Compounds > n,n'-bis(benzyl)-1,3-diaminopropane
Page last updated: 2024-12-08

n,n'-bis(benzyl)-1,3-diaminopropane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,N'-bis(benzyl)-1,3-diaminopropane: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID SourceID
PubMed CID151498
CHEMBL ID1950459
SCHEMBL ID893154
MeSH IDM0169497

Synonyms (23)

Synonym
AC-20397
n,n'-dibenzyl-1,3-propanediamine
10239-34-6
n,n'-dibenzylpropane-1,3-diamine
AKOS004909976
n,n'-bis(benzyl)-1,3-diaminopropane
1,3-propanediamine, n,n'-bis(phenylmethyl)-
n1,n3-dibenzylpropane-1,3-diamine
CHEMBL1950459
SCHEMBL893154
propane-1,3-diamine, n,n'-dibenzyl-
n,n'-bis(phenylmethyl)-1,3-propanediamine
DTXSID70144985
n,n'-dibenzyl-1,3-diaminopropane
FT-0769101
F21421
mfcd06661418
AS-17253
1,3-propanediamine, n1,n3-bis(phenylmethyl)-
A896810
SY102371
n,n inverted exclamation mark -dibenzyl-1,3-propanediamine
CS-0047703
[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay IDTitleYearJournalArticle
AID647904Selectivity ratio of IC50 for african green monkey Vero cells to IC50 for Leishmania donovani S1 promastigotes2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348961Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055494Cytotoxicity against human HuH7 cells2013European journal of medicinal chemistry, , Volume: 70Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID1348964Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 48 hrs2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055493Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for cell culture derived HCV expressing NS5A-GFP fusion protein2013European journal of medicinal chemistry, , Volume: 70Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID647901Cytotoxicity against african green monkey Vero cells at 4.76 ug/ml after 48 hrs by neutral red assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID647903Selectivity ratio of IC50 for african green monkey Vero cells to IC50 for Trypanosoma brucei MITat 427 clone 221a trypomastigotes2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348962Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for chloroquine-resistant Plasmodium falciparum W22018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1348959Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID647776Antitrypanosomal activity against Trypanosoma brucei MITat 427 clone 221a trypomastigotes after 3 days by alamar blue assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348963Growth inhibition of GFP-fused Toxoplasma gondii RH infected in HFF at 1 uM after 3 days by fluorescence microscopic method relative to control2018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID647778Antileishmanial activity against Leishmania donovani S1 promastigotes after 72 hrs by alamar blue assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348960Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for chloroquine-sensitive Plasmodium falciparum D62018European journal of medicinal chemistry, Jan-01, Volume: 143A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055495Antiviral activity against cell culture derived HCV expressing NS5A-GFP fusion protein infected in human HuH7 cells assessed as inhibition of viral life cycle after 72 hrs by Hoechst-33342 staining-based confocal microscopy2013European journal of medicinal chemistry, , Volume: 70Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID647777Antitrypanosomal activity against Trypanosoma cruzi clone CL-Brener epimastigotes after 14 days by alamar blue assay2012Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4
Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

TimeframeStudies, This Drug (%)All Drugs %
pre-19901 (20.00)18.7374
1990's1 (20.00)18.2507
2000's0 (0.00)29.6817
2010's3 (60.00)24.3611
2020's0 (0.00)2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

MetricThis Compound (vs All)
Research Demand Index12.53 (24.57)
Research Supply Index1.79 (2.92)
Research Growth Index4.32 (4.65)
Search Engine Demand Index0.00 (26.88)
Search Engine Supply Index0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication TypeThis drug (%)All Drugs (%)
Trials0 (0.00%)5.53%
Reviews0 (0.00%)6.00%
Case Studies0 (0.00%)4.05%
Observational0 (0.00%)0.25%
Other5 (100.00%)84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]
SubstanceRelationship StrengthStudiesTrialsClassesRoles
benzaldehyde
[no description available]		1.9710benzaldehydesEC 3.1.1.3 (triacylglycerol lipase) inhibitor;
EC 3.5.5.1 (nitrilase) inhibitor;
flavouring agent;
fragrance;
odorant receptor agonist;
plant metabolite
cadaverine
[no description available]		1.9910alkane-alpha,omega-diamineDaphnia magna metabolite;
Escherichia coli metabolite;
mouse metabolite;
plant metabolite
trimethylenediamine
trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.		1.9710alkane-alpha,omega-diaminehuman metabolite;
mouse metabolite;
reagent
putrescine
[no description available]		2.3920alkane-alpha,omega-diamineantioxidant;
fundamental metabolite
spermine
[no description available]		2.0810polyazaalkane;
tetramine		antioxidant;
fundamental metabolite;
immunosuppressive agent
chloroquine
Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.		2.1710aminoquinoline;
organochlorine compound;
secondary amino compound;
tertiary amino compound		anticoronaviral agent;
antimalarial;
antirheumatic drug;
autophagy inhibitor;
dermatologic drug
pentamidine
Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.		2.0710aromatic ether;
carboxamidine;
diether		anti-inflammatory agent;
antifungal agent;
calmodulin antagonist;
chemokine receptor 5 antagonist;
EC 2.3.1.48 (histone acetyltransferase) inhibitor;
NMDA receptor antagonist;
S100 calcium-binding protein B inhibitor;
trypanocidal drug;
xenobiotic
pyrimethamine
Maloprim: contains above 2 cpds		2.1710aminopyrimidine;
monochlorobenzenes		antimalarial;
antiprotozoal drug;
EC 1.5.1.3 (dihydrofolate reductase) inhibitor
benzathine
benzathine: RN given refers to parent cpd with specified locants for phenylmethyl groups; structure		2.0810diamine
artemisinin
(+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.		2.1710organic peroxide;
sesquiterpene lactone		antimalarial;
plant metabolite
amphotericin b
Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.		2.0710antibiotic antifungal drug;
macrolide antibiotic;
polyene antibiotic		antiamoebic agent;
antiprotozoal drug;
bacterial metabolite
nifurtimox
Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.		2.0710nitrofuran antibiotic
ConditionIndicatedRelationship StrengthStudiesTrials
Black Fever
[description not available]		02.0710
African Sleeping Sickness
[description not available]		02.0710
American Trypanosomiasis
[description not available]		02.0710
Leishmaniasis, Visceral
A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.		02.0710
Trypanosomiasis, African
A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.		02.0710
Chagas Disease
Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.		02.0710
Carcinoma, Epidermoid
[description not available]		01.9910
Experimental Hepatoma
[description not available]		01.9910
Carcinoma, Squamous Cell
A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)		01.9910