kusunokinin

Description Research Excerpts Clinical Trials Roles Classes Pathways Study Profile Bioassays Related Drugs Related Conditions Protein Interactions Research Growth Market Indicators

Description

kusunokinin: a trypanocidal agent isolated from Aristolochia cymbifera; structure in first source [Medical Subject Headings (MeSH), National Library of Medicine, extracted Dec-2023]

Flora	Rank	Flora Definition	Family	Family Definition
Aristolochia	genus	A plant genus of the family ARISTOLOCHIACEAE. Species of this genus have been used in traditional medicine but they contain aristolochic acid which is associated with nephropathy. These are sometimes called 'snakeroot' but that name is also used with a number of other plants such as POLYGALA; SANICULA; ASARUM; ARISTOLOCHIA; AGERATINA; and others.[MeSH]	Aristolochiaceae	A plant family of the order Aristolochiales subclass Magnoliidae class Magnoliopsida. They are mostly tropical woody vines and a few temperate-zone species. The flowers are 3-parted; some species lack petals while others are large and foul smelling.[MeSH]

Cross-References

ID Source	ID
PubMed CID	384876
CHEMBL ID	2228191
MeSH ID	M0555534

Synonyms (14)

Synonym
nsc-675472
nsc675472
kusunokinin
(3r,4r)-3-(1,3-benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]oxolan-2-one
CHEMBL2228191
(-)-kusunokinin
LEVKKQBBEVGIKN-JKSUJKDBSA-N
2(3h)-furanone, 3-(1,3-benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]dihydro-, (3r,4r)-
(3r,4r)-3-(benzo[d][1,3]dioxol-5-ylmethyl)-4-(3,4-dimethoxybenzyl)dihydrofuran-2(3h)-one
2(3h)-furanone, 3-(1,3-benzodioxol-5-ylmethyl)-4-[(3,4-dimethoxyphenyl)methyl]dihydro-, (3r-trans)-
CS-0636350
HY-N10798
FS-7617
AKOS040734704

[information is derived through text-mining from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Bioassays (3)

Assay ID	Title	Year	Journal	Article
AID1080350	Insecticidal activity against Anticarsia gemmatalis (velvetbean caterpillar) third-instar larvae exposed to compound through topical dosing at mesothorax region assessed as induction of larval mortality	2008	Journal of agricultural and food chemistry, Apr-23, Volume: 56, Issue:8	Evaluation of insecticidal activity of diterpenes and lignans from Aristolochia malmeana against Anticarsia gemmatalis.
AID1662706	Cytotoxicity against Spodoptera frugiperda Sf9 cells assessed as reduction in cell viability	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Discovery of stereospecific cytotoxicity of (8R,8'R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring.
AID1662704	Cytotoxicity against Aedes albopictus NIAS-AeAl-2 cells assessed as reduction in cell viability	2020	Bioorganic & medicinal chemistry letters, 07-01, Volume: 30, Issue:13	Discovery of stereospecific cytotoxicity of (8R,8'R)-trans-arctigenin against insect cells and structure-activity relationship on aromatic ring.
[information is prepared from bioassay data collected from National Library of Medicine (NLM), extracted Dec-2023]

Research

Studies (8)

Timeframe	Studies, This Drug (%)	All Drugs %
pre-1990	0 (0.00)	18.7374
1990's	0 (0.00)	18.2507
2000's	1 (12.50)	29.6817
2010's	2 (25.00)	24.3611
2020's	5 (62.50)	2.80
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Market Indicators

Research Demand Index: 12.66

According to the monthly volume, diversity, and competition of internet searches for this compound, as well the volume and growth of publications, there is estimated to be weak demand-to-supply ratio for research on this compound.

Metric	This Compound (vs All)
Research Demand Index	12.66 (24.57)
Research Supply Index	2.20 (2.92)
Research Growth Index	4.86 (4.65)
Search Engine Demand Index	0.00 (26.88)
Search Engine Supply Index	0.00 (0.95)

This Compound (12.66)

All Compounds (24.57)

Study Types

Publication Type	This drug (%)	All Drugs (%)
Trials	0 (0.00%)	5.53%
Reviews	0 (0.00%)	6.00%
Case Studies	0 (0.00%)	4.05%
Observational	0 (0.00%)	0.25%
Other	8 (100.00%)	84.16%
[information is prepared from research data collected from National Library of Medicine (NLM), extracted Dec-2023]

Substance	Relationship Strength	Studies	Classes	Roles
methylnitrosourea Methylnitrosourea: A nitrosourea compound with alkylating, carcinogenic, and mutagenic properties.. N-methyl-N-nitrosourea : A member of the class of N-nitrosoureas that is urea in which one of the nitrogens is substituted by methyl and nitroso groups.	2.25	1	N-nitrosoureas	alkylating agent; carcinogenic agent; mutagen; teratogenic agent
arctigenin arctigenin: precursor to catechols; in many plants	2.25	1	lignan
bursehernin bursehernin: a dibenzylbutyrolactone found in PODOPHYLLIN; analog of podorhizol; RN & N1 from CA Vol 90 Form Index; structure in first source. (-)-bursehernin : A butan-4-olide that is (-)-pluviatolide in which the phenolic hydroxy group has been converted to the corresponding methyl ether.	7.21	1	aromatic ether; benzodioxoles; butan-4-olide; lignan	plant metabolite
hinokinin hinokinin: suppresses expression of both HBsAg and HBeAg. hinokinin : A lignan that is dihydrofuran-2(3H)-one (gamma-butyrolactone) substituted by a 3,4-methylenedioxybenzyl group at positions 3 and 4 (the 3R,4R-diastereoisomer).	2.04	1	benzodioxoles; gamma-lactone; lignan	trypanocidal drug
lignans Lignans: A class of dibenzylbutane derivatives which occurs in higher plants and in fluids (bile, serum, urine, etc.) in man and other animals. These compounds, which have a potential anti-cancer role, can be synthesized in vitro by human fecal flora. (From Singleton & Sainsbury, Dictionary of Microbiology and Molecular Biology, 2d ed)	3.27	5
hki 272 [no description available]	2.31	1	nitrile; quinolines	antineoplastic agent; tyrosine kinase inhibitor
copalic acid copalic acid: a trypanocidal agent isolated from Aristolochia cymbifera; structure in first source	2.05	1	diterpenoid
cyclin d1 Cyclin D1: Protein encoded by the bcl-1 gene which plays a critical role in regulating the cell cycle. Overexpression of cyclin D1 is the result of bcl-1 rearrangement, a t(11;14) translocation, and is implicated in various neoplasms.	2.25	1

Condition	Relationship Strength	Studies
Cholangiocellular Carcinoma [description not available]	3.33	4
Bile Duct Cancer [description not available]	3.33	4
Breast Cancer [description not available]	3.61	6
Bile Duct Neoplasms Tumors or cancer of the BILE DUCTS.	3.33	4
Breast Neoplasms Tumors or cancer of the human BREAST.	3.61	6
Cholangiocarcinoma A malignant tumor arising from the epithelium of the BILE DUCTS.	3.33	4
Experimental Mammary Neoplasms [description not available]	2.25	1
Benign Neoplasms [description not available]	2.21	1
Neoplasms New abnormal growth of tissue. Malignant neoplasms show a greater degree of anaplasia and have the properties of invasion and metastasis, compared to benign neoplasms.	2.21	1
American Trypanosomiasis [description not available]	2.05	1
Chagas Disease Infection with the protozoan parasite TRYPANOSOMA CRUZI, a form of TRYPANOSOMIASIS endemic in Central and South America. It is named after the Brazilian physician Carlos Chagas, who discovered the parasite. Infection by the parasite (positive serologic result only) is distinguished from the clinical manifestations that develop years later, such as destruction of PARASYMPATHETIC GANGLIA; CHAGAS CARDIOMYOPATHY; and dysfunction of the ESOPHAGUS or COLON.	2.05	1

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