pyrithidium bromide profile

Pyrithidium bromide is a quaternary ammonium compound that has been investigated for its potential use as an antimicrobial agent. It exhibits activity against a variety of bacteria, including *Staphylococcus aureus*, *Escherichia coli*, and *Pseudomonas aeruginosa*. Research into the synthesis of pyrithidium bromide has focused on developing efficient and scalable methods for its production. The compound's potential effects on human health and the environment are also being studied to assess its safety and environmental impact. Pyrithidium bromide is studied for its potential therapeutic applications, particularly in the treatment of skin and eye infections. Its antimicrobial properties, along with its relative safety profile, make it a promising candidate for topical medications. The compound's mechanism of action is believed to involve disruption of bacterial cell membranes, leading to cell death.'

ID Source	ID
PubMed CID	71865
CHEMBL ID	2105390
SCHEMBL ID	2732830
MeSH ID	M0045966

Synonym
prothidium
pyrithidium bromide
CHEMBL2105390
rd-2801
rd 2801
pyrithidium bromide [mart.]
phenanthridinium, 3-amino-6-(4-aminophenyl)-8-((1,2-dihydro-2-imino-1,6-dimethyl-4-pyrimidinyl)amino)-5-methyl-, bromide, hydrobromide (1:1:1)
SCHEMBL2732830

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	14 (100.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	0 (0.00)	29.6817
2010's	0 (0.00)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	14 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
bromide Bromides: Salts of hydrobromic acid, HBr, with the bromine atom in the 1- oxidation state. (From McGraw-Hill Dictionary of Scientific and Technical Terms, 4th ed)	2.34	2	halide anion; monoatomic bromine
diminazene Diminazene: An effective trypanocidal agent.. diminazene : A triazene derivative that is triazene in which each of the terminal nitrogens is substituted by a 4-carbamimidoylphenyl group.	2.36	2	carboxamidine; triazene derivative	antiparasitic agent; trypanocidal drug
ethidium Ethidium: A trypanocidal agent and possible antiviral agent that is widely used in experimental cell biology and biochemistry. Ethidium has several experimentally useful properties including binding to nucleic acids, noncompetitive inhibition of nicotinic acetylcholine receptors, and fluorescence among others. It is most commonly used as the bromide.. ethidium : The fluorescent compound widely used in experimental cell biology and biochemistry to reveal double-stranded DNA and RNA.	3.05	5	phenanthridines	fluorochrome; intercalator
ronidazole Ronidazole: Antiprotozoal and antimicrobial agent used mainly in veterinary practice.. ronidazole : A carbamate ester that is 5-nitroimidazole in which the hydrogens at positions 1 and 2 are replaced by methyl and (carbamoyloxy)methyl groups, respectively. An antiprotozoal agent, it is used in veterinary medicine for the treatment of histomoniasis and swine dysentery.	1.95	1	C-nitro compound; carbamate ester; imidazoles	antiparasitic agent; antiprotozoal drug
suramin Suramin: A polyanionic compound with an unknown mechanism of action. It is used parenterally in the treatment of African trypanosomiasis and it has been used clinically with diethylcarbamazine to kill the adult Onchocerca. (From AMA Drug Evaluations Annual, 1992, p1643) It has also been shown to have potent antineoplastic properties.. suramin : A member of the class of phenylureas that is urea in which each of the amino groups has been substituted by a 3-({2-methyl-5-[(4,6,8-trisulfo-1-naphthyl)carbamoyl]phenyl}carbamoyl)phenyl group. An activator of both the rabbit skeletal muscle RyR1 and sheep cardiac RyR2 isoform ryanodine receptor channels, it has been used for the treatment of human African trypanosomiasis for over 100 years.	1.93	1	naphthalenesulfonic acid; phenylureas; secondary carboxamide	angiogenesis inhibitor; antinematodal drug; antineoplastic agent; apoptosis inhibitor; EC 2.7.11.13 (protein kinase C) inhibitor; GABA antagonist; GABA-gated chloride channel antagonist; purinergic receptor P2 antagonist; ryanodine receptor agonist; trypanocidal drug
isoxazoles Isoxazoles: Azoles with an OXYGEN and a NITROGEN next to each other at the 1,2 positions, in contrast to OXAZOLES that have nitrogens at the 1,3 positions.. isoxazole : A monocyclic heteroarene with a structure consisting of a 5-membered ring containing three carbon atoms and an oxygen and nitrogen atom adjacent to each other. It is the parent of the class of isoxazoles.. isoxazoles : Oxazoles in which the N and O atoms are adjacent.	1.95	1	isoxazoles; mancude organic heteromonocyclic parent; monocyclic heteroarene
azomycin azomycin: RN given refers to parent cpd with specified locant; structure	2.36	2	C-nitro compound; imidazoles	antitubercular agent
dimidium dimidium: RN given refers to parent cpd	1.96	1
isometamidium chloride isometamidium chloride: Samorin & Veridium are tradenames	7.65	3	organic molecular entity
mk 436 MK 436: structure	1.95	1
quinapyramine quinapyramine: RN given refers to hydride; structure	2.34	2
diminazene aceturate diminazene diaceturate : An N-acetylglycinate salt resulting from the reaction of diminazene with 2 mol eq. of N-acetylglycine.	2.36	2	N-acetylglycinate salt	antiparasitic agent; trypanocidal drug
nifurtimox Nifurtimox: A nitrofuran thiazine that has been used against TRYPANOSOMIASIS.	1.96	1	nitrofuran antibiotic

Condition	Relationship Strength	Studies
Bovine Diseases [description not available]	2.85	4
Trypanosomiasis, Bovine Infection in cattle caused by various species of trypanosomes.	2.85	4
Trypanosomiasis Infection with protozoa of the genus TRYPANOSOMA.	3.44	8
African Sleeping Sickness [description not available]	2.86	4
Trypanosomiasis, African A disease endemic among people and animals in Central Africa. It is caused by various species of trypanosomes, particularly T. gambiense and T. rhodesiense. Its second host is the TSETSE FLY. Involvement of the central nervous system produces African sleeping sickness. Nagana is a rapidly fatal trypanosomiasis of horses and other animals.	2.86	4
American Trypanosomiasis [description not available]	1.96	1
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	1.96	1
Central Nervous System Disease [description not available]	1.95	1
Central Nervous System Diseases Diseases of any component of the brain (including the cerebral hemispheres, diencephalon, brain stem, and cerebellum) or the spinal cord.	1.95	1
Canine Diseases [description not available]	1.95	1

pyrithidium bromide

Cross-References

Synonyms (8)

Research

Studies (14)

Market Indicators

Research Demand Index: 11.74

Study Types