melatonin has been researched along with Chagas Disease in 15 studies
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "With melatonin treatment, orchiectomized animals (CMOR and IMOR) displayed the highest concentrations of IFN-γ and TNF-α." | 5.38 | Does orchiectomy enhance the immune-stimulatory effects of melatonin during experimental Chagas' disease? ( Brazão, V; Caetano, LC; Caetano, LN; do Prado, JC; Filipin, Mdel V; Santello, FH; Toldo, MP, 2012) |
| "Chagas' disease is a severe health problem in Latin America, causing approximately 50 000 deaths a year, with approximately 18 million infected people." | 5.37 | Melatonin in Chagas' disease. Possible therapeutic value. ( Alvarez, CB; Cardinali, DP, 2011) |
| "The melatonin therapy was provided in one of two different treatment regimens, that is, either beginning 7 days prior to infection or concomitant with the infection." | 5.35 | Melatonin enhances pro-inflammatory cytokine levels and protects against Chagas disease. ( AlonsoToldo, MP; Caetano, LC; do Prado, JC; Frare, EO; Santello, FH, 2008) |
| "Melatonin has remarkably diverse actions." | 2.66 | T. cruzi infection among aged rats: Melatonin as a promising therapeutic molecule. ( Brazão, V; Colato, RP; do Prado, JC; Santello, FH, 2020) |
| "Melatonin (MEL) has emerged as a promising therapy for CD due to its antioxidant and immunomodulatory properties; however, the protective action of MEL in the cardiac tissue, as well as its direct action on the parasite cycle, is not fully understood." | 1.62 | Melatonin decreases circulating ( Anchieta, NF; da Silva, CBP; de Albuquerque, S; Oliveira, PAS; Portapilla, GB; Providello, MV; Tirapelli, CR, 2021) |
| "Melatonin has a remarkable functional versatility, being associated with important antioxidant, anti-inflammatory, and anti-apoptotic effects." | 1.42 | Immunoregulatory actions of melatonin and zinc during chronic Trypanosoma cruzi infection. ( Azevedo, AP; Brazão, V; de Morais, FR; do Prado, JC; Filipin, Mdel V; Santello, FH; Toldo, MP, 2015) |
| "With melatonin treatment, orchiectomized animals (CMOR and IMOR) displayed the highest concentrations of IFN-γ and TNF-α." | 1.38 | Does orchiectomy enhance the immune-stimulatory effects of melatonin during experimental Chagas' disease? ( Brazão, V; Caetano, LC; Caetano, LN; do Prado, JC; Filipin, Mdel V; Santello, FH; Toldo, MP, 2012) |
| "The etiology of Chagas' disease, caused by a protozoan parasite Trypanosoma cruzi, has been the focus of considerable discussion, although chronic phase still remains not fully understood." | 1.37 | Melatonin and zinc treatment: distinctive modulation of cytokine production in chronic experimental Trypanosoma cruzi infection. ( Abrahão, AA; Brazão, V; Caetano, LC; Del Vecchio Filipin, M; do Prado, JC; Santello, FH; Toldo, MP, 2011) |
| "Chagas' disease is a severe health problem in Latin America, causing approximately 50 000 deaths a year, with approximately 18 million infected people." | 1.37 | Melatonin in Chagas' disease. Possible therapeutic value. ( Alvarez, CB; Cardinali, DP, 2011) |
| "Treatment with melatonin, DHEA and the association showed a significant reduction in the number of blood trypomastigotes during the acute phase of infection as compared to untreated animals (P < 0." | 1.35 | Melatonin and dehydroepiandrosterone combination: does this treatment exert a synergistic effect during experimental Trypanosoma cruzi infection? ( Alonso Toldo, MP; de Albuquerque, S; do Prado, JC; Ferreira, DS; Kuehn, CC; Rodrigues Oliveira, LG; Santos, CD, 2009) |
| "The melatonin therapy was provided in one of two different treatment regimens, that is, either beginning 7 days prior to infection or concomitant with the infection." | 1.35 | Melatonin enhances pro-inflammatory cytokine levels and protects against Chagas disease. ( AlonsoToldo, MP; Caetano, LC; do Prado, JC; Frare, EO; Santello, FH, 2008) |
| "Melatonin is an effective regulator of the immune system." | 1.35 | Suppressive action of melatonin on the TH-2 immune response in rats infected with Trypanosoma cruzi. ( Alonso Toldo, MP; Caetano, LC; do Prado, JC; dos Santos, CD; Frare, EO; Santello, FH, 2008) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 5 (33.33) | 29.6817 |
| 2010's | 8 (53.33) | 24.3611 |
| 2020's | 2 (13.33) | 2.80 |
| Authors | Studies |
|---|---|
| Brazão, V | 8 |
| Santello, FH | 11 |
| Colato, RP | 3 |
| do Prado, JC | 12 |
| Providello, MV | 1 |
| Portapilla, GB | 1 |
| Oliveira, PAS | 1 |
| da Silva, CBP | 1 |
| Anchieta, NF | 1 |
| Tirapelli, CR | 3 |
| de Albuquerque, S | 2 |
| Mazotti, TT | 1 |
| Tazinafo, LF | 1 |
| Toldo, MPA | 1 |
| do Vale, GT | 1 |
| Vale, GTD | 1 |
| Gonzaga, NA | 1 |
| Prado, JCD | 1 |
| Filipin, Mdel V | 3 |
| Azevedo, AP | 2 |
| Toldo, MP | 6 |
| de Morais, FR | 2 |
| Del Vecchio Filipin, M | 2 |
| Caetano, LC | 5 |
| Caetano, LN | 2 |
| Dos Santos, CD | 3 |
| Alonso Toldo, MP | 3 |
| Kuehn, CC | 2 |
| Rodrigues Oliveira, LG | 1 |
| Santos, CD | 2 |
| Ferreira, DS | 1 |
| Oliveira, LG | 1 |
| Abrahão, AA | 1 |
| Cardinali, DP | 1 |
| Alvarez, CB | 1 |
| Frare, EO | 3 |
| Kawasse, LM | 1 |
| Zucoloto, S | 1 |
| AlonsoToldo, MP | 1 |
1 review available for melatonin and Chagas Disease
| Article | Year |
|---|---|
T. cruzi infection among aged rats: Melatonin as a promising therapeutic molecule.
Topics: Animals; Antioxidants; Chagas Disease; Melatonin; Rats; Rats, Wistar; Trypanosoma cruzi | 2020 |
14 other studies available for melatonin and Chagas Disease
| Article | Year |
|---|---|
Melatonin decreases circulating
Topics: Animals; Chagas Disease; Heart; Melatonin; Mice; Trypanosoma cruzi | 2021 |
Melatonin: Antioxidant and modulatory properties in age-related changes during Trypanosoma cruzi infection.
Topics: Aging; Animals; Antioxidants; CD28 Antigens; Chagas Disease; Macrophages, Peritoneal; Male; Melatoni | 2017 |
Effects of melatonin on thymic and oxidative stress dysfunctions during Trypanosoma cruzi infection.
Topics: Animals; Antioxidants; Chagas Disease; Male; Melatonin; Oxidative Stress; Rats; Rats, Wistar; Supero | 2018 |
Immunomodulatory properties and anti-apoptotic effects of zinc and melatonin in an experimental model of chronic Chagas disease.
Topics: Animals; Antigens, CD; Apoptosis; CD4-Positive T-Lymphocytes; CD8-Positive T-Lymphocytes; Cell Separ | 2015 |
Immunoregulatory actions of melatonin and zinc during chronic Trypanosoma cruzi infection.
Topics: Animals; Chagas Disease; Forkhead Transcription Factors; Immunologic Factors; Interferon-gamma; Inte | 2015 |
Influence of melatonin therapy and orchiectomy on T cell subsets in male Wistar rats infected with Trypanosoma cruzi.
Topics: Animals; CD3 Complex; CD4-Positive T-Lymphocytes; Central Nervous System Depressants; Chagas Disease | 2009 |
Melatonin and dehydroepiandrosterone combination: does this treatment exert a synergistic effect during experimental Trypanosoma cruzi infection?
Topics: Adjuvants, Immunologic; Animals; Antioxidants; Chagas Disease; Dehydroepiandrosterone; Drug Combinat | 2009 |
Enhanced protection by melatonin and meloxicam combination in experimental infection by Trypanosoma cruzi.
Topics: Animals; Chagas Disease; Dinoprostone; Drug Synergism; Immunologic Factors; Interferon-gamma; Interl | 2010 |
Melatonin and zinc treatment: distinctive modulation of cytokine production in chronic experimental Trypanosoma cruzi infection.
Topics: Animals; Antigens, CD; Cell Count; Cell Proliferation; Chagas Disease; Chronic Disease; Concanavalin | 2011 |
Melatonin in Chagas' disease. Possible therapeutic value.
Topics: Animals; Antioxidants; Central Nervous System Depressants; Chagas Cardiomyopathy; Chagas Disease; Ch | 2011 |
Does orchiectomy enhance the immune-stimulatory effects of melatonin during experimental Chagas' disease?
Topics: Animals; Chagas Disease; Gene Expression Regulation; Interferon-gamma; Lipopolysaccharides; Macropha | 2012 |
Melatonin treatment reduces the severity of experimental Trypanosoma cruzi infection.
Topics: Adjuvants, Immunologic; Animals; Chagas Disease; Heart; Interleukin-2; Male; Melatonin; Myocardium; | 2007 |
Melatonin enhances pro-inflammatory cytokine levels and protects against Chagas disease.
Topics: Animals; Antiprotozoal Agents; Cells, Cultured; Chagas Disease; Cytokines; Female; Humans; Inflammat | 2008 |
Suppressive action of melatonin on the TH-2 immune response in rats infected with Trypanosoma cruzi.
Topics: Analysis of Variance; Animals; Chagas Disease; Concanavalin A; Cytokines; Immunity, Active; Immunity | 2008 |