Page last updated: 2024-10-29

indomethacin and Chagas Disease

indomethacin has been researched along with Chagas Disease in 11 studies

Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.

Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.

Research Excerpts

ExcerptRelevanceReference
"Indomethacin-treated infected mice had higher mortality compared to untreated infected animals."1.30Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection. ( Abrahamsohn, IA; Pinge-Filho, P; Tadokoro, CE, 1999)
"PGE2 involvement in experimental Trypanosoma cruzi infection depends on the lethal capacity of the parasite subpopulation used."1.29PGE2 involvement in experimental infection with Trypanosoma cruzi subpopulations. ( Borda, E; Celentano, AM; González Cappa, SM; Gorelik, G; Solana, ME; Sterin-Borda, L, 1995)
"The effect of Trypanosoma cruzi infection on the ability of mature and immature murine peritoneal macrophage (MPM) subpopulations to catabolize the bacteriophage lambda repressor cI protein (cI) has been investigated."1.29Impaired protein catabolism in Trypanosoma cruzi-infected macrophages: possible involvement in antigen presentation. ( Guillet, JG; Plasman, N; Vray, B, 1995)

Research

Studies (11)

TimeframeStudies, this research(%)All Research%
pre-19905 (45.45)18.7374
1990's5 (45.45)18.2507
2000's0 (0.00)29.6817
2010's1 (9.09)24.3611
2020's0 (0.00)2.80

Authors

AuthorsStudies
Gomes, JA1
Molica, AM1
Keesen, TS1
Morato, MJ1
de Araujo, FF1
Fares, RC1
Fiuza, JA1
Chaves, AT1
Pinheiro, V1
Nunes, Mdo C1
Correa-Oliveira, R1
da Costa Rocha, MO1
de Bracco, MM2
Sterin-Borda, L4
Fink, S1
Finiasz, M2
Borda, E4
Kierszenbaum, F1
Celentano, AM1
Gorelik, G2
Solana, ME1
González Cappa, SM1
Plasman, N1
Guillet, JG1
Vray, B1
Motrán, C1
Gruppi, A1
Vullo, CM1
Pistoresi-Palencia, MC1
Serra, HM1
Cremaschi, G1
Pinge-Filho, P1
Tadokoro, CE1
Abrahamsohn, IA1
Cangiani, S1
Storino, R1
Diez, C1
Castes, M1
Panagiotopoulos, A1
Mosca, W1
Harel-Bellan, A1
Joskowicz, M1
Fradelizi, D1
Eisen, H1

Other Studies

11 other studies available for indomethacin and Chagas Disease

ArticleYear
Inflammatory mediators from monocytes down-regulate cellular proliferation and enhance cytokines production in patients with polar clinical forms of Chagas disease.
    Human immunology, 2014, Volume: 75, Issue:1

    Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, Protozoan; B-Lymphocytes; Cell Proliferation; Cel

2014
Stimulatory effect of lymphocytes from Chagas' patients on spontaneously beating rat atria.
    Clinical and experimental immunology, 1984, Volume: 55, Issue:2

    Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Catechols; Chagas Cardiomyopathy; Chagas Disease;

1984
Immunologic deficiency during experimental Chagas' disease (Trypanosoma cruzi infection): role of adherent, nonspecific esterase-positive splenic cells.
    Journal of immunology (Baltimore, Md. : 1950), 1982, Volume: 129, Issue:5

    Topics: Acute Disease; Animals; Cell Adhesion; Chagas Disease; Esterases; Immune Tolerance; Immunologic Defi

1982
PGE2 involvement in experimental infection with Trypanosoma cruzi subpopulations.
    Prostaglandins, 1995, Volume: 49, Issue:3

    Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Cell Adhesion; Chagas Disease; Dinoprostone; Indom

1995
Impaired protein catabolism in Trypanosoma cruzi-infected macrophages: possible involvement in antigen presentation.
    Immunology, 1995, Volume: 86, Issue:4

    Topics: Animals; Antigen Presentation; Arginine; CD4-Positive T-Lymphocytes; Cell Culture Techniques; Cellul

1995
Involvement of accessory cells in the Trypanosoma cruzi-induced inhibition of the polyclonal response of T lymphocytes.
    Parasite immunology, 1996, Volume: 18, Issue:1

    Topics: Animals; Antigen-Presenting Cells; Cell Communication; Chagas Disease; Cyclooxygenase Inhibitors; HL

1996
Trypanosoma cruzi antigens down-regulate T lymphocyte proliferation by muscarinic cholinergic receptor-dependent release of PGE2.
    Acta physiologica, pharmacologica et therapeutica latinoamericana : organo de la Asociacion Latinoamericana de Ciencias Fisiologicas y [de] la Asociacion Latinoamericana de Farmacologia, 1998, Volume: 48, Issue:3

    Topics: Animals; Antigens, Protozoan; Atropine; Cell Division; Chagas Disease; Chronic Disease; Concanavalin

1998
Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection.
    Cellular immunology, 1999, Apr-10, Volume: 193, Issue:1

    Topics: Acute Disease; Animals; Chagas Disease; Cytokines; Indomethacin; Interferon-gamma; Interleukin-2; Ly

1999
Modification of the contractile activity of isolated atria by T4 lymphocytes from patients with Chagas' disease: effect of soluble factors.
    International journal of immunopharmacology, 1986, Volume: 8, Issue:6

    Topics: Animals; Atrial Function; Chagas Disease; Chromones; Heart Atria; Heart Rate; Humans; In Vitro Techn

1986
Demonstration of an indomethacin-sensitive mechanism regulating immune reactivity in Chagas' disease patients.
    Immunopharmacology, 1986, Volume: 12, Issue:3

    Topics: Animals; Chagas Disease; Chronic Disease; Concanavalin A; Female; Humans; Indomethacin; Lymphocyte A

1986
T lymphocyte function during experimental Chagas' disease: production of and response to interleukin 2.
    European journal of immunology, 1985, Volume: 15, Issue:5

    Topics: Animals; Catalase; Chagas Disease; Concanavalin A; Immune Tolerance; Indomethacin; Interleukin-2; Ly

1985