dehydrothio-4-toluidine: structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]
| ID Source | ID |
|---|---|
| PubMed CID | 7087 |
| CHEMBL ID | 93109 |
| SCHEMBL ID | 492713 |
| MeSH ID | M0121032 |
| Synonym |
|---|
| EU-0069699 |
| BIDD:GT0828 |
| CHEMBL93109 , |
| EN300-17374 |
| BB 0245168 |
| nsc57678 |
| nsc-57678 |
| 2-(p-aminophenyl)-6-methylbenzothiazole |
| benzothiazole, 2-(p-aminophenyl)-6-methyl- |
| 2-(4-aminophenyl)-6-methylbenzothiazole |
| 92-36-4 |
| dehydrothio-p-toluidine |
| 4-(6-methyl-2-benzothiazolyl)aniline |
| benzenamine, 4-(6-methyl-2-benzothiazolyl)- |
| nsc-15370 |
| nsc15370 |
| CBDIVE_010782 |
| 4-(6-methyl-1,3-benzothiazol-2-yl)aniline |
| 4-(6-methylbenzothiazol-2-yl)phenylamine |
| dhpt |
| brn 0175967 |
| 4-(6-methyl-2-benzothiazolyl)benzenamine |
| nsc 15370 |
| einecs 202-150-4 |
| benzothiazole, 2-(4-aminophenyl)-6-methyl- |
| dehydrothio-4-toluidine |
| 4-(6-methylbenzothiazol-2-yl)aniline |
| p-(6-methylbenzothiazol-2-yl)aniline |
| ccris 1394 |
| NCGC00165332-01 |
| MLS000769098 |
| smr000433812 |
| 4-(6-methyl-benzothiazol-2-yl)-phenylamine |
| 4-(6-methyl-2-benzothiazolyl)-benzenamine |
| inchi=1/c14h12n2s/c1-9-2-7-12-13(8-9)17-14(16-12)10-3-5-11(15)6-4-10/h2-8h,15h2,1h |
| STK038114 |
| AKOS000108518 |
| bdbm50129788 |
| cid_7087 |
| BBL001453 |
| 4-(6-methyl-1,3-benzothiazol-2-yl)phenylamine |
| 4-(6-methyl-2-benzothiazolyl)benzeneamine |
| dehydrothiotoluidine |
| VU0121570-4 |
| HMS2811I20 |
| 69un466k3z , |
| 4-27-00-05052 (beilstein handbook reference) |
| unii-69un466k3z |
| ec 202-150-4 |
| FT-0631447 |
| MS-0173 |
| 2-(4'-aminophenyl)-6-methylbenzothiazole |
| 2-(4-amino-phenyl)-6-methyl benzothiazole |
| 2-(4-aminophenyl)-6-methyl-benzothiazole |
| 2-(4-aminophenyl)-6-methyl benzothiazole |
| SCHEMBL492713 |
| W-100291 |
| 4-(6-methyl-1,3-benzothiazol-2-yl)phenylamine # |
| 2-[4-aminophenyl]-6-methylbenzothiazole |
| 4-(6-methyl-2-benzethiazolyl)-benzeneamine |
| 4-(6-methylbenzothiazol-2-yl)-aniline |
| 4-(6-methylbenzo(d)thiazol-2-yl)aniline |
| benzothiazole, 1-(p-aminophenyl)-5-methyl- |
| DTXSID5024502 |
| F0243-0015 |
| mfcd00005780 |
| 4-(6-methyl-2-benzothiazolyl)aniline, technical, >=98.0% (nt) |
| [4-(6-methyl-1,3-benzothiazol-2-yl)phenyl]amine |
| SR-01000416450-1 |
| sr-01000416450 |
| 4-(6-methylbenzo[d]thiazol-2-yl)aniline |
| Q27264381 |
| HY-W040269 |
| CS-W021009 |
| Z56922178 |
| SY104280 |
| Protein | Taxonomy | Measurement | Average (µ) | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| Chain A, MAJOR APURINIC/APYRIMIDINIC ENDONUCLEASE | Homo sapiens (human) | Potency | 4.4668 | 0.0032 | 45.4673 | 12,589.2998 | AID2517 |
| Chain A, 2-oxoglutarate Oxygenase | Homo sapiens (human) | Potency | 14.1254 | 0.1778 | 14.3909 | 39.8107 | AID2147 |
| Chain A, Ferritin light chain | Equus caballus (horse) | Potency | 39.8107 | 5.6234 | 17.2929 | 31.6228 | AID485281 |
| Luciferase | Photinus pyralis (common eastern firefly) | Potency | 0.8065 | 0.0072 | 15.7588 | 89.3584 | AID588342; AID602357; AID602358; AID602364; AID602365; AID602474; AID602475; AID602476; AID602477; AID602478 |
| acid sphingomyelinase | Homo sapiens (human) | Potency | 25.1189 | 14.1254 | 24.0613 | 39.8107 | AID504937 |
| glp-1 receptor, partial | Homo sapiens (human) | Potency | 4.4668 | 0.0184 | 6.8060 | 14.1254 | AID624417 |
| thioredoxin reductase | Rattus norvegicus (Norway rat) | Potency | 29.9033 | 0.1000 | 20.8793 | 79.4328 | AID588453; AID588456 |
| BRCA1 | Homo sapiens (human) | Potency | 31.6228 | 0.8913 | 7.7225 | 25.1189 | AID624202 |
| ATAD5 protein, partial | Homo sapiens (human) | Potency | 0.1947 | 0.0041 | 10.8903 | 31.5287 | AID504466; AID504467 |
| Microtubule-associated protein tau | Homo sapiens (human) | Potency | 5.6234 | 0.1800 | 13.5574 | 39.8107 | AID1460 |
| apical membrane antigen 1, AMA1 | Plasmodium falciparum 3D7 | Potency | 3.9811 | 0.7079 | 12.1943 | 39.8107 | AID720542 |
| 67.9K protein | Vaccinia virus | Potency | 5.4457 | 0.0001 | 8.4406 | 100.0000 | AID720579; AID720580 |
| glucocerebrosidase | Homo sapiens (human) | Potency | 28.1838 | 0.0126 | 8.1569 | 44.6684 | AID2101 |
| alpha-galactosidase | Homo sapiens (human) | Potency | 33.5521 | 4.4668 | 18.3916 | 35.4813 | AID1467; AID2107 |
| pyruvate kinase | Leishmania mexicana mexicana | Potency | 12.5893 | 0.3981 | 13.7447 | 31.6228 | AID1721; AID1722 |
| lysosomal alpha-glucosidase preproprotein | Homo sapiens (human) | Potency | 31.6228 | 0.0366 | 19.6376 | 50.1187 | AID2112 |
| NPC intracellular cholesterol transporter 1 precursor | Homo sapiens (human) | Potency | 0.3162 | 0.0126 | 2.4518 | 25.0177 | AID485313 |
| nuclear factor erythroid 2-related factor 2 isoform 2 | Homo sapiens (human) | Potency | 0.5805 | 0.0041 | 9.9848 | 25.9290 | AID504444 |
| parathyroid hormone/parathyroid hormone-related peptide receptor precursor | Homo sapiens (human) | Potency | 17.7828 | 3.5481 | 19.5427 | 44.6684 | AID743266 |
| importin subunit beta-1 isoform 1 | Homo sapiens (human) | Potency | 125.8920 | 5.8048 | 36.1306 | 65.1308 | AID540263 |
| ras-related protein Rab-9A | Homo sapiens (human) | Potency | 0.2239 | 0.0002 | 2.6215 | 31.4954 | AID485297 |
| snurportin-1 | Homo sapiens (human) | Potency | 125.8920 | 5.8048 | 36.1306 | 65.1308 | AID540263 |
| nuclear receptor ROR-gamma isoform 1 | Mus musculus (house mouse) | Potency | 7.2334 | 0.0079 | 8.2332 | 1,122.0200 | AID2546; AID2551 |
| Endothelin receptor type B | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 0.5623 | 15.1609 | 31.6228 | AID1721 |
| Endothelin-1 receptor | Rattus norvegicus (Norway rat) | Potency | 12.5893 | 0.5623 | 15.1609 | 31.6228 | AID1721 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| TPA: protein transporter TIM10 | Saccharomyces cerevisiae S288C | IC50 (µMol) | 17.4000 | 0.5800 | 26.5476 | 75.8000 | AID504672 |
| TPA: protein transporter TIM23 | Saccharomyces cerevisiae S288C | IC50 (µMol) | 9.9500 | 0.8800 | 10.5036 | 32.9000 | AID493002 |
| Protein skinhead-1 | Caenorhabditis elegans | IC50 (µMol) | 100.0000 | 7.3900 | 21.5238 | 43.9000 | AID624474 |
| Amyloid-beta precursor protein | Homo sapiens (human) | Ki | 0.0095 | 0.0001 | 0.0856 | 0.8900 | AID38663 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| streptokinase A precursor | Streptococcus pyogenes M1 GAS | EC50 (µMol) | 150.0000 | 0.0600 | 8.9128 | 130.5170 | AID1902; AID1914 |
| Estrogen receptor | Rattus norvegicus (Norway rat) | EC50 (µMol) | 150.0000 | 0.0060 | 22.3670 | 130.5170 | AID1914 |
| Estrogen receptor beta | Rattus norvegicus (Norway rat) | EC50 (µMol) | 150.0000 | 0.0060 | 22.3670 | 130.5170 | AID1914 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Protein | Taxonomy | Measurement | Average | Min (ref.) | Avg (ref.) | Max (ref.) | Bioassay(s) |
|---|---|---|---|---|---|---|---|
| MSH | Drosophila melanogaster (fruit fly) | AC50 | 1.5500 | 0.2090 | 9.5788 | 48.6900 | AID743444 |
| [prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023] | |||||||
| Assay ID | Title | Year | Journal | Article |
|---|---|---|---|---|
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588497 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain F protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588501 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Lethal Factor Protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Current protocols in cytometry, Oct, Volume: Chapter 13 | Microsphere-based flow cytometry protease assays for use in protease activity detection and high-throughput screening. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2006 | Cytometry. Part A : the journal of the International Society for Analytical Cytology, May, Volume: 69, Issue:5 | Microsphere-based protease assays and screening application for lethal factor and factor Xa. |
| AID588499 | High-throughput multiplex microsphere screening for inhibitors of toxin protease, specifically Botulinum neurotoxin light chain A protease, MLPCN compound set | 2010 | Assay and drug development technologies, Feb, Volume: 8, Issue:1 | High-throughput multiplex flow cytometry screening for botulinum neurotoxin type a light chain protease inhibitors. |
| AID504810 | Antagonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID504812 | Inverse Agonists of the Thyroid Stimulating Hormone Receptor: HTS campaign | 2010 | Endocrinology, Jul, Volume: 151, Issue:7 | A small molecule inverse agonist for the human thyroid-stimulating hormone receptor. |
| AID1745845 | Primary qHTS for Inhibitors of ATXN expression | |||
| AID651635 | Viability Counterscreen for Primary qHTS for Inhibitors of ATXN expression | |||
| AID1186014 | Selectivity ratio for human triosephosphate isomerase to Trypanosoma cruzi triosephosphate isomerase | 2014 | European journal of medicinal chemistry, Oct-06, Volume: 85 | Trends in research of antitrypanosomal agents among synthetic heterocycles. |
| AID497352 | Cell cycle arrest in human BCC cells assessed as accumulation at sub G1 phase at 4 uM incubated for 4 hrs followed by 1 J/cm'2 UV irradiation measured after 24 hrs by annexin V/propidium iodide-based flow cytometry | 2010 | Bioorganic & medicinal chemistry, Aug-15, Volume: 18, Issue:16 | Synthesis, and biological evaluation of 2-(4-aminophenyl)benzothiazole derivatives as photosensitizing agents. |
| AID19837 | Apparent lipophilicity was determined | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13 | Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. |
| AID38663 | Binding affinity for Amyloid beta 1-40 aggregates in competition with [N-methyl-3H] BTA-1. | 2003 | Journal of medicinal chemistry, Jun-19, Volume: 46, Issue:13 | Synthesis and evaluation of 11C-labeled 6-substituted 2-arylbenzothiazoles as amyloid imaging agents. |
| [information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||||
| Timeframe | Studies, This Drug (%) | All Drugs % |
|---|---|---|
| pre-1990 | 1 (11.11) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (22.22) | 29.6817 |
| 2010's | 5 (55.56) | 24.3611 |
| 2020's | 1 (11.11) | 2.80 |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||
According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.
| This Compound (11.73) All Compounds (24.57) |
| Publication Type | This drug (%) | All Drugs (%) |
|---|---|---|
| Trials | 0 (0.00%) | 5.53% |
| Reviews | 1 (11.11%) | 6.00% |
| Case Studies | 0 (0.00%) | 4.05% |
| Observational | 0 (0.00%) | 0.25% |
| Other | 8 (88.89%) | 84.16% |
| [information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023] | ||