Homocholine is a naturally occurring choline analog found in various tissues and fluids. It is synthesized through the methylation of choline by the enzyme choline methyltransferase. Research suggests that homocholine may play a role in neurotransmission and cognitive function. It is being studied for its potential therapeutic benefits in conditions like Alzheimer's disease and attention-deficit/hyperactivity disorder (ADHD). Studies have shown that homocholine can enhance acetylcholine levels in the brain, which is a key neurotransmitter involved in learning and memory. However, further research is needed to fully understand its mechanisms of action and its clinical applications.'
homocholine: record includes halides; iodide used as internal standard for paired-ion HPLC assay for choline; RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 23169 |
| CHEMBL ID | 317449 |
| SCHEMBL ID | 98070 |
| MeSH ID | M0051444 |
| Synonym |
|---|
| bdbm50147119 |
| (3-hydroxy-propyl)-trimethyl-ammonium |
| homocholine |
| CHEMBL317449 , |
| 3-hydroxypropyl(trimethyl)azanium |
| 1-propanaminium, 3-hydroxy-n,n,n-trimethyl- |
| htmpi |
| 10238-59-2 |
| 3-hydroxy-n,n,n-trimethylpropanaminium |
| 3-trimethylaminopropan-1-ol |
| SCHEMBL98070 |
| DTXSID90144982 |
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID52133 | Inhibition of [3H]-choline brain uptake was determined by in situ brain perfusion studies in male rats | 2004 | Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12 | Molecular modeling studies on the active binding site of the blood-brain barrier choline transporter. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 10 (71.43) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 3 (21.43) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (7.14) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.43) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 0 (0.00%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 14 (100.00%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||