo sapiens (human)
endoplasmic reticulumCellular tumor antigen p53Homo sapiens (human)
centrosomeCellular tumor antigen p53Homo sapiens (human)
cytosolCellular tumor antigen p53Homo sapiens (human)
nuclear matrixCellular tumor antigen p53Homo sapiens (human)
PML bodyCellular tumor antigen p53Homo sapiens (human)
transcription repressor complexCellular tumor antigen p53Homo sapiens (human)
site of double-strand breakCellular tumor antigen p53Homo sapiens (human)
germ cell nucleusCellular tumor antigen p53Homo sapiens (human)
chromatinCellular tumor antigen p53Homo sapiens (human)
transcription regulator complexCellular tumor antigen p53Homo sapiens (human)
protein-containing complexCellular tumor antigen p53Homo sapiens (human)
extracellular spaceInterferon betaHomo sapiens (human)
extracellular regionInterferon betaHomo sapiens (human)
Golgi membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
endoplasmic reticulumHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
Golgi apparatusHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
cell surfaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
ER to Golgi transport vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
secretory granule membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
phagocytic vesicle membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
early endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
recycling endosome membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular exosomeHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
lumenal side of endoplasmic reticulum membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
MHC class I protein complexHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
extracellular spaceHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
external side of plasma membraneHLA class I histocompatibility antigen, B alpha chain Homo sapiens (human)
plasma membraneGamma-aminobutyric acid receptor subunit gamma-2Rattus norvegicus (Norway rat)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
nucleoplasmNuclear receptor ROR-gammaHomo sapiens (human)
nuclear bodyNuclear receptor ROR-gammaHomo sapiens (human)
chromatinNuclear receptor ROR-gammaHomo sapiens (human)
nucleusNuclear receptor ROR-gammaHomo sapiens (human)
plasma membraneGamma-aminobutyric acid receptor subunit alpha-1Rattus norvegicus (Norway rat)
plasma membraneGamma-aminobutyric acid receptor subunit beta-2Rattus norvegicus (Norway rat)
fibrillar centerInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
cytosolInositol hexakisphosphate kinase 1Homo sapiens (human)
nucleusInositol hexakisphosphate kinase 1Homo sapiens (human)
cytoplasmInositol hexakisphosphate kinase 1Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (57)

Assay IDTitleYearJournalArticle
AID588519A screen for compounds that inhibit viral RNA polymerase binding and polymerization activities2011Antiviral research, Sep, Volume: 91, Issue:3
High-throughput screening identification of poliovirus RNA-dependent RNA polymerase inhibitors.
AID540299A screen for compounds that inhibit the MenB enzyme of Mycobacterium tuberculosis2010Bioorganic & medicinal chemistry letters, Nov-01, Volume: 20, Issue:21
Synthesis and SAR studies of 1,4-benzoxazine MenB inhibitors: novel antibacterial agents against Mycobacterium tuberculosis.
AID1103627Induction of precocious metamorphosis in allatectomized fourth-instar larvae of Bombyx mori Shunei x Shougetsu assessed as juvenile hormone activity at 1 ug applied topically to dorsal abdomen of larvae2007Bioscience, biotechnology, and biochemistry, Sep, Volume: 71, Issue:9
Juvenile hormone activity of ethyl 4-(2-aryloxyhexyloxy)benzoates with precocious metamorphosis-inducing activity.
AID1091973Inhibition of metamorphosis in freshly molted Pyrrhocoris apterus (red firebug) fifth-instar nymph assessed as compound dose per individual causing reduction in metamorphosis by topical screening test2010Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids.
AID1105546Juvenile hormone mimicking activity against fifth-instar larval stage of Pieris brassicae reared on cabbage plants assessed as morphogenetic changes measured per larvae applied topically to dorsal surface of larvae measured post pupal ecdysis1996Archives of insect biochemistry and physiology, , Volume: 32, Issue:3-4
Projuvenoids: synthesis and biological evaluation of sulfenylated, sulfinylated, and sulfonylated carbamates.
AID1091972Inhibition of metamorphosis in freshly molted Pyrrhocoris apterus (red firebug) fourth-instar nymph assessed as compound dose per individual causing reduction in metamorphosis by oral drinking assay2010Bioorganic & medicinal chemistry, Dec-01, Volume: 18, Issue:23
Steroid conjugates: Synthesis and preliminary biological testing of pro-juvenoids.
AID1105530Lipophilicity, log P of the compound1996Archives of insect biochemistry and physiology, , Volume: 32, Issue:3-4
Projuvenoids: synthesis and biological evaluation of sulfenylated, sulfinylated, and sulfonylated carbamates.
AID1105543Juvenile hormone mimicking activity against adult Sitophilus oryzae (rice weevil) infested wheat kernels assessed as suppression of progeny development at 1 to 100 ppm applied through diet for 21 days measured after 9 weeks1996Archives of insect biochemistry and physiology, , Volume: 32, Issue:3-4
Projuvenoids: synthesis and biological evaluation of sulfenylated, sulfinylated, and sulfonylated carbamates.
AID1159607Screen for inhibitors of RMI FANCM (MM2) intereaction2016Journal of biomolecular screening, Jul, Volume: 21, Issue:6
A High-Throughput Screening Strategy to Identify Protein-Protein Interaction Inhibitors That Block the Fanconi Anemia DNA Repair Pathway.
AID1296008Cytotoxic Profiling of Annotated Libraries Using Quantitative High-Throughput Screening2020SLAS discovery : advancing life sciences R & D, 01, Volume: 25, Issue:1
Cytotoxic Profiling of Annotated and Diverse Chemical Libraries Using Quantitative High-Throughput Screening.
AID1346986P-glycoprotein substrates identified in KB-3-1 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1346987P-glycoprotein substrates identified in KB-8-5-11 adenocarcinoma cell line, qHTS therapeutic library screen2019Molecular pharmacology, 11, Volume: 96, Issue:5
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
AID1347424RapidFire Mass Spectrometry qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347425Rhodamine-PBP qHTS Assay for Modulators of WT P53-Induced Phosphatase 1 (WIP1)2019The Journal of biological chemistry, 11-15, Volume: 294, Issue:46
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
AID1347095qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB-EBc1 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347082qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: LASV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347407qHTS to identify inhibitors of the type 1 interferon - major histocompatibility complex class I in skeletal muscle: primary screen against the NCATS Pharmaceutical Collection2020ACS chemical biology, 07-17, Volume: 15, Issue:7
High-Throughput Screening to Identify Inhibitors of the Type I Interferon-Major Histocompatibility Complex Class I Pathway in Skeletal Muscle.
AID1347106qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for control Hh wild type fibroblast cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347098qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-SH cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1745845Primary qHTS for Inhibitors of ATXN expression
AID1347104qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for RD cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347105qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for MG 63 (6-TG R) cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347096qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for U-2 OS cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347097qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Saos-2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347102qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh18 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347089qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for TC32 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347091qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SJ-GBM2 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347100qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for LAN-5 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347092qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for A673 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347154Primary screen GU AMC qHTS for Zika virus inhibitors2020Proceedings of the National Academy of Sciences of the United States of America, 12-08, Volume: 117, Issue:49
Therapeutic candidates for the Zika virus identified by a high-throughput screen for Zika protease inhibitors.
AID1347107qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh30 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347090qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for DAOY cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347083qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lassa (LASV) Arenavirus: Viability assay - alamar blue signal for LASV Primary Screen2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID651635Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression
AID1347094qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-37 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1508630Primary qHTS for small molecule stabilizers of the endoplasmic reticulum resident proteome: Secreted ER Calcium Modulated Protein (SERCaMP) assay2021Cell reports, 04-27, Volume: 35, Issue:4
A target-agnostic screen identifies approved drugs to stabilize the endoplasmic reticulum-resident proteome.
AID1347108qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for Rh41 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347093qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for SK-N-MC cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347086qHTS for Inhibitors of the Functional Ribonucleoprotein Complex (vRNP) of Lymphocytic Choriomeningitis Arenaviruses (LCMV): LCMV Primary Screen - GLuc reporter signal2020Antiviral research, 01, Volume: 173A cell-based, infectious-free, platform to identify inhibitors of lassa virus ribonucleoprotein (vRNP) activity.
AID1347101qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for BT-12 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347103qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for OHS-50 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID1347099qHTS of pediatric cancer cell lines to identify multiple opportunities for drug repurposing: Primary screen for NB1643 cells2018Oncotarget, Jan-12, Volume: 9, Issue:4
Quantitative high-throughput phenotypic screening of pediatric cancer cell lines identifies multiple opportunities for drug repurposing.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588499High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588501High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Current protocols in cytometry, Oct, Volume: Chapter 13Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2006Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5
Microsphere-based protease assays and screening application for lethal factor and factor Xa.
AID588497High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set2010Assay and drug development technologies, Feb, Volume: 8, Issue:1
High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors.
AID504812Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID504810Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign2010Endocrinology, Jul, Volume: 151, Issue:7
A small molecule inverse agonist for the human thyroid-stimulating hormone receptor.
AID220250Juvenile hormone mimetic activity in Aedes aegypti (yellow-fever mosquito)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Quantitative structure-activity relationship of insect juvenile hormone mimetic compounds.
AID220245Juvenile hormone mimetic activity in Tenebrio molitor (yellow mealworm)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Quantitative structure-activity relationship of insect juvenile hormone mimetic compounds.
AID23280Partition coefficient (logP)1984Journal of medicinal chemistry, Nov, Volume: 27, Issue:11
Quantitative structure-activity relationship of insect juvenile hormone mimetic compounds.
AID504749qHTS profiling for inhibitors of Plasmodium falciparum proliferation2011Science (New York, N.Y.), Aug-05, Volume: 333, Issue:6043
Chemical genomic profiling for antimalarial therapies, response signatures, and molecular targets.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (617)

TimeframeStudies, This Drug (%)All Drugs %
pre-199092 (14.91)18.7374
1990's86 (13.94)18.2507
2000's166 (26.90)29.6817
2010's193 (31.28)24.3611
2020's80 (12.97)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Trials26 (4.02%)5.53%
Reviews0 (0.00%)6.00%
Reviews16 (2.47%)6.00%
Case Studies0 (0.00%)4.05%
Case Studies1 (0.15%)4.05%
Observational0 (0.00%)0.25%
Observational0 (0.00%)0.25%
Other6 (100.00%)84.16%
Other604 (93.35%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceDescriptionRelationhip StrengthStudiesTrialsClassesRoles
malathion[no description available]medium10diester;
ethyl ester;
organic thiophosphate
fenoxycarb[no description available]medium20aromatic ether;
carbamate ester		environmental contaminant;
insecticide;
juvenile hormone mimic;
xenobiotic
pyriproxyfen[no description available]medium10aromatic ether;
pyridines		juvenile hormone mimic
zr-512[no description available]medium160ethyl ester;
farnesane sesquiterpenoid		juvenile hormone mimic
zr 777[no description available]medium40farnesane sesquiterpenoid;
terminal acetylenic compound		juvenile hormone mimic
diflubenzuron[no description available]medium170benzoylurea insecticide;
monochlorobenzenes		insect sterilant
novaluron[no description available]medium20aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound
pyriproxyfen[no description available]medium300aromatic ether;
pyridines		juvenile hormone mimic
fipronil[no description available]medium6524(trifluoromethyl)benzenes;
dichlorobenzene;
nitrile;
primary amino compound;
pyrazoles;
sulfoxide
praziquantel[no description available]medium205isoquinolines
dextrothyroxine[no description available]medium205
fenoxycarb[no description available]medium160aromatic ether;
carbamate ester		environmental contaminant;
insecticide;
juvenile hormone mimic;
xenobiotic
diallyl trisulfide[no description available]medium10organic trisulfideanti-inflammatory agent;
antilipemic drug;
antineoplastic agent;
antioxidant;
antiprotozoal drug;
apoptosis inducer;
estrogen receptor antagonist;
insecticide;
platelet aggregation inhibitor;
vasodilator agent
ecdysone[no description available]medium16014alpha-hydroxy steroid;
22-hydroxy steroid;
25-hydroxy steroid;
2beta-hydroxy steroid;
3beta-sterol;
6-oxo steroid;
ecdysteroid		prohormone
allyl sulfide[no description available]medium10organic sulfide
ecdysterone[no description available]medium43014alpha-hydroxy steroid;
20-hydroxy steroid;
22-hydroxy steroid;
25-hydroxy steroid;
2beta-hydroxy steroid;
3beta-sterol;
ecdysteroid;
phytoecdysteroid		animal metabolite;
plant metabolite
temefos[no description available]medium140organic sulfide;
organic thiophosphate;
organothiophosphate insecticide		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
ectoparasiticide
tretinoin[no description available]medium70retinoic acid;
vitamin A		anti-inflammatory agent;
antineoplastic agent;
antioxidant;
AP-1 antagonist;
human metabolite;
keratolytic drug;
retinoic acid receptor agonist;
retinoid X receptor agonist;
signalling molecule
citral[no description available]medium20enal;
monoterpenoid;
polyprenal		plant metabolite;
volatile oil component
isotretinoin[no description available]medium10retinoic acidantineoplastic agent;
keratolytic drug;
teratogenic agent
retinaldehyde[no description available]medium10retinal;
vitamin A		gap junctional intercellular communication inhibitor;
human metabolite;
mouse metabolite
retinol[no description available]medium10retinol;
vitamin A		human metabolite;
mouse metabolite;
plant metabolite
decamethrin[no description available]medium20aromatic ether;
cyclopropanecarboxylate ester;
nitrile;
organobromine compound		agrochemical;
antifeedant;
calcium channel agonist;
EC 3.1.3.16 (phosphoprotein phosphatase) inhibitor;
pyrethroid ester insecticide
mifepristone[no description available]medium103-oxo-Delta(4) steroid;
acetylenic compound;
tertiary amino compound		abortifacient;
contraceptive drug;
hormone antagonist;
synthetic oral contraceptive
glycogen[no description available]medium20
sirolimus[no description available]medium10antibiotic antifungal drug;
cyclic acetal;
cyclic ketone;
ether;
macrolide lactam;
organic heterotricyclic compound;
secondary alcohol		antibacterial drug;
anticoronaviral agent;
antineoplastic agent;
bacterial metabolite;
geroprotector;
immunosuppressive agent;
mTOR inhibitor
pyrethrins[no description available]medium191
methyl farnesoate[no description available]medium30enoate ester;
fatty acid methyl ester;
juvenile hormone		crustacean metabolite
piperonyl butoxide[no description available]medium50benzodioxolespesticide synergist
metformin[no description available]medium10guanidinesenvironmental contaminant;
geroprotector;
hypoglycemic agent;
xenobiotic
sesquiterpenes[no description available]medium140
raspberry ketone[no description available]medium10methyl ketone;
phenols		androgen antagonist;
cosmetic;
flavouring agent;
fragrance;
hepatoprotective agent;
metabolite
isoxazoles[no description available]medium11isoxazoles;
mancude organic heteromonocyclic parent;
monocyclic heteroarene
spinetoram[no description available]medium10organic molecular entity
imidacloprid[no description available]medium147imidacloprid;
imidazolidines;
monochloropyridine		environmental contaminant;
genotoxin;
neonicotinoid insectide;
nicotinic acetylcholine receptor agonist;
xenobiotic
paraquat[no description available]medium20organic cationgeroprotector;
herbicide
amitraz[no description available]medium159formamidines;
tertiary amino compound		acaricide;
environmental contaminant;
insecticide;
xenobiotic
fenvalerate[no description available]medium20aromatic ether;
carboxylic ester;
monochlorobenzenes		pyrethroid ester acaricide;
pyrethroid ester insecticide
permethrin[no description available]medium186cyclopropanecarboxylate ester;
cyclopropanes		agrochemical;
ectoparasiticide;
pyrethroid ester acaricide;
pyrethroid ester insecticide;
scabicide
1-anilino-8-naphthalenesulfonate[no description available]medium10aminonaphthalene;
naphthalenesulfonic acid		fluorescent probe
octopamine[no description available]medium40phenylethanolamines;
tyramines		neurotransmitter
alpha-farnesene[no description available]medium10alpha-farnesene
precocene i[no description available]medium20aromatic ether;
chromenes		plant metabolite;
precocenes
epofenonane[no description available]medium10
piperidines[no description available]medium20
sr141716[no description available]medium10amidopiperidine;
carbohydrazide;
dichlorobenzene;
monochlorobenzenes;
pyrazoles		anti-obesity agent;
appetite depressant;
CB1 receptor antagonist
3-(2-hydroxy-4-(1,1-dimethylheptyl)phenyl)-4-(3-hydroxypropyl)cyclohexanol[no description available]medium10alkylbenzene;
ring assembly
sanguinarine[no description available]medium20alkaloid antibiotic;
benzophenanthridine alkaloid;
botanical anti-fungal agent
chelerythrine[no description available]medium20benzophenanthridine alkaloid;
organic cation		antibacterial agent;
antineoplastic agent;
EC 2.7.11.13 (protein kinase C) inhibitor
glutamic acid[no description available]medium10glutamic acid;
glutamine family amino acid;
L-alpha-amino acid;
proteinogenic amino acid		Escherichia coli metabolite;
ferroptosis inducer;
micronutrient;
mouse metabolite;
neurotransmitter;
nutraceutical
cyclohexanol[no description available]medium10cyclohexanols;
secondary alcohol		solvent
indoxacarb[no description available]medium11methyl ester;
organochlorine insecticide		voltage-gated sodium channel blocker
nikkomycin[no description available]medium10
tyrosine[no description available]medium10amino acid zwitterion;
erythrose 4-phosphate/phosphoenolpyruvate family amino acid;
L-alpha-amino acid;
proteinogenic amino acid;
tyrosine		EC 1.3.1.43 (arogenate dehydrogenase) inhibitor;
fundamental metabolite;
micronutrient;
nutraceutical
inositol 1,4,5-trisphosphate[no description available]medium10myo-inositol trisphosphatemouse metabolite
flumethrin[no description available]medium21
arachidonic acid[no description available]medium10icosa-5,8,11,14-tetraenoic acid;
long-chain fatty acid;
omega-6 fatty acid		Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
human metabolite;
mouse metabolite
cyphenothrin[no description available]medium10cyclopropanecarboxylate esteragrochemical;
pyrethroid ester insecticide
riboflavin[no description available]medium10flavin;
vitamin B2		anti-inflammatory agent;
antioxidant;
cofactor;
Escherichia coli metabolite;
food colouring;
fundamental metabolite;
human urinary metabolite;
mouse metabolite;
photosensitizing agent;
plant metabolite
palmitoleic acid[no description available]medium10hexadec-9-enoic acidalgal metabolite;
Daphnia galeata metabolite;
EC 3.1.1.1 (carboxylesterase) inhibitor;
Escherichia coli metabolite;
human blood serum metabolite
linoleic acid[no description available]medium10octadecadienoic acid;
omega-6 fatty acid		algal metabolite;
Daphnia galeata metabolite;
plant metabolite
metaflumizone[no description available]medium31semicarbazone;
stilbenoid
diphenylhexatriene[no description available]medium10alkatrienefluorochrome
1-(4'-carboxyethyl)-6-diphenyl-1,3,5-hexatriene[no description available]medium10
selamectin[no description available]medium10
transforming growth factor beta[no description available]medium10
pyriprole[no description available]medium11pyrazoles;
ring assembly
trehalose[no description available]medium20trehaloseEscherichia coli metabolite;
geroprotector;
human metabolite;
mouse metabolite;
Saccharomyces cerevisiae metabolite
am 251[no description available]medium10amidopiperidine;
carbohydrazide;
dichlorobenzene;
organoiodine compound;
pyrazoles		antidepressant;
antineoplastic agent;
apoptosis inducer;
CB1 receptor antagonist
tebufenozide[no description available]medium40carbohydrazideecdysone agonist;
environmental contaminant;
xenobiotic
hydrazine[no description available]medium60azane;
hydrazines		EC 4.3.1.10 (serine-sulfate ammonia-lyase) inhibitor
methoxyfenozide[no description available]medium20carbohydrazide;
monomethoxybenzene		environmental contaminant;
insecticide;
xenobiotic
acetone[no description available]medium40ketone body;
methyl ketone;
propanones;
volatile organic compound		EC 3.5.1.4 (amidase) inhibitor;
human metabolite;
polar aprotic solvent
isoflurophate[no description available]medium10dialkyl phosphate
3-octylthio-1,1,1-trifluoro-2-propanone[no description available]medium20
bombykol[no description available]medium10long-chain primary fatty alcoholpheromone
ethyl oleate[no description available]medium10long-chain fatty acid ethyl esteracaricide;
plant metabolite
cellulase[no description available]medium10cellotriose
bifenthrin[no description available]medium10carboxylic ester;
cyclopropanecarboxylate ester;
cyclopropanes;
organochlorine compound;
organofluorine compound		pyrethroid ester acaricide;
pyrethroid ester insecticide
biliverdine[no description available]medium10
butyl phosphorotrithioate[no description available]medium10organic thiophosphatedefoliant
dactinomycin[no description available]medium20actinomycinmutagen
puromycin[no description available]medium10puromycinsantiinfective agent;
antimicrobial agent;
antineoplastic agent;
EC 3.4.11.14 (cytosol alanyl aminopeptidase) inhibitor;
EC 3.4.14.2 (dipeptidyl-peptidase II) inhibitor;
nucleoside antibiotic;
protein synthesis inhibitor
amanitins[no description available]medium10
(3S,5S,6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid[no description available]medium10(6E)-7-[3-(4-fluorophenyl)-1-(propan-2-yl)-1H-indol-2-yl]-3,5-dihydroxyhept-6-enoic acid
carbaryl[no description available]medium10carbamate ester;
naphthalenes		acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
plant growth retardant
phenothrin[no description available]medium20cyclopropanecarboxylate esterpyrethroid ester insecticide
n-(2-ethylhexyl)-5-norbornene-2,3-dicarboxamide[no description available]medium10
malathion[no description available]medium20diester;
ethyl ester;
organic thiophosphate
sucrose[no description available]medium10glycosyl glycosidealgal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
osmolyte;
Saccharomyces cerevisiae metabolite;
sweetening agent
cyromazine[no description available]medium40triamino-1,3,5-triazinemouse metabolite;
triazine insecticide
carbamates[no description available]medium100amino-acid anion
1,2-dibenzoyl-tert-butylhydrazine[no description available]medium20bisacylhydrazine insecticide
transferrin[no description available]medium10
benfuracarb[no description available]medium101-benzofurans;
carbamate ester;
ethyl ester		agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
beta-alanine[no description available]medium10amino acid zwitterion;
beta-amino acid		agonist;
fundamental metabolite;
human metabolite;
inhibitor;
neurotransmitter
benzofurans[no description available]medium10
rh-0345[no description available]medium10bisacylhydrazine insecticide;
monochlorobenzenes
bisphenol a[no description available]medium10bisphenolendocrine disruptor;
environmental contaminant;
xenobiotic;
xenoestrogen
phytol[no description available]medium10
glycine[no description available]medium20alpha-amino acid;
amino acid zwitterion;
proteinogenic amino acid;
serine family amino acid		EC 2.1.2.1 (glycine hydroxymethyltransferase) inhibitor;
fundamental metabolite;
hepatoprotective agent;
micronutrient;
neurotransmitter;
NMDA receptor agonist;
nutraceutical
estrone[no description available]medium1017-oxo steroid;
3-hydroxy steroid;
phenolic steroid;
phenols		antineoplastic agent;
bone density conservation agent;
estrogen;
human metabolite;
mouse metabolite
am 580[no description available]medium10amidobenzoic acid;
tetralins		antineoplastic agent;
retinoic acid receptor alpha/beta agonist
4-(2-(5,6,7,8-tetrahydro-5,5,8,8-tetramethyl-2-naphthalenyl)-1-propenyl)benzoic acid[no description available]medium10benzoic acids;
naphthalenes;
retinoid		antineoplastic agent;
retinoic acid receptor agonist;
teratogenic agent
lactic acid[no description available]medium202-hydroxy monocarboxylic acidalgal metabolite;
Daphnia magna metabolite
D-fructopyranose[no description available]medium10cyclic hemiketal;
D-fructose;
fructopyranose		sweetening agent
allatotropin[no description available]medium10
pirimiphos methyl[no description available]medium20aminopyrimidine;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
environmental contaminant;
insecticide
precocene ii[no description available]medium30chromenesprecocenes
2-methylpentane[no description available]medium10alkane
alitretinoin[no description available]medium20retinoic acidantineoplastic agent;
keratolytic drug;
metabolite;
retinoid X receptor agonist
gold[no description available]medium10copper group element atom;
elemental gold
floxuridine[no description available]medium10nucleoside analogue;
organofluorine compound;
pyrimidine 2'-deoxyribonucleoside		antimetabolite;
antineoplastic agent;
antiviral drug;
radiosensitizing agent
farnesol[no description available]medium30farnesolplant metabolite
cyclopren[no description available]medium10
lignin[no description available]medium10
cellulose[no description available]medium10glycoside
levamisole[no description available]medium106-phenyl-2,3,5,6-tetrahydroimidazo[2,1-b][1,3]thiazoleantinematodal drug;
antirheumatic drug;
EC 3.1.3.1 (alkaline phosphatase) inhibitor;
immunological adjuvant;
immunomodulator
methomyl[no description available]medium10aliphatic sulfide;
carbamate ester		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
environmental contaminant;
insecticide;
nematicide;
xenobiotic
ethoxyprecocene[no description available]medium20chromenesprecocenes
leucine[no description available]medium20amino acid zwitterion;
L-alpha-amino acid;
leucine;
proteinogenic amino acid;
pyruvate family amino acid		algal metabolite;
Escherichia coli metabolite;
human metabolite;
mouse metabolite;
plant metabolite;
Saccharomyces cerevisiae metabolite
resmethrin[no description available]medium10cyclopropanecarboxylate ester;
furans		agrochemical;
pyrethroid ester insecticide
fluphenacur[no description available]medium20aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organofluorine compound
phencyclidine[no description available]medium40benzenes;
piperidines		anaesthetic;
neurotoxin;
NMDA receptor antagonist;
psychotropic drug
teflubenzuron[no description available]medium20dichlorobenzene;
difluorobenzene;
N-acylurea		environmental contaminant;
insecticide;
xenobiotic
flufenoxuron[no description available]medium10(trifluoromethyl)benzenes;
benzoylurea insecticide;
difluorobenzene;
monochlorobenzenes;
monofluorobenzenes		mite growth regulator
thymidine[no description available]medium20pyrimidine 2'-deoxyribonucleosideEscherichia coli metabolite;
human metabolite;
metabolite;
mouse metabolite
dichlorvos[no description available]medium20alkenyl phosphate;
dialkyl phosphate;
organochlorine acaricide;
organophosphate insecticide		anthelminthic drug;
antibacterial agent;
antifungal agent;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor
fenitrothion[no description available]medium10C-nitro compound;
organic thiophosphate		acaricide;
agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
methionine[no description available]medium10aspartate family amino acid;
L-alpha-amino acid;
methionine zwitterion;
methionine;
proteinogenic amino acid		antidote to paracetamol poisoning;
human metabolite;
micronutrient;
mouse metabolite;
nutraceutical
c.i. fluorescent brightening agent 28[no description available]medium10
citronellal[no description available]medium10aldehyde;
monoterpenoid		antifungal agent;
metabolite
triflumuron[no description available]medium20aromatic ether;
benzoylurea insecticide;
monochlorobenzenes;
organofluorine compound
endosulfan[no description available]medium10cyclic sulfite ester;
cyclodiene organochlorine insecticide		acaricide;
agrochemical;
GABA-gated chloride channel antagonist;
persistent organic pollutant
glutamine[no description available]medium10amino acid zwitterion;
glutamine family amino acid;
glutamine;
L-alpha-amino acid;
polar amino acid zwitterion;
proteinogenic amino acid		EC 1.14.13.39 (nitric oxide synthase) inhibitor;
Escherichia coli metabolite;
human metabolite;
metabolite;
micronutrient;
mouse metabolite;
nutraceutical;
Saccharomyces cerevisiae metabolite
cycloheximide[no description available]medium10antibiotic fungicide;
cyclic ketone;
dicarboximide;
piperidine antibiotic;
piperidones;
secondary alcohol		anticoronaviral agent;
bacterial metabolite;
ferroptosis inhibitor;
neuroprotective agent;
protein synthesis inhibitor
uridine[no description available]medium20uridinesdrug metabolite;
fundamental metabolite;
human metabolite
pilocarpine[no description available]medium10pilocarpineantiglaucoma drug
dieldrin[no description available]medium10epoxide;
organochlorine compound;
organochlorine insecticide		carcinogenic agent;
xenobiotic
ddt[no description available]medium20benzenoid aromatic compound;
chlorophenylethane;
monochlorobenzenes;
organochlorine insecticide		bridged diphenyl acaricide;
carcinogenic agent;
endocrine disruptor;
persistent organic pollutant
deoxycholic acid[no description available]medium10bile acid;
C24-steroid;
dihydroxy-5beta-cholanic acid		human blood serum metabolite
phenyl acetate[no description available]medium20benzenes;
phenyl acetates
caseins[no description available]medium10
lactose[no description available]medium10lactose
alkenes[no description available]medium10
tricalcium phosphate[no description available]medium10calcium phosphate
hexadimethrine bromide[no description available]medium10
calcium phosphate, dibasic, anhydrous[no description available]medium10calcium phosphate
calcium phosphate, monobasic, anhydrous[no description available]medium10calcium phosphatefertilizer
calcium pyrophosphate[no description available]medium10
arosurf[no description available]medium10
1,1-difluoroethane[no description available]medium10
propoxur[no description available]medium10aromatic ether;
carbamate ester		acaricide;
agrochemical;
carbamate insecticide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
1,1,1-trichloroethane[no description available]medium10chloroethanespolar solvent
methylene chloride[no description available]medium10chloromethanes;
volatile organic compound		carcinogenic agent;
polar aprotic solvent;
refrigerant
hexafluoron[no description available]medium10aromatic ether;
benzoylurea insecticide;
dichlorobenzene;
N-acylurea;
organochlorine insecticide;
organofluorine insecticide
fenthion[no description available]medium10organic thiophosphateacaricide;
agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor;
EC 3.1.1.8 (cholinesterase) inhibitor;
insecticide
exudates[no description available]medium10
eye[no description available]medium21
glyphosate[no description available]medium20glycine derivative;
phosphonic acid		agrochemical;
EC 2.5.1.19 (3-phosphoshikimate 1-carboxyvinyltransferase) inhibitor;
herbicide
ants[no description available]medium150
trazodone hydrochloride[no description available]medium40hydrochlorideadrenergic antagonist;
antidepressant;
H1-receptor antagonist;
sedative;
serotonin uptake inhibitor
sabinene[no description available]medium10thujeneplant metabolite
methanol[no description available]medium20alkyl alcohol;
one-carbon compound;
primary alcohol;
volatile organic compound		amphiprotic solvent;
Escherichia coli metabolite;
fuel;
human metabolite;
mouse metabolite;
Mycoplasma genitalium metabolite
fenofibrate[no description available]low00aromatic ether;
chlorobenzophenone;
isopropyl ester;
monochlorobenzenes		antilipemic drug;
environmental contaminant;
geroprotector;
xenobiotic
isradipine[no description available]low00benzoxadiazole;
dihydropyridine;
isopropyl ester;
methyl ester
diisopropyl 1,3-dithiol-2-ylidenemalonate[no description available]low00isopropyl ester
nilvadipine[no description available]low00dihydropyridine;
isopropyl ester;
methyl ester;
nitrile
nimodipine[no description available]low002-methoxyethyl ester;
C-nitro compound;
dicarboxylic acids and O-substituted derivatives;
diester;
dihydropyridine;
isopropyl ester		antihypertensive agent;
calcium channel blocker;
cardiovascular drug;
vasodilator agent
isopropyl palmitate[no description available]low00fatty acid ester;
isopropyl ester		human metabolite
isofenphos[no description available]low00isopropyl ester;
organic phosphonate;
organothiophosphate insecticide;
phosphonic ester;
salicylates		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
isoprothiolane[no description available]low00dithiolanes;
isopropyl ester;
malonate ester		antifungal agrochemical;
environmental contaminant;
insecticide;
phospholipid biosynthesis inhibitor
Nitrothal-isopropyl[no description available]low00diester;
isopropyl ester;
nitrobenzoic acid
azelnidipine[no description available]low00isopropyl ester
npk 1886[no description available]low00dihydropyridine;
isopropyl ester;
methyl ester
bay 93820[no description available]low00isopropyl ester;
organic phosphonate;
organothiophosphate insecticide;
phosphonic ester;
salicylates		agrochemical;
avicide;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
pn 202-791[no description available]low00benzoxadiazole;
isopropyl ester
yh 439[no description available]low00aromatic amide;
isopropyl ester;
secondary carboxamide
sandoz-21-009[no description available]low00indolyl carboxylate ester;
isopropyl ester
2-[(5,5-dimethyl-6H-[1,2,4]triazolo[3,4-a]isoquinolin-3-yl)thio]acetic acid propan-2-yl ester[no description available]low00isopropyl ester;
triazolopyridine
4-[(3-cyano-4,6-dimethyl-2-pyridinyl)thio]-3-oxobutanoic acid propan-2-yl ester[no description available]low00aryl sulfide;
isopropyl ester
2-[[4-amino-5-(4-tert-butylphenyl)-1,2,4-triazol-3-yl]thio]acetic acid propan-2-yl ester[no description available]low00isopropyl ester;
triazoles
2-[(3-methyl-6-oxo-7,8,9,10-tetrahydrobenzo[c][1]benzopyran-1-yl)oxy]acetic acid propan-2-yl ester[no description available]low00coumarins;
isopropyl ester
4-[[2-furanyl(oxo)methyl]amino]benzoic acid propan-2-yl ester[no description available]low00aromatic amide;
furans;
isopropyl ester;
secondary carboxamide
2-amino-5-[diethylamino(oxo)methyl]-4-methyl-3-thiophenecarboxylic acid propan-2-yl ester[no description available]low00aromatic amine;
isopropyl ester;
tertiary carboxamide;
thiophenes
2-[[oxo(thiophen-2-yl)methyl]amino]-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester[no description available]low00aromatic amide;
isopropyl ester;
secondary carboxamide;
thiophenes
4-[[(4-bromo-2-ethyl-3-pyrazolyl)-oxomethyl]amino]benzoic acid propan-2-yl ester[no description available]low00aromatic amide;
isopropyl ester;
secondary carboxamide
4-[[[5-[(4-chloro-3,5-dimethyl-1-pyrazolyl)methyl]-2-furanyl]-oxomethyl]amino]benzoic acid propan-2-yl ester[no description available]low00aromatic amide;
furans;
isopropyl ester
2-[3-oxo-1-[[[oxo(thiophen-2-yl)methyl]amino]-sulfanylidenemethyl]-2-piperazinyl]acetic acid propan-2-yl ester[no description available]low00isopropyl ester;
piperazines
2-[1-[[[(4-methoxyphenyl)-oxomethyl]amino]-sulfanylidenemethyl]-3-oxo-2-piperazinyl]acetic acid propan-2-yl ester[no description available]low00isopropyl ester;
piperazines
3,4-dimethyl-6-phenyl-2-sulfanylidene-1,6-dihydropyrimidine-5-carboxylic acid propan-2-yl ester[no description available]low00isopropyl ester;
pyrimidinethione
1-methyl-4-[2-oxo-2-(N-(phenylmethyl)anilino)ethyl]-5-pyrrolo[3,2-b]pyrrolecarboxylic acid propan-2-yl ester[no description available]low00isopropyl ester;
tertiary carboxamide
1-(4-amino-1,2,5-oxadiazol-3-yl)-5-[(2-pyridinylthio)methyl]-4-triazolecarboxylic acid propan-2-yl ester[no description available]low00aryl sulfide;
azole;
isopropyl ester;
oxadiazole;
pyridines
2-[(4-oxo-2-pyrido[1,2-a]pyrimidinyl)methylthio]-3-pyridinecarboxylic acid propan-2-yl ester[no description available]low00isopropyl ester;
pyridopyrimidine
2-[4-(3-chlorophenyl)-1-piperazinyl]-3-pyridinecarboxylic acid propan-2-yl ester[no description available]low00isopropyl ester;
piperazines;
pyridines
2-[[2-(3,4-dimethoxyanilino)-2-oxoethyl]thio]-3-pyridinecarboxylic acid propan-2-yl ester[no description available]low00dimethoxybenzene;
isopropyl ester;
secondary carboxamide
2-(benzenesulfonamido)-6-methyl-4,5,6,7-tetrahydro-1-benzothiophene-3-carboxylic acid propan-2-yl ester[no description available]low00isopropyl ester;
sulfonamide
uf 021[no description available]low00isopropyl ester;
ketone;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
prodrug
travoprost[no description available]low00(trifluoromethyl)benzenes;
isopropyl ester;
prostaglandins Falpha		antiglaucoma drug;
antihypertensive agent;
ophthalmology drug;
prodrug;
prostaglandin receptor agonist
latanoprost[no description available]low00isopropyl ester;
prostaglandins Falpha;
triol		antiglaucoma drug;
antihypertensive agent;
EC 4.2.1.1 (carbonic anhydrase) inhibitor;
prodrug
propetamphos[no description available]low00isopropyl ester;
organophosphate insecticide;
phosphoramidate ester		agrochemical;
EC 3.1.1.7 (acetylcholinesterase) inhibitor
l 744832[no description available]low00benzenes;
ether;
isopropyl ester;
secondary carboxamide;
sulfone;
thiol		antineoplastic agent;
EC 2.5.1.58 (protein farnesyltransferase) inhibitor;
geroprotector
gs-7340[no description available]low006-aminopurines;
ether;
isopropyl ester;
L-alanine derivative;
phosphoramidate ester		antiviral drug;
HIV-1 reverse transcriptase inhibitor;
prodrug
tafluprost[no description available]low00isopropyl ester;
organofluorine compound;
prostaglandins Falpha		prostaglandin receptor agonist
t 98475[no description available]low00isopropyl ester;
thienopyridine
sofosbuvir[no description available]low00isopropyl ester;
L-alanyl ester;
nucleotide conjugate;
organofluorine compound;
phosphoramidate ester		antiviral drug;
hepatitis C protease inhibitor;
prodrug
molnupiravir[no description available]low00isopropyl ester;
ketoxime;
nucleoside analogue		anticoronaviral agent;
antiviral drug;
prodrug
ConditionIndicatedRelationship StrengthStudiesTrials
Anemia, Fanconi0low10
Encephalitis, Polio0low10
Epidemic Acute Poliomyelitis0low10
Fanconi Anemia0low10
Fanconi Hypoplastic Anemia0low10
Fanconi Pancytopenia0low10
Fanconi Panmyelopathy0low10
Fanconi's Anemia0low10
Infantile Paralysis0low10
Polio0low10
Polio Encephalitis0low10
Poliomyelitis0low10
Poliomyelitis Infection0low10
Poliomyelitis, Acute0low10
Poliomyelitis, Nonpoliovirus0low10
Poliomyelitis, Preparalytic0low10
Abnormalities, Drug-Induced0low20
Acariasis0medium43
Acute Disease0low10
African Sleeping Sickness0low10
African Trypanosomiasis0low10
Aggression0low10
Aging0low120
Allergic Reaction0low10
Allergy0low10
Alpha Virus Infections0low20
Alphavirus Infections0low20
American Trypanosomiasis0low10
Ancylostomiasis0low10
Anesthesia0low10
Angiostrongylus Infections0medium21
Avian Diseases0low10
B. burgdorferi Infection0medium11
Babesia Infection0medium11
Babesia Parasite Infection0medium11
Babesiasis0medium11
Babesiosis0medium11
Barmah Forest Virus Infection0low20
Bertielliasis0medium41
Bird Diseases0low10
Bites0low10
Bites and Stings0low10
Black Death0low10
Black Plague0low10
Body Weight0low70
Borrelia burgdorferi Infection0medium11
Break-Bone Fever0low30
Breakbone Fever0low30
Bubonic Plague0low10
Canine Diseases0medium3818
Capillaria hepatica Infection0low10
Capillaria Infections0low10
Capillaria philippinensis Infection0low10
Capillariasis0low10
Cat Diseases0medium298
Cenuriasis0medium41
Cestode Infections0medium41
Chagas Disease0low10
Chagas' Disease0low10
Classical Dengue0low30
Classical Dengue Fever0low30
Coenuriasis0medium41
Communicable Diseases, Emerging0low20
Communicable Diseases, Re-Emerging0low20
Communicable Diseases, Reemerging0low20
Congenital Zika Syndrome0low20
Congenital Zika Virus Infection0low20
Cross Infection0low10
Cystic Echinococcosis0low10
Cysts, Hydatid0low10
Decapitation0low10
Dengue0low30
Dengue Fever0low30
Dermatitis0medium21
Diabetes Insipidus0low10
Diabetes Mellitus, Adult-Onset0low10
Diabetes Mellitus, Ketosis-Resistant0low10
Diabetes Mellitus, Maturity-Onset0low10
Diabetes Mellitus, Non Insulin Dependent0low10
Diabetes Mellitus, Non-Insulin-Dependent0low10
Diabetes Mellitus, Noninsulin Dependent0low10
Diabetes Mellitus, Noninsulin-Dependent0low10
Diabetes Mellitus, Slow-Onset0low10
Diabetes Mellitus, Stable0low10
Diabetes Mellitus, Type 20low10
Diabetes Mellitus, Type II0low10
Dioctophyma renale Infections0low10
Dipylidiasis0medium41
Dirofilariasis0low10
Disease Models, Animal0low10
Dog Diseases0medium3818
Drug-Induced Abnormalities0low20
E chaffeensis Infection0medium32
E ewingii Infection0medium32
E. chaffeensis Infection0medium32
E. ewingii Infection0medium32
Ear Diseases0medium11
Echinococcosis0low10
Echinococcus Granulosus Infection0low10
Echinococcus Infection0low10
Ectoparasitic Infestations0low50
Ehrlichia chaffeensis Infection0medium32
Ehrlichia ewingii Infection0medium32
Ehrlichia Infection0medium32
Ehrlichiosis0medium32
Encephalitis, Equine0low10
Encephalitis, West Nile Fever0low60
Encephalomyelitis, Equine0low10
Enoplida Infections0low10
Equine Encephalitis0low10
Equine Encephalomyelitis Viral Infections0low10
Equine Encephalomyelitis Virus Infections0low10
Experimental Neoplasms0low10
Feline Diseases0medium298
Fever, Zika0low20
Flea Infestations0medium147
Habronemiasis0medium11
Health Care Associated Infection0low10
Health Care Associated Infections0low10
Healthcare Associated Infections0low10
Heartworm Disease0low10
Hepatic Capillariasis0low10
Hospital Infections0low10
Human Babesiosis0medium11
Human Ehrlichiosis0medium32
Hydatid Cyst0low10
Hydatid Disease0low10
Hydatidosis0low10
Hypersensitivity0low10
Hypertrophy0low10
Infection, Cross0low10
Infections, Alphavirus0low20
Infections, Dioctophyma renale0low10
Infections, Enoplida0low10
Infections, Equine Encephalomyelitis Virus0low10
Infections, Hospital0low10
Infections, Nematode0low20
Infections, Nosocomial0low10
Infections, Plasmodium0low30
Infections, Spirurida0medium11
Infections, Stephanurus dentatus0medium21
Infections, Strongylida0medium21
Infections, Tick-Borne0low20
Infectious Diseases, Emerging0low20
Infectious Diseases, Re-Emerging0low20
Infectious Diseases, Reemerging0low20
Infertility, Male0low10
Inflammation0medium21
Innate Inflammatory Response0medium21
Insect Bites0medium21
Insect Bites and Stings0medium21
Insect Stings0medium21
Intestinal Capillariasis0low10
Intestinal Diseases, Parasitic0low10
Itching0medium21
Leishmaniasis, American0low20
Leishmaniasis, Cutaneous0low20
Leishmaniasis, New World0low20
Leishmaniasis, Old World0low20
Lyme Arthritis0medium11
Lyme Borreliosis0medium11
Lyme Disease0medium11
Maggot Infestations0low10
Malaria0low30
Mange0medium43
Marsh Fever0low30
Maturity-Onset Diabetes0low10
Maturity-Onset Diabetes Mellitus0low10
Mayaro Virus Infection0low20
Meningeal Plague0low10
Mite Infestations0medium43
MODY0low10
Myiasis0low10
Nagana0low10
Nematode Infections0low20
Neoplasms, Experimental0low10
NIDDM0low10
Noninsulin-Dependent Diabetes Mellitus0low10
Nosocomial Infections0low10
O'nyong-nyong Virus Infection0low20
Oriental Sore0low20
Otologic Diseases0medium11
Otological Diseases0medium11
Ovine Diseases0low10
Paludism0low30
Parasitemia0low20
Parasitic Diseases, Animal0low10
Parasitic Infections, Animal0low10
Parasitic Intestinal Diseases0low10
Pemphigus0low10
Pemphigus Foliaceus0low10
Pemphigus Vulgaris0low10
Piroplasmosis0medium11
Plague0low10
Plasmodium Infections0low30
Pneumonic Plague0low10
Polyploid0low10
Polyploid Cell0low10
Polyploidy0low10
Poultry Diseases0low10
Pregnancy0medium21
Pruritis0medium21
Pruritus0medium21
Pulmonic Plague0low10
Raillietiniasis0medium41
Remittent Fever0low30
Rift Valley Fever0low10
Ross River Virus Infection0low20
Sensitivity and Specificity0low20
Septicemic Plague0low10
Sheep Diseases0low10
Spirurida Infections0medium11
Starvation0low30
Stephanurus dentatus Infections0medium21
Sterility, Male0low10
Stings0low10
Stings and Bites0low10
Strongylida Infections0medium21
Sub-Fertility, Male0low10
Subfertility, Male0low10
Syngamiasis0medium21
Tapeworm Infection0medium41
Tick Borne Disease0low20
Tick Infestations0medium2511
Tick Paralysis0low10
Tick-Borne Diseases0low20
Tick-Borne Infection0low20
Tick-Borne Infections0low20
Toxascariasis0low10
Toxocariasis0low10
Trypanosoma cruzi Infection0low10
Trypanosomiasis, African0low10
Trypanosomiasis, South American0low10
Type 2 Diabetes0low10
Type 2 Diabetes Mellitus0low10
West Nile Fever0low60
West Nile Fever Encephalitis0low60
West Nile Fever Meningitis0low60
West Nile Fever Meningoencephalitis0low60
West Nile Fever Myelitis0low60
West Nile Virus Infection0low60
WNV Infection0low60
Yellow Fever0low20
Yersinia pestis Infection0low10
Zika Fever0low20
Zika Virus Disease0low20
Zika Virus Infection0low20
ZikV Infection0low20

Research Highlights

Safety/Toxicity (8)

ArticleYear
A randomized, controlled field study to assess the efficacy and safety of lotilaner (Credelio™) in controlling fleas in client-owned cats in Europe.
Parasites & vectors, Jul-13, Volume: 11, Issue: 1		2018
Environmental safety review of methoprene and bacterially-derived pesticides commonly used for sustained mosquito control.
Ecotoxicology and environmental safety, Volume: 139		2017
Efficacy against nematode and cestode infections and safety of a novel topical fipronil, (S)-methoprene, eprinomectin and praziquantel combination product in domestic cats under field conditions in Europe.
Veterinary parasitology, Apr-28, Volume: 202, Issue: 1-2		2014
Toxicity of methoprene as assessed by the use of a model microorganism.
Toxicology in vitro : an international journal published in association with BIBRA, Volume: 19, Issue: 7		2005
Developmental toxicity of methoprene and several degradation products in Xenopus laevis.
Aquatic toxicology (Amsterdam, Netherlands), Jun-19, Volume: 64, Issue: 1		2003
Acute toxicity of selected pesticides to the estuarine shrimp Leander tenuicornis (Decapoda:Palaemonidae).
Journal of the American Mosquito Control Association, Volume: 12, Issue: 4		1996
Toxicity of methoprene to all stages of the salt marsh copepod, Apocyclops spartinus (Cyclopoida).
Journal of the American Mosquito Control Association, Volume: 4, Issue: 4		1988
[Toxicity of juvemon--a preparation with hormonal activity].
Gigiena i sanitariia, Issue: 10		1991
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Pharmacokinetics (1)

ArticleYear
Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel.
Veterinary parasitology, Apr-28, Volume: 202, Issue: 1-2		2014
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioavailability (3)

ArticleYear
A High-Throughput Screen of a Library of Therapeutics Identifies Cytotoxic Substrates of P-glycoprotein.
Molecular pharmacology, Volume: 96, Issue: 5		2019
Physiologically relevant orthogonal assays for the discovery of small-molecule modulators of WIP1 phosphatase in high-throughput screens.
The Journal of biological chemistry, 11-15, Volume: 294, Issue: 46		2019
Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel.
Veterinary parasitology, Apr-28, Volume: 202, Issue: 1-2		2014
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Dosage (20)

ArticleYear
Lethal and Sublethal Effects of Ingested Hydroprene and Methoprene on Development and Fecundity of the Common Bed Bug (Hemiptera: Cimicidae).
Journal of medical entomology, 07-04, Volume: 57, Issue: 4		2020
Efficacy of a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel against adult and immature stages of the cat flea (Ctenocephalides felis) on cats.
Veterinary parasitology, Apr-28, Volume: 202, Issue: 1-2		2014
Pharmacokinetics and metabolism of eprinomectin in cats when administered in a novel topical combination of fipronil, (S)-methoprene, eprinomectin and praziquantel.
Veterinary parasitology, Apr-28, Volume: 202, Issue: 1-2		2014
Methoprene effects on survival and reproductive performance of adult female and male Aedes aegypti.
Journal of the American Mosquito Control Association, Volume: 29, Issue: 4		2013
Susceptibility of eggs and adult fecundity of the lesser grain borer, Rhyzopertha dominca, exposed to methoprene.
Journal of insect science (Online), Volume: 8		2008
Susceptibility of Culex pipiens (Diptera: Culicidae) field populations in Cyprus to conventional organic insecticides, Bacillus thuringiensis subsp. israelensis, and methoprene.
Journal of medical entomology, Volume: 46, Issue: 4		2009
Control of arbovirus vector Verrallina funerea (Diptera: Culicidae) in southeast Queensland, Australia.
Journal of economic entomology, Volume: 100, Issue: 5		2007
Monitoring the fate of methoprene larvicide for West Nile virus management.
Water science and technology : a journal of the International Association on Water Pollution Research, Volume: 54, Issue: 11-12		2006
Effectiveness of methoprene, an insect growth regulator, against temephos-resistant Aedes aegypti populations from different Brazilian localities, under laboratory conditions.
Journal of medical entomology, Volume: 42, Issue: 5		2005
Comparative larvicidal toxicities of three ecdysone agonists on the mosquitoes Aedes aegypti, Culex quinquefasciatus, and Anopheles gambiae.
Archives of insect biochemistry and physiology, Volume: 57, Issue: 3		2004
Regulation of cytosolic malate dehydrogenase by juvenile hormone in Drosophila melanogaster.
Cell biochemistry and biophysics, Volume: 37, Issue: 1		2002
Exogenous juvenile hormone and methoprene, but not male accessory gland substances or ovariectomy, affect the blood/nectar choice of female Culex nigripalpus mosquitoes.
Medical and veterinary entomology, Volume: 14, Issue: 4		2000
Effects of methoprene and permethrin on paedogenetic larvae of Heteropeza pygmaea and Mycophila speyeri (Diptera: Cecidomyiidae).
Journal of economic entomology, Volume: 93, Issue: 4		2000
Acute and sublethal effects of (S)-methoprene on some Australian mosquitoes.
Journal of the American Mosquito Control Association, Volume: 13, Issue: 2		1997
Efficiency of Altosid (S-methoprene) liquid larvicide formulated on Biodac (granular carrier) against spring Aedes species in flooded woodlots.
Journal of the American Mosquito Control Association, Volume: 12, Issue: 3 Pt 1		1996
Effects of sublethal dosages of methoprene on Anopheles dirus species A and B.
Journal of the American Mosquito Control Association, Volume: 12, Issue: 3 Pt 1		1996
[Control of Monomorium pharaonis using a methoprene bait in the Berlin Zoo and its combined application with a residue insecticide in the Olomouc Children's Clinic].
Angewandte Parasitologie, Volume: 25, Issue: 2		1984
Effects of sublethal dosages of insecticides on Culex quinquefasciatus.
Journal of the American Mosquito Control Association, Volume: 5, Issue: 2		1989
Evaluation of methoprene, temephos and Bacillus thuringiensis var. israelensis against Coquillettidia perturbans larvae in Minnesota.
Journal of the American Mosquito Control Association, Volume: 2, Issue: 3		1986
Efficacy and persistence of Bacillus sphaericus, Bacillus thuringiensis var. israelensis, and methoprene against Culiseta incidens (Diptera: Culicidae) in tires.
Journal of economic entomology, Volume: 83, Issue: 4		1990
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Interactions (2)

ArticleYear
Economic feasibility of methoprene applied as a surface treatment and as an aerosol alone and in combination with two other insecticides.
Journal of economic entomology, Volume: 106, Issue: 3		2013
Efficacy of fipronil-(S)-methoprene, metaflumizone combined with amitraz, and pyriprole commercial spot-on products in preventing Culex pipiens pipiens from feeding on dogs.
The Veterinary record, Aug-01, Volume: 165, Issue: 5		2009
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]