Page last updated: 2024-12-05

bromelia

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

Bromelia: A plant genus of the family BROMELIACEAE. Members contain karatasin and balansain (ENDOPEPTIDASES) and BROMELAINS. [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Bromelia	genus	A plant genus of the family BROMELIACEAE. Members contain karatasin and balansain (ENDOPEPTIDASES) and BROMELAINS.[MeSH]	Bromeliaceae	A plant family of the order Bromeliales, subclass Zingiberidae, class Liliopsida (monocotyledons).[MeSH]

Cross-References

ID Source	ID
PubMed CID	7129
CHEBI ID	173790
SCHEMBL ID	111274
MeSH ID	M0396901

Synonyms (60)

Synonym
CHEBI:173790
ai3-00132
brn 2042397
ethyl beta-naphthyl ether
ethyl beta-naphtholate
beta-naphthol ethyl ether
nsc 1319
beta-naphthyl ethyl ether
einecs 202-226-7
fema no. 2768
ethyl-beta-napthylether
naphthalene, 2-ethoxy-
wln: l66j co2
nerolin (new)
2-ethoxynaphthalene
neroline
ethyl .beta.-naphthyl ether
nsc-1319
bromelia
2-naphthol ethyl ether
bromelia (compound)
.beta.-naphthol ethyl ether
93-18-5
ethyl 2-naphthyl ether
.beta.-naphthyl ethyl ether
nerolin new
nerolin ii
nsc1319
ethyl .beta.-naphtholate
nerolin bromelia, >=99%, fg
gumojenffhzafp-uhfffaoysa-
inchi=1/c12h12o/c1-2-13-12-8-7-10-5-3-4-6-11(10)9-12/h3-9h,2h2,1h3
AKOS000280859
N0431
A844468
4-06-00-04257 (beilstein handbook reference)
unii-zf3is6g3r7
zf3is6g3r7 ,
FT-0612215
beta-naphthyl ethyl ether [fcc]
2-ethoxynaphthalene [mi]
.beta.-naphthyl ethyl ether [fhfi]
nerolin bromelia
SCHEMBL111274
2-ethoxynapthalene
DTXSID2049684
.beta.-ethoxynaphthalene
W-100248
mfcd00016808
2-ethoxynaphthalene, analytical standard
Z53835291
2-ethoxy-naphthalene
b-naphthyl ethyl ether
fema 2768
beta-ethoxynaphthalene
Q1371468
AS-57148
CS-W010770
E82989
EN300-16134

Research Excerpts

Overview

Bromelia balansae is a relatively unexplored medicinal species that is used for nutritional purposes and in folk medicine to treat cough or wounds. Bromelia pinguin L. is a plant broadly distributed in Central America and Caribbean islands.

Excerpt	Reference	Relevance
"Bromelia karatas L. is a plant species from the Americas. "	( Protein extract of Bromelia karatas L. rich in cysteine proteases (ananain- and bromelain-like) has antibacterial activity against foodborne pathogens Listeria monocytogenes and Salmonella Typhimurium. Ávalos-Flores, E; Hupfer, Y; López-Castillo, LM; Magaña-Ortiz, D; Wielsch, N; Winkler, R, 2022)	2.49
"Bromelia balansae is a relatively unexplored medicinal species that is used for nutritional purposes and in folk medicine to treat cough or wounds."	( Toxicological evaluation and anti-inflammatory potential of an ethanolic extract from Bromelia balansae (Bromeliaceae) fruit. Arena, AC; Cardoso, CAL; da Silva Balin, P; Jorge, BC; Kassuya, CAL; Kassuya, RM; Leitão, M; Zanatta, FC, 2018)	2.15
"Bromelia pinguin L. is a plant native to Sinaloa, Mexico, where its fruit is used as food or as a phytotherapeutic agent. "	( Physicochemical, nutritional and antibacterial characteristics of the fruit of Bromelia pinguin L. Delgado-Vargas, F; Díaz-Camacho, SP; López-Angulo, G; Paredes-López, O; Pío-León, JF; Uribe-Beltrán, Mde J, 2009)	2.02
"Bromelia pinguin L. is a plant broadly distributed in Central America and Caribbean islands. "	( Purification and characterization of four new cysteine endopeptidases from fruits of Bromelia pinguin L. grown in Cuba. Caffini, NO; Obregón, WD; Payrol, JA; Trejo, SA, 2008)	2.01

Effects

Excerpt	Reference	Relevance
"Bromelia antiacantha has ornithophilous and melittophilous features, and despite being pollinated by two kinds of agents, its reproductive success depends on a given set of circumstances."	( The pollination of Bromelia antiacantha (Bromeliaceae) in southeastern Brazil: ornithophilous versus melittophilous features. Canela, MB; Sazima, M, 2005)	1.38

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Drug Classes (1)

Class	Description
naphthalenes	Any benzenoid aromatic compound having a skeleton composed of two ortho-fused benzene rings.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Research

Studies (63)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (1.59)	18.7374
1990's	0 (0.00)	18.2507
2000's	17 (26.98)	29.6817
2010's	38 (60.32)	24.3611
2020's	7 (11.11)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 82.03

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be very strong demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	82.03 (24.57)
Research Supply Index	4.22 (2.92)
Research Growth Index	4.54 (4.65)
Search Engine Demand Index	206.23 (26.88)
Search Engine Supply Index	2.90 (0.95)

This Compound (82.03)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	1 (1.49%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	66 (98.51%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methanol Methanol: A colorless, flammable liquid used in the manufacture of FORMALDEHYDE and ACETIC ACID, in chemical synthesis, antifreeze, and as a solvent. Ingestion of methanol is toxic and may cause blindness.. primary alcohol : A primary alcohol is a compound in which a hydroxy group, -OH, is attached to a saturated carbon atom which has either three hydrogen atoms attached to it or only one other carbon atom and two hydrogen atoms attached to it.. methanol : The primary alcohol that is the simplest aliphatic alcohol, comprising a methyl and an alcohol group.	2.05	1	alkyl alcohol; one-carbon compound; primary alcohol; volatile organic compound	amphiprotic solvent; Escherichia coli metabolite; fuel; human metabolite; mouse metabolite; Mycoplasma genitalium metabolite
mercaptoethanol Mercaptoethanol: A water-soluble thiol derived from hydrogen sulfide and ethanol. It is used as a reducing agent for disulfide bonds and to protect sulfhydryl groups from oxidation.	2.15	1	alkanethiol; primary alcohol	geroprotector
malathion Malathion: A wide spectrum aliphatic organophosphate insecticide widely used for both domestic and commercial agricultural purposes.. malathion : A racemate comprising equimolar amounts of (R) and (S)-malathion. It is a broad spectrum organophosphate proinsecticide used to control a wide range of pests including Coleoptera, Diptera, fruit flies, mosquitos and spider mites.. diethyl 2-[(dimethoxyphosphorothioyl)thio]succinate : A diester that is diethyl succinate in which position 2 is substituted by a (dimethoxyphosphorothioyl)thio group.	2.15	1	diester; ethyl ester; organic thiophosphate
leucine Leucine: An essential branched-chain amino acid important for hemoglobin formation.. leucine : A branched-chain amino acid that consists of glycine in which one of the hydrogens attached to the alpha-carbon is substituted by an isobutyl group.	2.08	1	amino acid zwitterion; L-alpha-amino acid; leucine; proteinogenic amino acid; pyruvate family amino acid	algal metabolite; Escherichia coli metabolite; human metabolite; mouse metabolite; plant metabolite; Saccharomyces cerevisiae metabolite
asparagine Asparagine: A non-essential amino acid that is involved in the metabolic control of cell functions in nerve and brain tissue. It is biosynthesized from ASPARTIC ACID and AMMONIA by asparagine synthetase. (From Concise Encyclopedia Biochemistry and Molecular Biology, 3rd ed). asparagine : An alpha-amino acid in which one of the hydrogens attached to the alpha-carbon of glycine is substituted by a 2-amino-2-oxoethyl group.	2.13	1	amino acid zwitterion; asparagine; aspartate family amino acid; L-alpha-amino acid; proteinogenic amino acid	Escherichia coli metabolite; human metabolite; micronutrient; mouse metabolite; nutraceutical; plant metabolite; Saccharomyces cerevisiae metabolite
dithiothreitol 1,4-dimercaptobutane-2,3-diol : A glycol that is butane-2,3-diol in which a hydrogen from each of the methyl groups is replaced by a thiol group.. 1,4-dithiothreitol : The threo-diastereomer of 1,4-dimercaptobutane-2,3-diol.	2.15	1	1,4-dimercaptobutane-2,3-diol; butanediols; dithiol; glycol; thiol	chelator; human metabolite; reducing agent
permethrin hemoglobin Atlanta-Coventry: Leu replaced by Pro at beta75 and Leu deleted at beta141	2.17	1	cyclopropanecarboxylate ester; cyclopropanes	agrochemical; ectoparasiticide; pyrethroid ester acaricide; pyrethroid ester insecticide; scabicide
fibrinogen Fibrinogen: Plasma glycoprotein clotted by thrombin, composed of a dimer of three non-identical pairs of polypeptide chains (alpha, beta, gamma) held together by disulfide bonds. Fibrinogen clotting is a sol-gel change involving complex molecular arrangements: whereas fibrinogen is cleaved by thrombin to form polypeptides A and B, the proteolytic action of other enzymes yields different fibrinogen degradation products.. D-iditol : The D-enantiomer of iditol.	7.13	1	iditol	fungal metabolite
fibrin Fibrin: A protein derived from FIBRINOGEN in the presence of THROMBIN, which forms part of the blood clot.	7.13	1	peptide
bromochloroacetic acid Keratins: A class of fibrous proteins or scleroproteins that represents the principal constituent of EPIDERMIS; HAIR; NAILS; horny tissues, and the organic matrix of tooth ENAMEL. Two major conformational groups have been characterized, alpha-keratin, whose peptide backbone forms a coiled-coil alpha helical structure consisting of TYPE I KERATIN and a TYPE II KERATIN, and beta-keratin, whose backbone forms a zigzag or pleated sheet structure. alpha-Keratins have been classified into at least 20 subtypes. In addition multiple isoforms of subtypes have been found which may be due to GENE DUPLICATION.. bromochloroacetic acid : A monocarboxylic acid that is acetic acid in which one of the methyl hydrogens is replaced by bromine while a second is replaced by chlorine. A low-melting (27.5-31.5degreeC), hygroscopic crystalline solid, it can be formed during the disinfection (by chlorination) of water that contains bromide ions and organic matter, so can occur in drinking water as a byproduct of the disinfection process.	2.17	1	2-bromocarboxylic acid; monocarboxylic acid; organochlorine compound
sodium dodecyl sulfate Sodium Dodecyl Sulfate: An anionic surfactant, usually a mixture of sodium alkyl sulfates, mainly the lauryl; lowers surface tension of aqueous solutions; used as fat emulsifier, wetting agent, detergent in cosmetics, pharmaceuticals and toothpastes; also as research tool in protein biochemistry.. sodium dodecyl sulfate : An organic sodium salt that is the sodium salt of dodecyl hydrogen sulfate.	2.15	1	organic sodium salt	detergent; protein denaturant
cysteine Cysteine: A thiol-containing non-essential amino acid that is oxidized to form CYSTINE.. L-cysteinium : The L-enantiomer of cysteinium.. cysteine : A sulfur-containing amino acid that is propanoic acid with an amino group at position 2 and a sulfanyl group at position 3.	2.03	1	cysteinium	fundamental metabolite
ants Ants: Insects of the family Formicidae, very common and widespread, probably the most successful of all the insect groups. All ants are social insects, and most colonies contain three castes, queens, males, and workers. Their habits are often very elaborate and a great many studies have been made of ant behavior. Ants produce a number of secretions that function in offense, defense, and communication. (From Borror, et al., An Introduction to the Study of Insects, 4th ed, p676)	7.13	1
chlorophyll a Chlorophyll: Porphyrin derivatives containing magnesium that act to convert light energy in photosynthetic organisms.. chlorophyll : A family of magnesium porphyrins, defined by the presence of a fifth ring beyond the four pyrrole-like rings. The rings can have various side chains which usually include a long phytol chain.	2.52	2	chlorophyll; methyl ester	cofactor

Condition	Relationship Strength	Studies
Dehydration The condition that results from excessive loss of water from a living organism.	2.21	1
Anasarca [description not available]	2.52	2
Pleurisy INFLAMMATION of PLEURA, the lining of the LUNG. When PARIETAL PLEURA is involved, there is pleuritic CHEST PAIN.	2.17	1
Edema Abnormal fluid accumulation in TISSUES or body cavities. Most cases of edema are present under the SKIN in SUBCUTANEOUS TISSUE.	2.52	2
Congenital Zika Syndrome [description not available]	2.17	1
Zika Virus Infection A viral disease transmitted by the bite of AEDES mosquitoes infected with ZIKA VIRUS. Its mild DENGUE-like symptoms include fever, rash, headaches and ARTHRALGIA. The viral infection during pregnancy, in rare cases, is associated with congenital brain and ocular abnormalities, called Congenital Zika Syndrome, including MICROCEPHALY and may also lead to GUILLAIN-BARRE SYNDROME.	2.17	1
Break-Bone Fever [description not available]	2.49	2
Dengue An acute febrile disease transmitted by the bite of AEDES mosquitoes infected with DENGUE VIRUS. It is self-limiting and characterized by fever, myalgia, headache, and rash. SEVERE DENGUE is a more virulent form of dengue.	7.49	2
Polyploid [description not available]	2.06	1
American Trypanosomiasis [description not available]	2.07	1
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	2.07	1
Infections, Plasmodium [description not available]	1.93	1
Malaria A protozoan disease caused in humans by four species of the PLASMODIUM genus: PLASMODIUM FALCIPARUM; PLASMODIUM VIVAX; PLASMODIUM OVALE; and PLASMODIUM MALARIAE; and transmitted by the bite of an infected female mosquito of the genus ANOPHELES. Malaria is endemic in parts of Asia, Africa, Central and South America, Oceania, and certain Caribbean islands. It is characterized by extreme exhaustion associated with paroxysms of high FEVER; SWEATING; shaking CHILLS; and ANEMIA. Malaria in ANIMALS is caused by other species of plasmodia.	6.93	1

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