clomipramine has been researched along with Chagas Disease in 10 studies
Clomipramine: A tricyclic antidepressant similar to IMIPRAMINE that selectively inhibits the uptake of serotonin in the brain. It is readily absorbed from the gastrointestinal tract and demethylated in the liver to form its primary active metabolite, desmethylclomipramine.
clomipramine : A dibenzoazepine that is 10,11-dihydro-5H-dibenzo[b,f]azepine which is substituted by chlorine at position 3 and in which the hydrogen attached to the nitrogen is replaced by a 3-(dimethylamino)propyl group. One of the more sedating tricyclic antidepressants, it is used as the hydrochloride salt for the treatment of depression as well as obsessive-compulsive disorder and phobias.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chagas disease is an important public health problem in Latin America, and its treatment by chemotherapy with benznidazole (BZ) or nifurtimox remains unsatisfactory." | 5.43 | Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease. ( Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM, 2016) |
| "Clomipramine (CLO) has been found to modify the evolution of the experimental infection." | 1.48 | In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach. ( Báez, AL; Bazán, PC; Bustamante, JM; Lo Presti, MS; Nakamura, CV; Paglini-Oliva, P; Rivarola, HW; Rodrigues, JHS; Strauss, M, 2018) |
| "Chagas disease is an important public health problem in Latin America, and its treatment by chemotherapy with benznidazole (BZ) or nifurtimox remains unsatisfactory." | 1.43 | Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease. ( Aoki, MP; García, MC; Jimenez-Kairuz, AF; Manzo, RH; Ponce, NE; Sanmarco, LM, 2016) |
| "Clomipramine is a tricyclic antidepressant drug that inhibits Trypanosoma cruzi's trypanothione reductase, provoking the death of the parasite and preventing the cardiac damage when used for the treatment of acutely infected mice." | 1.35 | Chemotherapy of chronic indeterminate Chagas disease: a novel approach to treatment. ( Bazán, PC; Enders, J; Fernández, AR; Fretes, R; Lo Presti, MS; Paglini-Oliva, P; Rivarola, HW; Triquell, MF, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 2 (20.00) | 29.6817 |
| 2010's | 8 (80.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Engel, JC | 1 |
| Ang, KK | 1 |
| Chen, S | 1 |
| Arkin, MR | 1 |
| McKerrow, JH | 1 |
| Doyle, PS | 1 |
| Braga, SF | 1 |
| Alves, ÉV | 1 |
| Ferreira, RS | 1 |
| Fradico, JR | 1 |
| Lage, PS | 1 |
| Duarte, MC | 1 |
| Ribeiro, TG | 1 |
| Júnior, PA | 1 |
| Romanha, AJ | 1 |
| Tonini, ML | 1 |
| Steindel, M | 1 |
| Coelho, EF | 1 |
| de Oliveira, RB | 1 |
| Strauss, M | 4 |
| Rodrigues, JHS | 1 |
| Lo Presti, MS | 5 |
| Bazán, PC | 4 |
| Báez, AL | 2 |
| Paglini-Oliva, P | 4 |
| Nakamura, CV | 1 |
| Bustamante, JM | 2 |
| Rivarola, HW | 7 |
| Baez, A | 3 |
| Fauro, R | 2 |
| Esteves, B | 1 |
| Sanchez Negrete, O | 1 |
| Cremonezzi, D | 2 |
| Paglini-Oliva, PA | 2 |
| Lo Presti, S | 2 |
| Bazan, C | 1 |
| Triquell, F | 1 |
| Negrete, OS | 1 |
| Willhuber, GC | 1 |
| García, MC | 1 |
| Ponce, NE | 1 |
| Sanmarco, LM | 1 |
| Manzo, RH | 1 |
| Jimenez-Kairuz, AF | 1 |
| Aoki, MP | 1 |
| Miler, N | 1 |
| Paglini, PA | 1 |
| Triquell, MF | 1 |
| Fretes, R | 3 |
| Fernández, AR | 3 |
| Enders, J | 1 |
| Gobbi, P | 1 |
| Enders, JE | 2 |
| Gea, S | 2 |
10 other studies available for clomipramine and Chagas Disease
| Article | Year |
|---|---|
Image-based high-throughput drug screening targeting the intracellular stage of Trypanosoma cruzi, the agent of Chagas' disease.
Topics: Animals; Cattle; Cell Line; Cell Line, Tumor; Chagas Disease; Drug Evaluation, Preclinical; Hepatocy | 2010 |
Synthesis and evaluation of the antiparasitic activity of bis-(arylmethylidene) cycloalkanones.
Topics: Animals; Antiprotozoal Agents; Cell Line; Chagas Disease; Fibroblasts; Humans; Leishmania mexicana; | 2014 |
In vitro and in vivo drug combination for the treatment of Trypanosoma cruzi infection: A multivariate approach.
Topics: Animals; Chagas Disease; Clomipramine; Dose-Response Relationship, Drug; Drug Synergism; Drug Therap | 2018 |
Clomipramine and benznidazole association for the treatment of acute experimental Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Evaluation, Preclinical; Electro | 2013 |
Use of clomipramine as chemotherapy of the chronic phase of Chagas disease.
Topics: Animals; Antidepressive Agents, Tricyclic; Chagas Disease; Clomipramine; DNA, Protozoan; Female; Hea | 2013 |
Clomipramine and Benznidazole Act Synergistically and Ameliorate the Outcome of Experimental Chagas Disease.
Topics: Animals; Chagas Disease; Clomipramine; Disease Models, Animal; Drug Administration Schedule; Drug Co | 2016 |
Quantitative PCR and unconventional serological methods to evaluate clomipramine treatment effectiveness in experimental Trypanosoma cruzi infection.
Topics: Animals; Antibodies, Protozoan; Chagas Disease; Clomipramine; DNA, Protozoan; Electrocardiography; F | 2016 |
Chemotherapy of chronic indeterminate Chagas disease: a novel approach to treatment.
Topics: Animals; Antiprotozoal Agents; Chagas Disease; Clomipramine; Electrocardiography; Heart; Mice; Myoca | 2008 |
Association of clomipramine and allopurinol for the treatment of the experimental infection with Trypanosoma cruzi.
Topics: Allopurinol; Animals; Antibodies, Protozoan; Antigens, Protozoan; Antiprotozoal Agents; Chagas Disea | 2010 |
Trypanosoma cruzi: chemotherapeutic effects of clomipramine in mice infected with an isolate obtained from an endemic area.
Topics: Animals; Antibodies, Protozoan; Antidepressive Agents, Tricyclic; Antigens, Protozoan; Calmodulin; C | 2005 |