Page last updated: 2024-12-08

n,n'-bis(benzyl)-1,3-diaminopropane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,N'-bis(benzyl)-1,3-diaminopropane: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID151498
CHEMBL ID1950459
SCHEMBL ID893154
MeSH IDM0169497

Synonyms (23)

Synonym
AC-20397
n,n'-dibenzyl-1,3-propanediamine
10239-34-6
n,n'-dibenzylpropane-1,3-diamine
AKOS004909976
n,n'-bis(benzyl)-1,3-diaminopropane
1,3-propanediamine, n,n'-bis(phenylmethyl)-
n1,n3-dibenzylpropane-1,3-diamine
CHEMBL1950459
SCHEMBL893154
propane-1,3-diamine, n,n'-dibenzyl-
n,n'-bis(phenylmethyl)-1,3-propanediamine
DTXSID70144985
n,n'-dibenzyl-1,3-diaminopropane
FT-0769101
F21421
mfcd06661418
AS-17253
1,3-propanediamine, n1,n3-bis(phenylmethyl)-
A896810
SY102371
n,n inverted exclamation mark -dibenzyl-1,3-propanediamine
CS-0047703
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID647904Selectivity ratio of IC50 for african green monkey Vero cells to IC50 for Leishmania donovani S1 promastigotes2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348961Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055494Cytotoxicity against human HuH7 cells2013European journal of medicinal chemistry, , Volume: 70Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID1348964Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 48 hrs2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055493Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for cell culture derived HCV expressing NS5A-GFP fusion protein2013European journal of medicinal chemistry, , Volume: 70Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID647901Cytotoxicity against african green monkey Vero cells at 4.76 ug/ml after 48 hrs by neutral red assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID647903Selectivity ratio of IC50 for african green monkey Vero cells to IC50 for Trypanosoma brucei MITat 427 clone 221a trypomastigotes2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348962Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for chloroquine-resistant Plasmodium falciparum W22018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1348959Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID647776Antitrypanosomal activity against Trypanosoma brucei MITat 427 clone 221a trypomastigotes after 3 days by alamar blue assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348963Growth inhibition of GFP-fused Toxoplasma gondii RH infected in HFF at 1 uM after 3 days by fluorescence microscopic method relative to control2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID647778Antileishmanial activity against Leishmania donovani S1 promastigotes after 72 hrs by alamar blue assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348960Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for chloroquine-sensitive Plasmodium falciparum D62018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055495Antiviral activity against cell culture derived HCV expressing NS5A-GFP fusion protein infected in human HuH7 cells assessed as inhibition of viral life cycle after 72 hrs by Hoechst-33342 staining-based confocal microscopy2013European journal of medicinal chemistry, , Volume: 70Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID647777Antitrypanosomal activity against Trypanosoma cruzi clone CL-Brener epimastigotes after 14 days by alamar blue assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]