nimesulide has been researched along with Chagas Disease in 2 studies
nimesulide: structure
nimesulide : An aromatic ether having phenyl and 2-methylsulfonamido-5-nitrophenyl as the two aryl groups.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole." | 5.62 | Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action. ( Côrte-Real, S; Decote-Ricardo, D; Freire de Lima, ME; Freire-de-Lima, CG; Trindade, JDS, 2021) |
| "Chagas disease is a neglected illness caused by Trypanosoma cruzi and its treatment is done only with two drugs, nifurtimox and benznidazole." | 1.62 | Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action. ( Côrte-Real, S; Decote-Ricardo, D; Freire de Lima, ME; Freire-de-Lima, CG; Trindade, JDS, 2021) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 1 (50.00) | 29.6817 |
| 2010's | 0 (0.00) | 24.3611 |
| 2020's | 1 (50.00) | 2.80 |
| Authors | Studies |
|---|---|
| Trindade, JDS | 1 |
| Freire-de-Lima, CG | 1 |
| Côrte-Real, S | 1 |
| Decote-Ricardo, D | 1 |
| Freire de Lima, ME | 1 |
| Escalante, RD | 1 |
| de Oliveira, EC | 1 |
| Cunha, FQ | 1 |
| Vespúcio, MV | 1 |
| Ribeiro-Silva, A | 1 |
| Aprilli, F | 1 |
| Garcia, SB | 1 |
2 other studies available for nimesulide and Chagas Disease
| Article | Year |
|---|---|
Drug repurposing for Chagas disease: In vitro assessment of nimesulide against Trypanosoma cruzi and insights on its mechanisms of action.
Topics: Animals; Cell Death; Cell Survival; Chagas Disease; Drug Repositioning; Life Cycle Stages; Mice, Inb | 2021 |
Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis.
Topics: Animals; Anti-Inflammatory Agents, Non-Steroidal; Carcinogens; Chagas Disease; Colorectal Neoplasms; | 2006 |