thioridazine has been researched along with Chagas Disease in 5 studies
Thioridazine: A phenothiazine antipsychotic used in the management of PHYCOSES, including SCHIZOPHRENIA.
thioridazine : A phenothiazine derivative having a methylsulfanyl subsitituent at the 2-position and a (1-methylpiperidin-2-yl)ethyl] group at the N-10 position.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Thioridazine (TDZ) is a phenothiazine that has been shown to be one of the most potent phenothiazines to inhibit trypanothione reductase irreversibly." | 6.52 | Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease. ( Báez, AL; Bazán, PC; Lo Presti, MS; Paglini-Oliva, PA; Rivarola, HW; Strauss, M, 2015) |
| "Thioridazine (TDZ) is a phenothiazine that has been shown to be one of the most potent phenothiazines to inhibit trypanothione reductase irreversibly." | 2.52 | Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease. ( Báez, AL; Bazán, PC; Lo Presti, MS; Paglini-Oliva, PA; Rivarola, HW; Strauss, M, 2015) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (20.00) | 18.2507 |
| 2000's | 2 (40.00) | 29.6817 |
| 2010's | 1 (20.00) | 24.3611 |
| 2020's | 1 (20.00) | 2.80 |
| Authors | Studies |
|---|---|
| Mendonça, AAS | 1 |
| Gonçalves-Santos, E | 1 |
| Souza-Silva, TG | 1 |
| González-Lozano, KJ | 1 |
| Caldas, IS | 1 |
| Gonçalves, RV | 1 |
| Diniz, LF | 1 |
| Novaes, RD | 1 |
| Lo Presti, MS | 2 |
| Bazán, PC | 1 |
| Strauss, M | 1 |
| Báez, AL | 1 |
| Rivarola, HW | 4 |
| Paglini-Oliva, PA | 2 |
| Bustamante, JM | 2 |
| Fernández, AR | 3 |
| Enders, JE | 3 |
| Fretes, R | 2 |
| Gea, S | 2 |
| Presti, MS | 1 |
| Fretes, RE | 1 |
| Paglini-Oliva, P | 2 |
| Suligoy, M | 1 |
| Palma, JA | 1 |
1 review available for thioridazine and Chagas Disease
| Article | Year |
|---|---|
Trypanothione reductase inhibitors: Overview of the action of thioridazine in different stages of Chagas disease.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Enzyme Inhibitors; Mice; NADH, NADPH Oxid | 2015 |
4 other studies available for thioridazine and Chagas Disease
| Article | Year |
|---|---|
Thioridazine aggravates skeletal myositis, systemic and liver inflammation in Trypanosoma cruzi-infected and benznidazole-treated mice.
Topics: Acetylglucosaminidase; Animals; Chagas Disease; Cytokines; Disease Models, Animal; Drug Combinations | 2020 |
Thioridazine treatment prevents cardiopathy in Trypanosoma cruzi infected mice.
Topics: Animals; Antibodies, Protozoan; Chagas Cardiomyopathy; Chagas Disease; Disease Models, Animal; Elect | 2004 |
Treatment with benznidazole or thioridazine in the chronic phase of experimental Chagas disease improves cardiopathy.
Topics: Animals; Chagas Cardiomyopathy; Chagas Disease; Chronic Disease; Disease Models, Animal; Drug Evalua | 2007 |
Thioridazine treatment modifies the evolution of Trypanosoma cruzi infection in mice.
Topics: Animals; Chagas Disease; Drug Evaluation, Preclinical; Mice; Thioridazine; Trypanocidal Agents; Tryp | 1999 |