n,n'-bis(benzyl)-1,3-diaminopropane

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

N,N'-bis(benzyl)-1,3-diaminopropane: RN given refers to parent cpd [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Cross-References

ID Source	ID
PubMed CID	151498
CHEMBL ID	1950459
SCHEMBL ID	893154
MeSH ID	M0169497

Synonyms (23)

Synonym
AC-20397
n,n'-dibenzyl-1,3-propanediamine
10239-34-6
n,n'-dibenzylpropane-1,3-diamine
AKOS004909976
n,n'-bis(benzyl)-1,3-diaminopropane
1,3-propanediamine, n,n'-bis(phenylmethyl)-
n1,n3-dibenzylpropane-1,3-diamine
CHEMBL1950459
SCHEMBL893154
propane-1,3-diamine, n,n'-dibenzyl-
n,n'-bis(phenylmethyl)-1,3-propanediamine
DTXSID70144985
n,n'-dibenzyl-1,3-diaminopropane
FT-0769101
F21421
mfcd06661418
AS-17253
1,3-propanediamine, n1,n3-bis(phenylmethyl)-
A896810
SY102371
n,n inverted exclamation mark -dibenzyl-1,3-propanediamine
CS-0047703

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (15)

Assay ID	Title	Year	Journal	Article
AID647904	Selectivity ratio of IC50 for african green monkey Vero cells to IC50 for Leishmania donovani S1 promastigotes	2012	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4	Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348961	Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH release assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055494	Cytotoxicity against human HuH7 cells	2013	European journal of medicinal chemistry, , Volume: 70	Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID1348964	Cytotoxicity against African green monkey Vero cells assessed as reduction in cell viability after 48 hrs	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055493	Selectivity index, ratio of CC50 for human HuH7 cells to EC50 for cell culture derived HCV expressing NS5A-GFP fusion protein	2013	European journal of medicinal chemistry, , Volume: 70	Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID647901	Cytotoxicity against african green monkey Vero cells at 4.76 ug/ml after 48 hrs by neutral red assay	2012	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4	Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID647903	Selectivity ratio of IC50 for african green monkey Vero cells to IC50 for Trypanosoma brucei MITat 427 clone 221a trypomastigotes	2012	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4	Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348962	Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for chloroquine-resistant Plasmodium falciparum W2	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1348959	Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH release assay	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID647776	Antitrypanosomal activity against Trypanosoma brucei MITat 427 clone 221a trypomastigotes after 3 days by alamar blue assay	2012	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4	Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348963	Growth inhibition of GFP-fused Toxoplasma gondii RH infected in HFF at 1 uM after 3 days by fluorescence microscopic method relative to control	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID647778	Antileishmanial activity against Leishmania donovani S1 promastigotes after 72 hrs by alamar blue assay	2012	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4	Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
AID1348960	Selectivity index, ratio of IC50 for African green monkey Vero cells to IC50 for chloroquine-sensitive Plasmodium falciparum D6	2018	European journal of medicinal chemistry, Jan-01, Volume: 143	A minimalistic approach to develop new anti-apicomplexa polyamines analogs.
AID1055495	Antiviral activity against cell culture derived HCV expressing NS5A-GFP fusion protein infected in human HuH7 cells assessed as inhibition of viral life cycle after 72 hrs by Hoechst-33342 staining-based confocal microscopy	2013	European journal of medicinal chemistry, , Volume: 70	Synthesis and evaluation of hexahydropyrimidines and diamines as novel hepatitis C virus inhibitors.
AID647777	Antitrypanosomal activity against Trypanosoma cruzi clone CL-Brener epimastigotes after 14 days by alamar blue assay	2012	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 22, Issue:4	Synthesis and antikinetoplastid activity of a series of N,N'-substituted diamines.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (5)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (20.00)	18.7374
1990's	1 (20.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	3 (60.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.53

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.53 (24.57)
Research Supply Index	1.79 (2.92)
Research Growth Index	4.32 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.53)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	5 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
benzaldehyde [no description available]	1.97	1	benzaldehydes	EC 3.1.1.3 (triacylglycerol lipase) inhibitor; EC 3.5.5.1 (nitrilase) inhibitor; flavouring agent; fragrance; odorant receptor agonist; plant metabolite
cadaverine [no description available]	1.99	1	alkane-alpha,omega-diamine	Daphnia magna metabolite; Escherichia coli metabolite; mouse metabolite; plant metabolite
trimethylenediamine trimethylenediamine: RN given refers to parent cpd; structure. trimethylenediamine : An alkane-alpha,omega-diamine comprising a propane skeleton with amino substituents at positions 1 and 3.	1.97	1	alkane-alpha,omega-diamine	human metabolite; mouse metabolite; reagent
putrescine [no description available]	2.39	2	alkane-alpha,omega-diamine	antioxidant; fundamental metabolite
spermine [no description available]	2.08	1	polyazaalkane; tetramine	antioxidant; fundamental metabolite; immunosuppressive agent
chloroquine Chloroquine: The prototypical antimalarial agent with a mechanism that is not well understood. It has also been used to treat rheumatoid arthritis, systemic lupus erythematosus, and in the systemic therapy of amebic liver abscesses.. chloroquine : An aminoquinoline that is quinoline which is substituted at position 4 by a [5-(diethylamino)pentan-2-yl]amino group at at position 7 by chlorine. It is used for the treatment of malaria, hepatic amoebiasis, lupus erythematosus, light-sensitive skin eruptions, and rheumatoid arthritis.	2.17	1	aminoquinoline; organochlorine compound; secondary amino compound; tertiary amino compound	anticoronaviral agent; antimalarial; antirheumatic drug; autophagy inhibitor; dermatologic drug
pentamidine Pentamidine: Antiprotozoal agent effective in trypanosomiasis, leishmaniasis, and some fungal infections; used in treatment of PNEUMOCYSTIS pneumonia in HIV-infected patients. It may cause diabetes mellitus, central nervous system damage, and other toxic effects.. pentamidine : A diether consisting of pentane-1,5-diol in which both hydroxyl hydrogens have been replaced by 4-amidinophenyl groups. A trypanocidal drug that is used for treatment of cutaneous leishmaniasis and Chagas disease.	2.07	1	aromatic ether; carboxamidine; diether	anti-inflammatory agent; antifungal agent; calmodulin antagonist; chemokine receptor 5 antagonist; EC 2.3.1.48 (histone acetyltransferase) inhibitor; NMDA receptor antagonist; S100 calcium-binding protein B inhibitor; trypanocidal drug; xenobiotic
pyrimethamine Maloprim: contains above 2 cpds	2.17	1	aminopyrimidine; monochlorobenzenes	antimalarial; antiprotozoal drug; EC 1.5.1.3 (dihydrofolate reductase) inhibitor
benzathine benzathine: RN given refers to parent cpd with specified locants for phenylmethyl groups; structure	2.08	1	diamine
artemisinin (+)-artemisinin : A sesquiterpene lactone obtained from sweet wormwood, Artemisia annua, which is used as an antimalarial for the treatment of multi-drug resistant strains of falciparum malaria.	2.17	1	organic peroxide; sesquiterpene lactone	antimalarial; plant metabolite
amphotericin b Amphotericin B: Macrolide antifungal antibiotic produced by Streptomyces nodosus obtained from soil of the Orinoco river region of Venezuela.. amphotericin B : A macrolide antibiotic used to treat potentially life-threatening fungal infections.	2.07	1	antibiotic antifungal drug; macrolide antibiotic; polyene antibiotic	antiamoebic agent; antiprotozoal drug; bacterial metabolite
nifurtimox Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.	2.07	1	nitrofuran antibiotic

Condition	Relationship Strength	Studies
Black Fever [description not available]	2.07	1
African Sleeping Sickness [description not available]	2.07	1
American Trypanosomiasis [description not available]	2.07	1
Leishmaniasis, Visceral A chronic disease caused by LEISHMANIA DONOVANI and transmitted by the bite of several sandflies of the genera Phlebotomus and Lutzomyia. It is commonly characterized by fever, chills, vomiting, anemia, hepatosplenomegaly, leukopenia, hypergammaglobulinemia, emaciation, and an earth-gray color of the skin. The disease is classified into three main types according to geographic distribution: Indian, Mediterranean (or infantile), and African.	2.07	1
Trypanosomiasis, African A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.	2.07	1
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	2.07	1
Carcinoma, Epidermoid [description not available]	1.99	1
Experimental Hepatoma [description not available]	1.99	1
Carcinoma, Squamous Cell A carcinoma derived from stratified SQUAMOUS EPITHELIAL CELLS. It may also occur in sites where glandular or columnar epithelium is normally present. (From Stedman, 25th ed)	1.99	1

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