urea has been researched along with Chagas Disease in 2 studies
pseudourea: clinical use; structure
isourea : A carboximidic acid that is the imidic acid tautomer of urea, H2NC(=NH)OH, and its hydrocarbyl derivatives.
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| "From a series of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol screened in vitro against Trypanosoma cruzi, eight (S1 to S8) were selected for in vivo screening by single-dose oral administration (200 mg/kg of body weight) to infected mice at 5 days postinfection (dpi)." | 3.76 | In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi. ( Barbosa, HS; Carvalho, SA; da Silva, EF; de Castro, SL; de Souza, EM; Fraga, CA; Salomão, K, 2010) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 2 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Machado, FC | 1 |
| Franco, CH | 1 |
| Dos Santos Neto, JV | 1 |
| Dias-Teixeira, KL | 1 |
| Moraes, CB | 1 |
| Lopes, UG | 1 |
| Aktas, BH | 1 |
| Schenkman, S | 1 |
| Salomão, K | 1 |
| de Souza, EM | 1 |
| Carvalho, SA | 1 |
| da Silva, EF | 1 |
| Fraga, CA | 1 |
| Barbosa, HS | 1 |
| de Castro, SL | 1 |
2 other studies available for urea and Chagas Disease
| Article | Year |
|---|---|
Identification of di-substituted ureas that prevent growth of trypanosomes through inhibition of translation initiation.
Topics: Animals; Cell Line, Tumor; Cell Proliferation; Chagas Disease; eIF-2 Kinase; Eukaryotic Initiation F | 2018 |
In vitro and in vivo activities of 1,3,4-thiadiazole-2-arylhydrazone derivatives of megazol against Trypanosoma cruzi.
Topics: Alanine Transaminase; Animals; Antiprotozoal Agents; Aspartate Aminotransferases; Body Weight; Cells | 2010 |