4-amino-6-chloro-1,3-benzenedisulfonamide profile

4-amino-6-chloro-1,3-benzenedisulfonamide: metabolite of hydrochlorothiazide [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

ID Source	ID
PubMed CID	67136
CHEMBL ID	266240
CHEBI ID	3602
SCHEMBL ID	310205
MeSH ID	M0154063

Synonym
AC-036
5-chloro-2,4-disulfamylaniline
1,3-disulfonamide, 4-amino-6-chlorobenzene-
nsc93772
salmid
nsc-93772
1, 4-amino-6-chloro-
su 5683
5-chloro-2,4-disulfamoylaniline
chloroaminophenamide
m-benzenedisulfonamide, 4-amino-6-chloro-
3-chloro-4,6-disulfamoylaniline
idorese
4-amino-6-chloro-m-benzenedisulfonamide
4-amino-6-chloro-1,3-benzenedisulfonamide
121-30-2
chloraminophenamide
C07460
4-amino-6-chlorobenzene-1,3-disulfonamide
i7b ,
bdbm10867
aromatic/heteroaromatic sulfonamide 12
chembl266240 ,
4-amino-6-chloro-1,3-benzenedisulfonamide, 98%
2POV
4-amino-6-chloro-benzene-1,3-disulfonamide
5-chloro-2,4-bis(sulfonamide)aniline
5(3)-chloroaniline-2,4(4,6)-disulfonamide
chebi:3602 ,
FT-0661667
ihjcxvzdysxxft-uhfffaoysa-
inchi=1/c6h8cln3o4s2/c7-3-1-4(8)6(16(10,13)14)2-5(3)15(9,11)12/h1-2h,8h2,(h2,9,11,12)(h2,10,13,14)
STK803151
AKOS000120232
A804710
BBL003489
4-amino-6-chloro-benzene-1,3-disulfonic acid diamide
2-amino-4-chloro-m-benzenedisulfonamide
1,3-benzenedisulfonamide, 4-amino-6-chloro-
3a52o8yrej ,
4-amino-6-chlorobenzene-1,3-disulphonamide
einecs 204-463-1
unii-3a52o8yrej
nsc 93772
ec 204-463-1
FT-0617536
4-amino-6-chloro-1,3-benzendisulfonamide
chloraminophenamide [mi]
altizide impurity a [ep impurity]
su-5683
hydrochlorothiazide impurity b [ep impurity]
1-amino-5-chloro-2,4-benzenedisulfonamide
SCHEMBL310205
2-amino-4-chloro-5-sulfamoylbenzenesulfonamide
smr002530008
MLS006011405
DTXSID1059521
W-108458
1-amino-3-chloro-4,6-benzenedisulfonamide
m-chloroaniline-4,6-disulfonamide
mfcd00007933
3-chloroaniline-4,6-disulfonamide
F0001-0341
SR-01000944745-1
sr-01000944745
4-amino-6-chlorobenzene-1,3-disulphonamide (salamide)
BCP24485
SY051012
Q27106146
AS-12956
5-chloro-2,4-disulfamyl aniline
AC1883
EN300-20263
4-amino-6-chlorobenzen-1,3-disulphonamide(salamide)
3-chloroaniline-4,6-disulfonamide, 4-amino-6-chlorobenzene-1,3-disulfonamide
SB82332
4-amino-6-chlorobenzene-1-3-disulfonamide
CS-0075543
PD053534
Z104477528

Class	Description
sulfonamide	An amide of a sulfonic acid RS(=O)2NR'2.
[compound class information is derived from Chemical Entities of Biological Interest (ChEBI), Hastings J, Owen G, Dekker A, Ennis M, Kale N, Muthukrishnan V, Turner S, Swainston N, Mendes P, Steinbeck C. (2016). ChEBI in 2016: Improved services and an expanding collection of metabolites. Nucleic Acids Res]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Chain A, Carbonic anhydrase 2	Homo sapiens (human)	Ki	0.0750	0.0380	0.0587	0.0750	AID977610
Chain A, Carbonic anhydrase 2	Homo sapiens (human)	Ki	0.0750	0.0380	0.0587	0.0750	AID977610
Chain A, Carbonic anhydrase 2	Homo sapiens (human)	Ki	0.0750	0.0380	0.0587	0.0750	AID977610
Carbonic anhydrase	Astrosclera willeyana	Ki	0.8200	0.0320	1.5172	9.6000	AID644379
Carbonic anhydrase	Sulfurihydrogenibium sp. YO3AOP1	Ki	0.0873	0.0045	0.1624	0.8760	AID1268964
Carbonic anhydrase	Stylophora pistillata	Ki	0.2950	0.0000	0.6867	10.0000	AID436565; AID552130
Carbonic anhydrase	Stylophora pistillata	Ki	0.8400	0.0000	0.5071	5.7100	AID552131
Carbonic anhydrase	Helicobacter pylori 26695	Ki	0.0450	0.0200	0.5486	4.3600	AID261581; AID263638
Carbonic anhydrase 12	Homo sapiens (human)	Ki	0.0440	0.0002	1.1043	9.9000	AID238316; AID239126
Carbonic anhydrase 1	Homo sapiens (human)	Ki	357,463,831.6998	0.0000	1.3726	10.0000	AID1142833; AID1188134; AID1190063; AID1194024; AID1195369; AID1268962; AID1275913; AID1287517; AID1291357; AID1434427; AID1453412; AID1628036; AID1796552; AID1798769; AID222125; AID238247; AID238276; AID238536; AID238957; AID261579; AID263048; AID263636; AID275807; AID349605; AID367820; AID369271; AID414955; AID427125; AID436563; AID47713; AID47717; AID497127; AID50353; AID50367; AID50370; AID50371; AID50374; AID552127; AID577526; AID612725; AID644380; AID725955; AID729566; AID743515
Carbonic anhydrase 2	Homo sapiens (human)	IC50 (µMol)	0.0960	0.0002	1.1060	8.3000	AID241604
Carbonic anhydrase 2	Homo sapiens (human)	Ki	875.9655	0.0000	0.7236	9.9200	AID1061069; AID1142834; AID1188135; AID1190064; AID1194025; AID1195370; AID1240217; AID1268963; AID1275912; AID1278409; AID1287518; AID1291358; AID1434428; AID1453413; AID1628037; AID1796552; AID1796582; AID1798769; AID222126; AID238255; AID238300; AID238574; AID238986; AID256963; AID261580; AID263049; AID263637; AID275808; AID349606; AID367821; AID369272; AID414956; AID427124; AID436564; AID437749; AID47901; AID47932; AID47935; AID47936; AID47939; AID48096; AID48104; AID481329; AID497129; AID552128; AID577527; AID612726; AID644381; AID648178; AID648179; AID648180; AID669115; AID725956; AID729565; AID743514
Carbonic anhydrase 3	Homo sapiens (human)	Ki	9.7000	0.0002	2.0102	10.0000	AID301578
5-hydroxytryptamine receptor 2C	Rattus norvegicus (Norway rat)	Ki	0.0750	0.0002	0.6677	10.0000	AID47936
5-hydroxytryptamine receptor 2A	Rattus norvegicus (Norway rat)	Ki	0.0750	0.0001	0.6017	10.0000	AID47936
Carbonic anhydrase 4	Homo sapiens (human)	Ki	0.2700	0.0002	1.9720	9.9200	AID222127; AID238575
Carbonic anhydrase 6	Homo sapiens (human)	Ki	0.6378	0.0001	1.4710	9.9200	AID1798769; AID275806; AID369273; AID552129
5-hydroxytryptamine receptor 2B	Rattus norvegicus (Norway rat)	Ki	0.0750	0.0002	0.5909	10.0000	AID47936
Delta-type opioid receptor	Mus musculus (house mouse)	Ki	4.2375	0.0000	0.5393	9.4000	AID1188134; AID1188135
Delta-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	0.0750	0.0000	0.6068	9.2330	AID1188135
Mu-type opioid receptor	Rattus norvegicus (Norway rat)	Ki	8.4000	0.0000	0.3845	8.6000	AID1188134
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	IC50 (µMol)	4.1700	0.0200	3.1081	9.4000	AID241574
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Ki	3.6563	0.0000	1.2725	9.9000	AID1796582; AID256964
Carbonic anhydrase	Methanosarcina thermophila	Ki	0.3650	0.0600	0.9714	8.5000	AID239145; AID239146
Carbonic anhydrase 7	Homo sapiens (human)	Ki	0.2100	0.0002	1.3737	9.9000	AID238256
Carbonic anhydrase	Saccharomyces cerevisiae S288C	Ki	0.1690	0.0820	0.5609	8.7000	AID367822
Mu-type opioid receptor	Cavia porcellus (domestic guinea pig)	Ki	0.0750	0.0000	0.2786	9.0000	AID1188135
Beta-carbonic anhydrase 1	Mycobacterium tuberculosis H37Rv	Ki	1.7200	0.0048	3.3841	9.8400	AID1798985; AID349607
Carbonic anhydrase 2	Mycobacterium tuberculosis H37Rv	Ki	32.5000	0.0090	2.2096	9.8400	AID437750
Carbonic anhydrase 9	Homo sapiens (human)	Ki	5.0700	0.0001	0.7874	9.9000	AID1798769; AID238987; AID239102; AID275809; AID369274; AID48296; AID48300
Carbonic anhydrase, alpha family	Hydrogenovibrio crunogenus XCL-2	Ki	0.0544	0.0025	0.3234	1.1000	AID1268965
Carbonic anhydrase	Cryptococcus neoformans var. grubii	Ki	0.3000	0.0100	0.7364	8.3470	AID669116
Carbonic anhydrase	Methanothermobacter thermautotrophicus str. Delta H	Ki	62.1000	5.3500	5.3500	5.3500	AID239250
Carbonic anhydrase	Candida albicans SC5314	Ki	0.7305	0.0105	1.4444	8.3470	AID1799266; AID427122; AID669117
Carbonic anhydrase	Anopheles gambiae (African malaria mosquito)	Ki	0.7560	0.0098	0.5117	4.3600	AID1195371
Delta carbonic anhydrase	Conticribra weissflogii	Ki	0.6620	0.0496	0.9978	9.2000	AID1061066
Carbonic anhydrase	Nakaseomyces glabratus CBS 138	Ki	0.0860	0.0070	1.2174	9.1700	AID744415
Carbonic anhydrase 4	Bos taurus (cattle)	Ki	35,553,998.3467	0.0030	0.5934	9.6500	AID238597; AID263050; AID48122; AID48279; AID48280; AID48281; AID48284; AID48289; AID48291
Carbonic anhydrase 15	Mus musculus (house mouse)	Ki	0.7073	0.0009	1.8846	10.0000	AID1798769; AID369275
Carbonic anhydrase 14	Homo sapiens (human)	Ki	0.5700	0.0002	1.5099	9.9000	AID239703
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Ki	4.1663	0.0000	1.3412	9.9700	AID1796582; AID256965
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Protein	Taxonomy	Measurement	Average	Min (ref.)	Avg (ref.)	Max (ref.)	Bioassay(s)
Carbonic anhydrase	Brucella suis 1330	Kinact	0.9400	0.0170	0.8628	5.8700	AID459696
Carbonic anhydrase 12	Homo sapiens (human)	Kinact	0.0440	0.0030	0.6674	9.6000	AID299547
Carbonic anhydrase 1	Homo sapiens (human)	Kinact	8.4000	0.0100	0.9387	8.6000	AID299242; AID299538
Carbonic anhydrase 2	Homo sapiens (human)	Kinact	0.0750	0.0030	0.7946	10.0000	AID299243; AID299539
Carbonic anhydrase 3	Homo sapiens (human)	Kinact	6.8000	3.3000	6.1657	8.0000	AID299540
Carbonic anhydrase 4	Homo sapiens (human)	Kinact	0.3800	0.0740	2.3934	8.5900	AID299541
Carbonic anhydrase 6	Homo sapiens (human)	Kinact	0.6080	0.0009	0.7261	5.3000	AID299544
Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)	Kinact	4.1500	0.0200	0.8580	9.4000	AID299542
Carbonic anhydrase 7	Homo sapiens (human)	Kinact	0.2100	0.0002	0.2852	5.7300	AID299545
Carbonic anhydrase 9	Homo sapiens (human)	Kinact	0.0390	0.0050	0.3197	6.6700	AID299546
Carbonic anhydrase 13	Mus musculus (house mouse)	Kinact	0.0210	0.0130	0.5669	8.2300	AID299548
Carbonic anhydrase 14	Homo sapiens (human)	Kinact	0.5700	0.0002	1.4495	8.5900	AID299549
Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)	Kinact	6.2000	0.0090	0.9231	9.0400	AID299543
[prepared from compound, protein, and bioassay information from National Library of Medicine (NLM), extracted Dec-2023]

Process	via Protein(s)	Taxonomy
estrous cycle	Carbonic anhydrase 12	Homo sapiens (human)
chloride ion homeostasis	Carbonic anhydrase 12	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 12	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 1	Homo sapiens (human)
morphogenesis of an epithelium	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of synaptic transmission, GABAergic	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of cellular pH reduction	Carbonic anhydrase 2	Homo sapiens (human)
angiotensin-activated signaling pathway	Carbonic anhydrase 2	Homo sapiens (human)
regulation of monoatomic anion transport	Carbonic anhydrase 2	Homo sapiens (human)
secretion	Carbonic anhydrase 2	Homo sapiens (human)
regulation of intracellular pH	Carbonic anhydrase 2	Homo sapiens (human)
neuron cellular homeostasis	Carbonic anhydrase 2	Homo sapiens (human)
positive regulation of dipeptide transmembrane transport	Carbonic anhydrase 2	Homo sapiens (human)
regulation of chloride transport	Carbonic anhydrase 2	Homo sapiens (human)
carbon dioxide transport	Carbonic anhydrase 2	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 2	Homo sapiens (human)
response to bacterium	Carbonic anhydrase 3	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 3	Homo sapiens (human)
bicarbonate transport	Carbonic anhydrase 4	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 4	Homo sapiens (human)
detection of chemical stimulus involved in sensory perception of bitter taste	Carbonic anhydrase 6	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 6	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
positive regulation of synaptic transmission, GABAergic	Carbonic anhydrase 7	Homo sapiens (human)
positive regulation of cellular pH reduction	Carbonic anhydrase 7	Homo sapiens (human)
neuron cellular homeostasis	Carbonic anhydrase 7	Homo sapiens (human)
regulation of chloride transport	Carbonic anhydrase 7	Homo sapiens (human)
regulation of intracellular pH	Carbonic anhydrase 7	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 7	Homo sapiens (human)
response to hypoxia	Carbonic anhydrase 9	Homo sapiens (human)
morphogenesis of an epithelium	Carbonic anhydrase 9	Homo sapiens (human)
response to xenobiotic stimulus	Carbonic anhydrase 9	Homo sapiens (human)
response to testosterone	Carbonic anhydrase 9	Homo sapiens (human)
secretion	Carbonic anhydrase 9	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 9	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 14	Homo sapiens (human)
response to bacterium	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
one-carbon metabolic process	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
zinc ion binding	Carbonic anhydrase 12	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 12	Homo sapiens (human)
arylesterase activity	Carbonic anhydrase 1	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
protein binding	Carbonic anhydrase 1	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 1	Homo sapiens (human)
hydro-lyase activity	Carbonic anhydrase 1	Homo sapiens (human)
cyanamide hydratase activity	Carbonic anhydrase 1	Homo sapiens (human)
arylesterase activity	Carbonic anhydrase 2	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 2	Homo sapiens (human)
protein binding	Carbonic anhydrase 2	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 2	Homo sapiens (human)
cyanamide hydratase activity	Carbonic anhydrase 2	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 3	Homo sapiens (human)
protein binding	Carbonic anhydrase 3	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 3	Homo sapiens (human)
nickel cation binding	Carbonic anhydrase 3	Homo sapiens (human)
protein binding	Carbonic anhydrase 4	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 4	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 4	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 6	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 6	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 7	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 7	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 9	Homo sapiens (human)
protein binding	Carbonic anhydrase 9	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 9	Homo sapiens (human)
molecular function activator activity	Carbonic anhydrase 9	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 4	Bos taurus (cattle)
zinc ion binding	Carbonic anhydrase 14	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 14	Homo sapiens (human)
carbonate dehydratase activity	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
zinc ion binding	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Process	via Protein(s)	Taxonomy
plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
membrane	Carbonic anhydrase 12	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
apical plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 12	Homo sapiens (human)
cytosol	Carbonic anhydrase 1	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 1	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 2	Homo sapiens (human)
cytosol	Carbonic anhydrase 2	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 2	Homo sapiens (human)
myelin sheath	Carbonic anhydrase 2	Homo sapiens (human)
apical part of cell	Carbonic anhydrase 2	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 2	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 2	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 2	Homo sapiens (human)
apical part of cell	Carbonic anhydrase 2	Homo sapiens (human)
cytosol	Carbonic anhydrase 3	Homo sapiens (human)
cytosol	Carbonic anhydrase 3	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 3	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
rough endoplasmic reticulum	Carbonic anhydrase 4	Homo sapiens (human)
endoplasmic reticulum-Golgi intermediate compartment	Carbonic anhydrase 4	Homo sapiens (human)
Golgi apparatus	Carbonic anhydrase 4	Homo sapiens (human)
trans-Golgi network	Carbonic anhydrase 4	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
external side of plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
cell surface	Carbonic anhydrase 4	Homo sapiens (human)
membrane	Carbonic anhydrase 4	Homo sapiens (human)
apical plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
transport vesicle membrane	Carbonic anhydrase 4	Homo sapiens (human)
secretory granule membrane	Carbonic anhydrase 4	Homo sapiens (human)
brush border membrane	Carbonic anhydrase 4	Homo sapiens (human)
perinuclear region of cytoplasm	Carbonic anhydrase 4	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 4	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 4	Homo sapiens (human)
extracellular region	Carbonic anhydrase 6	Homo sapiens (human)
extracellular space	Carbonic anhydrase 6	Homo sapiens (human)
cytosol	Carbonic anhydrase 6	Homo sapiens (human)
extracellular exosome	Carbonic anhydrase 6	Homo sapiens (human)
extracellular space	Carbonic anhydrase 6	Homo sapiens (human)
mitochondrial matrix	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
mitochondrion	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
mitochondrion	Carbonic anhydrase 5A, mitochondrial	Homo sapiens (human)
cytosol	Carbonic anhydrase 7	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 7	Homo sapiens (human)
nucleolus	Carbonic anhydrase 9	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
membrane	Carbonic anhydrase 9	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
microvillus membrane	Carbonic anhydrase 9	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 9	Homo sapiens (human)
side of membrane	Carbonic anhydrase 4	Bos taurus (cattle)
plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
membrane	Carbonic anhydrase 14	Homo sapiens (human)
basolateral plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
apical plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
plasma membrane	Carbonic anhydrase 14	Homo sapiens (human)
mitochondrion	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
mitochondrial matrix	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
mitochondrion	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
cytoplasm	Carbonic anhydrase 5B, mitochondrial	Homo sapiens (human)
[Information is prepared from geneontology information from the June-17-2024 release]

Bioassays (234)

Assay ID	Title	Year	Journal	Article
AID261579	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	2006	Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6	Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
AID1453411	Inhibition of Burkholderia pseudomallei beta-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
AID48281	Inhibitory activity against bovine lung microsomes carbonic anhydrase isozyme IV (bCA IV).	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
AID222127	Inhibition of cloned isozyme, human carbonic anhydrase IV	2001	Bioorganic & medicinal chemistry letters, Feb-26, Volume: 11, Issue:4	Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.
AID48104	Inhibition of human carbonic anhydrase II (CAII)	2003	Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3	Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.
AID1240217	Inhibition of human recombinant carbonic anhydrase-2 by stopped flow CO2 hydrase assay method	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID238987	Inhibitory activity against human carbonic anhydrase IX at 0.09 uM	2004	Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24	Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID1188137	Inhibition of Porphyromonas gingivalis Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.
AID1240216	Inhibition of Methanosarcina thermophila recombinant gamma carbonic anhydrase by stopped flow CO2 hydrase assay method	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID299546	Inhibition of human CA9 catalytic domain	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID238574	Inhibitory activity against human carbonic anhydrase II (hCAII)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
AID669117	Inhibition of Candida albicans CaNce103 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID743512	Inhibition of Sulfurihydrogenibium yellowstonense YO3AOP1 recombinant carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay	2013	Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6	The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
AID1061069	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by stopped flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1	Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.
AID436563	Inhibition of human recombinant CA1 by stopped-flow CO2 assay	2009	Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
AID238256	Ki value against human carbonic anhydrase VII	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
AID275809	Inhibition of catalytic domain of human recombinant CA IX	2007	Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2	Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
AID743515	Inhibition of human recombinant carbonic anhydrase 1 preincubated for 15 mins by CO2 hydration stopped-flow assay	2013	Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6	The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
AID1142834	Inhibition of human carbonic anhydrase-2 by stopped-flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry, Jun-01, Volume: 22, Issue:11	Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID244146	Selectivity for Carbonic anhydrase II to that of Carbonic anhydrase V	2004	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22	Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
AID222126	Inhibition of cloned isozyme, human carbonic anhydrase II	2001	Bioorganic & medicinal chemistry letters, Feb-26, Volume: 11, Issue:4	Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.
AID1628037	Inhibition of human cytosolic carbonic anhydrase 2 preincubated for 15 mins by stop flow CO2 hydrase assay	2016	Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17	Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.
AID1278410	Inhibition of Porphyromonas gingivalis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
AID1275912	Inhibition of human Carbonic anhydrase2 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID275808	Inhibition of human recombinant cytosolic isozyme CA II by stopped-flow CO2 hydrase method	2007	Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2	Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
AID669116	Inhibition of Cryptococcus neoformans Can2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID238536	Inhibitory activity against human carbonic anhydrase I (hCAI)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
AID1268962	Inhibition of recombinant human carbonic anhydrase-1 by stopped flow CO2 hydrase assay	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
AID367822	Inhibition of Saccharomyces cerevisiae recombinant CA expressed in Escherichia coli by stopped-flow CO2 hydrase assay	2009	Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3	Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
AID648181	Inhibition of human wild type carbonic anhydrase 2 Leu204Ser mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	2012	Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7	Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.
AID644381	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by stopped flow CO2 hydration assay	2012	Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4	Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
AID1268963	Inhibition of recombinant human carbonic anhydrase-2 by stopped flow CO2 hydrase assay	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
AID239145	Inhibitory activity against alpha carbonic anhydrase (Co-Cam) from Methanosarcina thermophila	2004	Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24	Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID669119	Inhibition of GST-tagged Malassezia globosa ATCC 96807/CBS 7966 MG-CA expressed in Escherichia coli BL21(DE3) cells preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID1142837	Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-2 assessed as CO2 hydrase activity by stopped-flow assay	2014	Bioorganic & medicinal chemistry, Jun-01, Volume: 22, Issue:11	Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID1190063	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydration assay	2015	Bioorganic & medicinal chemistry, Feb-01, Volume: 23, Issue:3	Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.
AID1275913	Inhibition of human Carbonic anhydrase1 using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID577527	Inhibition of human carbonic anhydrase II by spectrophotometry at pH 7.5	2011	Bioorganic & medicinal chemistry, Feb-01, Volume: 19, Issue:3	A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
AID612725	Inhibition of human recombinant carbonic anhydrase 1 at pH 7.5 by stopped flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16	Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
AID1061169	Inhibition of recombinant Methanosarcina thermophila gamma-CA CAM by stopped flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.
AID1453410	Inhibition of Francisella tularensis beta-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
AID1278413	Inhibition of recombinant Colwellia psychrerythraea gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
AID256964	Inhibitory activity against human recombinant mitochondrial isozyme CA VA	2005	Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24	Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
AID263639	Selectivity for Helicobacter pylori recombinant CA over human recombinant CA2	2006	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8	Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
AID256963	Inhibitory activity against human recombinant cytosolic CA2	2005	Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24	Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
AID577526	Inhibition of human carbonic anhydrase I by spectrophotometry at pH 7.5	2011	Bioorganic & medicinal chemistry, Feb-01, Volume: 19, Issue:3	A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
AID367820	Inhibition of human recombinant CA1 by stopped-flow CO2 hydrase assay	2009	Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3	Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
AID427122	Inhibition of Candida albicans recombinant Nce103 by stopped-flow CO2 hydration assay	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
AID1287518	Inhibition of human carbonic anhydrase 2 incubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.
AID239250	Inhibitory activity against beta carbonic anhydrase (Cab) from Methanobacterium thermoautotrophicum	2004	Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24	Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID648180	Inhibition of human wild type carbonic anhydrase 2 Gln92Val mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	2012	Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7	Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.
AID349607	Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase 1 encoded by Rv1284 by stopped flow CO2 hydration assay	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
AID239146	Inhibitory activity against alpha carbonic anhydrase (Zn-Cam) from Methanosarcina thermophila	2004	Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24	Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID1628036	Inhibition of full length human cytosolic carbonic anhydrase 1 preincubated for 15 mins by stop flow CO2 hydrase assay	2016	Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17	Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.
AID299242	Inhibition of human carbonic anhydrase 1 by stopped-flow CO2 hydrase assay	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
AID427124	Inhibition of Helicobacter pylori beta-carbonic anhydrase by stopped-flow CO2 hydration assay	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
AID299243	Inhibition of human carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
AID299250	Inhibition of Helicobacter pylori beta carbonic anhydrase by stopped-flow CO2 hydrase assay	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
AID612731	Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 1 at pH 8.3 by stopped flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16	Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
AID238247	Ki value against human carbonic anhydrase I	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
AID261580	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydrase assay	2006	Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6	Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
AID726232	Inhibition of Trypanosoma cruzi CL Brener recombinant alpha-carbonic anhydrase expressed in insect Sf9 cell Baculovirus system by stopped flow CO2 hydration assay	2013	Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4	Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.
AID725956	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	2013	Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4	Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.
AID1142838	Inhibition of Helicobacter pylori carbonic anhydrase by stopped-flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry, Jun-01, Volume: 22, Issue:11	Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID299540	Inhibition of human CA3	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID275806	Inhibition of full length human recombinant CA VI	2007	Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2	Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
AID1195369	Inhibition of human carbonic anhydrase 1 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	2015	Bioorganic & medicinal chemistry, May-15, Volume: 23, Issue:10	The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.
AID48300	Inhibitory activity against human cloned carbonic anhydrase isozyme IX, by CO2 hydrase assay method.	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
AID1204106	Inhibition of recombinant Streptococcus mutans UA159 beta-carbonic anhydrase expressed in Escherichia coli Arctic cells preincubated for 15 mins by stopped flow CO2 hydrase assay	2015	Bioorganic & medicinal chemistry letters, Jun-01, Volume: 25, Issue:11	Sulfonamide inhibition study of the β-class carbonic anhydrase from the caries producing pathogen Streptococcus mutans.
AID47901	Inhibitory activity against Human carbonic anhydrase II	2002	Journal of medicinal chemistry, Mar-28, Volume: 45, Issue:7	Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
AID367821	Inhibition of human recombinant CA2 by stopped-flow CO2 hydrase assay	2009	Bioorganic & medicinal chemistry, Feb-01, Volume: 17, Issue:3	Carbonic anhydrase inhibitors: inhibition of the beta-class enzyme from the yeast Saccharomyces cerevisiae with sulfonamides and sulfamates.
AID299544	Inhibition of human CA6	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID1434428	Inhibition of human carbonic anhydrase 2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
AID1188135	Inhibition of human recombinant Carbonic anhydrase 2 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.
AID436564	Inhibition of human recombinant CA2 by stopped-flow CO2 assay	2009	Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
AID239102	Inhibitory constant against catalytic domain of human carbonic anhydrase IX	2005	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17	Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
AID648178	Inhibition of human wild type carbonic anhydrase 2 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	2012	Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7	Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.
AID1240215	Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase by CO2 hydration assay	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID1278411	Inhibition of Nostoc commune gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
AID301578	Inhibition of human recombinant CA 3 assessed as CO2 hydration by stopped flow kinetic assay	2007	Bioorganic & medicinal chemistry, Dec-01, Volume: 15, Issue:23	Carbonic anhydrase inhibitors: cloning, characterization, and inhibition studies of the cytosolic isozyme III with sulfonamides.
AID552129	Inhibition of human recombinant CA6 by stopped-flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID238986	Inhibitory activity against human carbonic anhydrase II at 0.01 uM	2004	Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24	Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID299541	Inhibition of human CA4	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID349608	Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 3 expressed in Escherichia coli BL21 by stopped flow CO2 hydration assay	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
AID222125	Inhibition of cloned isozyme, human carbonic anhydrase I	2001	Bioorganic & medicinal chemistry letters, Feb-26, Volume: 11, Issue:4	Carbonic anhydrase inhibitors: synthesis of sulfonamides incorporating dtpa tails and of their zinc complexes with powerful topical antiglaucoma properties.
AID552127	Inhibition of human recombinant CA1 by stopped-flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID497127	Inhibition of wild type human recombinant carbonic anhydrase 1 expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.
AID243011	Selectivity ratio against human carbonic anhydrases II and XII	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
AID243090	Ratio of inhibition of carbonic anhydrase IV in human to that of carbonic anhydrase IV in bovine	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
AID47935	Inhibitory activity against human recombinant carbonic anhydrase II	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
AID1188138	Inhibition of Porphyromonas gingivalis Gamma-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.
AID239703	Inhibitory constant against human carbonic anhydrase XIV in CO2 hydrase assay	2005	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17	Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
AID729566	Inhibition of human esterase activity of carbonic anhydrase 1 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6	Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.
AID299549	Inhibition of human CA14	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID50371	Inhibitory activity against human cloned carbonic anhydrase isozyme I by esterase assay method.	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
AID299551	Inhibition of Helicobacter pylori beta CA	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID48280	Inhibitory activity against bovine carbonic anhydrase isozyme IV isolated from bovine lung microsomes, by esterase assay method.	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
AID263048	Inhibition of human CA1	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.
AID48096	Inhibition of human carbonic anhydrase II (hCA II)	2000	Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10	Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.
AID1195370	Inhibition of human carbonic anhydrase 2 pre-incubated for 15 mins by stopped-flow CO2 hydration assay	2015	Bioorganic & medicinal chemistry, May-15, Volume: 23, Issue:10	The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.
AID50353	Inhibitory activity against Human carbonic anhydrase I	2002	Journal of medicinal chemistry, Mar-28, Volume: 45, Issue:7	Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
AID1275910	Inhibition of Vibrio cholerae beta-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID1061068	Inhibition of Leishmania donovani chagasi recombinant beta-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1	Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.
AID50367	Inhibitory activity against human carbonic anhydrase I (CA1)	2000	Journal of medicinal chemistry, Jan-27, Volume: 43, Issue:2	Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
AID48284	Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes	1999	Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18	Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
AID1188136	Inhibition of Helicobacter pylori Beta-carbonic anhydrase compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.
AID238567	Ki value against murine carbonic anhydrase XIII was determined; (not tested)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
AID47932	Inhibitory activity against human carbonic anhydrase II (CA2)	2000	Journal of medicinal chemistry, Jan-27, Volume: 43, Issue:2	Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
AID1278409	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins by CO2 hydrase stopped flow assay	2016	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
AID263049	Inhibition of human CA2	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.
AID1061170	Inhibition of Porphyromonas gingivalis gamma-carbonic anhydrase expressed in Escherichia coli preincubated for 15 mins by stopped flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the oral pathogen Porphyromonas gingivalis.
AID459696	Inhibition of Brucella suis CA1 expressed in Escherichia coli BL21(DE3) by stopped-flow CO2-hydration assay	2010	Journal of medicinal chemistry, Mar-11, Volume: 53, Issue:5	Cloning, characterization, and inhibition studies of a beta-carbonic anhydrase from Brucella suis.
AID238300	Ki value against human carbonic anhydrase II (hCA II)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
AID238957	Inhibitory activity against human carbonic anhydrase I at 0.09 uM	2004	Bioorganic & medicinal chemistry letters, Dec-20, Volume: 14, Issue:24	Carbonic anhydrase inhibitors. Inhibition of the prokariotic beta and gamma-class enzymes from Archaea with sulfonamides.
AID1278412	Inhibition of Pseudoalteromonas haloplanktis gamma carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 26, Issue:4	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Colwellia psychrerythraea.
AID1194024	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	2015	Bioorganic & medicinal chemistry, Apr-15, Volume: 23, Issue:8	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
AID47717	Inhibition of human carbonic anhydrase I (CAI)	2003	Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3	Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.
AID1434430	Inhibition of Vibrio cholerae Gamma-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
AID1194028	Inhibition of recombinant Nostoc commune gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydrase assay	2015	Bioorganic & medicinal chemistry, Apr-15, Volume: 23, Issue:8	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
AID299547	Inhibition of human CA12	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID238575	Inhibitory activity against human carbonic anhydrase IV (hCAIV)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
AID669121	Antimicrobial activity against Malassezia dermatis CBS 9145 after 7 days	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID369275	Inhibition of mouse recombinant carbonic anhydrase 15 by stopped flow CO2 hydrase assay	2009	Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
AID1291363	Inhibition of recombinant Vibrio cholerae gamma-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID729567	Inhibition of sheep kidney esterase activity of carbonic anhydrase using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6	Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.
AID50370	Inhibitory activity against human cloned carbonic anhydrase isozyme I (hCA I, cytosolic form).	1999	Journal of medicinal chemistry, Jul-15, Volume: 42, Issue:14	Carbonic anhydrase inhibitors. Synthesis of water-soluble, topically effective, intraocular pressure-lowering aromatic/heterocyclic sulfonamides containing cationic or anionic moieties: is the tail more important than the ring?
AID48291	Inhibition of bovine carbonic anhydrase IV (CAIV)	2003	Bioorganic & medicinal chemistry letters, Feb-10, Volume: 13, Issue:3	Modelling of carbonic anhydrase inhibitory activity of sulfonamides using molecular negentropy.
AID349605	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
AID261582	Selectivity ratio for human carbonic anhydrase 2 over Helicobacter pylori carbonic anhydrase	2006	Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6	Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
AID238255	Ki value against human carbonic anhydrase II	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the human cytosolic isozyme VII with aromatic and heterocyclic sulfonamides.
AID299542	Inhibition of human CA5A	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID1142836	Inhibition of Legionella pneumophilia subsp. Pneumophila strain Philadelphia-1 carbonic anhydrase-1 assessed as CO2 hydrase activity by stopped-flow assay	2014	Bioorganic & medicinal chemistry, Jun-01, Volume: 22, Issue:11	Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID299550	Inhibition of Helicobacter pylori alpha CA	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID1453413	Inhibition of human carbonic anhydrase-2 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
AID299545	Inhibition of human CA7	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID414961	Inhibition of Mycobacterium tuberculosis H37Rv recombinant beta-carbonic anhydrase 1 expressed in Escherichia coli BL21 by stopped flow CO2 hydration method	2009	Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8	Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
AID48122	Inhibitory activity against bovine carbonic anhydrase IV	2002	Journal of medicinal chemistry, Mar-28, Volume: 45, Issue:7	Carbonic anhydrase inhibitors. A general approach for the preparation of water-soluble sulfonamides incorporating polyamino-polycarboxylate tails and of their metal complexes possessing long-lasting, topical intraocular pressure-lowering properties.
AID263638	Inhibition of Helicobacter pylori recombinant CA	2006	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8	Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
AID1142833	Inhibition of human carbonic anhydrase-1 by stopped-flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry, Jun-01, Volume: 22, Issue:11	Sulfonamide inhibition studies of two β-carbonic anhydrases from the bacterial pathogen Legionella pneumophila.
AID263050	Inhibition of bovine CA4	2006	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 16, Issue:7	QSAR study on topically acting sulfonamides incorporating GABA moieties: a molecular connectivity approach.
AID552128	Inhibition of human recombinant CA2 by stopped-flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID427125	Inhibition of human recombinant carbonic anhydrase 1 by stopped-flow CO2 hydrase method	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
AID47713	Inhibition of human carbonic anhydrase I (CAI)	2000	Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10	Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.
AID238597	Inhibitory activity against bovine carbonic anhydrase IV (bCAIV)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the membrane-bound human and bovine isozymes IV with sulfonamides.
AID1291355	Inhibition of recombinant Vibrio cholerae beta-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID241604	Inhibitory concentration against human cystolic isozyme II of Carbonic anhydrase	2004	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22	Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
AID1195371	Inhibition of Anopheles gambiae carbonic anhydrase pre-incubated for 15 mins by stopped-flow CO2 hydration assay	2015	Bioorganic & medicinal chemistry, May-15, Volume: 23, Issue:10	The β-carbonic anhydrase from the malaria mosquito Anopheles gambiae is highly inhibited by sulfonamides.
AID299552	Inhibition of Methanosarcina thermophila gamma CA	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID263637	Inhibition of human recombinant CA2	2006	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8	Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
AID1291358	Inhibition of recombinant human carbonic anhydrase 2 preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID729565	Inhibition of human esterase activity of carbonic anhydrase 2 using 4-nitrophenylacetate as substrate after 3 mins by spectrophotometric analysis	2013	Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6	Purification and characterization of carbonic anhydrase from sheep kidney and effects of sulfonamides on enzyme activity.
AID48296	Inhibitory activity against human tumor-associated transmembrane carbonic anhydrase IX.	2004	Bioorganic & medicinal chemistry letters, Jun-21, Volume: 14, Issue:12	Carbonic anhydrase inhibitors: the first QSAR study on inhibition of tumor-associated isoenzyme IX with aromatic and heterocyclic sulfonamides.
AID497128	Inhibition of human recombinant carbonic anhydrase 1 Phe91Asn mutant expressed in Escherichia coli BL21 (DE3) after 15 mins by CO2 hydration method	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.
AID369274	Inhibition of human recombinant carbonic anhydrase 9 catalytic domain by stopped flow CO2 hydrase assay	2009	Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
AID239126	Inhibitory constant against catalytic domain of human carbonic anhydrase XII	2005	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 15, Issue:17	Carbonic anhydrase inhibitors: inhibition of the transmembrane isozyme XIV with sulfonamides.
AID669115	Inhibition of human carbonic anhydrase 2 preincubated for 15 mins measured for 10 to 100 sec by stopped-flow method	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID414956	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration method	2009	Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8	Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
AID47936	Inhibition of human carbonic anhydrase II	2003	Bioorganic & medicinal chemistry letters, Mar-24, Volume: 13, Issue:6	Carbonic anhydrase inhibitors: inhibition of the tumor-associated isozyme IX with aromatic and heterocyclic sulfonamides.
AID1287519	Inhibition of Vibrio cholerae beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.
AID612726	Inhibition of human recombinant carbonic anhydrase 2 at pH 7.5 by stopped flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16	Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
AID238276	Ki value against human carbonic anhydrase I (hCA I)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
AID1287517	Inhibition of human carbonic anhydrase 1 incubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.
AID552130	Inhibition of Stylophora pistillata carbonic anhydrase by stopped-flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID1190064	Inhibition of human recombinant carbonic anhydrase 2 by stopped-flow CO2 hydration assay	2015	Bioorganic & medicinal chemistry, Feb-01, Volume: 23, Issue:3	Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.
AID299548	Inhibition of mouse CA13	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID711212	Inhibition of recombinant Vibrio cholerae carbonic anhydrase expressed in Escherichia coli (DE3) preincubated for 15 mins by stopped-flow CO2 hydrase assay	2012	Journal of medicinal chemistry, Dec-13, Volume: 55, Issue:23	DNA cloning, characterization, and inhibition studies of an α-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID552131	Inhibition of Stylophora pistillata carbonic anhydrase 2 by stopped-flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 21, Issue:2	Carbonic anhydrase inhibitors. Inhibition studies with anions and sulfonamides of a new cytosolic enzyme from the scleractinian coral Stylophora pistillata.
AID1287520	Inhibition of recombinant Enterobacter sp. B13 beta carbonic anhydrase incubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-01, Volume: 26, Issue:7	Sulfonamide inhibition studies of the β-carbonic anhydrase from the newly discovered bacterium Enterobacter sp. B13.
AID263636	Inhibition of human recombinant CA1	2006	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 16, Issue:8	Carbonic anhydrase inhibitors: cloning and sulfonamide inhibition studies of a carboxyterminal truncated alpha-carbonic anhydrase from Helicobacter pylori.
AID481329	Inhibition of human carbonic anhydrase 2	2010	Bioorganic & medicinal chemistry letters, May-15, Volume: 20, Issue:10	3D-QSAR study of benzene sulfonamide analogs as carbonic anhydrase II inhibitors.
AID669123	Antimicrobial activity against Malassezia globosa CBS 7966 after 7 days	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID349606	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydration assay	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
AID261581	Inhibition of Helicobacter pylori recombinant carbonic anhydrase by stopped-flow CO2 hydrase assay	2006	Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6	Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
AID436565	Inhibition of cloned Stylophora pistillata alpha-CA expressed in human HEK293 cells by stopped-flow CO2 assay	2009	Bioorganic & medicinal chemistry, Jul-15, Volume: 17, Issue:14	Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides.
AID497129	Inhibition of human recombinant carbonic anhydrase 2 after 15 mins by CO2 hydration method	2010	Bioorganic & medicinal chemistry, Aug-01, Volume: 18, Issue:15	Mutation of Phe91 to Asn in human carbonic anhydrase I unexpectedly enhanced both catalytic activity and affinity for sulfonamide inhibitors.
AID437750	Inhibition of full length Mycobacterium tuberculosis H37Rv recombinant carbonic anhydrase 2 encoded by RV3588c by stopped flow CO2 hydration assay	2009	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23	Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
AID299539	Inhibition of human CA2	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID1268964	Inhibition of recombinant Sulfurihydrogenibium yellowstonense YO3AOP1 carbonic anhydrase by stopped flow CO2 hydrase assay	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
AID1240214	Inhibition of Nostoc commune gamma carbonic anhydrase by CO2 hydration assay	2015	Bioorganic & medicinal chemistry letters, Sep-01, Volume: 25, Issue:17	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic bacterium Pseudoalteromonas haloplanktis.
AID1275911	Inhibition of Vibrio cholerae alpha-carbonic anhydrase using CO2 as substrate preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry, Mar-01, Volume: 24, Issue:5	Sulfonamide inhibition studies of the β-carbonic anhydrase from the pathogenic bacterium Vibrio cholerae.
AID299543	Inhibition of human CA5B	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID577530	Inhibition of Brucella suis carbonic anhydrase II by spectrophotometry at pH 8.3	2011	Bioorganic & medicinal chemistry, Feb-01, Volume: 19, Issue:3	A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
AID743513	Inhibition of Helicobacter pylori recombinant alpha carbonic anhydrase preincubated for 15 mins by CO2 hydration stopped-flow assay	2013	Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6	The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
AID1291361	Inhibition of recombinant Vibrio cholerae alpha-carbonic anhydrase preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID1061066	Inhibition of Thalassiosira weissflogii delta carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1	Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.
AID1268965	Inhibition of recombinant Thiomicrospira crunogena XCL-2 carbonic anhydrase by stopped flow CO2 hydrase assay	2016	Bioorganic & medicinal chemistry letters, Jan-15, Volume: 26, Issue:2	Sulfonamide inhibition studies of the α-carbonic anhydrase from the gammaproteobacterium Thiomicrospira crunogena XCL-2, TcruCA.
AID644379	Inhibition of GST-tagged astrosclera willeyana Astrosclerin-3 expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	2012	Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4	Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
AID299538	Inhibition of human CA1	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID1434427	Inhibition of recombinant human carbonic anhydrase 1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
AID414955	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration method	2009	Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8	Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
AID48289	Inhibition of bovine carbonic anhydrase IV from bovine lung microsomes	2000	Bioorganic & medicinal chemistry letters, May-15, Volume: 10, Issue:10	Carbonic anhydrase inhibitors: synthesis of N-morpholylthiocarbonylsulfenylamino aromatic/heterocyclic sulfonamides and their interaction with isozymes I, II and IV.
AID778725	Inhibition of recombinant Leishmania donovani chagasi beta-carbonic anhydrase expressed in baculovirus infected insect Sf9 cells incubated for 15 mins prior to testing by stopped flow CO2 hydrase assay	2013	Journal of medicinal chemistry, Sep-26, Volume: 56, Issue:18	Cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Leishmania donovani chagasi, the protozoan parasite responsible for leishmaniasis.
AID256965	Inhibitory activity against human recombinant mitochondrial isozyme CA VB	2005	Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24	Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
AID1194025	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	2015	Bioorganic & medicinal chemistry, Apr-15, Volume: 23, Issue:8	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
AID238316	Ki value against human carbonic anhydrase XII (hCA XII)	2005	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 15, Issue:4	Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglaucoma drugs?
AID612732	Inhibition of Salmonella Typhimurium recombinant carbonic anhydrase 2 at pH 8.3 by stopped flow CO2 hydration assay	2011	Bioorganic & medicinal chemistry, Aug-15, Volume: 19, Issue:16	Inhibition studies of the β-carbonic anhydrases from the bacterial pathogen Salmonella enterica serovar Typhimurium with sulfonamides and sulfamates.
AID1291357	Inhibition of recombinant human carbonic anhydrase 1 preincubated for 15 mins by stopped-flow CO2 hydration assay	2016	Bioorganic & medicinal chemistry letters, Apr-15, Volume: 26, Issue:8	Comparison of the sulfonamide inhibition profiles of the α-, β- and γ-carbonic anhydrases from the pathogenic bacterium Vibrio cholerae.
AID577531	Inhibition of Brucella suis carbonic anhydrase I by spectrophotometry at pH 8.3	2011	Bioorganic & medicinal chemistry, Feb-01, Volume: 19, Issue:3	A new β-carbonic anhydrase from Brucella suis, its cloning, characterization, and inhibition with sulfonamides and sulfamates, leading to impaired pathogen growth.
AID241574	Inhibitory concentration against human cystolic isozyme V of Carbonic anhydrase	2004	Bioorganic & medicinal chemistry letters, Nov-15, Volume: 14, Issue:22	Carbonic anhydrase inhibitors: inhibition of human cytosolic isozyme II and mitochondrial isozyme V with a series of benzene sulfonamide derivatives.
AID644380	Inhibition of human recombinant carbonic anhydrase 1 after 15 mins by stopped flow CO2 hydration assay	2012	Bioorganic & medicinal chemistry, Feb-15, Volume: 20, Issue:4	Cloning, characterization and sulfonamide inhibition studies of an α-carbonic anhydrase from the living fossil sponge Astrosclera willeyana.
AID648179	Inhibition of human wild type carbonic anhydrase 2 Asn67Ile mutant expressed in Escherichia coli after 15 mins preincubation by stopped flow CO2 hydration assay	2012	Bioorganic & medicinal chemistry, Apr-01, Volume: 20, Issue:7	Mutation of active site residues Asn67 to Ile, Gln92 to Val and Leu204 to Ser in human carbonic anhydrase II: influences on the catalytic activity and affinity for inhibitors.
AID437749	Inhibition of human recombinant CA2 by stopped-flow hydration assay	2009	Bioorganic & medicinal chemistry letters, Dec-01, Volume: 19, Issue:23	Carbonic anhydrase inhibitors. Characterization and inhibition studies of the most active beta-carbonic anhydrase from Mycobacterium tuberculosis, Rv3588c.
AID725955	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydration assay	2013	Journal of medicinal chemistry, Feb-28, Volume: 56, Issue:4	Cloning, characterization, and sulfonamide and thiol inhibition studies of an α-carbonic anhydrase from Trypanosoma cruzi, the causative agent of Chagas disease.
AID1434429	Inhibition of Burkholderia pseudomallei Gamma-carbonic anhydrase assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 sec by Line-Weaver Burk plot analysis
AID427123	Inhibition of Cryptococcus neoformans recombinant Can2 by stopped-flow CO2 hydration assay	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
AID1628038	Inhibition of recombinant Plasmodium falciparum eta-carbonic anhydrase (181 to 538 residues) expressed in Escherichia coli artic express (DE3) preincubated for 15 mins by stop flow CO2 hydrase assay	2016	Bioorganic & medicinal chemistry letters, 09-01, Volume: 26, Issue:17	Cloning, expression, purification and sulfonamide inhibition profile of the complete domain of the η-carbonic anhydrase from Plasmodium falciparum.
AID1194026	Inhibition of recombinant Methanosarcina thermophila gamma-carbonic anhydrase by stopped flow CO2 hydrase assay	2015	Bioorganic & medicinal chemistry, Apr-15, Volume: 23, Issue:8	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
AID275807	Inhibition of human recombinant cytosolic isozyme CA I by stopped-flow CO2 hydrase method	2007	Journal of medicinal chemistry, Jan-25, Volume: 50, Issue:2	Carbonic anhydrase inhibitors. DNA cloning, characterization, and inhibition studies of the human secretory isoform VI, a new target for sulfonamide and sulfamate inhibitors.
AID744415	Inhibition of recombinant full length Candida glabrata NCE103 expressed in Escherichia coli BL21 preincubated for 15 mins by stopped-flow CO2 hydrase assay	2013	Bioorganic & medicinal chemistry letters, May-01, Volume: 23, Issue:9	Carbonic anhydrase inhibitors: inhibition of the β-class enzyme from the pathogenic yeast Candida glabrata with sulfonamides, sulfamates and sulfamides.
AID743514	Inhibition of human recombinant carbonic anhydrase 2 preincubated for 15 mins by CO2 hydration stopped-flow assay	2013	Bioorganic & medicinal chemistry, Mar-15, Volume: 21, Issue:6	The alpha-carbonic anhydrase from the thermophilic bacterium Sulfurihydrogenibium yellowstonense YO3AOP1 is highly susceptible to inhibition by sulfonamides.
AID1061067	Inhibition of Porphyromonas gingivalis recombinant gamma-carbonic anhydrase preincubated for 15 mins by stopped flow CO2 hydration assay	2014	Bioorganic & medicinal chemistry letters, Jan-01, Volume: 24, Issue:1	Sulfonamide inhibition studies of the δ-carbonic anhydrase from the diatom Thalassiosira weissflogii.
AID1453412	Inhibition of human carbonic anhydrase-1 assessed as reduction in CO2 hydration preincubated for 15 mins followed by CO2 addition measured for 10 to 100 secs by stopped-flow assay
AID470873	Inhibition of carbonic anhydrase 2 assessed as inhibition of carbon dioxide hydration	2009	European journal of medicinal chemistry, Sep, Volume: 44, Issue:9	A QSAR study on relationship between structure of sulfonamides and their carbonic anhydrase inhibitory activity using the eigenvalue (EVA) method.
AID369272	Inhibition of human recombinant carbonic anhydrase 2 by stopped flow CO2 hydrase assay	2009	Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
AID48279	Inhibitory activity against bovine carbonic anhydrase IV (CA4), isolated from bovine lung microsomes	2000	Journal of medicinal chemistry, Jan-27, Volume: 43, Issue:2	Carbonic anhydrase inhibitors: synthesis of membrane-impermeant low molecular weight sulfonamides possessing in vivo selectivity for the membrane-bound versus cytosolic isozymes.
AID50374	Inhibitory activity against human recombinant carbonic anhydrase I (CA1)	1999	Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18	Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
AID299249	Inhibition of Helicobacter pylori alpha carbonic anhydrase by stopped-flow CO2 hydrase assay	2007	Bioorganic & medicinal chemistry letters, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors: the beta-carbonic anhydrase from Helicobacter pylori is a new target for sulfonamide and sulfamate inhibitors.
AID669120	Antimicrobial activity against Malassezia furfur CBS 9569 after 7 days	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID1188134	Inhibition of human recombinant Carbonic anhydrase 1 compound preincubated for 15 mins by stopped flow CO2 hydrase assay method	2014	Bioorganic & medicinal chemistry, Sep-01, Volume: 22, Issue:17	Sulfonamide inhibition study of the carbonic anhydrases from the bacterial pathogen Porphyromonas gingivalis: the β-class (PgiCAb) versus the γ-class (PgiCA) enzymes.
AID1194027	Inhibition of recombinant Porphyromonas gingivalis gamma-carbonic anhydrase by stopped flow CO2 hydrase assay	2015	Bioorganic & medicinal chemistry, Apr-15, Volume: 23, Issue:8	Sulfonamide inhibition studies of the γ-carbonic anhydrase from the Antarctic cyanobacterium Nostoc commune.
AID369273	Inhibition of human full length recombinant carbonic anhydrase 6 by stopped flow CO2 hydrase assay	2009	Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
AID369271	Inhibition of human recombinant carbonic anhydrase 1 by stopped flow CO2 hydrase assay	2009	Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
AID392788	Potentiation of AMPA receptor mediated KA-induced current in Sprague-Dawley rat primary cerebellar granule neurons at 200 uM	2009	Bioorganic & medicinal chemistry letters, Feb-15, Volume: 19, Issue:4	A novel class of allosteric modulators of AMPA/Kainate receptors.
AID1190065	Inhibition of Plasmodium falciparum Eta-carbonic anhydrase pre-incubated for 15 mins before CO2 substrate addition by stopped-flow CO2 hydration assay	2015	Bioorganic & medicinal chemistry, Feb-01, Volume: 23, Issue:3	Sulfonamide inhibition studies of the η-class carbonic anhydrase from the malaria pathogen Plasmodium falciparum.
AID47939	Inhibitory activity against human recombinant carbonic anhydrase II (CA2)	1999	Journal of medicinal chemistry, Sep-09, Volume: 42, Issue:18	Carbonic anhydrase inhibitors: synthesis of water-soluble, aminoacyl/dipeptidyl sulfonamides possessing long-lasting intraocular pressure-lowering properties via the topical route.
AID669122	Antimicrobial activity against Malassezia pachydermatis CBS 6536 after 7 days	2012	Journal of medicinal chemistry, Apr-12, Volume: 55, Issue:7	Molecular cloning, characterization, and inhibition studies of a β-carbonic anhydrase from Malassezia globosa, a potential antidandruff target.
AID1798769	CA Inhibition Assay from Article 10.1021/jm801267c: \\Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.\\	2009	Journal of medicinal chemistry, Feb-12, Volume: 52, Issue:3	Cloning, expression, post-translational modifications and inhibition studies on the latest mammalian carbonic anhydrase isoform, CA XV.
AID1796582	CA Inhibition Assay from Article 10.1021/jm050483n: \\Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.\\	2005	Journal of medicinal chemistry, Dec-01, Volume: 48, Issue:24	Carbonic anhydrase inhibitors. The mitochondrial isozyme VB as a new target for sulfonamide and sulfamate inhibitors.
AID1798985	CA Inhibition Assay from Article 10.1021/jm9000488: \\Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.\\	2009	Journal of medicinal chemistry, Apr-23, Volume: 52, Issue:8	Molecular cloning, characterization, and inhibition studies of the Rv1284 beta-carbonic anhydrase from Mycobacterium tuberculosis with sulfonamides and a sulfamate.
AID1796552	CA Inhibition Assay from Article 10.1021/jm0512600: \\Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.\\	2006	Journal of medicinal chemistry, Mar-23, Volume: 49, Issue:6	Carbonic anhydrase inhibitors: DNA cloning and inhibition studies of the alpha-carbonic anhydrase from Helicobacter pylori, a new target for developing sulfonamide and sulfamate gastric drugs.
AID1799266	CA Inhibition Assay from Article 10.1016/j.bmc.2009.05.002: \\Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.\\	2009	Bioorganic & medicinal chemistry, Jul-01, Volume: 17, Issue:13	Carbonic anhydrase inhibitors. Inhibition and homology modeling studies of the fungal beta-carbonic anhydrase from Candida albicans with sulfonamides.
AID1798982	CA Inhibition Assay from Article 10.1021/jm9003126: \\Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.\\	2009	Journal of medicinal chemistry, May-14, Volume: 52, Issue:9	Carbonic anhydrase inhibitors. Cloning, characterization, and inhibition studies of a new beta-carbonic anhydrase from Mycobacterium tuberculosis.
AID977610	Experimentally measured binding affinity data (Ki) for protein-ligand complexes derived from PDB	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
AID1811	Experimentally measured binding affinity data derived from PDB	2007	Bioorganic & medicinal chemistry letters, Aug-01, Volume: 17, Issue:15	Carbonic anhydrase inhibitors: inhibition of human, bacterial, and archaeal isozymes with benzene-1,3-disulfonamides--solution and crystallographic studies.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	1 (1.47)	18.7374
1990's	4 (5.88)	18.2507
2000's	31 (45.59)	29.6817
2010's	32 (47.06)	24.3611
2020's	0 (0.00)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	68 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
hydrobromic acid Hydrobromic Acid: Hydrobromic acid (HBr). A solution of hydrogen bromide gas in water.. hydrobromide : Salts formally resulting from the reaction of hydrobromic acid with an organic base.. hydrogen bromide : A diatomic molecule containing covalently bonded hydrogen and bromine atoms.	2.06	1	gas molecular entity; hydrogen halide; mononuclear parent hydride	mouse metabolite
hydrochloric acid Hydrochloric Acid: A strong corrosive acid that is commonly used as a laboratory reagent. It is formed by dissolving hydrogen chloride in water. GASTRIC ACID is the hydrochloric acid component of GASTRIC JUICE.. hydrogen chloride : A mononuclear parent hydride consisting of covalently bonded hydrogen and chlorine atoms.	2.06	1	chlorine molecular entity; gas molecular entity; hydrogen halide; mononuclear parent hydride	mouse metabolite
hydrogen sulfide Hydrogen Sulfide: A flammable, poisonous gas with a characteristic odor of rotten eggs. It is used in the manufacture of chemicals, in metallurgy, and as an analytical reagent. (From Merck Index, 11th ed). hydrogen sulfide : A sulfur hydride consisting of a single sulfur atom bonded to two hydrogen atoms. A highly poisonous, flammable gas with a characteristic odour of rotten eggs, it is often produced by bacterial decomposition of organic matter in the absence of oxygen.. thiol : An organosulfur compound in which a thiol group, -SH, is attached to a carbon atom of any aliphatic or aromatic moiety.	2.06	1	gas molecular entity; hydracid; mononuclear parent hydride; sulfur hydride	Escherichia coli metabolite; genotoxin; metabolite; signalling molecule; toxin; vasodilator agent
cyanic acid [no description available]	2.06	1	one-carbon compound; pseudohalogen oxoacid
carbonic acid Carbonic Acid: Carbonic acid (H2C03). The hypothetical acid of carbon dioxide and water. It exists only in the form of its salts (carbonates), acid salts (hydrogen carbonates), amines (carbamic acid), and acid chlorides (carbonyl chloride). (From Grant & Hackh's Chemical Dictionary, 5th ed)	2.06	1	carbon oxoacid; chalcocarbonic acid	mouse metabolite
hydrogen cyanide Hydrogen Cyanide: Hydrogen cyanide (HCN); A toxic liquid or colorless gas. It is found in the smoke of various tobacco products and released by combustion of nitrogen-containing organic materials.. hydrogen cyanide : A one-carbon compound consisting of a methine group triple bonded to a nitrogen atom	2.06	1	hydracid; one-carbon compound	Escherichia coli metabolite; human metabolite; poison
thiocyanic acid thiocyanic acid : A hydracid that is cyanic acid in which the oxygen is replaced by a sulfur atom.	2.06	1	hydracid; one-carbon compound; organosulfur compound	Escherichia coli metabolite
nitric acid Nitric Acid: Nitric acid (HNO3). A colorless liquid that is used in the manufacture of inorganic and organic nitrates and nitro compounds for fertilizers, dye intermediates, explosives, and many different organic chemicals. Continued exposure to vapor may cause chronic bronchitis; chemical pneumonitis may occur. (From Merck Index, 11th ed). nitric acid : A nitrogen oxoacid of formula HNO3 in which the nitrogen atom is bonded to a hydroxy group and by equivalent bonds to the remaining two oxygen atoms.	2.06	1	nitrogen oxoacid	protic solvent; reagent
sulfurous acid [no description available]	2.06	1	sulfur oxoacid
sulfuric acid sulfuric acid : A sulfur oxoacid that consists of two oxo and two hydroxy groups joined covalently to a central sulfur atom.	2.06	1	sulfur oxoacid	catalyst
acetazolamide Acetazolamide: One of the CARBONIC ANHYDRASE INHIBITORS that is sometimes effective against absence seizures. It is sometimes useful also as an adjunct in the treatment of tonic-clonic, myoclonic, and atonic seizures, particularly in women whose seizures occur or are exacerbated at specific times in the menstrual cycle. However, its usefulness is transient often because of rapid development of tolerance. Its antiepileptic effect may be due to its inhibitory effect on brain carbonic anhydrase, which leads to an increased transneuronal chloride gradient, increased chloride current, and increased inhibition. (From Smith and Reynard, Textbook of Pharmacology, 1991, p337)	5.38	55	monocarboxylic acid amide; sulfonamide; thiadiazoles	anticonvulsant; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor
althiazide [no description available]	2.05	1	benzothiadiazine
celecoxib [no description available]	5.04	38	organofluorine compound; pyrazoles; sulfonamide; toluenes	cyclooxygenase 2 inhibitor; geroprotector; non-narcotic analgesic; non-steroidal anti-inflammatory drug
chlorothiazide Chlorothiazide: A thiazide diuretic with actions and uses similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p812). thiazide : Heterocyclic compound with sulfur and nitrogen in the ring.. chlorothiazide : 4H-1,2,4-benzothiadiazine 1,1-dioxide in which the hydrogen at position is substituted by chlorine and that at position 7 is substituted by a sulfonamide group. A diuretic, it is used for treatment of oedema and hypertension.	2.41	2	benzothiadiazine	antihypertensive agent; diuretic
dichlorphenamide Dichlorphenamide: A carbonic anhydrase inhibitor that is used in the treatment of glaucoma.. diclofenamide : A sulfonamide that is benzene-1,3-disulfonamide in which the hydrogens at positions 4 and 5 are substituted by chlorine. An oral carbonic anhydrase inhibitor, it partially suppresses the secretion (inflow) of aqueous humor in the eye and so reduces intraocular pressure. It is used for the treatment of glaucoma.	5.28	49	dichlorobenzene; sulfonamide	antiglaucoma drug; EC 4.2.1.1 (carbonic anhydrase) inhibitor; ophthalmology drug
ethoxzolamide Ethoxzolamide: A carbonic anhydrase inhibitor used as diuretic and in glaucoma. It may cause hypokalemia.. ethoxzolamide : A sulfonamide that is 1,3-benzothiazole-2-sulfonamide which is substituted by an ethoxy group at position 6. A carbonic anhydrase inhibitor, it has been used in the treatment of glaucoma, and as a diuretic.	5.33	52	aromatic ether; benzothiazoles; sulfonamide	antiglaucoma drug; diuretic; EC 4.2.1.1 (carbonic anhydrase) inhibitor
hydrochlorothiazide Hydrochlorothiazide: A thiazide diuretic often considered the prototypical member of this class. It reduces the reabsorption of electrolytes from the renal tubules. This results in increased excretion of water and electrolytes, including sodium, potassium, chloride, and magnesium. It is used in the treatment of several disorders including edema, hypertension, diabetes insipidus, and hypoparathyroidism.. hydrochlorothiazide : A benzothiadiazine that is 3,4-dihydro-2H-1,2,4-benzothiadiazine 1,1-dioxide substituted by a chloro group at position 6 and a sulfonamide at 7. It is diuretic used for the treatment of hypertension and congestive heart failure.	4.63	25	benzothiadiazine; organochlorine compound; sulfonamide	antihypertensive agent; diuretic; environmental contaminant; xenobiotic
idra 21 IDRA 21: modulates AMPA receptor desensitization ; structure given in first source	2.05	1	benzothiadiazine
ketoconazole 1-acetyl-4-(4-{[2-(2,4-dichlorophenyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methoxy}phenyl)piperazine : A dioxolane that is 1,3-dioxolane which is substituted at positions 2, 2, and 4 by imidazol-1-ylmethyl, 2,4-dichlorophenyl, and [para-(4-acetylpiperazin-1-yl)phenoxy]methyl groups, respectively.	2.07	1	dichlorobenzene; dioxolane; ether; imidazoles; N-acylpiperazine; N-arylpiperazine
mafenide Mafenide: A sulfonamide that inhibits the enzyme CARBONIC ANHYDRASE and is used as a topical anti-bacterial agent, especially in burn therapy.	5.43	58	aromatic amine
methazolamide Methazolamide: A carbonic anhydrase inhibitor that is used as a diuretic and in the treatment of glaucoma.	5.33	52	sulfonamide; thiadiazoles
saccharin Saccharin: Flavoring agent and non-nutritive sweetener.. saccharin : A 1,2-benzisothiazole having a keto-group at the 3-position and two oxo substituents at the 1-position. It is used as an artificial sweetening agent.	4.82	30	1,2-benzisothiazole; N-sulfonylcarboxamide	environmental contaminant; sweetening agent; xenobiotic
sulfaguanidine Sulfaguanidine: A sulfanilamide antimicrobial agent that is used to treat enteric infections.. sulfaguanidine : A sulfonamide incorporating a guanidine moiety used to block the synthesis of folic acid; mostly used in veterinary medicine	2.02	1	sulfonamide antibiotic	antiinfective agent
sulfanilamide [no description available]	5.43	58	substituted aniline; sulfonamide antibiotic; sulfonamide	antibacterial agent; drug allergen; EC 4.2.1.1 (carbonic anhydrase) inhibitor
sulpiride Sulpiride: A dopamine D2-receptor antagonist. It has been used therapeutically as an antidepressant, antipsychotic, and as a digestive aid. (From Merck Index, 11th ed). sulpiride : A member of the class of benzamides obtained from formal condensation between the carboxy group of 2-methoxy-5-sulfamoylbenzoic acid and the primary amino group of (1-ethylpyrrolidin-2-yl)methylamine.	5.09	40	benzamides; N-alkylpyrrolidine; sulfonamide	antidepressant; antiemetic; antipsychotic agent; dopaminergic antagonist
sulthiame sulthiame: was heading 1964-94 (see under THIAZINES 1964-90); use THIAZINES to search SULTHIAME 1966-94	4.79	29	organic molecular entity
trichlormethiazide Trichlormethiazide: A thiazide diuretic with properties similar to those of HYDROCHLOROTHIAZIDE. (From Martindale, The Extra Pharmacopoeia, 30th ed, p830). trichlormethiazide : A benzothiadiazine, hydrogenated at positions 2, 3 and 4 and substituted with an aminosulfonyl group at C-7, a chloro substituent at C-6 and a dichloromethyl group at C-3 and with S-1 as an S,S-dioxide. A sulfonamide antibiotic, it is used as a diuretic to treat oedema (including that associated with heart failure) and hypertension.	2.03	1	benzothiadiazine; sulfonamide antibiotic	antihypertensive agent; diuretic
zonisamide Zonisamide: A benzisoxazole and sulfonamide derivative that acts as a CALCIUM CHANNEL blocker. It is used primarily as an adjunctive antiepileptic agent for the treatment of PARTIAL SEIZURES, with or without secondary generalization.. zonisamide : A 1,2-benzoxazole compound having a sulfamoylmethyl substituent at the 3-position.	5.09	40	1,2-benzoxazoles; sulfonamide	anticonvulsant; antioxidant; central nervous system drug; protective agent; T-type calcium channel blocker
sulfamic acid sulfamic acid: standard in alkalimetry; RN given refers to parent cpd; structure. sulfamic acid : The simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to hydroxy and amino groups and by double bonds to two oxygen atoms.	2.44	2	sulfamic acids
4-toluenesulfonamide 4-toluenesulfonamide: RN given refers to parent cpd. toluene-4-sulfonamide : A sulfonamide that is benzenesulfonamide bearing a methyl group at position 4.	5.13	42	sulfonamide
benzenearsonic acid benzenearsonic acid: RN given refers to parent cpd; structure	2.06	1	arsonic acids; organoarsonic acid
benzenesulfonamide [no description available]	2.48	2	sulfonamide
neoprontosil neoprontosil: RN given refers to parent cpd	2.03	1
carzenide [no description available]	5.2	45	sulfonamide
hydrofluoric acid Hydrofluoric Acid: Hydrofluoric acid. A solution of hydrogen fluoride in water. It is a colorless fuming liquid which can cause painful burns.. hydrogen fluoride : A diatomic molecule containing covalently bonded hydrogen and fluorine atoms.. organofluorine compound : An organofluorine compound is a compound containing at least one carbon-fluorine bond.	2.06	1	hydrogen halide; mononuclear parent hydride	NMR chemical shift reference compound
benzolamide Benzolamide: Selective renal carbonic anhydrase inhibitor. It may also be of use in certain cases of respiratory failure.	5.15	43
nitrous acid Nitrous Acid: Nitrous acid (HNO2). A weak acid that exists only in solution. It can form water-soluble nitrites and stable esters. (From Merck Index, 11th ed)	2.06	1	nitrogen oxoacid
hydrazoic acid [no description available]	2.06	1	nitrogen hydride
hydroiodic acid hydrogen iodide : A diatomic molecule containing covalently bonded hydrogen and iodine atoms.	2.06	1	gas molecular entity; hydrogen halide; mononuclear parent hydride	mouse metabolite
benzonidazole benzonidazole: used in treatment of Chagas' disease. benznidazole : A monocarboxylic acid amide obtained by formal condensation of the carboxy group of (2-nitroimidazol-1-yl)acetic acid with the aromatic amino group of benzylamine. Used for treatment of Chagas disease.	2.08	1	C-nitro compound; imidazoles; monocarboxylic acid amide	antiprotozoal drug
2-aminosulfonyl-benzoic acid methyl ester 2-aminosulfonyl-benzoic acid methyl ester : A benzoate ester that is methyl benzoate substituted by a sulfamoyl group at position 2. It is a metabolite of the herbicide metsulfuron-methyl.	2.02	1	benzoate ester; methyl ester; sulfonamide	marine xenobiotic metabolite
benzeneboronic acid [no description available]	2.06	1	boronic acids
2-benzothiazolesulfonamide 2-benzothiazolesulfonamide: structure given in first source	2.02	1	benzothiazoles; sulfonamide
disulphane [no description available]	4.63	25
brinzolamide brinzolamide: an antiglaucoma agent	5.27	49	sulfonamide; thienothiazine	antiglaucoma drug; EC 4.2.1.1 (carbonic anhydrase) inhibitor
2,4-disulfamyl-5-trifluoromethylaniline 2,4-disulfamyl-5-trifluoromethylaniline: precursor of hydroflumethiazide	5.27	49
4-bromobenzenesulfonamide 4-bromobenzenesulfonamide: a metabolite of ebrotidine	2.07	1
2-aminobenzenesulfonamide [no description available]	5.03	39	benzenes; sulfonamide
sulfamide sulfamide : The simplest of the sulfamic acids consisting of a single sulfur atom covalently bound by single bonds to two amino groups and by double bonds to two oxygen atoms.	2.44	2	sulfamides
5-amino-1,3,4-thiadiazole-2-sulfonamide 5-amino-1,3,4-thiadiazole-2-sulfonamide: structure in first source	5.38	55
aminozolamide aminozolamide: used in therapy of ocular hypertension	3.52	8
6-hydroxyethoxzolamide 6-hydroxyethoxzolamide: structure given in first source	3.4	7
valdecoxib [no description available]	4.99	36	isoxazoles; sulfonamide	antipyretic; antirheumatic drug; cyclooxygenase 2 inhibitor; non-narcotic analgesic; non-steroidal anti-inflammatory drug
naphthalenesulfonamide [no description available]	2.72	3
chlorzolamide chlorzolamide: structure	4.49	22
4-(2-aminoethyl)benzenesulfonamide [no description available]	5.47	60
n-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide N-(3-chloro-7-indolyl)-1,4-benzenedisulphonamide: structure in first source. indisulam : A chloroindole that is 3-chloro-1H-indole substituted by a [(4-sulfamoylphenyl)sulfonyl]nitrilo group at position 7. It is a carbonic anhydrase inhibitor and a potential anti-cancer agent currently in clinical development.	5.07	39	chloroindole; organochlorine compound; sulfonamide	antineoplastic agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor
1-(4-chlorophenyl)-3-(4-sulfamoylphenyl)urea [no description available]	2.08	1	sulfonamide
2,6-dibromosulfanilamide 2,6-dibromosulfanilamide: structure in first source	3.15	5
benzene-1-3-disulfonamide [no description available]	4.25	16	sulfonamide
dorzolamide dorzolamide: topically effective ocular hypotensive carbonic anhydrase inhibitor; RN refers to mono-HCl (4S-trans)-isomer. dorzolamide : 5,6-Dihydro-4H-thieno[2,3-b]thiopyran-2-sulfonamide 7,7-dioxide in which hydrogens at the 4 and 6 positions are substituted by ethylamino and methyl groups, respectively (4S, trans-configuration). A carbonic anhydrase inhibitor, it is used as the hydrochloride in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.	5.35	53	sulfonamide; thiophenes	antiglaucoma drug; antihypertensive agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor
topiramate Topiramate: A sulfamate-substituted fructose analog that was originally identified as a hypoglycemic agent. It is used for the treatment of EPILEPSY and MIGRAINE DISORDERS, and may also promote weight loss.. topiramate : A hexose derivative that is 2,3:4,5-di-O-isopropylidene-beta-D-fructopyranose in which the hydroxy group has been converted to the corresponding sulfamate ester. It blocks voltage-dependent sodium channels and is used as an antiepileptic and for the prevention of migraine.	5.24	47	cyclic ketal; ketohexose derivative; sulfamate ester	anticonvulsant; sodium channel blocker
6-hydroxybenzothiazide-2-sulfonamide 6-hydroxybenzothiazide-2-sulfonamide: structure given in first source	4.51	23
l 671152 dorzolamide hydrochloride : The hydrochloride salt of dorzolamide. It is used in ophthalmic solutions to lower increased intraocular pressure in the treatment of open-angle glaucoma and ocular hypertension.	2	1	hydrochloride; organoammonium salt	antiglaucoma drug; antihypertensive agent; EC 4.2.1.1 (carbonic anhydrase) inhibitor

Condition	Relationship Strength	Studies
Intraocular Pressure The pressure of the fluids in the eye.	2.69	3
Disease Models, Animal Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	2	1
Glaucoma An ocular disease, occurring in many forms, having as its primary characteristics an unstable or a sustained increase in the intraocular pressure which the eye cannot withstand without damage to its structure or impairment of its function. The consequences of the increased pressure may be manifested in a variety of symptoms, depending upon type and severity, such as excavation of the optic disk, hardness of the eyeball, corneal anesthesia, reduced visual acuity, seeing of colored halos around lights, disturbed dark adaptation, visual field defects, and headaches. (Dictionary of Visual Science, 4th ed)	2.92	4
Benign Neoplasms [description not available]	2.01	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.01	1
Cancer of Stomach [description not available]	2.44	2
Gastric Ulcer [description not available]	2.44	2
Gastritis Inflammation of the GASTRIC MUCOSA, a lesion observed in a number of unrelated disorders.	2.03	1
Stomach Neoplasms Tumors or cancer of the STOMACH.	2.44	2
Stomach Ulcer Ulceration of the GASTRIC MUCOSA due to contact with GASTRIC JUICE. It is often associated with HELICOBACTER PYLORI infection or consumption of nonsteroidal anti-inflammatory drugs (NSAIDS).	2.44	2
Brucella Infection [description not available]	2.05	1
Brucellosis Infection caused by bacteria of the genus BRUCELLA mainly involving the MONONUCLEAR PHAGOCYTE SYSTEM. This condition is characterized by fever, weakness, malaise, and weight loss.	2.05	1
Infections, Salmonella [description not available]	2.06	1
Dermatomycoses Superficial infections of the skin or its appendages by any of various fungi.	2.07	1
Scalp Dermatoses Skin diseases involving the SCALP.	2.07	1
American Trypanosomiasis [description not available]	2.08	1
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	2.08	1
Leishmania Infection [description not available]	2.08	1
Leishmaniasis A disease caused by any of a number of species of protozoa in the genus LEISHMANIA. There are four major clinical types of this infection: cutaneous (Old and New World) (LEISHMANIASIS, CUTANEOUS), diffuse cutaneous (LEISHMANIASIS, DIFFUSE CUTANEOUS), mucocutaneous (LEISHMANIASIS, MUCOCUTANEOUS), and visceral (LEISHMANIASIS, VISCERAL).	2.08	1
Vibrio cholerae Infection [description not available]	2.13	1
Cholera An acute diarrheal disease endemic in India and Southeast Asia whose causative agent is VIBRIO CHOLERAE. This condition can lead to severe dehydration in a matter of hours unless quickly treated.	2.13	1
Cronobacter Infections [description not available]	2.13	1
Enterobacteriaceae Infections Infections with bacteria of the family ENTEROBACTERIACEAE.	2.13	1
Sensitivity and Specificity Binary classification measures to assess test results. Sensitivity or recall rate is the proportion of true positives. Specificity is the probability of correctly determining the absence of a condition. (From Last, Dictionary of Epidemiology, 2d ed)	2.05	1

4-amino-6-chloro-1,3-benzenedisulfonamide

Description

Cross-References

Synonyms (80)

Drug Classes (1)

Protein Targets (41)

Inhibition Measurements

Other Measurements

Biological Processes (20)

Molecular Functions (8)

Ceullar Components (26)

Bioassays (234)

Research

Studies (68)

Market Indicators

Research Demand Index: 24.54

Study Types

4-amino-6-chloro-1,3-benzenedisulfonamide

Description

Cross-References

Synonyms (80)

Drug Classes (1)

Protein Targets (41)

Inhibition Measurements

Other Measurements

Biological Processes (20)

Molecular Functions (8)

Ceullar Components (26)

Bioassays (234)

Research

Studies (68)

Market Indicators

Research Demand Index: 24.54

Study Types

Related Drugs (64)

Related Conditions (24)