indomethacin has been researched along with Chagas Disease in 11 studies
Indomethacin: A non-steroidal anti-inflammatory agent (NSAID) that inhibits CYCLOOXYGENASE, which is necessary for the formation of PROSTAGLANDINS and other AUTACOIDS. It also inhibits the motility of POLYMORPHONUCLEAR LEUKOCYTES.
indometacin : A member of the class of indole-3-acetic acids that is indole-3-acetic acid in which the indole ring is substituted at positions 1, 2 and 5 by p-chlorobenzoyl, methyl, and methoxy groups, respectively. A non-steroidal anti-inflammatory drug, it is used in the treatment of musculoskeletal and joint disorders including osteoarthritis, rheumatoid arthritis, gout, bursitis and tendinitis.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
Excerpt | Relevance | Reference |
---|---|---|
"Indomethacin-treated infected mice had higher mortality compared to untreated infected animals." | 1.30 | Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection. ( Abrahamsohn, IA; Pinge-Filho, P; Tadokoro, CE, 1999) |
"PGE2 involvement in experimental Trypanosoma cruzi infection depends on the lethal capacity of the parasite subpopulation used." | 1.29 | PGE2 involvement in experimental infection with Trypanosoma cruzi subpopulations. ( Borda, E; Celentano, AM; González Cappa, SM; Gorelik, G; Solana, ME; Sterin-Borda, L, 1995) |
"The effect of Trypanosoma cruzi infection on the ability of mature and immature murine peritoneal macrophage (MPM) subpopulations to catabolize the bacteriophage lambda repressor cI protein (cI) has been investigated." | 1.29 | Impaired protein catabolism in Trypanosoma cruzi-infected macrophages: possible involvement in antigen presentation. ( Guillet, JG; Plasman, N; Vray, B, 1995) |
Timeframe | Studies, this research(%) | All Research% |
---|---|---|
pre-1990 | 5 (45.45) | 18.7374 |
1990's | 5 (45.45) | 18.2507 |
2000's | 0 (0.00) | 29.6817 |
2010's | 1 (9.09) | 24.3611 |
2020's | 0 (0.00) | 2.80 |
Authors | Studies |
---|---|
Gomes, JA | 1 |
Molica, AM | 1 |
Keesen, TS | 1 |
Morato, MJ | 1 |
de Araujo, FF | 1 |
Fares, RC | 1 |
Fiuza, JA | 1 |
Chaves, AT | 1 |
Pinheiro, V | 1 |
Nunes, Mdo C | 1 |
Correa-Oliveira, R | 1 |
da Costa Rocha, MO | 1 |
de Bracco, MM | 2 |
Sterin-Borda, L | 4 |
Fink, S | 1 |
Finiasz, M | 2 |
Borda, E | 4 |
Kierszenbaum, F | 1 |
Celentano, AM | 1 |
Gorelik, G | 2 |
Solana, ME | 1 |
González Cappa, SM | 1 |
Plasman, N | 1 |
Guillet, JG | 1 |
Vray, B | 1 |
Motrán, C | 1 |
Gruppi, A | 1 |
Vullo, CM | 1 |
Pistoresi-Palencia, MC | 1 |
Serra, HM | 1 |
Cremaschi, G | 1 |
Pinge-Filho, P | 1 |
Tadokoro, CE | 1 |
Abrahamsohn, IA | 1 |
Cangiani, S | 1 |
Storino, R | 1 |
Diez, C | 1 |
Castes, M | 1 |
Panagiotopoulos, A | 1 |
Mosca, W | 1 |
Harel-Bellan, A | 1 |
Joskowicz, M | 1 |
Fradelizi, D | 1 |
Eisen, H | 1 |
11 other studies available for indomethacin and Chagas Disease
Article | Year |
---|---|
Inflammatory mediators from monocytes down-regulate cellular proliferation and enhance cytokines production in patients with polar clinical forms of Chagas disease.
Topics: Anti-Inflammatory Agents, Non-Steroidal; Antigens, Protozoan; B-Lymphocytes; Cell Proliferation; Cel | 2014 |
Stimulatory effect of lymphocytes from Chagas' patients on spontaneously beating rat atria.
Topics: 5,8,11,14-Eicosatetraynoic Acid; Animals; Aspirin; Catechols; Chagas Cardiomyopathy; Chagas Disease; | 1984 |
Immunologic deficiency during experimental Chagas' disease (Trypanosoma cruzi infection): role of adherent, nonspecific esterase-positive splenic cells.
Topics: Acute Disease; Animals; Cell Adhesion; Chagas Disease; Esterases; Immune Tolerance; Immunologic Defi | 1982 |
PGE2 involvement in experimental infection with Trypanosoma cruzi subpopulations.
Topics: 16,16-Dimethylprostaglandin E2; Animals; Aspirin; Cell Adhesion; Chagas Disease; Dinoprostone; Indom | 1995 |
Impaired protein catabolism in Trypanosoma cruzi-infected macrophages: possible involvement in antigen presentation.
Topics: Animals; Antigen Presentation; Arginine; CD4-Positive T-Lymphocytes; Cell Culture Techniques; Cellul | 1995 |
Involvement of accessory cells in the Trypanosoma cruzi-induced inhibition of the polyclonal response of T lymphocytes.
Topics: Animals; Antigen-Presenting Cells; Cell Communication; Chagas Disease; Cyclooxygenase Inhibitors; HL | 1996 |
Trypanosoma cruzi antigens down-regulate T lymphocyte proliferation by muscarinic cholinergic receptor-dependent release of PGE2.
Topics: Animals; Antigens, Protozoan; Atropine; Cell Division; Chagas Disease; Chronic Disease; Concanavalin | 1998 |
Prostaglandins mediate suppression of lymphocyte proliferation and cytokine synthesis in acute Trypanosoma cruzi infection.
Topics: Acute Disease; Animals; Chagas Disease; Cytokines; Indomethacin; Interferon-gamma; Interleukin-2; Ly | 1999 |
Modification of the contractile activity of isolated atria by T4 lymphocytes from patients with Chagas' disease: effect of soluble factors.
Topics: Animals; Atrial Function; Chagas Disease; Chromones; Heart Atria; Heart Rate; Humans; In Vitro Techn | 1986 |
Demonstration of an indomethacin-sensitive mechanism regulating immune reactivity in Chagas' disease patients.
Topics: Animals; Chagas Disease; Chronic Disease; Concanavalin A; Female; Humans; Indomethacin; Lymphocyte A | 1986 |
T lymphocyte function during experimental Chagas' disease: production of and response to interleukin 2.
Topics: Animals; Catalase; Chagas Disease; Concanavalin A; Immune Tolerance; Indomethacin; Interleukin-2; Ly | 1985 |