chloroquine has been researched along with Chagas Disease in 12 studies
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.
chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Patients with chronic Trypanosoma cruzi infections have peripheral auto-anti-idiotype (Id) T cells that proliferate on exposure to immunoaffinity-purified antibodies against T." | 1.28 | Two modes of idiotypic stimulation of T lymphocytes from patients with Chagas' disease: correlations with clinical forms of infection. ( Brener, Z; Cançado, JR; Cardoso, JE; Colley, DG; Gazzinelli, G; Gazzinelli, RT, 1990) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (16.67) | 18.7374 |
| 1990's | 1 (8.33) | 18.2507 |
| 2000's | 1 (8.33) | 29.6817 |
| 2010's | 5 (41.67) | 24.3611 |
| 2020's | 3 (25.00) | 2.80 |
| Authors | Studies |
|---|---|
| Bollini, M | 1 |
| Casal, JJ | 1 |
| Alvarez, DE | 1 |
| Boiani, L | 1 |
| González, M | 1 |
| Cerecetto, H | 1 |
| Bruno, AM | 1 |
| Long, TE | 1 |
| Lu, X | 1 |
| Galizzi, M | 1 |
| Docampo, R | 1 |
| Gut, J | 1 |
| Rosenthal, PJ | 1 |
| Patrick, DA | 1 |
| Ismail, MA | 1 |
| Arafa, RK | 1 |
| Wenzler, T | 1 |
| Zhu, X | 1 |
| Pandharkar, T | 1 |
| Jones, SK | 1 |
| Werbovetz, KA | 1 |
| Brun, R | 2 |
| Boykin, DW | 1 |
| Tidwell, RR | 1 |
| Parra, LLL | 1 |
| Bertonha, AF | 1 |
| Severo, IRM | 1 |
| Aguiar, ACC | 1 |
| de Souza, GE | 1 |
| Oliva, G | 1 |
| Guido, RVC | 1 |
| Grazzia, N | 1 |
| Costa, TR | 1 |
| Miguel, DC | 1 |
| Gadelha, FR | 1 |
| Ferreira, AG | 1 |
| Hajdu, E | 1 |
| Romo, D | 1 |
| Berlinck, RGS | 1 |
| Saccoliti, F | 1 |
| Madia, VN | 1 |
| Tudino, V | 1 |
| De Leo, A | 1 |
| Pescatori, L | 1 |
| Messore, A | 1 |
| De Vita, D | 1 |
| Scipione, L | 1 |
| Kaiser, M | 2 |
| Mäser, P | 1 |
| Calvet, CM | 1 |
| Jennings, GK | 1 |
| Podust, LM | 1 |
| Costi, R | 1 |
| Di Santo, R | 1 |
| Wang, X | 1 |
| Cal, M | 1 |
| Buckner, FS | 1 |
| Lepesheva, GI | 1 |
| Sanford, AG | 1 |
| Wallick, AI | 1 |
| Davis, PH | 1 |
| Vennerstrom, JL | 1 |
| Pandey, RP | 1 |
| Nascimento, MS | 1 |
| Franco, CH | 1 |
| Bortoluci, K | 1 |
| Silva, MN | 1 |
| Zingales, B | 1 |
| Gibaldi, D | 1 |
| Castaño Barrios, L | 1 |
| Lannes-Vieira, J | 1 |
| Cariste, LM | 1 |
| Vasconcelos, JR | 1 |
| Moraes, CB | 1 |
| Freitas-Junior, LH | 1 |
| Kalil, J | 1 |
| Alcântara, L | 1 |
| Cunha-Neto, E | 1 |
| da Cruz Filho, IJ | 1 |
| Duarte, DMFA | 1 |
| da Conceição Alves de Lima, D | 1 |
| Marques, DSC | 1 |
| Dos Santos, FAB | 1 |
| Alves, LC | 1 |
| de Lima Aires, A | 1 |
| Nogueira, F | 1 |
| do Carmo Alves de Lima, M | 1 |
| Min-Oo, G | 1 |
| Ayi, K | 1 |
| Bongfen, SE | 1 |
| Tam, M | 1 |
| Radovanovic, I | 1 |
| Gauthier, S | 1 |
| Santiago, H | 1 |
| Rothfuchs, AG | 1 |
| Roffê, E | 1 |
| Sher, A | 1 |
| Mullick, A | 1 |
| Fortin, A | 1 |
| Stevenson, MM | 1 |
| Kain, KC | 1 |
| Gros, P | 1 |
| TELLA, A | 1 |
| Gazzinelli, RT | 1 |
| Gazzinelli, G | 1 |
| Cançado, JR | 1 |
| Cardoso, JE | 1 |
| Brener, Z | 1 |
| Colley, DG | 1 |
| Bruce-Chwatt, LJ | 1 |
1 review available for chloroquine and Chagas Disease
| Article | Year |
|---|---|
Transfusion associated parasitic infections.
Topics: Animals; Babesiosis; Blood Donors; Blood Transfusion; Carrier State; Chagas Disease; Chloroquine; He | 1985 |
11 other studies available for chloroquine and Chagas Disease
| Article | Year |
|---|---|
New potent imidazoisoquinolinone derivatives as anti-Trypanosoma cruzi agents: biological evaluation and structure-activity relationships.
Topics: Animals; Chagas Disease; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; HeLa Cells; | 2009 |
Phosphonium lipocations as antiparasitic agents.
Topics: Animals; Antiparasitic Agents; Cations; Chagas Disease; Chlorocebus aethiops; Humans; Inhibitory Con | 2012 |
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
Topics: Animals; Antiprotozoal Agents; Benzene; Chagas Disease; Female; Leishmania donovani; Mice; Mice, Inb | 2013 |
Isolation, Derivative Synthesis, and Structure-Activity Relationships of Antiparasitic Bromopyrrole Alkaloids from the Marine Sponge Tedania brasiliensis.
Topics: Alkaloids; Animals; Antimalarials; Antiparasitic Agents; Antiprotozoal Agents; Chagas Disease; Leish | 2018 |
Biological evaluation and structure-activity relationships of imidazole-based compounds as antiprotozoal agents.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Female; Humans; Imidazoles; Inhibitory Con | 2018 |
A new chemotype with promise against Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Humans; Structure-Activity Relationship; Trypanocidal Agents; Trypanosoma c | 2020 |
Drug Repurposing in Chagas Disease: Chloroquine Potentiates Benznidazole Activity against Trypanosoma cruzi
Topics: Animals; Chagas Disease; Chloroquine; Drug Repositioning; Mice; Nitroimidazoles; Trypanocidal Agents | 2022 |
In vitro evaluation of alkaline lignins as antiparasitic agents and their use as an excipient in the release of benznidazole.
Topics: Animals; Antioxidants; Antiparasitic Agents; Chagas Disease; Chloroquine; Excipients; Lignin; Trypan | 2023 |
Cysteamine, the natural metabolite of pantetheinase, shows specific activity against Plasmodium.
Topics: Amidohydrolases; Animals; Antimalarials; Candidiasis; Chagas Disease; Chloroquine; Cysteamine; Cytok | 2010 |
CHEMOTHERAPY OF TROPICAL DISEASES.
Topics: Amebiasis; Amebicides; Anti-Bacterial Agents; Antimalarials; Antimony; Arsenicals; Chagas Disease; C | 1964 |
Two modes of idiotypic stimulation of T lymphocytes from patients with Chagas' disease: correlations with clinical forms of infection.
Topics: Adult; Animals; Antibodies, Anti-Idiotypic; Antibodies, Protozoan; Antigen-Presenting Cells; Antigen | 1990 |