4-aminopyridine has been researched along with Chagas Disease in 1 studies
Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.
| Excerpt | Relevance | Reference |
|---|---|---|
| " Optimization of both binding mode and pharmacokinetic properties of these compounds led to potent inhibitors against experimental T." | 1.40 | 4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency. ( Calvet, CM; Cameron, MD; Choi, JY; Gut, J; Johnston, JB; Kellar, D; Khan, S; Lin, L; McKerrow, JH; Podust, LM; Roush, WR; Siqueira-Neto, JL; Vieira, DF, 2014) |
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 0 (0.00) | 18.2507 |
| 2000's | 0 (0.00) | 29.6817 |
| 2010's | 1 (100.00) | 24.3611 |
| 2020's | 0 (0.00) | 2.80 |
| Authors | Studies |
|---|---|
| Calvet, CM | 1 |
| Vieira, DF | 1 |
| Choi, JY | 1 |
| Kellar, D | 1 |
| Cameron, MD | 1 |
| Siqueira-Neto, JL | 1 |
| Gut, J | 1 |
| Johnston, JB | 1 |
| Lin, L | 1 |
| Khan, S | 1 |
| McKerrow, JH | 1 |
| Roush, WR | 1 |
| Podust, LM | 1 |
1 other study available for 4-aminopyridine and Chagas Disease
| Article | Year |
|---|---|
4-Aminopyridyl-based CYP51 inhibitors as anti-Trypanosoma cruzi drug leads with improved pharmacokinetic profile and in vivo potency.
Topics: 14-alpha Demethylase Inhibitors; 4-Aminopyridine; Administration, Oral; Animals; Biological Availabi | 2014 |