eflornithine has been researched along with Chagas Disease in 5 studies
Eflornithine: An inhibitor of ORNITHINE DECARBOXYLASE, the rate limiting enzyme of the polyamine biosynthetic pathway.
eflornithine : A fluoroamino acid that is ornithine substituted by a difluoromethyl group at position 2.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Nifurtimox is one of the two molecules used for treatment of Chagas disease." | 7.77 | [Nifurtimox, a bright future for treatment of Chagas disease]. ( Beranger, C; Boulliat, C; Coillot, C; Gaillard, K; Oliver, M; Rouault, M; Wolf, A, 2011) |
| "Nifurtimox is one of the two molecules used for treatment of Chagas disease." | 3.77 | [Nifurtimox, a bright future for treatment of Chagas disease]. ( Beranger, C; Boulliat, C; Coillot, C; Gaillard, K; Oliver, M; Rouault, M; Wolf, A, 2011) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 2 (40.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (20.00) | 29.6817 |
| 2010's | 2 (40.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Sanchez, LM | 1 |
| Knudsen, GM | 1 |
| Helbig, C | 1 |
| De Muylder, G | 1 |
| Mascuch, SM | 1 |
| Mackey, ZB | 1 |
| Gerwick, L | 1 |
| Clayton, C | 1 |
| McKerrow, JH | 1 |
| Linington, RG | 1 |
| Wolf, A | 1 |
| Boulliat, C | 1 |
| Coillot, C | 1 |
| Rouault, M | 1 |
| Gaillard, K | 1 |
| Beranger, C | 1 |
| Oliver, M | 1 |
| Heby, O | 1 |
| Persson, L | 1 |
| Rentala, M | 1 |
| Van Bogaert, I | 1 |
| Haemers, A | 1 |
| Jennings, FW | 1 |
2 reviews available for eflornithine and Chagas Disease
| Article | Year |
|---|---|
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornith | 2007 |
Eflornithine. A new drug in the treatment of sleeping sickness.
Topics: Animals; Chagas Disease; Eflornithine; Humans; Trypanocidal Agents; Trypanosoma brucei gambiense; Tr | 1989 |
3 other studies available for eflornithine and Chagas Disease
| Article | Year |
|---|---|
Examination of the mode of action of the almiramide family of natural products against the kinetoplastid parasite Trypanosoma brucei.
Topics: Animals; Biological Products; Chagas Disease; Glycolysis; Humans; Leishmania donovani; Lipopeptides; | 2013 |
[Nifurtimox, a bright future for treatment of Chagas disease].
Topics: Chagas Cardiomyopathy; Chagas Disease; Drug Therapy, Combination; Eflornithine; Humans; Nifurtimox; | 2011 |
Chemotherapy of trypanosomiasis: the potentiation of melarsoprol by concurrent difluoromethylornithine (DFMO) treatment.
Topics: Animals; Arsenicals; Chagas Disease; Drug Synergism; Drug Therapy, Combination; Eflornithine; Melars | 1988 |