trypanothione has been researched along with Chagas Disease in 11 studies
*Chagas Disease: Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON. [MeSH]
| Timeframe | Studies, this research(%) | All Research% |
|---|---|---|
| pre-1990 | 0 (0.00) | 18.7374 |
| 1990's | 1 (9.09) | 18.2507 |
| 2000's | 2 (18.18) | 29.6817 |
| 2010's | 6 (54.55) | 24.3611 |
| 2020's | 2 (18.18) | 2.80 |
| Authors | Studies |
|---|---|
| Garg, NJ; Mesías, AC; Zago, MP | 1 |
| González-Chávez, Z; Moreno-Sánchez, R; Saavedra, E; Vázquez, C | 1 |
| Costi, R; Di Santo, R; Saccoliti, F | 1 |
| Beig, M; Garoff, L; Krauth-Siegel, RL; Noack, S; Oellien, F; Selzer, PM | 1 |
| Alberca, LN; Balcazar, D; Benitez, D; Carrillo, C; Comini, M; Fraccaroli, L; Medeiros, A; Sbaraglini, ML; Talevi, A | 1 |
| Campos-Estrada, C; Castro, L; Cortes, L; Díaz, MV; Kemmerling, U; Lapier, M; López-Muñoz, R; Maya, JD; Miranda, MR; Morello, A; Pereira, CA; Reigada, C; Seguel, V | 1 |
| Bocedi, A; Dawood, KF; Fabrini, R; Federici, G; Gradoni, L; Pedersen, JZ; Ricci, G | 1 |
| Campillo, NE; Páez, JA; Sánchez-Sancho, F | 1 |
| Heby, O; Persson, L; Rentala, M | 1 |
| D'Silva, C; Daunes, S | 1 |
| Bradley, M; Nadeau, K; Walsh, C | 1 |
6 review(s) available for trypanothione and Chagas Disease
| Article | Year |
|---|---|
Redox Balance Keepers and Possible Cell Functions Managed by Redox Homeostasis in
Topics: Animals; Antioxidants; Antiparasitic Agents; Chagas Disease; Glutathione; Homeostasis; Humans; Insect Vectors; Nitrosative Stress; Oxidants; Oxidation-Reduction; Oxidative Stress; Reactive Oxygen Species; Signal Transduction; Spermidine; Trypanosoma cruzi | 2019 |
Recent Advancement in the Search of Innovative Antiprotozoal Agents Targeting Trypanothione Metabolism.
Topics: Amide Synthases; Amidohydrolases; Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmania; Leishmaniasis; NADH, NADPH Oxidoreductases; Protozoan Proteins; Spermidine; Trypanocidal Agents; Trypanosoma | 2020 |
Chagas disease: progress and new perspectives.
Topics: Chagas Disease; Enzyme Inhibitors; Ergosterol; Glutathione; Humans; Hypoxanthine Phosphoribosyltransferase; Spermidine; Trypanosoma cruzi | 2010 |
Targeting the polyamine biosynthetic enzymes: a promising approach to therapy of African sleeping sickness, Chagas' disease, and leishmaniasis.
Topics: Adenosine; Adenosylmethionine Decarboxylase; Animals; Biogenic Polyamines; Chagas Disease; Eflornithine; Enzyme Inhibitors; Glutathione; Humans; Leishmania; Leishmaniasis; Ornithine Decarboxylase Inhibitors; Robenidine; Spermidine; Spermidine Synthase; Trypanocidal Agents; Trypanosoma brucei gambiense; Trypanosoma brucei rhodesiense; Trypanosoma cruzi; Trypanosomiasis, African | 2007 |
The therapeutic potential of inhibitors of the trypanothione cycle.
Topics: Animals; Chagas Disease; Enzyme Inhibitors; Glutathione; Humans; Leishmaniasis; NADH, NADPH Oxidoreductases; Receptors, Peptide; Spermidine; Structure-Activity Relationship; Thioredoxins; Trypanocidal Agents; Trypanosomiasis, African | 2002 |
Molecular studies on trypanothione reductase: an antiparasitic target enzyme.
Topics: Amino Acid Sequence; Animals; Antiprotozoal Agents; Binding Sites; Chagas Disease; Crithidia; Drug Design; Glutathione; Glutathione Reductase; Leishmania; Molecular Sequence Data; Mutagenesis, Site-Directed; NADH, NADPH Oxidoreductases; Oxidation-Reduction; Prevalence; Protein Engineering; Protozoan Proteins; Spermidine; Substrate Specificity; Trypanosoma; Trypanosoma congolense; Trypanosomiasis, African | 1992 |
5 other study(ies) available for trypanothione and Chagas Disease
| Article | Year |
|---|---|
Metabolic Control Analysis for Drug Target Prioritization in Trypanosomatids.
Topics: Cell Extracts; Chagas Disease; Computer Simulation; Drug Development; Glutathione; Humans; Kinetics; Metabolic Networks and Pathways; Metabolomics; Models, Biological; Molecular Targeted Therapy; Protozoan Proteins; Recombinant Proteins; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 2020 |
Trypanothione reductase: a target protein for a combined in vitro and in silico screening approach.
Topics: Chagas Disease; Chlorhexidine; Computer Simulation; Drug Evaluation, Preclinical; Enzyme Inhibitors; Glutathione; Inhibitory Concentration 50; Kinetics; Models, Molecular; NADH, NADPH Oxidoreductases; Protozoan Proteins; Quinacrine; Spermidine; Trypanocidal Agents; Trypanosoma cruzi | 2015 |
Discovery of novel polyamine analogs with anti-protozoal activity by computer guided drug repositioning.
Topics: Amide Synthases; Antiprotozoal Agents; Chagas Disease; Computer Simulation; Drug Repositioning; Glutathione; Humans; Imidazoles; Nitroimidazoles; Polyamines; Spermidine; Thiophenes; Trypanosoma cruzi; User-Computer Interface | 2016 |
Pentamidine antagonizes the benznidazole's effect in vitro, and lacks of synergy in vivo: Implications about the polyamine transport as an anti-Trypanosoma cruzi target.
Topics: Animals; Chagas Disease; Chlorocebus aethiops; DNA, Protozoan; Dose-Response Relationship, Drug; Glutathione; Macrophages; Male; Mice; Mice, Inbred BALB C; Myocardium; Nitroimidazoles; Parasitemia; Pentamidine; Putrescine; Random Allocation; Spermidine; Thymidine; Trypanocidal Agents; Trypanosoma cruzi; Vero Cells | 2016 |
Trypanothione efficiently intercepts nitric oxide as a harmless iron complex in trypanosomatid parasites.
Topics: Animals; Chagas Disease; Dose-Response Relationship, Drug; Glutathione; Iron; Leishmania infantum; NADH, NADPH Oxidoreductases; Nitric Oxide; Nitrogen Oxides; Protozoan Proteins; Spermidine; Trypanosoma brucei brucei; Trypanosomiasis, African | 2010 |