pentamidine has been researched along with Chagas Disease in 19 studies
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.
pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " For Chagas disease, two anti-fungal triazoles are now in clinical trial." | 4.88 | Management of trypanosomiasis and leishmaniasis. ( Barrett, MP; Croft, SL, 2012) |
| "In the search for new treatments against Chagas disease and leishmaniasis, several studies have shown that hybrid molecules display high antiprotozoal activity and this emerging strategy is quite promising in the field of new drug discovery and development." | 2.58 | Hybrid Molecules: Promising Compounds for the Development of New Treatments Against Leishmaniasis and Chagas Disease. ( Cardona-G, W; Herrera-R, A; Yepes, AF, 2018) |
| "Pentamidine is an antiprotozoal and fungicide drug used in the treatment of leishmaniasis and African trypanosomiasis." | 1.40 | Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi. ( Campos-Estrada, C; Díaz, MV; López-Muñoz, R; Maya, JD; Miranda, MR; Pereira, CA; Reigada, C, 2014) |
| "Chagas' disease is a neglected tropical disease caused by Trypanosoma cruzi and constitutes a serious public health problem for Latin America." | 1.40 | In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi. ( Batista, MM; Boykin, DW; Da Silva, PB; Farahat, AA; Kumar, A; Soeiro, MN; Timm, BL, 2014) |
| "The chemotherapy of Chagas disease is quite unsatisfactory mainly due to its poor efficacy especially during the later chronic phase and the considerable well-known side effects." | 1.37 | Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi. ( Arafa, RK; Boykin, DW; da Silva, PB; De Souza, EM; Ismail, MA; Nefertiti, AS; Nixon-Smith, CK; Soeiro, MN; Tao, B, 2011) |
| "cruzi, the etiological agent of Chagas' disease." | 1.35 | In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi. ( Batista, Dda G; Batista, MM; Boykin, DW; da Silva, CF; da Silva, PB; de Oliveira, GM; de Souza, EM; Meuser, AS; Shareef, AR; Soeiro, Mde N, 2008) |
| "Chagas' disease is an important parasitic illness caused by the flagellated protozoan Trypanosoma cruzi." | 1.34 | Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro". ( Batista, MM; Boykin, DW; de Souza, EM; Mota, RA; Silva, CF; Soeiro, Mde N; Som, P; Stephens, CE, 2007) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 1 (5.26) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 6 (31.58) | 29.6817 |
| 2010's | 12 (63.16) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Boiani, M | 1 |
| Boiani, L | 1 |
| Denicola, A | 1 |
| Torres de Ortiz, S | 1 |
| Serna, E | 1 |
| Vera de Bilbao, N | 1 |
| Sanabria, L | 1 |
| Yaluff, G | 1 |
| Nakayama, H | 1 |
| Rojas de Arias, A | 1 |
| Vega, C | 1 |
| Rolan, M | 1 |
| Gómez-Barrio, A | 1 |
| Cerecetto, H | 1 |
| Gonzalez, M | 1 |
| Caminos, AP | 1 |
| Panozzo-Zenere, EA | 1 |
| Wilkinson, SR | 1 |
| Tekwani, BL | 1 |
| Labadie, GR | 1 |
| Sanchez, LM | 1 |
| Knudsen, GM | 1 |
| Helbig, C | 1 |
| De Muylder, G | 1 |
| Mascuch, SM | 1 |
| Mackey, ZB | 1 |
| Gerwick, L | 1 |
| Clayton, C | 1 |
| McKerrow, JH | 1 |
| Linington, RG | 1 |
| Patrick, DA | 1 |
| Ismail, MA | 2 |
| Arafa, RK | 2 |
| Wenzler, T | 1 |
| Zhu, X | 1 |
| Pandharkar, T | 1 |
| Jones, SK | 1 |
| Werbovetz, KA | 1 |
| Brun, R | 1 |
| Boykin, DW | 7 |
| Tidwell, RR | 1 |
| Bhambra, AS | 1 |
| Ruparelia, KC | 1 |
| Tan, HL | 1 |
| Tasdemir, D | 1 |
| Burrell-Saward, H | 1 |
| Yardley, V | 1 |
| Beresford, KJM | 1 |
| Arroo, RRJ | 1 |
| Linciano, P | 1 |
| Moraes, CB | 1 |
| Alcantara, LM | 1 |
| Franco, CH | 1 |
| Pascoalino, B | 1 |
| Freitas-Junior, LH | 1 |
| Macedo, S | 1 |
| Santarem, N | 1 |
| Cordeiro-da-Silva, A | 1 |
| Gul, S | 1 |
| Witt, G | 1 |
| Kuzikov, M | 1 |
| Ellinger, B | 1 |
| Ferrari, S | 1 |
| Luciani, R | 1 |
| Quotadamo, A | 1 |
| Costantino, L | 1 |
| Costi, MP | 1 |
| Cardona-G, W | 1 |
| Yepes, AF | 1 |
| Herrera-R, A | 1 |
| Díaz, MV | 2 |
| Miranda, MR | 2 |
| Campos-Estrada, C | 2 |
| Reigada, C | 2 |
| Maya, JD | 2 |
| Pereira, CA | 2 |
| López-Muñoz, R | 2 |
| Timm, BL | 1 |
| Da Silva, PB | 3 |
| Batista, MM | 4 |
| Farahat, AA | 1 |
| Kumar, A | 1 |
| Soeiro, MN | 3 |
| Sbaraglini, ML | 1 |
| Vanrell, MC | 1 |
| Bellera, CL | 1 |
| Benaim, G | 1 |
| Carrillo, C | 1 |
| Talevi, A | 1 |
| Romano, PS | 1 |
| Seguel, V | 1 |
| Castro, L | 1 |
| Cortes, L | 1 |
| Lapier, M | 1 |
| Morello, A | 1 |
| Kemmerling, U | 1 |
| da Silva, CF | 1 |
| Batista, Dda G | 1 |
| de Souza, EM | 5 |
| de Oliveira, GM | 1 |
| Meuser, AS | 1 |
| Shareef, AR | 1 |
| Soeiro, Mde N | 3 |
| Dantas, AP | 1 |
| Daliry, A | 1 |
| Silva, CF | 3 |
| Batista, DG | 2 |
| Oliveira, GM | 1 |
| Salomão, K | 1 |
| Pacheco, MG | 1 |
| Silva, PB | 1 |
| Santa-Rita, RM | 1 |
| Barreto, RF | 1 |
| Castro, SL | 1 |
| de Castro, SL | 1 |
| Nefertiti, AS | 1 |
| Tao, B | 1 |
| Nixon-Smith, CK | 1 |
| Barrett, MP | 1 |
| Croft, SL | 1 |
| Werbovetz, K | 1 |
| Mota, RA | 1 |
| Stephens, CE | 1 |
| Som, P | 1 |
| Gutteridge, WE | 1 |
6 reviews available for pentamidine and Chagas Disease
| Article | Year |
|---|---|
Hybrid Molecules: Promising Compounds for the Development of New Treatments Against Leishmaniasis and Chagas Disease.
Topics: Antiprotozoal Agents; Chagas Disease; Chalcone; Humans; Hydrazones; Leishmaniasis; Pentamidine; Quin | 2018 |
Neglected Tropical Protozoan Diseases: Drug Repositioning as a Rational Option.
Topics: Antiprotozoal Agents; Chagas Disease; Drug Repositioning; Humans; Leishmaniasis; Neglected Diseases; | 2016 |
Diamidine activity against trypanosomes: the state of the art.
Topics: Animals; Chagas Disease; Drug Resistance; Humans; Pentamidine; Trypanocidal Agents; Trypanosoma bruc | 2008 |
Management of trypanosomiasis and leishmaniasis.
Topics: Administration, Oral; Africa; Amphotericin B; Antiprotozoal Agents; Benzamides; Boron Compounds; Cha | 2012 |
Diamidines as antitrypanosomal, antileishmanial and antimalarial agents.
Topics: Animals; Antimalarials; Antiprotozoal Agents; Benzamidines; Chagas Disease; Clinical Trials as Topic | 2006 |
Existing chemotherapy and its limitations.
Topics: Chagas Disease; Gentian Violet; Humans; Melarsoprol; Nifurtimox; Nitroimidazoles; Pentamidine; Suram | 1985 |
13 other studies available for pentamidine and Chagas Disease
| Article | Year |
|---|---|
2H-benzimidazole 1,3-dioxide derivatives: a new family of water-soluble anti-trypanosomatid agents.
Topics: Acute Disease; Animals; Benzimidazoles; Cell Line; Chagas Disease; Cyclic N-Oxides; Leishmania; Macr | 2006 |
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Diamines; Humans; Inhibitory Concentration 50; Kineto | 2012 |
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.
Topics: Animals; Biological Products; Chagas Disease; Glycolysis; Humans; Leishmania donovani; Lipopeptides; | 2013 |
Synthesis and antiprotozoal activity of dicationic m-terphenyl and 1,3-dipyridylbenzene derivatives.
Topics: Animals; Antiprotozoal Agents; Benzene; Chagas Disease; Female; Leishmania donovani; Mice; Mice, Inb | 2013 |
Synthesis and antitrypanosomal activities of novel pyridylchalcones.
Topics: Animals; Cells, Cultured; Chagas Disease; Chalcones; Humans; Leishmania donovani; Leishmaniasis, Vis | 2017 |
Aryl thiosemicarbazones for the treatment of trypanosomatidic infections.
Topics: Antiprotozoal Agents; Chagas Disease; Dose-Response Relationship, Drug; Humans; Macrophages; Molecul | 2018 |
Pentamidine exerts in vitro and in vivo anti Trypanosoma cruzi activity and inhibits the polyamine transport in Trypanosoma cruzi.
Topics: Animals; Antiprotozoal Agents; Biological Transport; Cell Survival; Chagas Disease; Disease Models, | 2014 |
In vitro investigation of the efficacy of novel diamidines against Trypanosoma cruzi.
Topics: Amidines; Animals; Cell Culture Techniques; Chagas Disease; Dose-Response Relationship, Drug; Heart; | 2014 |
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glu | 2016 |
In vitro and in vivo studies of the trypanocidal activity of a diarylthiophene diamidine against Trypanosoma cruzi.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chlorocebus aethiops; Electrocardiography; Heart; Ma | 2008 |
Experimental chemotherapy for Chagas disease: 15 years of research contributions from in vivo and in vitro studies.
Topics: Animals; Chagas Disease; Humans; Naphthoquinones; Pentamidine; Propolis; Trypanocidal Agents; Trypan | 2009 |
Trypanocidal activity and selectivity in vitro of aromatic amidine compounds upon bloodstream and intracellular forms of Trypanosoma cruzi.
Topics: Amidines; Animals; Chagas Disease; Dose-Response Relationship, Drug; Lethal Dose 50; Mice; Myocytes, | 2011 |
Activity of "reversed" diamidines against Trypanosoma cruzi "in vitro".
Topics: Animals; Chagas Disease; Chlorocebus aethiops; Dose-Response Relationship, Drug; Furans; Guanidine; | 2007 |